UY36251A - Procedimiento para la preparación de (4s)- 4-(4-ciano-2-metoxifenilo)-5-toxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridin-3-carbox-amida y su purificación para su uso como principio activo farmacéutico - Google Patents

Procedimiento para la preparación de (4s)- 4-(4-ciano-2-metoxifenilo)-5-toxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridin-3-carbox-amida y su purificación para su uso como principio activo farmacéutico

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Publication number
UY36251A
UY36251A UY0001036251A UY36251A UY36251A UY 36251 A UY36251 A UY 36251A UY 0001036251 A UY0001036251 A UY 0001036251A UY 36251 A UY36251 A UY 36251A UY 36251 A UY36251 A UY 36251A
Authority
UY
Uruguay
Prior art keywords
dihydro
dimethyl
preparation
naftiridin
metoxyphenyl
Prior art date
Application number
UY0001036251A
Other languages
English (en)
Inventor
Dr Johannes Platzek
Dr Gunnar Garke
Dr Alfons Grunenberg
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51260727&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY36251(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of UY36251A publication Critical patent/UY36251A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A—HUMAN NECESSITIES
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a un procedimiento nuevo y mejorado para la preparación de (4S)-5 4-(4-Ciano-2-metoxifenilo)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridin-3-carbox-amida de la fórmula (I) así como la preparación y utilización de la modificación cristalina I de (4S)- 4-(4-Ciano-2-metoxifenilo)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridin-3-carbox-amida de la fórmula (I)..
UY0001036251A 2014-08-01 2015-07-31 Procedimiento para la preparación de (4s)- 4-(4-ciano-2-metoxifenilo)-5-toxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridin-3-carbox-amida y su purificación para su uso como principio activo farmacéutico UY36251A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14179544 2014-08-01

Publications (1)

Publication Number Publication Date
UY36251A true UY36251A (es) 2016-01-29

Family

ID=51260727

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001036251A UY36251A (es) 2014-08-01 2015-07-31 Procedimiento para la preparación de (4s)- 4-(4-ciano-2-metoxifenilo)-5-toxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridin-3-carbox-amida y su purificación para su uso como principio activo farmacéutico

Country Status (30)

Country Link
US (4) US10059707B2 (es)
EP (2) EP3660015A1 (es)
JP (1) JP6818674B2 (es)
KR (2) KR102527893B1 (es)
CN (4) CN116655627A (es)
AR (1) AR101403A1 (es)
AU (1) AU2015295376C1 (es)
BR (1) BR112017001678B1 (es)
CA (2) CA3146285C (es)
CL (1) CL2017000263A1 (es)
CO (1) CO2017000886A2 (es)
DK (1) DK3174875T3 (es)
ES (1) ES2828704T3 (es)
HR (1) HRP20201800T1 (es)
HU (1) HUE051350T2 (es)
IL (1) IL250239B (es)
JO (1) JO3648B1 (es)
LT (1) LT3174875T (es)
MX (1) MX369467B (es)
MY (1) MY198066A (es)
PE (1) PE20170141A1 (es)
PL (1) PL3174875T3 (es)
PT (1) PT3174875T (es)
RS (1) RS60921B1 (es)
RU (1) RU2729998C9 (es)
SG (1) SG11201700785UA (es)
SI (1) SI3174875T1 (es)
TW (1) TWI684593B (es)
UY (1) UY36251A (es)
WO (1) WO2016016287A1 (es)

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WO2021254896A1 (en) 2020-06-16 2021-12-23 Bayer Aktiengesellschaft Process for preparing (4s)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide enabled by a catalytic asymmetric hantzsch ester reduction
CN112237573B (zh) * 2020-10-29 2023-12-22 瑞阳制药股份有限公司 含finerenone的片剂及其制备方法
WO2022214206A1 (en) 2021-04-08 2022-10-13 Bayer Aktiengesellschaft Combination of finerenone and pecavaptan for the treatment and/or prevention of cardiovascular and/or renal diseases
CN114149427A (zh) * 2021-12-18 2022-03-08 上海鼎雅药物化学科技有限公司 非奈利酮及其中间体的合成方法
CN115340540A (zh) * 2022-01-20 2022-11-15 奥锐特药业股份有限公司 制备非奈利酮及其中间体的方法
CN114524812A (zh) * 2022-03-18 2022-05-24 湖南凯铂生物药业有限公司 1,4-二氢-1,6-萘啶化合物的晶型制备以及合成方法
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RU2729998C9 (ru) 2020-10-20
PL3174875T3 (pl) 2021-01-25
CN116655630A (zh) 2023-08-29
LT3174875T (lt) 2020-11-25
CN116655629A (zh) 2023-08-29
IL250239B (en) 2019-09-26
RU2729998C2 (ru) 2020-08-13
US10399977B2 (en) 2019-09-03
AU2015295376A1 (en) 2017-02-16
CO2017000886A2 (es) 2017-05-10
PT3174875T (pt) 2020-11-05
BR112017001678A2 (pt) 2018-07-17
MX2017001507A (es) 2017-05-23
JP2017522357A (ja) 2017-08-10
EP3174875A1 (de) 2017-06-07
RS60921B1 (sr) 2020-11-30
USRE49860E1 (en) 2024-03-05
CA2956529A1 (en) 2016-02-04
MX369467B (es) 2019-11-08
KR20170040278A (ko) 2017-04-12
SI3174875T1 (sl) 2020-12-31
CL2017000263A1 (es) 2017-09-29
US20170217957A1 (en) 2017-08-03
RU2017106602A3 (es) 2019-02-21
USRE49575E1 (en) 2023-07-11
NZ728558A (en) 2023-08-25
CN106795155A (zh) 2017-05-31
EP3174875B1 (de) 2020-08-19
JP6818674B2 (ja) 2021-01-20
CN116655627A (zh) 2023-08-29
PE20170141A1 (es) 2017-04-02
MY198066A (en) 2023-07-31
CA3146285A1 (en) 2016-02-04
BR112017001678B1 (pt) 2024-01-16
US20190127369A1 (en) 2019-05-02
SG11201700785UA (en) 2017-02-27
IL250239A0 (en) 2017-03-30
JO3648B1 (ar) 2020-08-27
RU2017106602A (ru) 2018-09-05
US10059707B2 (en) 2018-08-28
WO2016016287A1 (de) 2016-02-04
AR101403A1 (es) 2016-12-14
AU2015295376C1 (en) 2020-07-16
ES2828704T3 (es) 2021-05-27
DK3174875T3 (da) 2020-11-16
CN106795155B (zh) 2023-06-16
CA3146285C (en) 2024-01-02
KR102527893B1 (ko) 2023-05-02
TW201619155A (zh) 2016-06-01
HRP20201800T1 (hr) 2020-12-25
AU2015295376B2 (en) 2019-10-03
EP3660015A1 (de) 2020-06-03
TWI684593B (zh) 2020-02-11
HUE051350T2 (hu) 2021-03-01

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