MX2012007870A - Derivados de acido carboxilico que comprende un anillo de oxazolopirimidina 2, 5, 7-sustituido. - Google Patents

Derivados de acido carboxilico que comprende un anillo de oxazolopirimidina 2, 5, 7-sustituido.

Info

Publication number
MX2012007870A
MX2012007870A MX2012007870A MX2012007870A MX2012007870A MX 2012007870 A MX2012007870 A MX 2012007870A MX 2012007870 A MX2012007870 A MX 2012007870A MX 2012007870 A MX2012007870 A MX 2012007870A MX 2012007870 A MX2012007870 A MX 2012007870A
Authority
MX
Mexico
Prior art keywords
carboxylic acid
acid derivatives
oxazolopyrimidine ring
substituted oxazolopyrimidine
substituted
Prior art date
Application number
MX2012007870A
Other languages
English (en)
Inventor
Matthias Schaefer
Dieter Kadereit
Stephanie Hachtel
Axel Dietrich
Thomas Huebschle
Andreas Gille
Katrin Hiss
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX2012007870A publication Critical patent/MX2012007870A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

La presente invención se refiere a compuestos de oxazolopirimidina de la fórmula I, (Ver Formula) en la que A, R1, R2, R3, R4 y X se definen como se ha indicado en las reivindicaciones. Los compuestos de la fórmula I son adecuados, por ejemplo, para la curación de heridas.
MX2012007870A 2010-01-13 2011-01-12 Derivados de acido carboxilico que comprende un anillo de oxazolopirimidina 2, 5, 7-sustituido. MX2012007870A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10305036 2010-01-13
PCT/EP2011/050298 WO2011086077A1 (de) 2010-01-13 2011-01-12 Carbonsäurederivate mit einem 2,5,7-substituierten oxazolopyrimidinring

Publications (1)

Publication Number Publication Date
MX2012007870A true MX2012007870A (es) 2012-07-25

Family

ID=42111309

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012007870A MX2012007870A (es) 2010-01-13 2011-01-12 Derivados de acido carboxilico que comprende un anillo de oxazolopirimidina 2, 5, 7-sustituido.

Country Status (21)

Country Link
US (1) US8748436B2 (es)
EP (1) EP2523958B1 (es)
JP (1) JP5844277B2 (es)
KR (1) KR101759117B1 (es)
CN (1) CN103097392B (es)
AR (1) AR079981A1 (es)
AU (1) AU2011206613B2 (es)
BR (1) BR112012017485A2 (es)
CA (1) CA2799474C (es)
DK (1) DK2523958T3 (es)
ES (1) ES2453956T3 (es)
HK (1) HK1180314A1 (es)
IL (1) IL220706A (es)
MX (1) MX2012007870A (es)
MY (1) MY156960A (es)
PT (1) PT2523958E (es)
RU (1) RU2560876C2 (es)
SG (1) SG182477A1 (es)
TW (1) TWI478929B (es)
UY (1) UY33177A (es)
WO (1) WO2011086077A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY33176A (es) 2010-01-13 2011-08-31 Sanofi Aventis Derivados de oxazolopirimidina sustituida en 2, 5, 7.
JP5841067B2 (ja) * 2010-01-14 2016-01-06 サノフイ ２，５−置換されたオキサゾロピリミジン環を有するカルボン酸誘導体
ES2524712T3 (es) * 2010-01-14 2014-12-11 Sanofi Derivados de oxazolopirimidina 2,5-sustituidos en calidad de agonistas de EDG-1
WO2011086080A1 (de) * 2010-01-14 2011-07-21 Sanofi-Aventis Heterocyclische carbonsäurederivate mit einem 2,5-substituierten oxazolopyrimidinring
US9321787B2 (en) 2011-07-07 2016-04-26 Sanofi Carboxylic acid derivatives having an oxazolo[5,4-d]pyrimidine ring
WO2014175287A1 (ja) 2013-04-26 2014-10-30 国立大学法人 京都大学 脳動脈瘤の形成および／または増大の抑制若しくは縮小用医薬組成物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3679682A (en) * 1970-04-23 1972-07-25 Fmc Corp CERTAIN 5H-ISOXAZOLO{8 5,4-d{9 PYRIMIDIN-4-ONES
JP2006524672A (ja) 2003-04-25 2006-11-02 ユニバーシティー・カッレッジ・カーディフ・コンサルタンツ・リミテッド ウイルス感染の治療において使用するための複素環式化合物
WO2004103309A2 (en) * 2003-05-19 2004-12-02 Irm Llc Immunosuppressant compounds and compositions
PE20050158A1 (es) * 2003-05-19 2005-05-12 Irm Llc Compuestos inmunosupresores y composiciones
US7855193B2 (en) * 2005-11-23 2010-12-21 Epix Pharmaceuticals, Inc. S1P receptor modulating compounds and use thereof
EP2121648A2 (en) * 2007-03-21 2009-11-25 EPIX Pharmaceuticals, Inc. S1p receptor modulating compounds and use thereof
TW201000099A (en) * 2008-06-20 2010-01-01 Amgen Inc S1P1 receptor agonists and use thereof
EP2583720A1 (en) 2008-07-15 2013-04-24 Sanofi Oxazolopyrimidines as Edg-1 receptor agonists
JP5841067B2 (ja) 2010-01-14 2016-01-06 サノフイ ２，５−置換されたオキサゾロピリミジン環を有するカルボン酸誘導体
ES2524712T3 (es) 2010-01-14 2014-12-11 Sanofi Derivados de oxazolopirimidina 2,5-sustituidos en calidad de agonistas de EDG-1
WO2011086080A1 (de) 2010-01-14 2011-07-21 Sanofi-Aventis Heterocyclische carbonsäurederivate mit einem 2,5-substituierten oxazolopyrimidinring

Also Published As

Publication number Publication date
CN103097392A (zh) 2013-05-08
US20130079357A1 (en) 2013-03-28
KR20120115397A (ko) 2012-10-17
ES2453956T3 (es) 2014-04-09
CN103097392B (zh) 2015-05-13
CA2799474C (en) 2018-02-20
TWI478929B (zh) 2015-04-01
HK1180314A1 (en) 2013-10-18
JP2013517239A (ja) 2013-05-16
DK2523958T3 (da) 2014-03-31
SG182477A1 (en) 2012-08-30
PT2523958E (pt) 2014-03-27
RU2560876C2 (ru) 2015-08-20
IL220706A (en) 2015-06-30
RU2012134378A (ru) 2014-02-20
US8748436B2 (en) 2014-06-10
EP2523958A1 (de) 2012-11-21
CA2799474A1 (en) 2011-07-21
AU2011206613B2 (en) 2015-04-02
AU2011206613A1 (en) 2012-08-02
EP2523958B1 (de) 2013-12-25
UY33177A (es) 2011-08-31
AR079981A1 (es) 2012-03-07
IL220706A0 (en) 2012-08-30
KR101759117B1 (ko) 2017-07-18
WO2011086077A1 (de) 2011-07-21
BR112012017485A2 (pt) 2016-04-19
TW201136940A (en) 2011-11-01
MY156960A (en) 2016-04-15
JP5844277B2 (ja) 2016-01-13

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