MX2011011776A - Nuevos profarmacos de triptolite. - Google Patents

Nuevos profarmacos de triptolite.

Info

Publication number
MX2011011776A
MX2011011776A MX2011011776A MX2011011776A MX2011011776A MX 2011011776 A MX2011011776 A MX 2011011776A MX 2011011776 A MX2011011776 A MX 2011011776A MX 2011011776 A MX2011011776 A MX 2011011776A MX 2011011776 A MX2011011776 A MX 2011011776A
Authority
MX
Mexico
Prior art keywords
formula
compounds
triptolide prodrugs
triptolide
prodrugs
Prior art date
Application number
MX2011011776A
Other languages
English (en)
Inventor
Ingrid Gunda Georg
Satish Prakash Patil
Ashok K Saluja
Rohit Chugh
Selwyn M Vickers
Original Assignee
Univ Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minnesota filed Critical Univ Minnesota
Publication of MX2011011776A publication Critical patent/MX2011011776A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings

Abstract

La invención provee compuestos de formula (I) o una sal de los mismos. La invención también provee composiciones farmacéuticas que comprenden un compuesto de fórmula I, procesos para la preparación de compuestos de fórmula I, intermediarios útiles para la preparación de compuestos de fórmula I y métodos terapéuticos que usan los compuestos de fórmula I.
MX2011011776A 2009-05-07 2010-05-07 Nuevos profarmacos de triptolite. MX2011011776A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17624909P 2009-05-07 2009-05-07
PCT/US2010/034117 WO2010129918A1 (en) 2009-05-07 2010-05-07 Triptolide prodrugs

Publications (1)

Publication Number Publication Date
MX2011011776A true MX2011011776A (es) 2012-08-03

Family

ID=42244313

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011011776A MX2011011776A (es) 2009-05-07 2010-05-07 Nuevos profarmacos de triptolite.

Country Status (18)

Country Link
US (1) US8507552B2 (es)
EP (1) EP2427467B1 (es)
JP (3) JP6000122B2 (es)
KR (1) KR101821823B1 (es)
CN (1) CN102596977B (es)
AU (1) AU2010245669B2 (es)
BR (1) BRPI1014802B8 (es)
CA (2) CA2964631A1 (es)
DK (1) DK2427467T3 (es)
EA (1) EA021135B1 (es)
ES (1) ES2552163T3 (es)
HK (1) HK1168107A1 (es)
MX (1) MX2011011776A (es)
MY (1) MY160392A (es)
PL (1) PL2427467T3 (es)
PT (1) PT2427467E (es)
SG (1) SG175885A1 (es)
WO (1) WO2010129918A1 (es)

Families Citing this family (11)

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US9150600B2 (en) 2009-05-07 2015-10-06 Regents Of The University Of Minnesota Triptolide prodrugs
DK3510860T3 (da) 2012-08-23 2021-10-18 Senestech Inc Nedsættelse af pattedyrs reproduktive kapacitet
WO2014047783A1 (zh) * 2012-09-25 2014-04-03 鼎泓国际投资（香港）有限公司 含有雷公藤甲素及雷公藤甲素类衍生物和Bcl-2抑制剂的药物组合物及其应用
WO2014167581A2 (en) * 2013-04-01 2014-10-16 Laurus Labs Private Limited An improved process for the preparation of triptolide prodrugs
WO2017043613A1 (ja) * 2015-09-11 2017-03-16 ワイズエーシー株式会社 抗ｃｄ２６抗体と他の抗癌剤とを組み合わせた癌治療用組成物
CN109942665B (zh) * 2018-04-02 2021-04-06 欣凯医药化工中间体（上海）有限公司 雷公藤内酯醇衍生物及其制备方法和应用
CN110551171B (zh) * 2018-05-31 2021-07-27 欣凯医药化工中间体（上海）有限公司 一种雷公藤内酯醇衍生物的制备方法
US20200085784A1 (en) 2018-09-13 2020-03-19 Minneamrita Therapeutics, LLC Methods to treat fibrosis, nash, and nafld
WO2021221179A1 (ja) * 2020-04-28 2021-11-04 国立大学法人高知大学 ヒト膵癌オルガノイドを用いたマウスモデルの樹立
EP4200022A1 (en) 2020-08-21 2023-06-28 Reyoung Corporation Triptolide conjugates and uses thereof
CN115227829B (zh) * 2022-02-22 2023-10-13 成都中医药大学 酸敏感性适配体雷公藤甲素偶联物及应用

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US5759550A (en) 1993-05-06 1998-06-02 Pharmagenesis, Inc. Method for suppressing xenograft rejection
US5609991A (en) 1995-02-10 1997-03-11 Morton International, Inc. Photoimageable composition having improved alkaline process resistance and tack-free surface for contact imaging
US5663335A (en) 1996-03-01 1997-09-02 Pharmagenesis, Inc. Immunosuppressive compounds and methods
US5962516A (en) 1997-02-28 1999-10-05 Pharmagenesis, Inc. Immunosuppressive compounds and methods
US6204257B1 (en) * 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
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WO2000012483A1 (en) 1998-09-02 2000-03-09 Pharmagenesis, Inc. Triptolide prodrugs having high aqueous solubility
WO2000048619A1 (en) 1999-02-16 2000-08-24 The Board Of Trustees Of The Leland Stanford Junior University Combined therapy of diterpenoid triepoxides and trail for synergistic killing of tumor cells
WO2000063212A1 (en) 1999-04-16 2000-10-26 Chengdu Diao Pharmaceutical Group Company Limited Derivatives of triptolide, and preparation and uses thereof
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Also Published As

Publication number Publication date
AU2010245669A1 (en) 2011-12-01
EA201190293A1 (ru) 2012-11-30
EP2427467A1 (en) 2012-03-14
WO2010129918A8 (en) 2011-01-20
AU2010245669B2 (en) 2015-11-26
JP6000122B2 (ja) 2016-09-28
HK1168107A1 (en) 2012-12-21
PT2427467E (pt) 2015-11-19
PL2427467T3 (pl) 2016-04-29
WO2010129918A1 (en) 2010-11-11
JP2012526148A (ja) 2012-10-25
BRPI1014802A2 (pt) 2016-04-05
JP2014185181A (ja) 2014-10-02
CA2760953A1 (en) 2010-11-11
CA2964631A1 (en) 2010-11-11
SG175885A1 (en) 2011-12-29
MY160392A (en) 2017-03-15
ES2552163T3 (es) 2015-11-26
US8507552B2 (en) 2013-08-13
CN102596977A (zh) 2012-07-18
DK2427467T3 (en) 2015-11-09
BRPI1014802B1 (pt) 2020-09-24
EA021135B1 (ru) 2015-04-30
KR20120015339A (ko) 2012-02-21
US20120238529A1 (en) 2012-09-20
BRPI1014802B8 (pt) 2021-05-25
JP2016065099A (ja) 2016-04-28
EP2427467B1 (en) 2015-08-05
KR101821823B1 (ko) 2018-01-24
CN102596977B (zh) 2016-06-29
CA2760953C (en) 2017-05-30

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