UY37444A - Derivados sustituidos de 6-(1h-pirazol-1-il)pirimidin-4-amina y su uso - Google Patents
Derivados sustituidos de 6-(1h-pirazol-1-il)pirimidin-4-amina y su usoInfo
- Publication number
- UY37444A UY37444A UY0001037444A UY37444A UY37444A UY 37444 A UY37444 A UY 37444A UY 0001037444 A UY0001037444 A UY 0001037444A UY 37444 A UY37444 A UY 37444A UY 37444 A UY37444 A UY 37444A
- Authority
- UY
- Uruguay
- Prior art keywords
- compounds
- pirimidin
- pirazol
- amina
- substituted derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Abstract
La presente invención se refiere a compuestos sustituidos de 6-(1H-pirazol-1-il)pirimidin-4-amina de la fórmula general (I) tal como se describen y definen en el presente, procedimientos para preparar dichos compuestos, compuestos de productos intermedios útiles para preparar dichos compuestos, composiciones farmacéuticas y combinaciones que comprenden dichos compuestos, y el uso de dichos compuestos para la fabricación de composiciones farmacéuticas para el tratamiento o profilaxis de enfermedades, en particular para el tratamiento y/o profilaxis de enfermedades cardiovasculares y renales ,como agente único o en combinación con otros compuestos activos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16193953 | 2016-10-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY37444A true UY37444A (es) | 2018-05-31 |
Family
ID=57136772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001037444A UY37444A (es) | 2016-10-14 | 2017-10-13 | Derivados sustituidos de 6-(1h-pirazol-1-il)pirimidin-4-amina y su uso |
Country Status (28)
Country | Link |
---|---|
US (2) | US11208400B2 (es) |
EP (1) | EP3526212B1 (es) |
JP (1) | JP2019532961A (es) |
KR (1) | KR20190065402A (es) |
CN (1) | CN110191884A (es) |
AR (1) | AR109947A1 (es) |
AU (1) | AU2017341324A1 (es) |
BR (1) | BR112019007496A2 (es) |
CA (1) | CA3040166A1 (es) |
CL (1) | CL2019001004A1 (es) |
CO (1) | CO2019003761A2 (es) |
CR (1) | CR20190192A (es) |
CU (1) | CU24518B1 (es) |
DO (1) | DOP2019000099A (es) |
EA (1) | EA201990947A1 (es) |
EC (1) | ECSP19026563A (es) |
GE (1) | GEP20217269B (es) |
IL (1) | IL265923A (es) |
JO (1) | JOP20190080A1 (es) |
MA (1) | MA46514A (es) |
MX (1) | MX2019004347A (es) |
PE (1) | PE20191549A1 (es) |
PH (1) | PH12019500808A1 (es) |
SG (1) | SG11201903305XA (es) |
TN (1) | TN2019000114A1 (es) |
TW (1) | TW201825477A (es) |
UY (1) | UY37444A (es) |
WO (1) | WO2018069222A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110734428A (zh) * | 2019-10-24 | 2020-01-31 | 嘉兴特科罗生物科技有限公司 | 一种小分子化合物 |
CN115403524A (zh) * | 2021-05-26 | 2022-11-29 | 浙江省化工研究院有限公司 | 3-氟代吡唑羧酸酯、3-氟代烷基-1-取代吡唑-4-羧酸的制备方法 |
WO2024061768A1 (en) | 2022-09-19 | 2024-03-28 | Basf Se | Azole pesticidal compounds |
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US3966781A (en) | 1970-12-17 | 1976-06-29 | Merck Sharp & Dohme (I.A.) Corporation | Deuteration of functional group-containing hydrocarbons |
DE19834044A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
DE19834047A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
AU3213200A (en) | 1999-01-21 | 2000-08-07 | Board Of Regents, The University Of Texas System | Inhibitors of intestinal apical membrane na/phosphate co-transportation |
DE19943635A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
DE19943639A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften |
DE19943636A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
DE19943634A1 (de) | 1999-09-13 | 2001-04-12 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
AR031176A1 (es) | 2000-11-22 | 2003-09-10 | Bayer Ag | Nuevos derivados de pirazolpiridina sustituidos con piridina |
DE10110750A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
DE10110749A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituierte Aminodicarbonsäurederivate |
US7119120B2 (en) | 2001-12-26 | 2006-10-10 | Genzyme Corporation | Phosphate transport inhibitors |
DE10220570A1 (de) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamat-substituierte Pyrazolopyridine |
DE102008020113A1 (de) | 2008-04-23 | 2009-10-29 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Dihydropyrazolone und ihre Verwendung |
ATE519759T1 (de) | 2004-12-30 | 2011-08-15 | Exelixis Inc | Pyrimidinderivate als kinasemodulatoren und anwendungsverfahren |
WO2008130879A2 (en) * | 2007-04-16 | 2008-10-30 | Serenex, Inc. | Tetrahydroindole and tetrahydroindazole derivatives |
JP2008296610A (ja) | 2007-05-29 | 2008-12-11 | Toyota Motor Corp | 車両用動力伝達装置の制御装置 |
CN103353532B (zh) * | 2008-04-29 | 2016-05-11 | 诺瓦提斯公司 | 监测成纤维细胞生长因子受体的激酶活性的调节的方法及所述方法的应用 |
WO2010075376A2 (en) | 2008-12-23 | 2010-07-01 | Abbott Laboratories | Anti-viral compounds |
DE102010001064A1 (de) | 2009-03-18 | 2010-09-23 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung |
EA023221B1 (ru) | 2010-02-27 | 2016-05-31 | Байер Интеллектуэль Проперти Гмбх | СВЯЗАННЫЕ БИС-АРИЛЬНЫЕ АРИЛ-ТРИАЗОЛОНЫ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ, ИХ ПРИМЕНЕНИЕ, ЛЕКАРСТВЕННОЕ СРЕДСТВО НА ИХ ОСНОВЕ И ДВОЙНОЙ АНТАГОНИСТ V1a/V2-РЕЦЕПТОРОВ |
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GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
-
2017
- 2017-06-16 JO JOP/2019/0080A patent/JOP20190080A1/ar unknown
- 2017-10-09 TN TNP/2019/000114A patent/TN2019000114A1/en unknown
- 2017-10-09 CA CA3040166A patent/CA3040166A1/en active Pending
- 2017-10-09 GE GEAP201715076A patent/GEP20217269B/en unknown
- 2017-10-09 JP JP2019519748A patent/JP2019532961A/ja active Pending
- 2017-10-09 CU CU2019000035A patent/CU24518B1/es unknown
- 2017-10-09 BR BR112019007496A patent/BR112019007496A2/pt not_active Application Discontinuation
- 2017-10-09 WO PCT/EP2017/075630 patent/WO2018069222A1/en unknown
- 2017-10-09 MX MX2019004347A patent/MX2019004347A/es unknown
- 2017-10-09 CN CN201780074126.5A patent/CN110191884A/zh active Pending
- 2017-10-09 EP EP17780751.8A patent/EP3526212B1/en active Active
- 2017-10-09 MA MA046514A patent/MA46514A/fr unknown
- 2017-10-09 PE PE2019000822A patent/PE20191549A1/es unknown
- 2017-10-09 KR KR1020197013647A patent/KR20190065402A/ko not_active Application Discontinuation
- 2017-10-09 CR CR20190192A patent/CR20190192A/es unknown
- 2017-10-09 AU AU2017341324A patent/AU2017341324A1/en not_active Abandoned
- 2017-10-09 US US16/341,410 patent/US11208400B2/en active Active
- 2017-10-09 EA EA201990947A patent/EA201990947A1/ru unknown
- 2017-10-09 SG SG11201903305XA patent/SG11201903305XA/en unknown
- 2017-10-12 TW TW106134859A patent/TW201825477A/zh unknown
- 2017-10-13 UY UY0001037444A patent/UY37444A/es not_active Application Discontinuation
- 2017-10-13 AR ARP170102862A patent/AR109947A1/es unknown
-
2019
- 2019-04-08 IL IL265923A patent/IL265923A/en unknown
- 2019-04-12 EC ECSENADI201926563A patent/ECSP19026563A/es unknown
- 2019-04-12 CL CL2019001004A patent/CL2019001004A1/es unknown
- 2019-04-12 PH PH12019500808A patent/PH12019500808A1/en unknown
- 2019-04-12 CO CONC2019/0003761A patent/CO2019003761A2/es unknown
- 2019-04-12 DO DO2019000099A patent/DOP2019000099A/es unknown
-
2021
- 2021-11-04 US US17/519,329 patent/US20230065629A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JOP20190080A1 (ar) | 2019-04-11 |
WO2018069222A1 (en) | 2018-04-19 |
KR20190065402A (ko) | 2019-06-11 |
MX2019004347A (es) | 2019-07-01 |
TN2019000114A1 (en) | 2020-10-05 |
US11208400B2 (en) | 2021-12-28 |
SG11201903305XA (en) | 2019-05-30 |
CU24518B1 (es) | 2021-06-08 |
EA201990947A1 (ru) | 2019-08-30 |
CN110191884A (zh) | 2019-08-30 |
JP2019532961A (ja) | 2019-11-14 |
EP3526212A1 (en) | 2019-08-21 |
GEP20217269B (en) | 2021-06-25 |
DOP2019000099A (es) | 2019-07-15 |
CL2019001004A1 (es) | 2019-08-30 |
BR112019007496A2 (pt) | 2019-09-10 |
AU2017341324A1 (en) | 2019-05-02 |
PE20191549A1 (es) | 2019-10-24 |
AR109947A1 (es) | 2019-02-06 |
EP3526212B1 (en) | 2021-12-22 |
US20200055842A1 (en) | 2020-02-20 |
PH12019500808A1 (en) | 2020-01-20 |
ECSP19026563A (es) | 2019-04-30 |
TW201825477A (zh) | 2018-07-16 |
MA46514A (fr) | 2019-08-21 |
US20230065629A1 (en) | 2023-03-02 |
CR20190192A (es) | 2019-09-02 |
CO2019003761A2 (es) | 2019-04-30 |
IL265923A (en) | 2019-06-30 |
CA3040166A1 (en) | 2018-04-19 |
CU20190035A7 (es) | 2019-11-04 |
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Legal Events
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109 | Application deemed to be withdrawn |
Effective date: 20230705 |