AU4555800A - Use of 2,4-diamino-3-hydroxycarboxylic acid derivatives as proteasome inhibitors - Google Patents
Use of 2,4-diamino-3-hydroxycarboxylic acid derivatives as proteasome inhibitorsInfo
- Publication number
- AU4555800A AU4555800A AU45558/00A AU4555800A AU4555800A AU 4555800 A AU4555800 A AU 4555800A AU 45558/00 A AU45558/00 A AU 45558/00A AU 4555800 A AU4555800 A AU 4555800A AU 4555800 A AU4555800 A AU 4555800A
- Authority
- AU
- Australia
- Prior art keywords
- substituted
- alkyl
- unsubstituted
- arylalkyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Detergent Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
The present invention relates to the new use of 2,4-diamino-3-hydroxycarboxylic acids of formula (I), in which A and B independently represent a bond or an unsubstituted or substituted amino acyl moiety; R1 represents hydrogen; an amino protecting group; or a group of formula R5Y- wherein R5 represents hydrogen or an unsubstituted or substituted alkyl, alkenyl, alkinyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl group; and Y represents -CO-; -NH-CO-; -NH-CS-; -SO2-; -O-CO-; or -O-CS-; R2 represents the side chain of a natural amino acid; an alkyl, arylalkyl, heteroarylalkyl or cycloalkylalkyl group; or trimethylsilylmethyl, 2-thienylmethyl or styrylmethyl; R3 represents halogen, alkyl, alkoxy or hydroxyalkoxy; and R4 represents 2(R)-hydroxyindan-1(S)-yl; (S)-2-hydroxy-1-phenylethyl; or 2-hydroxy-benzyl unsubstituted or substituted in 4-position by methoxy; in the manufacture of a pharmaceutical composition for the treatment of a proliferative disease, e.g., of a solid tumor; to a method of treatment of warm-blooded animals; and to 2,4-diamino-3-hydroxycarboxylic acids of formula (I*), wherein A and B independently represent an unsubstituted or substituted amino acyl moiety; R2 represents arylalkyl; R3 represents halogen, alkyl, alkoxy or hydroxyalkoxy; R4 represents 2-hydroxy-benzyl unsubstituted or substituted in 4 position by methoxy; and R5 represents arylalkyl and Y represents -CO-; or R5 represents alkyl substituted by cycloalkyl, naphthyl, pyridyl or phenyl in which phenyl is substituted by alkyl or amino; and Y represents -O-CO; pharmaceutically acceptable salts thereof; and the use of such compounds of formula (I*) for the therapeutic treatment of the human or animal body, especially the treatment of proliferative diseases.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30077999A | 1999-04-27 | 1999-04-27 | |
US09300779 | 1999-04-27 | ||
US38870099A | 1999-09-02 | 1999-09-02 | |
US09388700 | 1999-09-02 | ||
PCT/EP2000/003688 WO2000064863A1 (en) | 1999-04-27 | 2000-04-25 | Use of 2,4-diamino-3-hydroxycarboxylic acid derivatives as proteasome inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
AU4555800A true AU4555800A (en) | 2000-11-10 |
Family
ID=26971977
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU45558/00A Abandoned AU4555800A (en) | 1999-04-27 | 2000-04-25 | Use of 2,4-diamino-3-hydroxycarboxylic acid derivatives as proteasome inhibitors |
Country Status (13)
Country | Link |
---|---|
US (1) | US20050026994A1 (en) |
EP (1) | EP1173413B1 (en) |
JP (1) | JP2002543058A (en) |
CN (1) | CN100357267C (en) |
AT (1) | ATE270268T1 (en) |
AU (1) | AU4555800A (en) |
BR (1) | BR0010134A (en) |
CA (1) | CA2370830C (en) |
DE (1) | DE60011889T2 (en) |
ES (1) | ES2223512T3 (en) |
HK (1) | HK1044931A1 (en) |
PT (1) | PT1173413E (en) |
WO (1) | WO2000064863A1 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU49055B (en) | 1996-04-25 | 2003-08-29 | Milenko dipl.ing. Pupović | A table for backbone setting |
GB0012795D0 (en) * | 2000-05-25 | 2000-07-19 | Novartis Ag | Organic compounds |
US6872382B1 (en) | 2001-05-21 | 2005-03-29 | Alcon, Inc. | Use of selective PDE IV inhibitors to treat dry eye disorders |
US7112588B2 (en) | 2001-05-21 | 2006-09-26 | Alcon, Inc. | Use of proteasome inhibitors to treat dry eye disorders |
DE60213230T2 (en) | 2001-05-21 | 2006-11-23 | Alcon Inc. | Use of NF-Kappa.B inhibitors to treat dry eye |
AU2002308760B2 (en) | 2001-05-21 | 2006-05-11 | Alcon, Inc. | Use of proteasome inhibitors to treat dry eye disorders |
US6645994B1 (en) | 2001-06-01 | 2003-11-11 | Alcon, Inc. | Method of treating dry eye disorders |
US7576206B2 (en) | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
US7223745B2 (en) | 2003-08-14 | 2007-05-29 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
EP1637529A1 (en) * | 2004-09-20 | 2006-03-22 | 4Sc Ag | Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof |
US7468383B2 (en) | 2005-02-11 | 2008-12-23 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
US8459852B2 (en) | 2007-10-05 | 2013-06-11 | Dental Equipment, Llc | LED-based dental exam lamp |
JP5783659B2 (en) | 2009-12-22 | 2015-09-24 | セファロン、インク. | Proteasome inhibitors and methods for their preparation, purification and use |
WO2018143145A1 (en) * | 2017-01-31 | 2018-08-09 | 中外製薬株式会社 | Method for synthesizing peptides in cell-free translation system |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5344634A (en) * | 1976-10-01 | 1978-04-21 | Kyowa Hakko Kogyo Co Ltd | Carcinostatic agent |
WO1993001166A1 (en) * | 1991-07-02 | 1993-01-21 | Sandoz Ltd. | 4-amino-3-hydroxycarboxylic acid derivatives |
US5538997A (en) * | 1993-03-12 | 1996-07-23 | Sandoz Ltd. | 2,4-diamino-3-hydroxycarboxylic acid derivatives |
DE4331135A1 (en) * | 1993-09-14 | 1995-03-16 | Bayer Ag | New antiviral valine-containing pseudopeptides |
-
2000
- 2000-04-25 EP EP00927038A patent/EP1173413B1/en not_active Expired - Lifetime
- 2000-04-25 BR BR0010134-6A patent/BR0010134A/en not_active Application Discontinuation
- 2000-04-25 CN CNB00807741XA patent/CN100357267C/en not_active Expired - Fee Related
- 2000-04-25 AT AT00927038T patent/ATE270268T1/en not_active IP Right Cessation
- 2000-04-25 AU AU45558/00A patent/AU4555800A/en not_active Abandoned
- 2000-04-25 JP JP2000613816A patent/JP2002543058A/en active Pending
- 2000-04-25 PT PT00927038T patent/PT1173413E/en unknown
- 2000-04-25 CA CA002370830A patent/CA2370830C/en not_active Expired - Fee Related
- 2000-04-25 DE DE60011889T patent/DE60011889T2/en not_active Expired - Fee Related
- 2000-04-25 ES ES00927038T patent/ES2223512T3/en not_active Expired - Lifetime
- 2000-04-25 WO PCT/EP2000/003688 patent/WO2000064863A1/en active IP Right Grant
-
2001
- 2001-10-25 US US10/035,301 patent/US20050026994A1/en not_active Abandoned
-
2002
- 2002-06-19 HK HK02104585A patent/HK1044931A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE270268T1 (en) | 2004-07-15 |
CA2370830A1 (en) | 2000-11-02 |
PT1173413E (en) | 2004-10-29 |
EP1173413A1 (en) | 2002-01-23 |
CN1351587A (en) | 2002-05-29 |
CA2370830C (en) | 2009-10-13 |
HK1044931A1 (en) | 2002-11-08 |
BR0010134A (en) | 2002-01-15 |
EP1173413B1 (en) | 2004-06-30 |
ES2223512T3 (en) | 2005-03-01 |
WO2000064863A1 (en) | 2000-11-02 |
CN100357267C (en) | 2007-12-26 |
US20050026994A1 (en) | 2005-02-03 |
DE60011889D1 (en) | 2004-08-05 |
JP2002543058A (en) | 2002-12-17 |
DE60011889T2 (en) | 2005-07-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |