BR112015020298A2 - pirimidinas de anel fundido substituídas com trifluormetil e uso das mesmas - Google Patents

pirimidinas de anel fundido substituídas com trifluormetil e uso das mesmas

Info

Publication number
BR112015020298A2
BR112015020298A2 BR112015020298A BR112015020298A BR112015020298A2 BR 112015020298 A2 BR112015020298 A2 BR 112015020298A2 BR 112015020298 A BR112015020298 A BR 112015020298A BR 112015020298 A BR112015020298 A BR 112015020298A BR 112015020298 A2 BR112015020298 A2 BR 112015020298A2
Authority
BR
Brazil
Prior art keywords
trifluoromethyl
substituted fused
fused ring
pyrimidines
prophylaxis
Prior art date
Application number
BR112015020298A
Other languages
English (en)
Inventor
Tersteegen Adrian
Vakalopoulos Alexandros
Lang Dieter
Wunder Frank
Redlich Gorden
Stasch Johannes-Peter
Follmann Markus
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47826961&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015020298(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of BR112015020298A2 publication Critical patent/BR112015020298A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

resumo “pirimidinas de anel fundido substituídas com trifluormetil e uso das mesmas” o presente pedido está relacionado a novas pirimidinas fundidas substituídas com trifluormetil, a processos para sua preparação, a seu uso isoladamente ou em combinações para o tratamento e/ou profilaxia de doenças, e a seu uso para a produção de medicamentos para o tratamento e/ou profilaxia de doenças, em particular para o tratamento e/ou profilaxia de distúrbios cardiovasculares.
BR112015020298A 2013-03-01 2014-02-25 pirimidinas de anel fundido substituídas com trifluormetil e uso das mesmas BR112015020298A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13157434 2013-03-01
PCT/EP2014/053636 WO2014131760A1 (de) 2013-03-01 2014-02-25 Trifluormethyl-substituierte annellierte pyrimidine und ihre verwendung

Publications (1)

Publication Number Publication Date
BR112015020298A2 true BR112015020298A2 (pt) 2017-07-18

Family

ID=47826961

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015020298A BR112015020298A2 (pt) 2013-03-01 2014-02-25 pirimidinas de anel fundido substituídas com trifluormetil e uso das mesmas

Country Status (28)

Country Link
US (1) US9266871B2 (pt)
EP (1) EP2961755B1 (pt)
JP (1) JP2016510010A (pt)
KR (1) KR20150121007A (pt)
CN (1) CN105308055B (pt)
AP (1) AP2015008637A0 (pt)
AR (1) AR094943A1 (pt)
AU (1) AU2014222739A1 (pt)
BR (1) BR112015020298A2 (pt)
CA (1) CA2902993A1 (pt)
CL (1) CL2015002343A1 (pt)
CR (1) CR20150448A (pt)
CU (1) CU20150095A7 (pt)
DO (1) DOP2015000185A (pt)
EA (1) EA027689B1 (pt)
HK (1) HK1220974A1 (pt)
IL (1) IL240637A0 (pt)
MA (1) MA38365A1 (pt)
MX (1) MX2015010966A (pt)
NI (1) NI201500117A (pt)
PE (1) PE20151755A1 (pt)
PH (1) PH12015501703A1 (pt)
SG (1) SG11201505974VA (pt)
TN (1) TN2015000370A1 (pt)
TW (1) TW201443066A (pt)
UY (1) UY35350A (pt)
WO (1) WO2014131760A1 (pt)
ZA (1) ZA201505911B (pt)

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Also Published As

Publication number Publication date
CN105308055B (zh) 2017-07-14
CN105308055A (zh) 2016-02-03
DOP2015000185A (es) 2015-11-15
NI201500117A (es) 2016-02-15
EP2961755A1 (de) 2016-01-06
EP2961755B1 (de) 2017-10-18
JP2016510010A (ja) 2016-04-04
PH12015501703A1 (en) 2015-10-12
CU20150095A7 (es) 2016-02-29
EA201591616A1 (ru) 2016-04-29
US9266871B2 (en) 2016-02-23
TW201443066A (zh) 2014-11-16
US20140249168A1 (en) 2014-09-04
WO2014131760A1 (de) 2014-09-04
CA2902993A1 (en) 2014-09-04
AP2015008637A0 (en) 2015-08-31
AR094943A1 (es) 2015-09-09
KR20150121007A (ko) 2015-10-28
UY35350A (es) 2014-09-30
MA38365A1 (fr) 2017-09-29
CR20150448A (es) 2016-01-11
ZA201505911B (en) 2016-10-26
SG11201505974VA (en) 2015-09-29
TN2015000370A1 (en) 2017-01-03
MX2015010966A (es) 2016-04-04
CL2015002343A1 (es) 2016-08-12
HK1220974A1 (zh) 2017-05-19
IL240637A0 (en) 2015-09-24
PE20151755A1 (es) 2015-12-04
AU2014222739A1 (en) 2015-09-03
EA027689B1 (ru) 2017-08-31

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2502 DE 18-12-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI