CO2018001466A2 - Procedimiento para la preparación de (4s)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridina-3-carboxamida y su purificación para su uso como principio activo farmacéutico - Google Patents
Procedimiento para la preparación de (4s)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridina-3-carboxamida y su purificación para su uso como principio activo farmacéuticoInfo
- Publication number
- CO2018001466A2 CO2018001466A2 CONC2018/0001466A CO2018001466A CO2018001466A2 CO 2018001466 A2 CO2018001466 A2 CO 2018001466A2 CO 2018001466 A CO2018001466 A CO 2018001466A CO 2018001466 A2 CO2018001466 A2 CO 2018001466A2
- Authority
- CO
- Colombia
- Prior art keywords
- naphthyridine
- carboxamide
- methoxyphenyl
- dihydro
- ethoxy
- Prior art date
Links
- BTBHLEZXCOBLCY-QGZVFWFLSA-N (4s)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide Chemical compound C1([C@@H]2C(=C(C)NC=3C(C)=CN=C(C2=3)OCC)C(N)=O)=CC=C(C#N)C=C1OC BTBHLEZXCOBLCY-QGZVFWFLSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A61P25/00—Drugs for disorders of the nervous system
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Abstract
La presente invención se refiere a un procedimiento nuevo y mejorado para la preparación de (4S)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridina-3-carboxamida de la fórmula (I) (I)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15182043 | 2015-08-21 | ||
| PCT/EP2016/069558 WO2017032673A1 (de) | 2015-08-21 | 2016-08-18 | Verfahren zur herstellung von (4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carboxamid und dessen aufreinigung für die verwendung als pharmazeutischer wirkstoff |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2018001466A2 true CO2018001466A2 (es) | 2018-02-28 |
Family
ID=53938271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2018/0001466A CO2018001466A2 (es) | 2015-08-21 | 2018-02-14 | Procedimiento para la preparación de (4s)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridina-3-carboxamida y su purificación para su uso como principio activo farmacéutico |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | USRE49826E1 (es) |
| EP (1) | EP3337800B1 (es) |
| JP (1) | JP6824247B2 (es) |
| KR (1) | KR20180041138A (es) |
| CN (1) | CN107849043B (es) |
| AR (1) | AR105774A1 (es) |
| AU (1) | AU2016312904C1 (es) |
| CA (1) | CA2995905A1 (es) |
| CL (1) | CL2018000427A1 (es) |
| CO (1) | CO2018001466A2 (es) |
| DK (1) | DK3337800T3 (es) |
| ES (1) | ES2739904T3 (es) |
| HK (1) | HK1251565A1 (es) |
| HR (1) | HRP20191431T1 (es) |
| HU (1) | HUE044574T2 (es) |
| IL (1) | IL257371B (es) |
| JO (1) | JOP20160186B1 (es) |
| LT (1) | LT3337800T (es) |
| MX (1) | MX367960B (es) |
| MY (1) | MY195226A (es) |
| PE (1) | PE20180554A1 (es) |
| PL (1) | PL3337800T3 (es) |
| PT (1) | PT3337800T (es) |
| RS (1) | RS59055B1 (es) |
| RU (1) | RU2743429C2 (es) |
| SG (1) | SG11201801110TA (es) |
| SI (1) | SI3337800T1 (es) |
| TW (1) | TWI725045B (es) |
| UY (1) | UY36864A (es) |
| WO (1) | WO2017032673A1 (es) |
| ZA (1) | ZA201801859B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110317265B (zh) * | 2018-03-28 | 2023-03-10 | 江苏豪森药业集团有限公司 | 比伐芦定晶型a及其制备方法 |
| EP3560922A1 (de) * | 2018-04-24 | 2019-10-30 | Bayer Aktiengesellschaft | Verfahren zur herstellung von (4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid durch racemat-spaltung mittels diastereomerer weinsäureester |
| EP3566704A1 (en) | 2018-05-11 | 2019-11-13 | Bayer Aktiengesellschaft | The use of non-steroidal mineralocorticoid receptor antagonists alone or in combination for the treatment of muscular or neuromuscular diseases |
| EP4045500A1 (de) * | 2019-10-17 | 2022-08-24 | Bayer Aktiengesellschaft | Verfahren zur herstellung von acyloxymethylestern der (4s) -(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbonsäure |
| CN114524812A (zh) * | 2022-03-18 | 2022-05-24 | 湖南凯铂生物药业有限公司 | 1,4-二氢-1,6-萘啶化合物的晶型制备以及合成方法 |
| WO2023205164A1 (en) | 2022-04-18 | 2023-10-26 | Teva Pharmaceuticals International Gmbh | Processes for the preparation of finerenone |
| WO2024075139A1 (en) * | 2022-10-06 | 2024-04-11 | Maithri Drugs Private Limited | A process for preparation of finerenone and intermediates thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL75987A (en) * | 1984-08-25 | 1991-07-18 | Goedecke Ag | Tri-and tetrasubstituted-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them |
| DE3431303A1 (de) * | 1984-08-25 | 1986-02-27 | Goedecke Ag | 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung |
| CN1283187A (zh) * | 1997-12-22 | 2001-02-07 | 味之素株式会社 | 新颖二氢吡啶衍生物 |
| DE19834047A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
| DE19834044A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
| DE19943635A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943636A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943634A1 (de) | 1999-09-13 | 2001-04-12 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943639A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften |
| AR031176A1 (es) | 2000-11-22 | 2003-09-10 | Bayer Ag | Nuevos derivados de pirazolpiridina sustituidos con piridina |
| DE10110750A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE10110749A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituierte Aminodicarbonsäurederivate |
| DE10220570A1 (de) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamat-substituierte Pyrazolopyridine |
| EP1902022A1 (en) | 2005-07-12 | 2008-03-26 | Glaxo Group Limited | Piperazine heteroaryl derivates as gpr38 agonists |
| DE102006026583A1 (de) * | 2006-06-07 | 2007-12-13 | Bayer Healthcare Aktiengesellschaft | Aryl-substituierte hetero-bicyclische Verbindungen und ihre Verwendung |
| DE102007009494A1 (de) | 2007-02-27 | 2008-08-28 | Bayer Healthcare Ag | Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung |
| USRE49575E1 (en) | 2014-08-01 | 2023-07-11 | Bayer Pharma Aktiengesellschaft | Method for the preparation of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-l,4-dihydro-1-6-naphthyridine-3-carbox-amide and the purification thereof for use as an active pharmaceutical ingredient |
-
2016
- 2016-08-18 DK DK16753388.4T patent/DK3337800T3/da active
- 2016-08-18 WO PCT/EP2016/069558 patent/WO2017032673A1/de active Application Filing
- 2016-08-18 CA CA2995905A patent/CA2995905A1/en active Pending
- 2016-08-18 JP JP2018509768A patent/JP6824247B2/ja active Active
- 2016-08-18 US US17/367,066 patent/USRE49826E1/en active Active
- 2016-08-18 PL PL16753388T patent/PL3337800T3/pl unknown
- 2016-08-18 JO JOP/2016/0186A patent/JOP20160186B1/ar active
- 2016-08-18 AU AU2016312904A patent/AU2016312904C1/en active Active
- 2016-08-18 RS RS20190985A patent/RS59055B1/sr unknown
- 2016-08-18 ES ES16753388T patent/ES2739904T3/es active Active
- 2016-08-18 LT LTEP16753388.4T patent/LT3337800T/lt unknown
- 2016-08-18 RU RU2018109761A patent/RU2743429C2/ru active
- 2016-08-18 MY MYPI2018700615A patent/MY195226A/en unknown
- 2016-08-18 SG SG11201801110TA patent/SG11201801110TA/en unknown
- 2016-08-18 PE PE2018000259A patent/PE20180554A1/es unknown
- 2016-08-18 MX MX2018002027A patent/MX367960B/es active IP Right Grant
- 2016-08-18 HU HUE16753388 patent/HUE044574T2/hu unknown
- 2016-08-18 US US15/753,849 patent/US10336749B2/en not_active Ceased
- 2016-08-18 TW TW105126338A patent/TWI725045B/zh active
- 2016-08-18 PT PT16753388T patent/PT3337800T/pt unknown
- 2016-08-18 EP EP16753388.4A patent/EP3337800B1/de active Active
- 2016-08-18 SI SI201630305T patent/SI3337800T1/sl unknown
- 2016-08-18 KR KR1020187004893A patent/KR20180041138A/ko active IP Right Grant
- 2016-08-18 CN CN201680047659.XA patent/CN107849043B/zh active Active
- 2016-08-19 UY UY0001036864A patent/UY36864A/es active IP Right Grant
- 2016-08-19 AR ARP160102552A patent/AR105774A1/es unknown
-
2018
- 2018-02-06 IL IL257371A patent/IL257371B/en active IP Right Grant
- 2018-02-14 CO CONC2018/0001466A patent/CO2018001466A2/es unknown
- 2018-02-16 CL CL2018000427A patent/CL2018000427A1/es unknown
- 2018-03-20 ZA ZA201801859A patent/ZA201801859B/en unknown
- 2018-08-28 HK HK18111022.9A patent/HK1251565A1/zh unknown
-
2019
- 2019-08-07 HR HRP20191431 patent/HRP20191431T1/hr unknown
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