HK1259183A1 - 一種吡咯並[3，2-d]嘧啶類化合物的製備方法及其中間體 - Google Patents

一種吡咯並[3，2-d]嘧啶類化合物的製備方法及其中間體

Info

Publication number
HK1259183A1
HK1259183A1 HK19101234.3A HK19101234A HK1259183A1 HK 1259183 A1 HK1259183 A1 HK 1259183A1 HK 19101234 A HK19101234 A HK 19101234A HK 1259183 A1 HK1259183 A1 HK 1259183A1
Authority
HK
Hong Kong
Prior art keywords
intermediates
pyrimidine compound
preparing pyrrolo
pyrrolo
preparing
Prior art date
Application number
HK19101234.3A
Other languages
English (en)
Inventor
丁照中
孫飛
胡迎虎
周義龍
趙銳
楊玲
Original Assignee
正大天晴藥業集團股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 正大天晴藥業集團股份有限公司 filed Critical 正大天晴藥業集團股份有限公司
Publication of HK1259183A1 publication Critical patent/HK1259183A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
HK19101234.3A 2016-02-05 2019-01-24 一種吡咯並[3，2-d]嘧啶類化合物的製備方法及其中間體 HK1259183A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610082028.3A CN107043378A (zh) 2016-02-05 2016-02-05 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体
PCT/CN2017/072893 WO2017133686A1 (zh) 2016-02-05 2017-02-04 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体

Publications (1)

Publication Number Publication Date
HK1259183A1 true HK1259183A1 (zh) 2019-11-29

Family

ID=59500148

Family Applications (1)

Application Number Title Priority Date Filing Date
HK19101234.3A HK1259183A1 (zh) 2016-02-05 2019-01-24 一種吡咯並[3，2-d]嘧啶類化合物的製備方法及其中間體

Country Status (29)

Country Link
US (2) US10654856B2 (zh)
EP (1) EP3412673B1 (zh)
JP (1) JP6877449B2 (zh)
KR (1) KR102371500B1 (zh)
CN (2) CN107043378A (zh)
AR (1) AR107549A1 (zh)
AU (1) AU2017214134B2 (zh)
BR (1) BR112018015879B1 (zh)
CA (1) CA3013520C (zh)
CL (1) CL2018002094A1 (zh)
DK (1) DK3412673T3 (zh)
EA (1) EA034581B1 (zh)
ES (1) ES2852323T3 (zh)
HK (1) HK1259183A1 (zh)
HR (1) HRP20210103T1 (zh)
HU (1) HUE053455T2 (zh)
IL (1) IL260999B (zh)
LT (1) LT3412673T (zh)
MX (1) MX2018009502A (zh)
MY (1) MY190551A (zh)
NZ (1) NZ744885A (zh)
PH (1) PH12018501642A1 (zh)
PL (1) PL3412673T3 (zh)
PT (1) PT3412673T (zh)
SG (1) SG11201806685VA (zh)
SI (1) SI3412673T1 (zh)
TW (1) TW201728590A (zh)
UA (1) UA124100C2 (zh)
WO (1) WO2017133686A1 (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107043380A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
WO2020162705A1 (ko) 2019-02-08 2020-08-13 성균관대학교산학협력단 톨-유사 수용체 7 또는 8 작용자와 콜레스테롤의 결합체 및 그 용도
US20230100429A1 (en) 2020-03-02 2023-03-30 Progeneer Inc. Live-pathogen-mimetic nanoparticles based on pathogen cell wall skeleton, and production method thereof
WO2022031021A1 (ko) 2020-08-04 2022-02-10 성균관대학교산학협력단 동력학적 제어가 가능한 아주번트를 포함하는 mrna 백신
CN116056725A (zh) 2020-08-04 2023-05-02 蛋白科技先鋒 活性位点暂时灭活的功能性药物与Toll样受体7或8激动剂的缀合物及其用途
JP2023536945A (ja) 2020-08-04 2023-08-30 プロジェニア インコーポレイテッド 動力学的に作用するアジュバントアンサンブル
AU2023206890A1 (en) 2022-01-12 2024-08-22 Denali Therapeutics Inc. Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009082247A1 (en) * 2007-12-21 2009-07-02 Industrial Research Limited Process for preparing immucillins having a methylene link
EA021377B9 (ru) 2008-12-09 2015-09-30 Джилид Сайэнс, Инк. Модуляторы толл-подобных рецепторов
NZ705589A (en) * 2012-10-10 2019-05-31 Janssen Sciences Ireland Uc Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases
WO2014081645A1 (en) * 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds
EP2922550B1 (en) * 2012-11-20 2017-04-19 Glaxosmithkline LLC Novel compounds
CR20160512A (es) * 2014-05-01 2016-12-21 Novartis Ag Compuestos y composiciones como agonistas del receptor tipo toll 7
CN105367576A (zh) 2014-08-15 2016-03-02 正大天晴药业集团股份有限公司 作为tlr7激动剂的吡咯并嘧啶化合物
EA032824B1 (ru) * 2014-08-15 2019-07-31 Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд. Пирролопиримидиновые соединения, используемые в качестве агониста tlr7
EA035116B1 (ru) * 2015-11-05 2020-04-29 Чиа Тай Тяньцин Фармасьютикал Груп Ко., Лтд. 7-(тиазол-5-ил)пирролопиримидин в качестве агониста рецептора tlr7
CN107043380A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
CN107043379A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的晶型a、其制备方法和医药用途
CN107043377A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的三氟乙酸盐、晶型b及其制备方法、药物组合物和用途

Also Published As

Publication number Publication date
AR107549A1 (es) 2018-05-09
KR102371500B1 (ko) 2022-03-07
EP3412673A1 (en) 2018-12-12
WO2017133686A1 (zh) 2017-08-10
US20190040072A1 (en) 2019-02-07
HUE053455T2 (hu) 2021-06-28
US20200239484A1 (en) 2020-07-30
PT3412673T (pt) 2021-02-15
PL3412673T3 (pl) 2021-07-26
UA124100C2 (uk) 2021-07-21
MX2018009502A (es) 2018-12-11
CN108602832A (zh) 2018-09-28
HRP20210103T1 (hr) 2021-03-05
MY190551A (en) 2022-04-27
JP2019505531A (ja) 2019-02-28
BR112018015879A2 (zh) 2018-12-26
BR112018015879B1 (pt) 2024-02-15
AU2017214134A1 (en) 2018-08-23
CA3013520C (en) 2022-07-19
NZ744885A (en) 2022-07-01
JP6877449B2 (ja) 2021-05-26
EP3412673B1 (en) 2020-11-25
TW201728590A (zh) 2017-08-16
PH12018501642B1 (en) 2019-06-03
PH12018501642A1 (en) 2019-06-03
SI3412673T1 (sl) 2021-04-30
EA034581B1 (ru) 2020-02-21
EP3412673A4 (en) 2019-07-03
SG11201806685VA (en) 2018-09-27
IL260999B (en) 2021-02-28
ES2852323T3 (es) 2021-09-13
DK3412673T3 (da) 2021-01-18
US10654856B2 (en) 2020-05-19
CL2018002094A1 (es) 2018-12-07
CN108602832B (zh) 2020-10-09
KR20180104724A (ko) 2018-09-21
EA201891769A1 (ru) 2019-04-30
AU2017214134B2 (en) 2020-08-27
CN107043378A (zh) 2017-08-15
CA3013520A1 (en) 2017-08-10
LT3412673T (lt) 2021-03-10

Similar Documents

Publication Publication Date Title
HK1259623A1 (zh) 作爲irak4調節劑的吡唑並[1，5a]嘧啶衍生物
HK1259183A1 (zh) 一種吡咯並[3，2-d]嘧啶類化合物的製備方法及其中間體
HK1251223A1 (zh) 7h-吡咯並[2，3-d]嘧啶衍生物的製備方法和其中間體
HK1257146A1 (zh) 新型的吡唑並[3，4-d]嘧啶化合物或其鹽
ZA201802743B (en) Novel pyrazolo pyrimidine derivatives
EP3260441A4 (en) Method for preparing formamide compound
EP3231805A4 (en) Salt of pyrrolo[2,3-d]pyrimidine compound and novel polymorph of salt
IL288080A (en) A process for the preparation of h7-pyrrolo[3,2-d]pyrimidine derivatives and their artificial intermediates
EP3265455A4 (en) CHEMICAL PROCESS FOR THE PREPARATION OF PYRIMIDINE DERIVATIVES AND INTERMEDIATE PRODUCTS THEREOF
IL262673A (en) A pyrazolo[5,1-a]pyrimidine compound
EP3472169A4 (en) PROCESS FOR PREPARING 4-CHLORO-7H-PYRROLO [2,3-D] PYRIMIDINE
ZA201807240B (en) Method for preparing azoxystrobin intermediates
EP3276042A4 (en) Method for producing plated article
EP3262025A4 (en) Novel intermediates for preparing dpp-iv inhibitors, preparing method thereof and preparing method of dpp-iv inhibitors using the same
EP3562936C0 (en) METHODS FOR CULTIVATION OF B CELLS
PL3436571T3 (pl) Sposób hodowli limfocytów B
IL291114A (en) A pyrimidine compound and a method for its preparation
ZA201807239B (en) Method for preparing azoxystrobin
EP3652158A4 (en) METHOD FOR PRODUCING A PYRIMIDONE COMPOUND
EP3719015A4 (en) SUBSTITUTED PYRIMIDINE COMPOUND AND MANUFACTURING METHOD FOR ITS AND USES THEREOF
EP3533856A4 (en) METHOD FOR PRODUCING HEXADECAHYDROPYRENE
HK1251232A1 (zh) 吡咯並[2，3-d]嘧啶化合物或其鹽
GB201600977D0 (en) Novel crystalline form of picoxystrobin, method of preparing use of the same
HUE050339T2 (hu) Eljárások ciklopenta[B]naftalenol származékok és azok intermedierjeinek elõállítására
UA107549C2 (uk) ПОХІДНІ 4,7-ДИГІДРО-5-АМІНО-3-КАРБОКСАМІДО-6-ЦІАНО[1,2,3]ТРИАЗОЛО[1,5-а]ПІРИМІДИНУ І СПОСІБ ЇХ ОДЕРЖАННЯ