CU20190035A7 - Derivados sustituidos de 6-(1h-pirazol-1-il)pirimidin-4-amina - Google Patents
Derivados sustituidos de 6-(1h-pirazol-1-il)pirimidin-4-aminaInfo
- Publication number
- CU20190035A7 CU20190035A7 CU2019000035A CU20190035A CU20190035A7 CU 20190035 A7 CU20190035 A7 CU 20190035A7 CU 2019000035 A CU2019000035 A CU 2019000035A CU 20190035 A CU20190035 A CU 20190035A CU 20190035 A7 CU20190035 A7 CU 20190035A7
- Authority
- CU
- Cuba
- Prior art keywords
- pyrimidin
- amine
- pirazol
- substitute derivatives
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Abstract
<p>La presente invención se refiere a compuestos sustituidos de 6-(1 H-pirazol-1-il)pirimidin-4-amina de la fórmula general (I) tal como se describen y definen en el presente, a procedimientos para preparar dichos compuestos, y a compuestos intermedios útiles para preparar dichos compuestos.</p>
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16193953 | 2016-10-14 | ||
PCT/EP2017/075630 WO2018069222A1 (en) | 2016-10-14 | 2017-10-09 | Substituted 6-(1h-pyrazol-1-yl)pyrimidin-4-amine derivatives and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CU20190035A7 true CU20190035A7 (es) | 2019-11-04 |
CU24518B1 CU24518B1 (es) | 2021-06-08 |
Family
ID=57136772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU2019000035A CU24518B1 (es) | 2016-10-14 | 2017-10-09 | Derivados sustituidos de 6-(1h-pirazol-1-il)pirimidin-4-amina |
Country Status (28)
Country | Link |
---|---|
US (2) | US11208400B2 (es) |
EP (1) | EP3526212B1 (es) |
JP (1) | JP2019532961A (es) |
KR (1) | KR20190065402A (es) |
CN (1) | CN110191884A (es) |
AR (1) | AR109947A1 (es) |
AU (1) | AU2017341324A1 (es) |
BR (1) | BR112019007496A2 (es) |
CA (1) | CA3040166A1 (es) |
CL (1) | CL2019001004A1 (es) |
CO (1) | CO2019003761A2 (es) |
CR (1) | CR20190192A (es) |
CU (1) | CU24518B1 (es) |
DO (1) | DOP2019000099A (es) |
EA (1) | EA201990947A1 (es) |
EC (1) | ECSP19026563A (es) |
GE (1) | GEP20217269B (es) |
IL (1) | IL265923A (es) |
JO (1) | JOP20190080A1 (es) |
MA (1) | MA46514A (es) |
MX (1) | MX2019004347A (es) |
PE (1) | PE20191549A1 (es) |
PH (1) | PH12019500808A1 (es) |
SG (1) | SG11201903305XA (es) |
TN (1) | TN2019000114A1 (es) |
TW (1) | TW201825477A (es) |
UY (1) | UY37444A (es) |
WO (1) | WO2018069222A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110734428A (zh) * | 2019-10-24 | 2020-01-31 | 嘉兴特科罗生物科技有限公司 | 一种小分子化合物 |
CN115403524A (zh) * | 2021-05-26 | 2022-11-29 | 浙江省化工研究院有限公司 | 3-氟代吡唑羧酸酯、3-氟代烷基-1-取代吡唑-4-羧酸的制备方法 |
WO2024061768A1 (en) | 2022-09-19 | 2024-03-28 | Basf Se | Azole pesticidal compounds |
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US3966781A (en) | 1970-12-17 | 1976-06-29 | Merck Sharp & Dohme (I.A.) Corporation | Deuteration of functional group-containing hydrocarbons |
DE19834044A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
DE19834047A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
WO2000043402A2 (en) | 1999-01-21 | 2000-07-27 | Board Of Regents, The University Of Texas System | Inhibitors of intestinal apical membrane na/phosphate co-transportation |
DE19943635A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
DE19943636A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
DE19943634A1 (de) | 1999-09-13 | 2001-04-12 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
DE19943639A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften |
AR031176A1 (es) | 2000-11-22 | 2003-09-10 | Bayer Ag | Nuevos derivados de pirazolpiridina sustituidos con piridina |
DE10110750A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
DE10110749A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituierte Aminodicarbonsäurederivate |
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DE10220570A1 (de) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamat-substituierte Pyrazolopyridine |
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ATE519759T1 (de) | 2004-12-30 | 2011-08-15 | Exelixis Inc | Pyrimidinderivate als kinasemodulatoren und anwendungsverfahren |
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JP2008296610A (ja) | 2007-05-29 | 2008-12-11 | Toyota Motor Corp | 車両用動力伝達装置の制御装置 |
BRPI0911491A2 (pt) * | 2008-04-29 | 2016-01-05 | Novartis Ag | métodos de monitoramento da modulação de atividade de quinase de receptor de fator de crescimento de fibroblasto e usos dos ditos métodos. |
EP2367824B1 (en) | 2008-12-23 | 2016-03-23 | AbbVie Inc. | Anti-viral derivatives of pyrimidine |
DE102010001064A1 (de) | 2009-03-18 | 2010-09-23 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung |
DK2539326T3 (en) | 2010-02-27 | 2017-08-28 | Bayer Ip Gmbh | BIS-ARYL-CONNECTED ARYLTRIZOLONES AND USE THEREOF |
DE102010021637A1 (de) | 2010-05-26 | 2011-12-01 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung |
AR088020A1 (es) | 2010-06-30 | 2014-05-07 | Ironwood Pharmaceuticals Inc | Compuestos heterociclicos como estimuladores de sgc |
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TWI582083B (zh) * | 2014-10-07 | 2017-05-11 | 美國禮來大藥廠 | 胺基吡啶基氧基吡唑化合物 |
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ES2949414T3 (es) | 2016-10-14 | 2023-09-28 | Novartis Ag | Formas cristalinas de 4-(2-((1R,2R)-2-hidroxiciclohexilamino)benzotiazol-6-iloxi)-N-metilpicolinamida |
-
2017
- 2017-06-16 JO JOP/2019/0080A patent/JOP20190080A1/ar unknown
- 2017-10-09 TN TNP/2019/000114A patent/TN2019000114A1/en unknown
- 2017-10-09 CN CN201780074126.5A patent/CN110191884A/zh active Pending
- 2017-10-09 MX MX2019004347A patent/MX2019004347A/es unknown
- 2017-10-09 PE PE2019000822A patent/PE20191549A1/es unknown
- 2017-10-09 JP JP2019519748A patent/JP2019532961A/ja active Pending
- 2017-10-09 EA EA201990947A patent/EA201990947A1/ru unknown
- 2017-10-09 KR KR1020197013647A patent/KR20190065402A/ko not_active Application Discontinuation
- 2017-10-09 BR BR112019007496A patent/BR112019007496A2/pt not_active Application Discontinuation
- 2017-10-09 SG SG11201903305XA patent/SG11201903305XA/en unknown
- 2017-10-09 CU CU2019000035A patent/CU24518B1/es unknown
- 2017-10-09 EP EP17780751.8A patent/EP3526212B1/en active Active
- 2017-10-09 GE GEAP201715076A patent/GEP20217269B/en unknown
- 2017-10-09 CR CR20190192A patent/CR20190192A/es unknown
- 2017-10-09 CA CA3040166A patent/CA3040166A1/en active Pending
- 2017-10-09 AU AU2017341324A patent/AU2017341324A1/en not_active Abandoned
- 2017-10-09 WO PCT/EP2017/075630 patent/WO2018069222A1/en unknown
- 2017-10-09 US US16/341,410 patent/US11208400B2/en active Active
- 2017-10-09 MA MA046514A patent/MA46514A/fr unknown
- 2017-10-12 TW TW106134859A patent/TW201825477A/zh unknown
- 2017-10-13 AR ARP170102862A patent/AR109947A1/es unknown
- 2017-10-13 UY UY0001037444A patent/UY37444A/es not_active Application Discontinuation
-
2019
- 2019-04-08 IL IL265923A patent/IL265923A/en unknown
- 2019-04-12 PH PH12019500808A patent/PH12019500808A1/en unknown
- 2019-04-12 DO DO2019000099A patent/DOP2019000099A/es unknown
- 2019-04-12 EC ECSENADI201926563A patent/ECSP19026563A/es unknown
- 2019-04-12 CL CL2019001004A patent/CL2019001004A1/es unknown
- 2019-04-12 CO CONC2019/0003761A patent/CO2019003761A2/es unknown
-
2021
- 2021-11-04 US US17/519,329 patent/US20230065629A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BR112019007496A2 (pt) | 2019-09-10 |
TW201825477A (zh) | 2018-07-16 |
CO2019003761A2 (es) | 2019-04-30 |
EP3526212B1 (en) | 2021-12-22 |
ECSP19026563A (es) | 2019-04-30 |
EP3526212A1 (en) | 2019-08-21 |
WO2018069222A1 (en) | 2018-04-19 |
CU24518B1 (es) | 2021-06-08 |
CN110191884A (zh) | 2019-08-30 |
US20200055842A1 (en) | 2020-02-20 |
IL265923A (en) | 2019-06-30 |
KR20190065402A (ko) | 2019-06-11 |
AU2017341324A1 (en) | 2019-05-02 |
US11208400B2 (en) | 2021-12-28 |
DOP2019000099A (es) | 2019-07-15 |
UY37444A (es) | 2018-05-31 |
MA46514A (fr) | 2019-08-21 |
PE20191549A1 (es) | 2019-10-24 |
PH12019500808A1 (en) | 2020-01-20 |
AR109947A1 (es) | 2019-02-06 |
CR20190192A (es) | 2019-09-02 |
GEP20217269B (en) | 2021-06-25 |
EA201990947A1 (ru) | 2019-08-30 |
SG11201903305XA (en) | 2019-05-30 |
CL2019001004A1 (es) | 2019-08-30 |
JP2019532961A (ja) | 2019-11-14 |
TN2019000114A1 (en) | 2020-10-05 |
CA3040166A1 (en) | 2018-04-19 |
MX2019004347A (es) | 2019-07-01 |
US20230065629A1 (en) | 2023-03-02 |
JOP20190080A1 (ar) | 2019-04-11 |
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