AR094943A1 - Pirimidas condensadas sustituidas con trifluorometilo - Google Patents

Pirimidas condensadas sustituidas con trifluorometilo

Info

Publication number
AR094943A1
AR094943A1 ARP140100657A ARP140100657A AR094943A1 AR 094943 A1 AR094943 A1 AR 094943A1 AR P140100657 A ARP140100657 A AR P140100657A AR P140100657 A ARP140100657 A AR P140100657A AR 094943 A1 AR094943 A1 AR 094943A1
Authority
AR
Argentina
Prior art keywords
pyrimids
trifluorometilo
condensed
replaced
solvates
Prior art date
Application number
ARP140100657A
Other languages
English (en)
Inventor
Dr Vakalopoulos Alexandros
Dr Wunder Frank
Dr Tersteegen Adrian
Dr Lang Dieter
Dr Follmann Markus
Prof Dr Stasch Johannes
Peter - Dr Redlich Gorden
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47826961&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR094943(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of AR094943A1 publication Critical patent/AR094943A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

Útiles para el tratamiento y/o la profilaxis de trastornos cardiovasculares. Reivindicación 1: Compuesto que tiene el nombre sistemático 2-{5-fluoro-1-[(3-fluoropiridin-2-iI)metil]-1H-pirazolo[3,4-b]piridin-3-il}-5-metil-5-(trifluorometil)-4-[(3,3,3-trifluoropropil)amino]-5,7-dihidro-6H-pirrolo[2,3-d]pirimidin-6-ona y la fórmula estructural (1) y las sales, los solvatos y los solvatos de las sales de los mismos.
ARP140100657A 2013-03-01 2014-02-28 Pirimidas condensadas sustituidas con trifluorometilo AR094943A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13157434 2013-03-01

Publications (1)

Publication Number Publication Date
AR094943A1 true AR094943A1 (es) 2015-09-09

Family

ID=47826961

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP140100657A AR094943A1 (es) 2013-03-01 2014-02-28 Pirimidas condensadas sustituidas con trifluorometilo

Country Status (28)

Country Link
US (1) US9266871B2 (es)
EP (1) EP2961755B1 (es)
JP (1) JP2016510010A (es)
KR (1) KR20150121007A (es)
CN (1) CN105308055B (es)
AP (1) AP2015008637A0 (es)
AR (1) AR094943A1 (es)
AU (1) AU2014222739A1 (es)
BR (1) BR112015020298A2 (es)
CA (1) CA2902993A1 (es)
CL (1) CL2015002343A1 (es)
CR (1) CR20150448A (es)
CU (1) CU20150095A7 (es)
DO (1) DOP2015000185A (es)
EA (1) EA027689B1 (es)
HK (1) HK1220974A1 (es)
IL (1) IL240637A0 (es)
MA (1) MA38365A1 (es)
MX (1) MX2015010966A (es)
NI (1) NI201500117A (es)
PE (1) PE20151755A1 (es)
PH (1) PH12015501703A1 (es)
SG (1) SG11201505974VA (es)
TN (1) TN2015000370A1 (es)
TW (1) TW201443066A (es)
UY (1) UY35350A (es)
WO (1) WO2014131760A1 (es)
ZA (1) ZA201505911B (es)

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ES2644781T3 (es) 2012-03-06 2017-11-30 Bayer Intellectual Property Gmbh Azabiciclos sustituidos y su uso
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WO2015106268A1 (en) 2014-01-13 2015-07-16 Ironwood Pharmaceuticals, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS
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US20190381039A1 (en) 2016-12-13 2019-12-19 Cyclerion Therapeutics, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF ESOPHAGEAL MOTILITY DISORDERS
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EP3609883B1 (en) 2017-04-11 2022-06-29 Sunshine Lake Pharma Co., Ltd. Fluorine-substituted indazole compounds and uses thereof
AU2018354785A1 (en) * 2017-10-24 2020-04-23 Bayer Aktiengesellschaft Substituted imidazopyridine amides and use thereof
EA202092680A1 (ru) 2018-05-15 2021-04-13 Байер Акциенгезельшафт 1,3-тиазол-2-ил-замещенные бензамиды для лечения заболеваний, ассоциированных с сенситизацией нервных волокон
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DE102012200349A1 (de) 2012-01-11 2013-07-11 Bayer Intellectual Property Gmbh Substituierte annellierte Pyrimidine und Triazine und ihre Verwendung
DE102012200360A1 (de) 2012-01-11 2013-07-11 Bayer Intellectual Property Gmbh Substituierte Triazine und ihre Verwendung
DE102012200352A1 (de) 2012-01-11 2013-07-11 Bayer Intellectual Property Gmbh Substituierte, annellierte Imidazole und Pyrazole und ihre Verwendung
ES2644781T3 (es) 2012-03-06 2017-11-30 Bayer Intellectual Property Gmbh Azabiciclos sustituidos y su uso

Also Published As

Publication number Publication date
MX2015010966A (es) 2016-04-04
EP2961755A1 (de) 2016-01-06
EP2961755B1 (de) 2017-10-18
CA2902993A1 (en) 2014-09-04
AU2014222739A1 (en) 2015-09-03
KR20150121007A (ko) 2015-10-28
CN105308055A (zh) 2016-02-03
DOP2015000185A (es) 2015-11-15
BR112015020298A2 (pt) 2017-07-18
AP2015008637A0 (en) 2015-08-31
NI201500117A (es) 2016-02-15
PE20151755A1 (es) 2015-12-04
CL2015002343A1 (es) 2016-08-12
HK1220974A1 (zh) 2017-05-19
US9266871B2 (en) 2016-02-23
EA027689B1 (ru) 2017-08-31
WO2014131760A1 (de) 2014-09-04
EA201591616A1 (ru) 2016-04-29
TW201443066A (zh) 2014-11-16
US20140249168A1 (en) 2014-09-04
TN2015000370A1 (en) 2017-01-03
SG11201505974VA (en) 2015-09-29
CU20150095A7 (es) 2016-02-29
CR20150448A (es) 2016-01-11
ZA201505911B (en) 2016-10-26
PH12015501703A1 (en) 2015-10-12
JP2016510010A (ja) 2016-04-04
MA38365A1 (fr) 2017-09-29
CN105308055B (zh) 2017-07-14
IL240637A0 (en) 2015-09-24
UY35350A (es) 2014-09-30

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