CO2017000886A2 - Procedimiento para la preparación de (4s)-4-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carbox-amida y su purificación para su uso como principio activo farmacéutico - Google Patents

Procedimiento para la preparación de (4s)-4-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carbox-amida y su purificación para su uso como principio activo farmacéutico

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Publication number
CO2017000886A2
CO2017000886A2 CONC2017/0000886A CO2017000886A CO2017000886A2 CO 2017000886 A2 CO2017000886 A2 CO 2017000886A2 CO 2017000886 A CO2017000886 A CO 2017000886A CO 2017000886 A2 CO2017000886 A2 CO 2017000886A2
Authority
CO
Colombia
Prior art keywords
naphthyridine
carboxamide
methoxyphenyl
dihydro
ethoxy
Prior art date
Application number
CONC2017/0000886A
Other languages
English (en)
Inventor
Johannes Platzek
Gunnar Garke
Alfons Grunenberg
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51260727&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO2017000886(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of CO2017000886A2 publication Critical patent/CO2017000886A2/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61P9/06—Antiarrhythmics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invención se refiere a un procedimiento nuevo y mejorado para la preparación de (4S)-4-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carbox-amida de fórmula (I) así como la preparación y utilización de la modificación cristalina I de (4S)-4-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carbox-amida de fórmula (I).
CONC2017/0000886A 2014-08-01 2017-01-31 Procedimiento para la preparación de (4s)-4-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carbox-amida y su purificación para su uso como principio activo farmacéutico CO2017000886A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14179544 2014-08-01
PCT/EP2015/067340 WO2016016287A1 (de) 2014-08-01 2015-07-29 Verfahren zur herstellung von (4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid und dessen aufreinigung für die verwendung als pharmazeutischer wirkstoff

Publications (1)

Publication Number Publication Date
CO2017000886A2 true CO2017000886A2 (es) 2017-05-10

Family

ID=51260727

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2017/0000886A CO2017000886A2 (es) 2014-08-01 2017-01-31 Procedimiento para la preparación de (4s)-4-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carbox-amida y su purificación para su uso como principio activo farmacéutico

Country Status (30)

Country Link
US (4) US10059707B2 (es)
EP (2) EP3174875B1 (es)
JP (1) JP6818674B2 (es)
KR (2) KR20230066477A (es)
CN (4) CN106795155B (es)
AR (1) AR101403A1 (es)
AU (1) AU2015295376C1 (es)
BR (1) BR112017001678B1 (es)
CA (2) CA3146285C (es)
CL (1) CL2017000263A1 (es)
CO (1) CO2017000886A2 (es)
DK (1) DK3174875T3 (es)
ES (1) ES2828704T3 (es)
HR (1) HRP20201800T1 (es)
HU (1) HUE051350T2 (es)
IL (1) IL250239B (es)
JO (1) JO3648B1 (es)
LT (1) LT3174875T (es)
MX (1) MX369467B (es)
MY (1) MY198066A (es)
PE (1) PE20170141A1 (es)
PL (1) PL3174875T3 (es)
PT (1) PT3174875T (es)
RS (1) RS60921B1 (es)
RU (1) RU2729998C9 (es)
SG (1) SG11201700785UA (es)
SI (1) SI3174875T1 (es)
TW (1) TWI684593B (es)
UY (1) UY36251A (es)
WO (1) WO2016016287A1 (es)

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KR20220084101A (ko) * 2019-10-17 2022-06-21 바이엘 악티엔게젤샤프트 부분입체이성질체 타르타르산 에스테르를 사용한 라세미체 분리에 의한 2-시아노에틸 (4s)-4-(4-시아노-2-메톡시페닐)-5-히드록시-2,8-디메틸-1,4-디히드로-1,6-나프티리딘-3-카르복실레이트의 제조 방법
WO2021074077A1 (de) * 2019-10-17 2021-04-22 Bayer Aktiengesellschaft Verfahren zur herstellung von acyloxymethylestern der (4s) -(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbonsäure
JP2023523596A (ja) 2020-04-22 2023-06-06 バイエル アクチェンゲゼルシャフト 心血管疾患および／または腎疾患を治療および／または予防するためのフィネレノンとｓｇｌｔ２阻害剤の組み合わせ
EP3900722A1 (en) 2020-04-22 2021-10-27 Bayer AG Combination of finerenone and pecavaptan for the treatment and/or prevention of cardiovascular and/or renal diseases
WO2021254896A1 (en) 2020-06-16 2021-12-23 Bayer Aktiengesellschaft Process for preparing (4s)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide enabled by a catalytic asymmetric hantzsch ester reduction
CN112237573B (zh) * 2020-10-29 2023-12-22 瑞阳制药股份有限公司 含finerenone的片剂及其制备方法
WO2022214206A1 (en) 2021-04-08 2022-10-13 Bayer Aktiengesellschaft Combination of finerenone and pecavaptan for the treatment and/or prevention of cardiovascular and/or renal diseases
CN114149427A (zh) * 2021-12-18 2022-03-08 上海鼎雅药物化学科技有限公司 非奈利酮及其中间体的合成方法
CN115340540A (zh) * 2022-01-20 2022-11-15 奥锐特药业股份有限公司 制备非奈利酮及其中间体的方法
CN114524812A (zh) * 2022-03-18 2022-05-24 湖南凯铂生物药业有限公司 1,4-二氢-1,6-萘啶化合物的晶型制备以及合成方法
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EP4286368A1 (de) 2022-05-31 2023-12-06 Bayer Aktiengesellschaft Verfahren zur herstellung von 4-formyl-3-methoxybenzonitril
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