PE20170141A1 - Procedimiento para la preparacion de (4s)-4-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carbox-amida y su purificacion para su uso como principio activo farmaceutico - Google Patents
Procedimiento para la preparacion de (4s)-4-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carbox-amida y su purificacion para su uso como principio activo farmaceuticoInfo
- Publication number
- PE20170141A1 PE20170141A1 PE2017000143A PE2017000143A PE20170141A1 PE 20170141 A1 PE20170141 A1 PE 20170141A1 PE 2017000143 A PE2017000143 A PE 2017000143A PE 2017000143 A PE2017000143 A PE 2017000143A PE 20170141 A1 PE20170141 A1 PE 20170141A1
- Authority
- PE
- Peru
- Prior art keywords
- preparation
- naftiridin
- metoxifenil
- dimetil
- cyane
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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- Neurosurgery (AREA)
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- Diabetes (AREA)
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- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se refiere al compuesto cristalino de (4S)-4-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxamida de formula I cuyos patrones de difraccion de rayos X en polvo (DRXP) en cuanto a 2(theta) son: 8.5°, 14.1°, 17.2°, 19.0°, 20.5°, 25.6° y 26.5° ± 0.2°. Tambien se refiere a su metodo de preparacion y un metodo de tratamiento. Dicho compuesto es antagonista no esteroideo del receptor mineralocorticoide siendo util en el tratamiento de enfermedades cardiovasculares y renales tales como insuficiencias cardiacas o nefropatia diabetica.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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EP14179544 | 2014-08-01 |
Publications (1)
Publication Number | Publication Date |
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PE20170141A1 true PE20170141A1 (es) | 2017-04-02 |
Family
ID=51260727
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2017000143A PE20170141A1 (es) | 2014-08-01 | 2015-07-29 | Procedimiento para la preparacion de (4s)-4-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carbox-amida y su purificacion para su uso como principio activo farmaceutico |
Country Status (30)
Country | Link |
---|---|
US (4) | US10059707B2 (es) |
EP (2) | EP3174875B1 (es) |
JP (1) | JP6818674B2 (es) |
KR (2) | KR102527893B1 (es) |
CN (4) | CN116655630A (es) |
AR (1) | AR101403A1 (es) |
AU (1) | AU2015295376C1 (es) |
BR (1) | BR112017001678B1 (es) |
CA (2) | CA3146285C (es) |
CL (1) | CL2017000263A1 (es) |
CO (1) | CO2017000886A2 (es) |
DK (1) | DK3174875T3 (es) |
ES (1) | ES2828704T3 (es) |
HR (1) | HRP20201800T1 (es) |
HU (1) | HUE051350T2 (es) |
IL (1) | IL250239B (es) |
JO (1) | JO3648B1 (es) |
LT (1) | LT3174875T (es) |
MX (1) | MX369467B (es) |
MY (1) | MY198066A (es) |
PE (1) | PE20170141A1 (es) |
PL (1) | PL3174875T3 (es) |
PT (1) | PT3174875T (es) |
RS (1) | RS60921B1 (es) |
RU (1) | RU2729998C9 (es) |
SG (1) | SG11201700785UA (es) |
SI (1) | SI3174875T1 (es) |
TW (1) | TWI684593B (es) |
UY (1) | UY36251A (es) |
WO (1) | WO2016016287A1 (es) |
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WO2016016287A1 (de) * | 2014-08-01 | 2016-02-04 | Bayer Pharma Aktiengesellschaft | Verfahren zur herstellung von (4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid und dessen aufreinigung für die verwendung als pharmazeutischer wirkstoff |
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EP3560922A1 (de) | 2018-04-24 | 2019-10-30 | Bayer Aktiengesellschaft | Verfahren zur herstellung von (4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid durch racemat-spaltung mittels diastereomerer weinsäureester |
JOP20210243A1 (ar) | 2019-03-05 | 2023-01-30 | Bayer Ag | طريقة لتحضير 4-أمينو-5-مثيل بيريدون |
JOP20210242A1 (ar) | 2019-03-05 | 2023-01-30 | Bayer Ag | تصنيع 4-أمينو-5-مثيل-1h- بيريدين-2(1h)-ون (مركب وسيط لتصنيع فينيرينون مضاد لـ mr) من أكسيد-2-كلورو-5-مثيل-4-نيترو-بيريدين-1 باستخدام المركب الوسيط 2-كلورو-5-مثيل-4-بيريدين أمين |
AU2020365314A1 (en) * | 2019-10-17 | 2022-05-12 | Bayer Aktiengesellschaft | Process for producing acyloxymethyl esters of (4S)-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carboxylic acid |
CR20220159A (es) * | 2019-10-17 | 2022-06-02 | Bayer Ag | Procedimiento para la preparación de (4s)–4–(4–ciano–2–metoxi–fenil)–5–hidroxi–2,8–dimetil–1,4–dihidro–1,6–naftiridin–3–carboxilato de 2–cianoetilo por separación de racematos por medio de éster de ácido tartárico diastereoisómero |
AU2020367978A1 (en) * | 2019-10-17 | 2022-05-12 | Bayer Aktiengesellschaft | Process for the preparation of 2-cyanoethyl (4S)-4-(4-cyano-2-methoxy-phenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate by resolution of racemates by means of diastereomeric tartaric acid esters |
EP4045502A1 (de) * | 2019-10-17 | 2022-08-24 | Bayer Aktiengesellschaft | Photochemisches verfahren zur herstellung von (4r, 4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid |
EP3900722A1 (en) | 2020-04-22 | 2021-10-27 | Bayer AG | Combination of finerenone and pecavaptan for the treatment and/or prevention of cardiovascular and/or renal diseases |
JP2023523596A (ja) | 2020-04-22 | 2023-06-06 | バイエル アクチェンゲゼルシャフト | 心血管疾患および/または腎疾患を治療および/または予防するためのフィネレノンとsglt2阻害剤の組み合わせ |
TW202214624A (zh) | 2020-06-16 | 2022-04-16 | 德商拜耳廠股份有限公司 | 藉由催化不對稱漢斯(hantzsch)酯還原法進行之製備(4s)-4-(4-氰基-2-甲氧基苯基)-5-乙氧基-2,8-二甲基-1,4-二氫-1,6-㖠啶-3-羧醯胺的方法 |
CN112237573B (zh) * | 2020-10-29 | 2023-12-22 | 瑞阳制药股份有限公司 | 含finerenone的片剂及其制备方法 |
WO2022214206A1 (en) | 2021-04-08 | 2022-10-13 | Bayer Aktiengesellschaft | Combination of finerenone and pecavaptan for the treatment and/or prevention of cardiovascular and/or renal diseases |
CN114149427A (zh) * | 2021-12-18 | 2022-03-08 | 上海鼎雅药物化学科技有限公司 | 非奈利酮及其中间体的合成方法 |
CN115340539B (zh) | 2022-01-19 | 2024-02-27 | 奥锐特药业股份有限公司 | 制备非奈利酮及其中间体的方法 |
CN115340540A (zh) * | 2022-01-20 | 2022-11-15 | 奥锐特药业股份有限公司 | 制备非奈利酮及其中间体的方法 |
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DE102006044696A1 (de) | 2006-09-22 | 2008-03-27 | Bayer Healthcare Ag | 3-Cyano-5-thiazaheteroaryl-dihydropyridine und ihre Verwendung |
DE102007009494A1 (de) * | 2007-02-27 | 2008-08-28 | Bayer Healthcare Ag | Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung |
CN102020587A (zh) | 2010-11-25 | 2011-04-20 | 大连凯飞精细化工有限公司 | 2-甲氧基-4-氰基苯甲醛的合成方法 |
WO2016016287A1 (de) * | 2014-08-01 | 2016-02-04 | Bayer Pharma Aktiengesellschaft | Verfahren zur herstellung von (4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid und dessen aufreinigung für die verwendung als pharmazeutischer wirkstoff |
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