EA201490998A1 - Способ получения сложных эфиров (5-фтор-2-метил-3-хинолин-2-илметил-индол-1-ил)-уксусной кислоты - Google Patents

Способ получения сложных эфиров (5-фтор-2-метил-3-хинолин-2-илметил-индол-1-ил)-уксусной кислоты

Info

Publication number
EA201490998A1
EA201490998A1 EA201490998A EA201490998A EA201490998A1 EA 201490998 A1 EA201490998 A1 EA 201490998A1 EA 201490998 A EA201490998 A EA 201490998A EA 201490998 A EA201490998 A EA 201490998A EA 201490998 A1 EA201490998 A1 EA 201490998A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ilmethil
catty
quinolin
fluor
indol
Prior art date
Application number
EA201490998A
Other languages
English (en)
Other versions
EA026617B1 (ru
Inventor
Жак Тоннель
Тони Пинтус
Ален Бурго
Original Assignee
Атопикс Терапьютикс Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Атопикс Терапьютикс Лимитед filed Critical Атопикс Терапьютикс Лимитед
Publication of EA201490998A1 publication Critical patent/EA201490998A1/ru
Publication of EA026617B1 publication Critical patent/EA026617B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Изобретение относится к способу получения соединения формулы (I)где Rпредставляет собой C-Cалкил или бензил; путем взаимодействия соединения формулы (II)где Rтот же, что и для формулы (I); с 2-хинолинкарбоксальдегидом. Способ подходит для использования в промышленных масштабах.
EA201490998A 2011-12-15 2012-12-14 Способ получения сложных эфиров (5-фтор-2-метил-3-хинолин-2-илметил-индол-1-ил)уксусной кислоты EA026617B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201121557A GB201121557D0 (en) 2011-12-15 2011-12-15 Process
PCT/GB2012/000903 WO2013088108A1 (en) 2011-12-15 2012-12-14 Process for the preparation of (5-fluoro-2-methyl-3-quinolin-2-ylmethyl-indol-1-yl)-acetic acid esters

Publications (2)

Publication Number Publication Date
EA201490998A1 true EA201490998A1 (ru) 2014-11-28
EA026617B1 EA026617B1 (ru) 2017-04-28

Family

ID=45560499

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490998A EA026617B1 (ru) 2011-12-15 2012-12-14 Способ получения сложных эфиров (5-фтор-2-метил-3-хинолин-2-илметил-индол-1-ил)уксусной кислоты

Country Status (28)

Country Link
US (1) US9102658B2 (ru)
EP (1) EP2791129B1 (ru)
JP (2) JP6300277B2 (ru)
KR (1) KR102018929B1 (ru)
CN (1) CN104114548B (ru)
AU (1) AU2012351341B2 (ru)
BR (1) BR112014014604B1 (ru)
CA (1) CA2859281C (ru)
CY (1) CY1117087T1 (ru)
DK (1) DK2791129T3 (ru)
EA (1) EA026617B1 (ru)
ES (1) ES2557762T3 (ru)
GB (1) GB201121557D0 (ru)
HK (1) HK1197671A1 (ru)
HR (1) HRP20151422T1 (ru)
HU (1) HUE028257T2 (ru)
IL (1) IL233132A (ru)
ME (1) ME02348B (ru)
MX (1) MX342273B (ru)
PL (1) PL2791129T3 (ru)
PT (1) PT2791129E (ru)
RS (1) RS54523B1 (ru)
SG (1) SG11201402798RA (ru)
SI (1) SI2791129T1 (ru)
SM (1) SMT201500327B (ru)
UA (1) UA111868C2 (ru)
WO (1) WO2013088108A1 (ru)
ZA (1) ZA201404246B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201103837D0 (en) 2011-03-07 2011-04-20 Oxagen Ltd Amorphous (5-Fluoro-2-Methyl-3-Quinolin-2-Ylmethyl-Indol-1-Yl)-acetic acid
GB201121557D0 (en) * 2011-12-15 2012-01-25 Oxagen Ltd Process
GB201322273D0 (en) * 2013-12-17 2014-01-29 Atopix Therapeutics Ltd Process
GB201407820D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
GB201407807D0 (en) * 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
WO2020136093A1 (en) 2018-12-27 2020-07-02 Chiesi Farmaceutici S.P.A. Process for preparing spherical agglomerates of timapiprant
CN111978245A (zh) * 2020-09-15 2020-11-24 上海毕得医药科技有限公司 一种3-氟-2-异丁基吡啶的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007508363A (ja) 2003-10-14 2007-04-05 オキサジェン リミテッド Ｃｒｔｈ２アンタゴニスト活性を有する化合物
GB0324763D0 (en) 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
GB0504150D0 (en) * 2005-03-01 2005-04-06 Oxagen Ltd Microcrystalline material
GB0505048D0 (en) 2005-03-11 2005-04-20 Oxagen Ltd Compounds with PGD antagonist activity
US7188489B2 (en) 2005-04-12 2007-03-13 Martello Russell A Portable air conditioner
GB0605743D0 (en) * 2006-03-22 2006-05-03 Oxagen Ltd Salts with CRTH2 antagonist activity
JP5270542B2 (ja) 2006-07-22 2013-08-21 オキサジェン リミテッド Ｃｒｔｈ２アンタゴニスト活性を有する化合物
US20110124683A1 (en) 2007-11-13 2011-05-26 Oxagen Limited Use of CRTH2 Antagonist Compounds
US7750027B2 (en) 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
DK2250161T3 (da) 2008-01-18 2014-01-27 Atopix Therapeutics Ltd Forbindelser med CRTH2-antagonistaktivitet
US20100022613A1 (en) 2008-01-22 2010-01-28 Oxagen Limited Compounds Having CRTH2 Antagonist Activity
WO2009093029A1 (en) 2008-01-22 2009-07-30 Oxagen Limited Compounds having crth2 antagonist activity
US20130052190A1 (en) 2011-02-22 2013-02-28 Oxagen Limited CRTH2 Antagonists for Treatment of Eosinophilic Diseases and Conditions
GB201103837D0 (en) 2011-03-07 2011-04-20 Oxagen Ltd Amorphous (5-Fluoro-2-Methyl-3-Quinolin-2-Ylmethyl-Indol-1-Yl)-acetic acid
GB201121557D0 (en) * 2011-12-15 2012-01-25 Oxagen Ltd Process
BR112014014558A8 (pt) 2011-12-16 2017-07-04 Atopix Therapeutics Ltd composição farmacêutica, uso de um antagonista de crth2 e de um inibidor de bomba de prótons, e, kit para o tratamento de esofagite eosinofílica

Also Published As

Publication number Publication date
SI2791129T1 (sl) 2016-02-29
PL2791129T3 (pl) 2016-05-31
CN104114548B (zh) 2016-01-20
ZA201404246B (en) 2016-10-26
US20140350264A1 (en) 2014-11-27
SMT201500327B (it) 2016-02-25
MX342273B (es) 2016-09-21
CY1117087T1 (el) 2017-04-05
ME02348B (me) 2016-06-20
CA2859281A1 (en) 2013-06-20
US9102658B2 (en) 2015-08-11
JP2018008985A (ja) 2018-01-18
CN104114548A (zh) 2014-10-22
AU2012351341A1 (en) 2014-07-24
KR102018929B1 (ko) 2019-09-05
BR112014014604A2 (pt) 2017-06-13
JP6300277B2 (ja) 2018-03-28
UA111868C2 (uk) 2016-06-24
EP2791129A1 (en) 2014-10-22
NZ626732A (en) 2015-09-25
PT2791129E (pt) 2016-01-26
CA2859281C (en) 2020-10-27
ES2557762T3 (es) 2016-01-28
SG11201402798RA (en) 2014-06-27
JP2015500325A (ja) 2015-01-05
AU2012351341B2 (en) 2017-08-24
EA026617B1 (ru) 2017-04-28
DK2791129T3 (en) 2015-12-14
HK1197671A1 (zh) 2015-02-06
IL233132A0 (en) 2014-08-03
HUE028257T2 (en) 2016-12-28
KR20140113927A (ko) 2014-09-25
GB201121557D0 (en) 2012-01-25
WO2013088108A1 (en) 2013-06-20
IL233132A (en) 2015-09-24
EP2791129B1 (en) 2015-10-07
RS54523B1 (en) 2016-06-30
BR112014014604B1 (pt) 2021-01-12
HRP20151422T1 (hr) 2016-02-26
MX2014007129A (es) 2014-09-04

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