MX2012007341A - Inhibidores de proteasoma y procesos para su preparacion, purificacion y uso. - Google Patents
Inhibidores de proteasoma y procesos para su preparacion, purificacion y uso.Info
- Publication number
- MX2012007341A MX2012007341A MX2012007341A MX2012007341A MX2012007341A MX 2012007341 A MX2012007341 A MX 2012007341A MX 2012007341 A MX2012007341 A MX 2012007341A MX 2012007341 A MX2012007341 A MX 2012007341A MX 2012007341 A MX2012007341 A MX 2012007341A
- Authority
- MX
- Mexico
- Prior art keywords
- purification
- preparation
- processes
- proteasome inhibitors
- proteasome
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
Abstract
La invención proporciona ésteres borónicos de la Fórmula I (Ver Formula) en donde R1, R2, R3 y son como se describe en la presente, y métodos para su preparación y purificación.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28895709P | 2009-12-22 | 2009-12-22 | |
PCT/US2010/061695 WO2011087822A1 (en) | 2009-12-22 | 2010-12-22 | Proteasome inhibitors and processes for their preparation, purification and use |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012007341A true MX2012007341A (es) | 2012-07-20 |
Family
ID=43530797
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012007341A MX2012007341A (es) | 2009-12-22 | 2010-12-22 | Inhibidores de proteasoma y procesos para su preparacion, purificacion y uso. |
Country Status (10)
Country | Link |
---|---|
US (1) | US8541590B2 (es) |
EP (1) | EP2516449A1 (es) |
JP (1) | JP5783659B2 (es) |
CN (1) | CN102725300B (es) |
AU (1) | AU2010341530B2 (es) |
CA (1) | CA2785300A1 (es) |
IL (1) | IL220190A0 (es) |
MX (1) | MX2012007341A (es) |
NZ (1) | NZ600786A (es) |
WO (1) | WO2011087822A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015532915A (ja) | 2012-09-11 | 2015-11-16 | シプラ・リミテッド | ボルテゾミブの製造方法 |
CN103897027A (zh) * | 2012-12-29 | 2014-07-02 | 曹亚英 | 关键中间体晶型,制备方法及其在硼替佐米合成中的运用 |
CN103897026A (zh) * | 2012-12-29 | 2014-07-02 | 朱继东 | 硼替佐米关键中间体的晶型,制备方法及其运用 |
ZA201402789B (en) | 2013-04-16 | 2015-11-25 | Cipla Ltd | Process for the preparation of bortezomib mannitol ester |
CZ2015233A3 (cs) | 2015-04-03 | 2016-10-12 | Zentiva, K.S. | Způsob přípravy Ixazomib citrátu |
CZ2015253A3 (cs) | 2015-04-15 | 2016-10-26 | Zentiva, K.S. | Nové formy Ixazomib citrátu |
WO2016205790A2 (en) | 2015-06-19 | 2016-12-22 | Hanlin Scientific, Inc. | Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis |
CZ2016204A3 (cs) | 2016-04-08 | 2017-11-01 | Zentiva, K.S. | Formulace Ixazomib citrátu formy 3 |
WO2018150386A1 (en) | 2017-02-17 | 2018-08-23 | Fresenius Kabi Oncology Ltd. | An improved process for the preparation of boronic acid esters |
JP7086987B2 (ja) * | 2017-03-21 | 2022-06-20 | ザ スクリプス リサーチ インスティテュート | 銅およびニッケル触媒による脱炭酸ホウ素化反応 |
CN110540547A (zh) * | 2018-05-28 | 2019-12-06 | 秦艳茹 | 一种肽硼酸酯类化合物的合成与用途 |
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DE3301354A1 (de) | 1983-01-18 | 1984-07-19 | Matth. Hohner Ag, 7218 Trossingen | Elektronisches musikinstrument |
US4537773A (en) | 1983-12-05 | 1985-08-27 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid derivatives |
US4499082A (en) | 1983-12-05 | 1985-02-12 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid peptides |
US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
US5242904A (en) | 1987-06-05 | 1993-09-07 | The Dupont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
US5250720A (en) | 1987-06-05 | 1993-10-05 | The Dupont Merck Pharmaceutical Company | Intermediates for preparing peptide boronic acid inhibitors of trypsin-like proteases |
EP0315574A3 (de) | 1987-11-05 | 1990-08-22 | Hoechst Aktiengesellschaft | Renin-Inhibitoren |
WO1989009225A1 (en) | 1988-03-28 | 1989-10-05 | The Regents Of The University Of California | Nerve growth factor peptides |
US5023236A (en) | 1988-04-07 | 1991-06-11 | Corvas, Inc. | Factor VII/VIIA active site inhibitors |
US5159060A (en) | 1988-05-27 | 1992-10-27 | Mayo Foundation For Medical Education And Research | Cytotoxic boronic acid peptide analogs |
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US4963655A (en) | 1988-05-27 | 1990-10-16 | Mayo Foundation For Medical Education And Research | Boron analogs of amino acid/peptide protease inhibitors |
DE3827340A1 (de) | 1988-08-12 | 1990-02-15 | Hoechst Ag | Verwendung von (alpha)-aminoboronsaeure-derivaten zur prophylaxe und behandlung von viruserkrankungen |
IE910713A1 (en) | 1990-03-05 | 1991-09-11 | Cephalon Inc | Chymotrypsin-like proteases |
ATE149563T1 (de) | 1992-08-14 | 1997-03-15 | Procter & Gamble | Alpha-aminoborsäurehaltige flüssige waschmittel |
EP0684829A4 (en) | 1993-02-10 | 1997-05-21 | Harvard College | THE ROLE OF ATP-UBIQUITIN-DEPENDENT PROTEOLYSIS IN MHC-1 DEPENDENT ANTIGENT PRESENTATION AND RELATED INHIBITORS. |
US5658885A (en) | 1993-04-27 | 1997-08-19 | The Dupont Merck Pharmaceutical Company | Amidino and guanidino substituted boronic acid inhibitors of trypsin-like enzymes |
IL109319A0 (en) | 1993-04-27 | 1994-07-31 | Du Pont Merck Pharma | Amidino and guanidino substituted boronic acid compounds |
CA2159834A1 (en) | 1993-04-30 | 1994-11-10 | Daniel F. Veber | Thrombin inhibitors |
US5672582A (en) | 1993-04-30 | 1997-09-30 | Merck & Co., Inc. | Thrombin inhibitors |
FR2707085B1 (fr) | 1993-06-30 | 1995-08-18 | Adir | Nouveaux dérivés d'alpha amino acides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
ES2170104T3 (es) | 1993-10-01 | 2002-08-01 | Merrell Pharma Inc | Inhibidores de la produccion de proteinas de beta-amiloide. |
IL111175A0 (en) | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them |
GB9401483D0 (en) | 1994-01-26 | 1994-03-23 | Sandoz Ltd | Organic compounds |
US5693617A (en) | 1994-03-15 | 1997-12-02 | Proscript, Inc. | Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein |
US6660268B1 (en) | 1994-03-18 | 2003-12-09 | The President And Fellows Of Harvard College | Proteasome regulation of NF-KB activity |
US6083903A (en) | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
US5614649A (en) | 1994-11-14 | 1997-03-25 | Cephalon, Inc. | Multicatalytic protease inhibitors |
US5550262A (en) | 1994-11-14 | 1996-08-27 | Cephalon, Inc. | Multicatalytic protease inhibitors |
US5834487A (en) | 1996-09-24 | 1998-11-10 | Cv Therapeutics | Inhibition of 26S and 20S proteasome by indanones |
BR9712544B1 (pt) | 1996-10-18 | 2013-10-22 | Inibidores de proteases de serina, composição farmacêutica compreendendo os mesmos e seus usos | |
GB9623908D0 (en) | 1996-11-18 | 1997-01-08 | Hoffmann La Roche | Amino acid derivatives |
US6096778A (en) | 1997-10-07 | 2000-08-01 | Cephalon, Inc. | α-ketoamide multicatalytic protease inhibitors |
CA2314259A1 (en) | 1997-12-16 | 1999-06-24 | Robert Siman | Multicatalytic protease inhibitors for use as anti-tumor agents |
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KR20040002905A (ko) | 2001-04-09 | 2004-01-07 | 알란 크리스챤 쇼우 | 세포내 세균으로부터 단백질을 동정하는 방법 |
WO2002094857A1 (en) | 2001-05-23 | 2002-11-28 | The Curators Of The University Of Missouri | Inverse solid phase synthesis of peptides |
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WO2003033507A1 (fr) | 2001-10-12 | 2003-04-24 | Kyorin Pharmaceutical Co., Ltd. | Derives d'acide benzylmalonique et inhibiteurs de proteasomes les contenant |
EP1463719A2 (en) | 2002-01-08 | 2004-10-06 | Eisai Co., Ltd | Eponemycin and epoxomicin analogs and uses thereof |
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UA88771C2 (ru) * | 2003-08-14 | 2009-11-25 | Сефалон, Инк. | Ингибиторы протеасомы и способ их применения (варианты) |
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-
2010
- 2010-12-22 CA CA2785300A patent/CA2785300A1/en not_active Abandoned
- 2010-12-22 MX MX2012007341A patent/MX2012007341A/es active IP Right Grant
- 2010-12-22 NZ NZ600786A patent/NZ600786A/en not_active IP Right Cessation
- 2010-12-22 CN CN201080058991.9A patent/CN102725300B/zh not_active Expired - Fee Related
- 2010-12-22 AU AU2010341530A patent/AU2010341530B2/en not_active Ceased
- 2010-12-22 EP EP10798930A patent/EP2516449A1/en not_active Withdrawn
- 2010-12-22 WO PCT/US2010/061695 patent/WO2011087822A1/en active Application Filing
- 2010-12-22 JP JP2012546173A patent/JP5783659B2/ja not_active Expired - Fee Related
-
2012
- 2012-06-05 IL IL220190A patent/IL220190A0/en not_active IP Right Cessation
- 2012-06-20 US US13/528,147 patent/US8541590B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN102725300B (zh) | 2015-03-11 |
IL220190A0 (en) | 2012-07-31 |
US8541590B2 (en) | 2013-09-24 |
AU2010341530B2 (en) | 2016-03-10 |
JP2013515082A (ja) | 2013-05-02 |
EP2516449A1 (en) | 2012-10-31 |
WO2011087822A1 (en) | 2011-07-21 |
NZ600786A (en) | 2013-12-20 |
AU2010341530A1 (en) | 2012-07-19 |
CN102725300A (zh) | 2012-10-10 |
CA2785300A1 (en) | 2011-07-21 |
US20120270840A1 (en) | 2012-10-25 |
JP5783659B2 (ja) | 2015-09-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |