MX2013000295A - Procedimiento de preparacion de un inhibidor especifico de la trombina. - Google Patents

Procedimiento de preparacion de un inhibidor especifico de la trombina.

Info

Publication number
MX2013000295A
MX2013000295A MX2013000295A MX2013000295A MX2013000295A MX 2013000295 A MX2013000295 A MX 2013000295A MX 2013000295 A MX2013000295 A MX 2013000295A MX 2013000295 A MX2013000295 A MX 2013000295A MX 2013000295 A MX2013000295 A MX 2013000295A
Authority
MX
Mexico
Prior art keywords
sup
preparing
specific inhibitor
thrombin specific
preparation
Prior art date
Application number
MX2013000295A
Other languages
English (en)
Inventor
Rodriguez Antoni Segade
Aguila Mireia Pasto
Original Assignee
Esteve Quimica Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Quimica Sa filed Critical Esteve Quimica Sa
Publication of MX2013000295A publication Critical patent/MX2013000295A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Procedimiento de preparación aplicable a escala industrial de un compuesto de fórmula (I), o una sal farmacéuticamente aceptable del mismo, (Ver Formula) donde R1 y R2 representan H; o bien R1 representa etilo y R2 representa n-hexiloxicarbonilo, nuevos intermedios útiles para su preparación, y procedimientos de preparación de dichos intermedios.
MX2013000295A 2010-07-09 2011-07-08 Procedimiento de preparacion de un inhibidor especifico de la trombina. MX2013000295A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES201031049 2010-07-09
PCT/EP2011/061678 WO2012004396A2 (en) 2010-07-09 2011-07-08 Process of preparing a thrombin specific inhibitor

Publications (1)

Publication Number Publication Date
MX2013000295A true MX2013000295A (es) 2013-05-28

Family

ID=44454039

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013000295A MX2013000295A (es) 2010-07-09 2011-07-08 Procedimiento de preparacion de un inhibidor especifico de la trombina.

Country Status (6)

Country Link
US (1) US8981105B2 (es)
EP (2) EP2937343A1 (es)
JP (1) JP2013532164A (es)
CN (1) CN102985416B (es)
MX (1) MX2013000295A (es)
WO (1) WO2012004396A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8336933B2 (en) 2010-11-04 2012-12-25 Sabic Innovative Plastics Ip B.V. Energy absorbing device and methods of making and using the same
WO2013111163A2 (en) * 2012-01-20 2013-08-01 Cadila Healthcare Limited Process for the preparation of dabigatran etexilate mesylate and polymorphs of intermediates thereof
WO2013144903A1 (en) * 2012-03-28 2013-10-03 Dr. Reddy's Laboratories Limited Processes for the preparation of dabigatran etexilate
EP2834224B1 (en) 2012-04-02 2018-06-06 MSN Laboratories Limited Process for the preparation of benzimidazole derivatives and salts thereof
CN102911160B (zh) * 2012-06-29 2014-10-22 上海奥博生物医药技术有限公司 一种制备和纯化达比加群酯中间体的方法
WO2014012880A1 (en) 2012-07-16 2014-01-23 Interquim, S.A. Process for the preparation of intermediates for the synthesis of dabigatran etexilate, and crystalline forms of said intermediates
WO2014020555A2 (en) * 2012-08-01 2014-02-06 Alembic Pharmaceuticals Limited An improved process for the preparation of dabigatran etexilate mesylate
CN103804354A (zh) * 2012-11-08 2014-05-21 天津药物研究院 一种达比加群酯的制备方法
CN104177337B (zh) * 2013-05-28 2019-04-23 海思科医药集团股份有限公司 达比加群酯的一种中间体及其制备方法
WO2015124764A1 (en) * 2014-02-24 2015-08-27 Erregierre S.P.A. Synthesis process of dabigatran etexilate mesylate, intermediates of the process and novel polymorph of dabigatran etexilate
CN105218519A (zh) * 2014-06-04 2016-01-06 天津药物研究院 一种达比加群酯中间体的制备方法
CN104744438A (zh) * 2014-12-17 2015-07-01 烟台东诚药业集团股份有限公司 一种用于合成制备达比加群酯苯并咪唑中间体的方法
CN105294651A (zh) * 2015-09-23 2016-02-03 烟台东诚药业集团股份有限公司 一种用于合成制备达比加群酯脒化中间体的方法
CN105153118A (zh) * 2015-09-24 2015-12-16 青岛黄海制药有限责任公司 一种甲磺酸达比加群酯制备过程中中间体的中控方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE121699A1 (es) 1997-02-18 1999-12-08 Boehringer Ingelheim Pharma Heterociclos biciclicos disustituidos como inhibidores de la trombina
NZ535663A (en) 2002-03-07 2006-06-30 Boehringer Ingelheim Pharma Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino] propionic acid ethyl ester and the salts thereof
EP1609784A1 (de) 2004-06-25 2005-12-28 Boehringer Ingelheim Pharma GmbH & Co.KG Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen
DE102005020002A1 (de) 2005-04-27 2006-11-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Physiologisch verträgliche Salze von 3-[(2-{[4-(Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester
US20100087488A1 (en) 2006-10-10 2010-04-08 Boehringer Ingelheim International Gmgh Physiologically Acceptable Salts of 3-[(2--1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester
EP1956018A1 (de) * 2007-02-06 2008-08-13 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung eines Benzimidazolderivats
CZ305085B6 (cs) 2008-03-14 2015-04-29 Zentiva, K.S. Způsob přípravy dabigatranu
EP2300431B1 (en) 2008-06-16 2016-01-06 Boehringer Ingelheim International GmbH Process for the manufacture of an intermediate in the synthesis of dabigatran
CZ2008669A3 (cs) 2008-10-24 2010-05-05 Zentiva, A. S. Zpusob prípravy dabigatranu a jeho meziprodukty

Also Published As

Publication number Publication date
EP2590962A2 (en) 2013-05-15
CN102985416A (zh) 2013-03-20
WO2012004396A2 (en) 2012-01-12
CN102985416B (zh) 2015-04-01
US20130116440A1 (en) 2013-05-09
EP2937343A1 (en) 2015-10-28
WO2012004396A3 (en) 2012-06-28
US8981105B2 (en) 2015-03-17
JP2013532164A (ja) 2013-08-15

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