WO2018084817A3 - A new form of active agent - Google Patents

A new form of active agent Download PDF

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Publication number
WO2018084817A3
WO2018084817A3 PCT/TR2017/000115 TR2017000115W WO2018084817A3 WO 2018084817 A3 WO2018084817 A3 WO 2018084817A3 TR 2017000115 W TR2017000115 W TR 2017000115W WO 2018084817 A3 WO2018084817 A3 WO 2018084817A3
Authority
WO
WIPO (PCT)
Prior art keywords
active agent
new form
crystalline form
new
treatment
Prior art date
Application number
PCT/TR2017/000115
Other languages
French (fr)
Other versions
WO2018084817A2 (en
Inventor
Mahmut Bilgic
Original Assignee
Si̇ma Patent Ve Li̇sanslama Hi̇zmetleri̇ Ltd. Şti̇
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Si̇ma Patent Ve Li̇sanslama Hi̇zmetleri̇ Ltd. Şti̇ filed Critical Si̇ma Patent Ve Li̇sanslama Hi̇zmetleri̇ Ltd. Şti̇
Priority to EP17868134.2A priority Critical patent/EP3430011A4/en
Publication of WO2018084817A2 publication Critical patent/WO2018084817A2/en
Publication of WO2018084817A3 publication Critical patent/WO2018084817A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Abstract

The present invention relates to a new crystalline form of an active agent, the preparation processes of said crystalline form, the pharmaceutical compounds containing said crystalline form and the use of said compounds in the treatment of respiratory system diseases.
PCT/TR2017/000115 2016-11-04 2017-11-03 A new form of active agent WO2018084817A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP17868134.2A EP3430011A4 (en) 2016-11-04 2017-11-03 A new form of active agent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2016/15765 2016-11-04
TR201615765 2016-11-04

Publications (2)

Publication Number Publication Date
WO2018084817A2 WO2018084817A2 (en) 2018-05-11
WO2018084817A3 true WO2018084817A3 (en) 2018-06-07

Family

ID=62076190

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2017/000115 WO2018084817A2 (en) 2016-11-04 2017-11-03 A new form of active agent

Country Status (2)

Country Link
EP (1) EP3430011A4 (en)
WO (1) WO2018084817A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012118460A1 (en) * 2011-02-28 2012-09-07 Mahmut Bilgic Crystalline compound comprising tiotropium bromide
WO2012118461A1 (en) * 2011-03-03 2012-09-07 Mahmut Bilgic Crystalline compound comprising tiotropium bromide
WO2014042605A1 (en) * 2012-09-11 2014-03-20 Mahmut Bilgic New tiotropium bromide crystalline form

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DZ3478A1 (en) * 2000-10-12 2002-04-18 Boehringer Ingelheim Pharma CRYSTALLINE MONOHYDRATE, PROCESS FOR ITS MANUFACTURE AND ITS USE FOR THE MANUFACTURE OF A MEDICAMENT.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012118460A1 (en) * 2011-02-28 2012-09-07 Mahmut Bilgic Crystalline compound comprising tiotropium bromide
WO2012118461A1 (en) * 2011-03-03 2012-09-07 Mahmut Bilgic Crystalline compound comprising tiotropium bromide
WO2014042605A1 (en) * 2012-09-11 2014-03-20 Mahmut Bilgic New tiotropium bromide crystalline form

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP3430011A4 *

Also Published As

Publication number Publication date
WO2018084817A2 (en) 2018-05-11
EP3430011A2 (en) 2019-01-23
EP3430011A4 (en) 2019-08-14

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