AR101403A1 - (4s)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridin-3-carboxamida, su purificación para su uso como principio activo farmacéutico, un procedimiento para su preparación y su empleo en el tratamiento de enfermedades cardiovasculares - Google Patents

(4s)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridin-3-carboxamida, su purificación para su uso como principio activo farmacéutico, un procedimiento para su preparación y su empleo en el tratamiento de enfermedades cardiovasculares

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Publication number
AR101403A1
AR101403A1 ARP150102475A ARP150102475A AR101403A1 AR 101403 A1 AR101403 A1 AR 101403A1 AR P150102475 A ARP150102475 A AR P150102475A AR P150102475 A ARP150102475 A AR P150102475A AR 101403 A1 AR101403 A1 AR 101403A1
Authority
AR
Argentina
Prior art keywords
dihydro
carboxamide
dimethyl
preparation
naftiridin
Prior art date
Application number
ARP150102475A
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English (en)
Inventor
Grunenberg Alfons
Garke Gunner
Platzek Johannes
Original Assignee
Bayer Pharma AG
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51260727&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR101403(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of AR101403A1 publication Critical patent/AR101403A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Biomedical Technology (AREA)
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  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedimiento para la preparación de (4S)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridin-3-carboxamida fórmula (1) así como la preparación y utilización de la modificación cristalina I de (4S)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridin-3-carboxamida de la fórmula (1). Reivindicación 1: El compuesto de la fórmula (1) en forma cristalina de la modificación I caracterizado porque el diagrama de difracción de rayos X del compuesto muestra un pico máximo del ángulo 2q a 8.5, 14.1, 17.2, 19.0, 20.5, 25.6, 26.5.
ARP150102475A 2014-08-01 2015-07-31 (4s)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridin-3-carboxamida, su purificación para su uso como principio activo farmacéutico, un procedimiento para su preparación y su empleo en el tratamiento de enfermedades cardiovasculares AR101403A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14179544 2014-08-01

Publications (1)

Publication Number Publication Date
AR101403A1 true AR101403A1 (es) 2016-12-14

Family

ID=51260727

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150102475A AR101403A1 (es) 2014-08-01 2015-07-31 (4s)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridin-3-carboxamida, su purificación para su uso como principio activo farmacéutico, un procedimiento para su preparación y su empleo en el tratamiento de enfermedades cardiovasculares

Country Status (31)

Country Link
US (4) US10059707B2 (es)
EP (2) EP3174875B1 (es)
JP (1) JP6818674B2 (es)
KR (2) KR102527893B1 (es)
CN (4) CN116655627A (es)
AR (1) AR101403A1 (es)
AU (1) AU2015295376C1 (es)
BR (1) BR112017001678B1 (es)
CA (2) CA2956529A1 (es)
CL (1) CL2017000263A1 (es)
CO (1) CO2017000886A2 (es)
DK (1) DK3174875T3 (es)
ES (1) ES2828704T3 (es)
HR (1) HRP20201800T1 (es)
HU (1) HUE051350T2 (es)
IL (1) IL250239B (es)
JO (1) JO3648B1 (es)
LT (1) LT3174875T (es)
MX (1) MX369467B (es)
MY (1) MY198066A (es)
PE (1) PE20170141A1 (es)
PL (1) PL3174875T3 (es)
PT (1) PT3174875T (es)
RS (1) RS60921B1 (es)
RU (1) RU2729998C9 (es)
SG (1) SG11201700785UA (es)
SI (1) SI3174875T1 (es)
TW (1) TWI684593B (es)
UA (1) UA122773C2 (es)
UY (1) UY36251A (es)
WO (1) WO2016016287A1 (es)

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CN107849043B (zh) * 2015-08-21 2020-10-16 拜耳制药股份公司 用于制备(4s)-4-(4-氰基-2-甲氧基苯基)-5-乙氧基-2,8-二甲基-1,4-二氢-1,6-萘啶-3-甲酰胺的方法
EP3560922A1 (de) 2018-04-24 2019-10-30 Bayer Aktiengesellschaft Verfahren zur herstellung von (4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid durch racemat-spaltung mittels diastereomerer weinsäureester
EP3935044B1 (de) 2019-03-05 2023-04-12 Bayer Aktiengesellschaft Verfahren zur herstellung von 4-amino-5-methylpyridon
WO2020178175A1 (de) 2019-03-05 2020-09-10 Bayer Aktiengesellschaft Synthese von 4-amino-5-methyl-1h-pyridin-2(1h)-on (zwischenverbindung der synthese des mr antagonisten finerenone) aus 2-chloro-5-methyl-4-nitro-pyridine-1-oxid über die zwischenverbindung 2-chloro-5-methyl-4-pyridinamin
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EP4045502A1 (de) * 2019-10-17 2022-08-24 Bayer Aktiengesellschaft Photochemisches verfahren zur herstellung von (4r, 4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid
CN114698375B (zh) * 2019-10-17 2024-08-02 拜耳公司 制备2-氰基乙基(4s)-4-(4-氰基-2-甲氧基苯基)-5-乙氧基-2,8-二甲基-1,4-二氢-1,6-萘啶-3-羧酸酯的方法
CN115916197A (zh) 2020-04-22 2023-04-04 拜耳公司 用于治疗和/或预防心血管和/或肾脏疾病的非奈利酮和sglt2抑制剂的组合
EP3900722A1 (en) 2020-04-22 2021-10-27 Bayer AG Combination of finerenone and pecavaptan for the treatment and/or prevention of cardiovascular and/or renal diseases
TW202214624A (zh) 2020-06-16 2022-04-16 德商拜耳廠股份有限公司 藉由催化不對稱漢斯（ｈａｎｔｚｓｃｈ）酯還原法進行之製備（４ｓ）－４－（４－氰基－２－甲氧基苯基）－５－乙氧基－２，８－二甲基－１，４－二氫－１，６－㖠啶－３－羧醯胺的方法
CN112237573B (zh) * 2020-10-29 2023-12-22 瑞阳制药股份有限公司 含finerenone的片剂及其制备方法
WO2022214206A1 (en) 2021-04-08 2022-10-13 Bayer Aktiengesellschaft Combination of finerenone and pecavaptan for the treatment and/or prevention of cardiovascular and/or renal diseases
CN114149427A (zh) * 2021-12-18 2022-03-08 上海鼎雅药物化学科技有限公司 非奈利酮及其中间体的合成方法
CN115340539B (zh) 2022-01-19 2024-02-27 奥锐特药业股份有限公司 制备非奈利酮及其中间体的方法
CN115340540A (zh) * 2022-01-20 2022-11-15 奥锐特药业股份有限公司 制备非奈利酮及其中间体的方法
CN114524812A (zh) * 2022-03-18 2022-05-24 湖南凯铂生物药业有限公司 1,4-二氢-1,6-萘啶化合物的晶型制备以及合成方法
WO2023205164A1 (en) 2022-04-18 2023-10-26 Teva Pharmaceuticals International Gmbh Processes for the preparation of finerenone
EP4286368A1 (de) 2022-05-31 2023-12-06 Bayer Aktiengesellschaft Verfahren zur herstellung von 4-formyl-3-methoxybenzonitril
WO2024075139A1 (en) * 2022-10-06 2024-04-11 Maithri Drugs Private Limited A process for preparation of finerenone and intermediates thereof
WO2024110523A1 (en) 2022-11-23 2024-05-30 Bayer Aktiengesellschaft Treatment of chronic kidney disease in type i diabetes mellitus
WO2024126694A1 (en) 2022-12-16 2024-06-20 Bayer Aktiengesellschaft Sequential one-pot synthesis for preparing 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide
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