MX2020008061A - Pirazolopirimidinas sustituidas con cicloalquilo que tienen actividad contra vrs. - Google Patents

Pirazolopirimidinas sustituidas con cicloalquilo que tienen actividad contra vrs.

Info

Publication number
MX2020008061A
MX2020008061A MX2020008061A MX2020008061A MX2020008061A MX 2020008061 A MX2020008061 A MX 2020008061A MX 2020008061 A MX2020008061 A MX 2020008061A MX 2020008061 A MX2020008061 A MX 2020008061A MX 2020008061 A MX2020008061 A MX 2020008061A
Authority
MX
Mexico
Prior art keywords
activity against
cycloalkyl substituted
against rsv
substituted pyrazolopyrimidines
compounds
Prior art date
Application number
MX2020008061A
Other languages
English (en)
Inventor
Antoine Benjamin Michaut
David Francis Alain Lançois
Dirk André Emmy Roymans
Pierre Jean- Marie Bernard RABOISSON
Peter Rigaux
Jérome Émile Georges Guillemont
Original Assignee
Janssen Sciences Ireland Unlimited Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Unlimited Co filed Critical Janssen Sciences Ireland Unlimited Co
Publication of MX2020008061A publication Critical patent/MX2020008061A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención trata sobre compuestos de formula (I) que tienen actividad antivirica, en particular, que tienen una actividad inhibidora sobre la replicación del virus respiratorio sincicial (VRS). La invención trata además sobre composiciones farmacéuticas que comprenden estos compuestos y los compuestos para su uso en el tratamiento de la infección por el virus respiratorio sincicial. (Ver Fórmula I).
MX2020008061A 2018-01-31 2019-01-30 Pirazolopirimidinas sustituidas con cicloalquilo que tienen actividad contra vrs. MX2020008061A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18154314 2018-01-31
PCT/EP2019/052209 WO2019149734A1 (en) 2018-01-31 2019-01-30 Cycloalkyl substituted pyrazolopyrimidines having activity against rsv

Publications (1)

Publication Number Publication Date
MX2020008061A true MX2020008061A (es) 2020-09-09

Family

ID=61132085

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020008061A MX2020008061A (es) 2018-01-31 2019-01-30 Pirazolopirimidinas sustituidas con cicloalquilo que tienen actividad contra vrs.

Country Status (11)

Country Link
US (1) US11491157B2 (es)
EP (1) EP3746444B1 (es)
JP (1) JP7305658B2 (es)
KR (1) KR20200116099A (es)
CN (1) CN111670189A (es)
AU (1) AU2019216260B2 (es)
CA (1) CA3087926A1 (es)
EA (1) EA202091835A1 (es)
MX (1) MX2020008061A (es)
SG (1) SG11202006141RA (es)
WO (1) WO2019149734A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA202091835A1 (ru) 2018-01-31 2020-10-20 Янссен Сайенсиз Айрлэнд Анлимитед Компани Замещенные циклоалкилом пиразолопиримидины, обладающие активностью против rsv
ES2957316T3 (es) 2018-04-23 2024-01-17 Janssen Sciences Ireland Unlimited Co Compuestos heteroaromáticos que tienen actividad contra VSR

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Also Published As

Publication number Publication date
AU2019216260A1 (en) 2020-07-02
US11491157B2 (en) 2022-11-08
EA202091835A1 (ru) 2020-10-20
EP3746444A1 (en) 2020-12-09
JP2021514347A (ja) 2021-06-10
CA3087926A1 (en) 2019-08-08
AU2019216260B2 (en) 2023-03-02
JP7305658B2 (ja) 2023-07-10
US20200360387A1 (en) 2020-11-19
EP3746444B1 (en) 2023-09-27
KR20200116099A (ko) 2020-10-08
SG11202006141RA (en) 2020-07-29
CN111670189A (zh) 2020-09-15
WO2019149734A1 (en) 2019-08-08

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