BR112018016708A2 - processo para preparar compostos de 7h-pirrolo[2,3-d]pirimidina - Google Patents
processo para preparar compostos de 7h-pirrolo[2,3-d]pirimidinaInfo
- Publication number
- BR112018016708A2 BR112018016708A2 BR112018016708-8A BR112018016708A BR112018016708A2 BR 112018016708 A2 BR112018016708 A2 BR 112018016708A2 BR 112018016708 A BR112018016708 A BR 112018016708A BR 112018016708 A2 BR112018016708 A2 BR 112018016708A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyrrolo
- preparing
- pyrimidine compounds
- pyrimidine
- methyl
- Prior art date
Links
- JJTNLWSCFYERCK-UHFFFAOYSA-N 7h-pyrrolo[2,3-d]pyrimidine Chemical class N1=CN=C2NC=CC2=C1 JJTNLWSCFYERCK-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- -1 pyrimidine-4-yl Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
- C07C303/22—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/19—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
a presente invenção refere-se a processos aprimorados para a preparação do composto 7h-pirrolo [2,3-d] pirimidina, n-metil-1- {trans-4- [metil (7h-pirrolo [2,3- d] pirimidina-4 -il) amino] ciclo-hexil} -metanossulfonamida, seus intermediários e seus sais veterinários aceitáveis (fórmula (1)).
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662295739P | 2016-02-16 | 2016-02-16 | |
US62/295,739 | 2016-02-16 | ||
US201662375040P | 2016-08-15 | 2016-08-15 | |
US62/375,040 | 2016-08-15 | ||
PCT/US2017/016778 WO2017142740A1 (en) | 2016-02-16 | 2017-02-07 | Process for preparing 7h-pyrrolo [2, 3-d] pyrimidine compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112018016708A2 true BR112018016708A2 (pt) | 2018-12-26 |
BR112018016708B1 BR112018016708B1 (pt) | 2023-11-07 |
Family
ID=58018338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018016708-8A BR112018016708B1 (pt) | 2016-02-16 | 2017-02-07 | Compostos de 7h-pirrolo[2,3-d]pirimidina e processo para preparar os ditos compostos |
Country Status (15)
Country | Link |
---|---|
US (1) | US9926327B2 (pt) |
EP (1) | EP3416965B1 (pt) |
JP (1) | JP6568324B2 (pt) |
KR (1) | KR102124449B1 (pt) |
CN (1) | CN108699072B (pt) |
AU (1) | AU2017221193B2 (pt) |
BR (1) | BR112018016708B1 (pt) |
CA (1) | CA3012589C (pt) |
CL (1) | CL2018002344A1 (pt) |
CO (1) | CO2018008253A2 (pt) |
MX (1) | MX2018009912A (pt) |
NZ (1) | NZ744341A (pt) |
RU (1) | RU2699034C1 (pt) |
WO (1) | WO2017142740A1 (pt) |
ZA (1) | ZA201804871B (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL2022471B1 (en) * | 2019-01-29 | 2020-08-18 | Vationpharma B V | Solid state forms of oclacitinib |
AU2019426113B2 (en) * | 2019-01-30 | 2022-06-16 | Felicamed Biotechnology Co., Ltd. | JAK inhibitor and preparation method therefor |
CA3152021A1 (en) * | 2019-08-26 | 2021-03-04 | Chemwerth, Inc. | Substituted (7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino compounds useful as jak1 inhibitors |
CN112279854B (zh) * | 2020-08-25 | 2022-04-05 | 常州齐晖药业有限公司 | 一种7H-吡咯并[2,3-d]嘧啶化合物的制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4424213A (en) | 1980-11-10 | 1984-01-03 | Sds Biotech Corporation | Biologically active heterobicyclic hydroximidates and thiolhydroximidates and carbamate ester derivatives thereof |
AU3951899A (en) | 1998-06-19 | 2000-01-05 | Pfizer Products Inc. | Pyrrolo(2,3-d)pyrimidine compounds |
EP1457485A1 (en) * | 2003-03-14 | 2004-09-15 | Dompé S.P.A. | Sulfonic acids, their derivatives and pharmaceutical compositions containing them |
US8193206B2 (en) | 2005-06-14 | 2012-06-05 | Taigen Biotechnology Co., Ltd. | Pyrimidine compounds |
KR100987870B1 (ko) | 2005-07-29 | 2010-10-13 | 화이자 프로덕츠 인코포레이티드 | 피롤로[2,3-d]피리미딘 유도체, 이들의 중간체 및 합성 |
CA2733359C (en) * | 2008-08-20 | 2014-08-05 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidine compounds |
KR20120083452A (ko) * | 2009-10-15 | 2012-07-25 | 화이자 인코포레이티드 | 피롤로[2,3-d]피리미딘 화합물 |
ES2461967T3 (es) * | 2009-12-18 | 2014-05-21 | Pfizer Inc. | Compuestos de pirrolo[2,3-d]pirimidina |
MX2012009798A (es) * | 2010-02-24 | 2012-09-12 | Pfizer | Composiciones veterinarias. |
-
2017
- 2017-02-07 NZ NZ744341A patent/NZ744341A/en unknown
- 2017-02-07 US US15/426,292 patent/US9926327B2/en active Active
- 2017-02-07 RU RU2018128023A patent/RU2699034C1/ru active
- 2017-02-07 EP EP17704986.3A patent/EP3416965B1/en active Active
- 2017-02-07 BR BR112018016708-8A patent/BR112018016708B1/pt active IP Right Grant
- 2017-02-07 AU AU2017221193A patent/AU2017221193B2/en active Active
- 2017-02-07 KR KR1020187023081A patent/KR102124449B1/ko active IP Right Grant
- 2017-02-07 CN CN201780011817.0A patent/CN108699072B/zh active Active
- 2017-02-07 MX MX2018009912A patent/MX2018009912A/es active IP Right Grant
- 2017-02-07 WO PCT/US2017/016778 patent/WO2017142740A1/en active Application Filing
- 2017-02-07 CA CA3012589A patent/CA3012589C/en active Active
- 2017-02-07 JP JP2018543332A patent/JP6568324B2/ja active Active
-
2018
- 2018-07-19 ZA ZA2018/04871A patent/ZA201804871B/en unknown
- 2018-08-03 CO CONC2018/0008253A patent/CO2018008253A2/es unknown
- 2018-08-16 CL CL2018002344A patent/CL2018002344A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP3416965A1 (en) | 2018-12-26 |
KR20180100225A (ko) | 2018-09-07 |
BR112018016708B1 (pt) | 2023-11-07 |
RU2699034C1 (ru) | 2019-09-03 |
CN108699072B (zh) | 2021-02-26 |
CA3012589C (en) | 2020-05-05 |
AU2017221193A1 (en) | 2018-08-09 |
NZ744341A (en) | 2019-06-28 |
MX2018009912A (es) | 2018-11-29 |
CN108699072A (zh) | 2018-10-23 |
JP6568324B2 (ja) | 2019-08-28 |
CO2018008253A2 (es) | 2018-08-21 |
ZA201804871B (en) | 2019-05-29 |
US9926327B2 (en) | 2018-03-27 |
AU2017221193B2 (en) | 2019-03-14 |
KR102124449B1 (ko) | 2020-06-26 |
JP2019505547A (ja) | 2019-02-28 |
US20170233397A1 (en) | 2017-08-17 |
CA3012589A1 (en) | 2017-08-24 |
WO2017142740A1 (en) | 2017-08-24 |
EP3416965B1 (en) | 2020-10-07 |
CL2018002344A1 (es) | 2018-09-14 |
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Legal Events
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 07/02/2017, OBSERVADAS AS CONDICOES LEGAIS |