BR112018015880A2 - forma cristalina a de agonista de tlr7, método de preparação e uso da mesma - Google Patents

forma cristalina a de agonista de tlr7, método de preparação e uso da mesma

Info

Publication number
BR112018015880A2
BR112018015880A2 BR112018015880-1A BR112018015880A BR112018015880A2 BR 112018015880 A2 BR112018015880 A2 BR 112018015880A2 BR 112018015880 A BR112018015880 A BR 112018015880A BR 112018015880 A2 BR112018015880 A2 BR 112018015880A2
Authority
BR
Brazil
Prior art keywords
preparation
tlr7 agonists
tlr7
crystalline form
agonists
Prior art date
Application number
BR112018015880-1A
Other languages
English (en)
Chinese (zh)
Other versions
BR112018015880B1 (pt
Inventor
Ding Zhaozhong
Sun Fei
Hu Yinghu
Zhou Yilong
Wang Zheng
Zhao Rui
Yang Ling
Original Assignee
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chia Tai Tianqing Pharmaceutical Group Co., Ltd. filed Critical Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Publication of BR112018015880A2 publication Critical patent/BR112018015880A2/pt
Publication of BR112018015880B1 publication Critical patent/BR112018015880B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

a presente invenção refere-se a forma cristalina a de um agonista de tlr7 2-butóxi-7-(4-(pirrolidin-1-ilmetil)-benzil)-5h-pirrolo [3,2-d]pirimidin-4-amina (fórmula i), um método para preparar a forma cristalina a, e o uso da mesma.
BR112018015880-1A 2016-02-05 2017-02-04 Forma cristalina a de agonista de tlr7, seu uso e seu processo de preparação, composição cristalina, e composição farmacêutica BR112018015880B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610082029.8 2016-02-05
CN201610082029.8A CN107043379A (zh) 2016-02-05 2016-02-05 一种tlr7激动剂的晶型a、其制备方法和医药用途
PCT/CN2017/072891 WO2017133684A1 (zh) 2016-02-05 2017-02-04 一种tlr7激动剂的晶型a、其制备方法和用途

Publications (2)

Publication Number Publication Date
BR112018015880A2 true BR112018015880A2 (pt) 2018-12-26
BR112018015880B1 BR112018015880B1 (pt) 2024-06-11

Family

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Also Published As

Publication number Publication date
WO2017133684A1 (zh) 2017-08-10
MX2018009501A (es) 2018-12-11
CN108602831A (zh) 2018-09-28
EP3412672B1 (en) 2020-07-15
JP6889171B2 (ja) 2021-06-18
IL260968B (en) 2022-05-01
SG11201806683UA (en) 2018-09-27
US20200039988A1 (en) 2020-02-06
ZA201805186B (en) 2024-08-28
KR102393280B1 (ko) 2022-05-02
CN108602831B (zh) 2020-11-03
CA3013518A1 (en) 2017-08-10
KR20180104117A (ko) 2018-09-19
PL3412672T3 (pl) 2021-01-25
HUE051399T2 (hu) 2021-03-01
LT3412672T (lt) 2020-11-10
PT3412672T (pt) 2020-11-11
EP3412672A4 (en) 2019-07-17
AU2017215801B2 (en) 2020-09-10
PH12018501643A1 (en) 2019-06-03
DK3412672T3 (da) 2020-10-19
CL2018002092A1 (es) 2018-12-07
TWI754629B (zh) 2022-02-11
CN107043379A (zh) 2017-08-15
UA121161C2 (uk) 2020-04-10
HK1259170A1 (zh) 2019-11-29
AR107548A1 (es) 2018-05-09
EP3412672A1 (en) 2018-12-12
ES2830443T3 (es) 2021-06-03
US10947245B2 (en) 2021-03-16
CN108602831B9 (zh) 2020-12-04
JP2019505533A (ja) 2019-02-28
EA035951B1 (ru) 2020-09-04
TW201728589A (zh) 2017-08-16
US20190040071A1 (en) 2019-02-07
CA3013518C (en) 2022-07-19
HRP20201644T1 (hr) 2020-12-25
EA201891768A1 (ru) 2019-01-31
NZ744884A (en) 2022-09-30
US10442811B2 (en) 2019-10-15
SI3412672T1 (sl) 2021-02-26
AU2017215801A1 (en) 2018-08-23

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI N? 10196/2001, QUE MODIFICOU A LEI N? 9279/96, A CONCESS?O DA PATENTE EST? CONDICIONADA ? ANU?NCIA PR?VIA DA ANVISA. CONSIDERANDO A APROVA??O DOS TERMOS DO PARECER N? 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL N? 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVID?NCIAS CAB?VEIS.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2631 DE 08/06/2021 POR TER SIDO INDEVIDA.

B350 Update of information on the portal [chapter 15.35 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 04/02/2017, OBSERVADAS AS CONDICOES LEGAIS