UA117849C2 - Спосіб одержання 3-заміщених складних ефірів (індол-1-іл)-оцтової кислоти - Google Patents

Спосіб одержання 3-заміщених складних ефірів (індол-1-іл)-оцтової кислоти

Info

Publication number
UA117849C2
UA117849C2 UAA201607416A UAA201607416A UA117849C2 UA 117849 C2 UA117849 C2 UA 117849C2 UA A201607416 A UAA201607416 A UA A201607416A UA A201607416 A UAA201607416 A UA A201607416A UA 117849 C2 UA117849 C2 UA 117849C2
Authority
UA
Ukraine
Prior art keywords
preparation
indol
substituted
acetic acid
acid esters
Prior art date
Application number
UAA201607416A
Other languages
English (en)
Inventor
Жак Тоннел
Сілвіє Бланчет
Гійом Леонард Пьер Деваеле
Original Assignee
Атопікс Терапеутікс Лімітед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Атопікс Терапеутікс Лімітед filed Critical Атопікс Терапеутікс Лімітед
Publication of UA117849C2 publication Critical patent/UA117849C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

Винахід стосується одержання в промисловому масштабі сполуки загальної формули (І): EMBED ISISServer , (I) де R1, R2 і R3 - як це визначено в цьому документі, причому спосіб включає введення у взаємну реакцію сполук загальної формул (II) і (III): EMBED ISISServer (II) EMBED ISISServer , (III) в присутності льюїсової кислоти з подальшим відновлення за допомогою триетилсилану.
UAA201607416A 2013-12-17 2014-12-12 Спосіб одержання 3-заміщених складних ефірів (індол-1-іл)-оцтової кислоти UA117849C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1322273.2A GB201322273D0 (en) 2013-12-17 2013-12-17 Process
PCT/GB2014/053686 WO2015092372A1 (en) 2013-12-17 2014-12-12 Process for the preparation of 3-substituted (indol-1-yl)-acetic acid esters

Publications (1)

Publication Number Publication Date
UA117849C2 true UA117849C2 (uk) 2018-10-10

Family

ID=50031022

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201607416A UA117849C2 (uk) 2013-12-17 2014-12-12 Спосіб одержання 3-заміщених складних ефірів (індол-1-іл)-оцтової кислоти

Country Status (16)

Country Link
US (1) US9828359B2 (uk)
EP (1) EP3083557B1 (uk)
JP (1) JP6312179B2 (uk)
DK (1) DK3083557T3 (uk)
ES (1) ES2660467T3 (uk)
GB (1) GB201322273D0 (uk)
HR (1) HRP20180298T1 (uk)
HU (1) HUE036184T2 (uk)
NO (1) NO3083557T3 (uk)
PL (1) PL3083557T3 (uk)
PT (1) PT3083557T (uk)
RU (1) RU2676332C1 (uk)
SI (1) SI3083557T1 (uk)
TR (1) TR201802657T4 (uk)
UA (1) UA117849C2 (uk)
WO (1) WO2015092372A1 (uk)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201407820D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
GB201407807D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
RU2756270C2 (ru) * 2016-07-21 2021-09-29 Чиа Тай Тянцин Фармасьютикал Груп Ко., Лтд. Производное индола, используемое в качестве ингибитора CRTH2
WO2020136093A1 (en) 2018-12-27 2020-07-02 Chiesi Farmaceutici S.P.A. Process for preparing spherical agglomerates of timapiprant

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3489767A (en) 1966-01-12 1970-01-13 Sumitomo Chemical Co 1-(phenylsulfonyl)-3-indolyl aliphatic acid derivatives
US3557142A (en) 1968-02-20 1971-01-19 Sterling Drug Inc 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters
BE790679A (fr) 1971-11-03 1973-04-27 Ici Ltd Derives de l'indole
GB1407658A (en) 1973-03-06 1975-09-24 Ici Ltd Process for the manufacture of indole derivatives
GB1460348A (en) 1974-02-04 1977-01-06 Ici Ltd Quinazoline derivativesa
DK151884C (da) 1979-03-07 1988-06-13 Pfizer Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf
US4363912A (en) 1980-12-15 1982-12-14 Pfizer Inc. Indole thromboxane synthetase inhibitors
US4966911A (en) 1984-11-20 1990-10-30 Washington Research Foundation Immunoregulatory agents
GB8607294D0 (en) 1985-04-17 1986-04-30 Ici America Inc Heterocyclic amide derivatives
WO1993012786A1 (en) 1986-07-10 1993-07-08 Howard Harry R Jr Indolinone derivatives
US5236945A (en) 1990-06-11 1993-08-17 Pfizer Inc. 1H-indazole-3-acetic acids as aldose reductase inhibitors
GB9122590D0 (en) 1991-10-24 1991-12-04 Lilly Industries Ltd Pharmaceutical compounds
US5612360A (en) 1992-06-03 1997-03-18 Eli Lilly And Company Angiotensin II antagonists
GB9317764D0 (en) 1993-08-26 1993-10-13 Pfizer Ltd Therapeutic compound
US5641800A (en) 1994-07-21 1997-06-24 Eli Lilly And Company 1H-indole-1-functional sPLA2 inhibitors
IL117208A0 (en) 1995-02-23 1996-06-18 Nissan Chemical Ind Ltd Indole type thiazolidines
JP3144805B2 (ja) 1996-06-05 2001-03-12 株式会社 ビー・エム・エル ヒトＴｈ２特異的タンパク質及びこれをコードする遺伝子（Ｂ１９）並びにこれに関連する形質転換体、組換えベクター及びモノクローナル抗体
US6916841B2 (en) 1998-02-25 2005-07-12 Genetics Institute, Llc Inhibitors of phospholipase enzymes
EP1056719A2 (en) 1998-02-25 2000-12-06 Genetics Institute, Inc. Inhibitors of phospholipase enzymes
EE200000573A (et) 1998-03-31 2002-04-15 The Institutes For Pharmaceutical Discovery, Llc Asendatud indoolalkaanhapped
TNSN99224A1 (fr) 1998-12-01 2005-11-10 Inst For Pharm Discovery Inc Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique
WO2001014882A1 (fr) 1999-08-23 2001-03-01 Bml, Inc. Identification des proprietes d'une substance pour les recepteurs de prostaglandine d
AU2001232785A1 (en) 2000-01-14 2001-07-24 The Institutes For Pharmaceutical Discovery, Llc Methods for lowering uric acid levels
WO2001064205A2 (en) 2000-03-02 2001-09-07 The Institutes For Pharmaceutical Discovery, Llc Compositions containing a substituted indolealkanoic acid and an angiotensin converting enzyme inhibitor
JP2001247570A (ja) 2000-03-08 2001-09-11 Japan Tobacco Inc インドール酢酸化合物及びその製造方法
US6878522B2 (en) 2000-07-07 2005-04-12 Baiyong Li Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2
SE0200356D0 (sv) 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
SE0200411D0 (sv) 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
EP1505061A4 (en) 2002-05-16 2007-08-22 Shionogi & Co CONNECTION WITH PGD-2 RECEPTOR ANTAGONISM
JPWO2003097042A1 (ja) 2002-05-16 2005-09-15 塩野義製薬株式会社 Ｐｇｄ２受容体拮抗剤
TW200307542A (en) 2002-05-30 2003-12-16 Astrazeneca Ab Novel compounds
SE0201635D0 (sv) 2002-05-30 2002-05-30 Astrazeneca Ab Novel compounds
EP1569899B1 (en) 2002-12-10 2006-06-28 Wyeth Substituted 3-alkyl- and 3-arylalkyl-1h-indol-1-yl-acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
KR20050111314A (ko) 2002-12-20 2005-11-24 암젠 인코포레이션 천식 및 알레르기성 염증 조절제들
JP2007508363A (ja) 2003-10-14 2007-04-05 オキサジェン リミテッド Ｃｒｔｈ２アンタゴニスト活性を有する化合物
GB0324763D0 (en) 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
GB0504150D0 (en) 2005-03-01 2005-04-06 Oxagen Ltd Microcrystalline material
GB0505048D0 (en) 2005-03-11 2005-04-20 Oxagen Ltd Compounds with PGD antagonist activity
GB0605743D0 (en) 2006-03-22 2006-05-03 Oxagen Ltd Salts with CRTH2 antagonist activity
JP5270542B2 (ja) 2006-07-22 2013-08-21 オキサジェン リミテッド Ｃｒｔｈ２アンタゴニスト活性を有する化合物
US20110124683A1 (en) 2007-11-13 2011-05-26 Oxagen Limited Use of CRTH2 Antagonist Compounds
EP2229358B1 (en) * 2007-12-14 2011-03-23 Pulmagen Therapeutics (Asthma) Limited Indoles and their therapeutic use
US7750027B2 (en) 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
DK2250161T3 (da) * 2008-01-18 2014-01-27 Atopix Therapeutics Ltd Forbindelser med CRTH2-antagonistaktivitet
US20100022613A1 (en) 2008-01-22 2010-01-28 Oxagen Limited Compounds Having CRTH2 Antagonist Activity
WO2009093029A1 (en) 2008-01-22 2009-07-30 Oxagen Limited Compounds having crth2 antagonist activity
WO2010142934A1 (en) * 2009-06-12 2010-12-16 Pulmagen Therapeutics (Asthma) Limited Indole derivatives as ligands of crth2 receptors
WO2011055270A1 (en) * 2009-11-04 2011-05-12 Wyeth Llc Indole based receptor crth2 antagonists
GB201103837D0 (en) 2011-03-07 2011-04-20 Oxagen Ltd Amorphous (5-Fluoro-2-Methyl-3-Quinolin-2-Ylmethyl-Indol-1-Yl)-acetic acid
GB201121557D0 (en) 2011-12-15 2012-01-25 Oxagen Ltd Process
GB201407820D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
GB201407807D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form

Also Published As

Publication number Publication date
SI3083557T1 (en) 2018-04-30
GB201322273D0 (en) 2014-01-29
US20170305879A1 (en) 2017-10-26
JP2017501222A (ja) 2017-01-12
EP3083557A1 (en) 2016-10-26
RU2676332C1 (ru) 2018-12-28
HUE036184T2 (hu) 2018-06-28
US9828359B2 (en) 2017-11-28
DK3083557T3 (en) 2018-03-12
PT3083557T (pt) 2018-03-05
JP6312179B2 (ja) 2018-04-18
NO3083557T3 (uk) 2018-04-28
WO2015092372A1 (en) 2015-06-25
HRP20180298T1 (hr) 2018-04-06
TR201802657T4 (tr) 2018-03-21
ES2660467T3 (es) 2018-03-22
EP3083557B1 (en) 2017-11-29
PL3083557T3 (pl) 2018-05-30

Similar Documents

Publication Publication Date Title
IN2012DN02751A (uk)
NZ707389A (en) Process for preparing bile acid derivatives
UA111142C2 (uk) Одержання заміщених похідних 2-фторакрилової кислоти
EP2590649A4 (en) PROCESS FOR SYNTHESIS OF SUBSTITUTED MORPHINANES
PT2462098E (pt) Processos para a preparação de derivados de ácido 1-(2- halobifenil-4-il)-ciclopropanocarboxílico
MY160677A (en) Fermented infant formula
MX2013000009A (es) Procedimiento de preparacion de la sal de l-arginina de perindoprilo.
UA117849C2 (uk) Спосіб одержання 3-заміщених складних ефірів (індол-1-іл)-оцтової кислоти
MX342273B (es) Proceso para la preparacion de esteres de acido (5-fluoro-2-metil-3-quinolina-2-ilmetil-indol-1-il)-acetico.
MX2011009898A (es) Proceso para la obtencion de derivados de acido propionico.
MX343787B (es) Proceso para la preparacion de derivados de esterol.
MX2012002818A (es) Nuevo procedimiento de sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable.
MX2012007870A (es) Derivados de acido carboxilico que comprende un anillo de oxazolopirimidina 2, 5, 7-sustituido.
MX337997B (es) Nuevo procedimiento de sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable.
MY164880A (en) Process for the preparation of isoxazolyl-methoxy-nicotinic acids
EP4282973A3 (en) Processes for the preparation of pyrimidinylcyclopentane compounds
GB2523674A (en) Compounds as inhibitor of DNA double-strand break repair, methods and applications thereof
MX2013004193A (es) Procedimiento para la preparacion de derivados de acido 3-(6-amino-piridin-3-il)-2-acrilico.
MX361998B (es) Procedimiento de preparacion de derivados de acido 4-haloalquil-3-mercapto-2 sustituido-hidroxibenzoico.
IN2013MU01290A (uk)
UA111329C2 (uk) Спосіб синтезу івабрадину і його адитивних солей з фармацевтично прийнятною кислотою
LT2012082A (lt) Nauji fotochrominiai junginiai, jų gamybos būdas ir tarpiniai junginiai jiems gauti
IN2014DE01203A (uk)
UA117900C2 (uk) Спосіб синтезу 3-(2-бром-4,5-диметоксифеніл)пропаннітрилу та застосування в синтезі івабрадину та його адитивних солей з фармацевтично прийнятною кислотою
MX2013002990A (es) Nuevo procedimiento de sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable.