MX2012007341A - Inhibidores de proteasoma y procesos para su preparacion, purificacion y uso. - Google Patents

Inhibidores de proteasoma y procesos para su preparacion, purificacion y uso.

Info

Publication number
MX2012007341A
MX2012007341A MX2012007341A MX2012007341A MX2012007341A MX 2012007341 A MX2012007341 A MX 2012007341A MX 2012007341 A MX2012007341 A MX 2012007341A MX 2012007341 A MX2012007341 A MX 2012007341A MX 2012007341 A MX2012007341 A MX 2012007341A
Authority
MX
Mexico
Prior art keywords
purification
preparation
processes
proteasome inhibitors
proteasome
Prior art date
Application number
MX2012007341A
Other languages
English (en)
Inventor
Renee Caroline Roemmele
Original Assignee
Cephalon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon Inc filed Critical Cephalon Inc
Publication of MX2012007341A publication Critical patent/MX2012007341A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención proporciona ésteres borónicos de la Fórmula I (Ver Formula) en donde R1, R2, R3 y son como se describe en la presente, y métodos para su preparación y purificación.
MX2012007341A 2009-12-22 2010-12-22 Inhibidores de proteasoma y procesos para su preparacion, purificacion y uso. MX2012007341A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28895709P 2009-12-22 2009-12-22
PCT/US2010/061695 WO2011087822A1 (en) 2009-12-22 2010-12-22 Proteasome inhibitors and processes for their preparation, purification and use

Publications (1)

Publication Number Publication Date
MX2012007341A true MX2012007341A (es) 2012-07-20

Family

ID=43530797

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012007341A MX2012007341A (es) 2009-12-22 2010-12-22 Inhibidores de proteasoma y procesos para su preparacion, purificacion y uso.

Country Status (10)

Country Link
US (1) US8541590B2 (es)
EP (1) EP2516449A1 (es)
JP (1) JP5783659B2 (es)
CN (1) CN102725300B (es)
AU (1) AU2010341530B2 (es)
CA (1) CA2785300A1 (es)
IL (1) IL220190A0 (es)
MX (1) MX2012007341A (es)
NZ (1) NZ600786A (es)
WO (1) WO2011087822A1 (es)

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CN103897027A (zh) * 2012-12-29 2014-07-02 曹亚英 关键中间体晶型，制备方法及其在硼替佐米合成中的运用
CN103897026A (zh) * 2012-12-29 2014-07-02 朱继东 硼替佐米关键中间体的晶型，制备方法及其运用
ZA201402789B (en) 2013-04-16 2015-11-25 Cipla Ltd Process for the preparation of bortezomib mannitol ester
CZ2015233A3 (cs) 2015-04-03 2016-10-12 Zentiva, K.S. Způsob přípravy Ixazomib citrátu
CZ2015253A3 (cs) 2015-04-15 2016-10-26 Zentiva, K.S. Nové formy Ixazomib citrátu
US10144761B2 (en) 2015-06-19 2018-12-04 Hanlin Scientific Inc. Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis
CZ2016204A3 (cs) 2016-04-08 2017-11-01 Zentiva, K.S. Formulace Ixazomib citrátu formy 3
EP3583110A1 (en) 2017-02-17 2019-12-25 Fresenius Kabi Oncology Ltd An improved process for the preparation of boronic acid esters
JP7086987B2 (ja) * 2017-03-21 2022-06-20 ザ スクリプス リサーチ インスティテュート 銅およびニッケル触媒による脱炭酸ホウ素化反応
CN110540547A (zh) * 2018-05-28 2019-12-06 秦艳茹 一种肽硼酸酯类化合物的合成与用途

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Also Published As

Publication number Publication date
NZ600786A (en) 2013-12-20
US20120270840A1 (en) 2012-10-25
CA2785300A1 (en) 2011-07-21
CN102725300A (zh) 2012-10-10
CN102725300B (zh) 2015-03-11
JP2013515082A (ja) 2013-05-02
WO2011087822A1 (en) 2011-07-21
US8541590B2 (en) 2013-09-24
IL220190A0 (en) 2012-07-31
AU2010341530B2 (en) 2016-03-10
EP2516449A1 (en) 2012-10-31
JP5783659B2 (ja) 2015-09-24
AU2010341530A1 (en) 2012-07-19

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