RU2676332C1 - Способ получения 3-замещённых сложных эфиров (индол-1-ил)-уксусной кислоты - Google Patents
Способ получения 3-замещённых сложных эфиров (индол-1-ил)-уксусной кислоты Download PDFInfo
- Publication number
- RU2676332C1 RU2676332C1 RU2016125326A RU2016125326A RU2676332C1 RU 2676332 C1 RU2676332 C1 RU 2676332C1 RU 2016125326 A RU2016125326 A RU 2016125326A RU 2016125326 A RU2016125326 A RU 2016125326A RU 2676332 C1 RU2676332 C1 RU 2676332C1
- Authority
- RU
- Russia
- Prior art keywords
- methyl
- fluoro
- acetic acid
- indol
- methylindol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1322273.2 | 2013-12-17 | ||
| GBGB1322273.2A GB201322273D0 (en) | 2013-12-17 | 2013-12-17 | Process |
| PCT/GB2014/053686 WO2015092372A1 (en) | 2013-12-17 | 2014-12-12 | Process for the preparation of 3-substituted (indol-1-yl)-acetic acid esters |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2676332C1 true RU2676332C1 (ru) | 2018-12-28 |
Family
ID=50031022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016125326A RU2676332C1 (ru) | 2013-12-17 | 2014-12-12 | Способ получения 3-замещённых сложных эфиров (индол-1-ил)-уксусной кислоты |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9828359B2 (uk) |
| EP (1) | EP3083557B1 (uk) |
| JP (1) | JP6312179B2 (uk) |
| DK (1) | DK3083557T3 (uk) |
| ES (1) | ES2660467T3 (uk) |
| GB (1) | GB201322273D0 (uk) |
| HR (1) | HRP20180298T1 (uk) |
| HU (1) | HUE036184T2 (uk) |
| NO (1) | NO3083557T3 (uk) |
| PL (1) | PL3083557T3 (uk) |
| PT (1) | PT3083557T (uk) |
| RU (1) | RU2676332C1 (uk) |
| SI (1) | SI3083557T1 (uk) |
| TR (1) | TR201802657T4 (uk) |
| UA (1) | UA117849C2 (uk) |
| WO (1) | WO2015092372A1 (uk) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201407807D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
| GB201407820D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
| WO2018014869A1 (zh) * | 2016-07-21 | 2018-01-25 | 正大天晴药业集团股份有限公司 | 作为crth2抑制剂的吲哚衍生物 |
| US20220184059A1 (en) | 2018-12-27 | 2022-06-16 | Chiesi Farmaceutici S.P.A. | Process for preparing spherical agglomerates of timapiprant |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005044260A1 (en) * | 2003-10-23 | 2005-05-19 | Oxagen Limited | Use of crth2 antagonist compounds in therapy |
| WO2006095183A1 (en) * | 2005-03-11 | 2006-09-14 | Oxagen Limited | 1-acetic acid-indole derivatives with pgd2 antagonist activity |
| WO2008012511A1 (en) * | 2006-07-22 | 2008-01-31 | Oxagen Limited | Compounds having crth2 antagonist activity |
| WO2009090414A1 (en) * | 2008-01-18 | 2009-07-23 | Oxagen Limited | Compounds having crth2 antagonist activity |
| EA017573B1 (ru) * | 2007-12-14 | 2013-01-30 | Пульмаджен Терапьютикс (Эсме) Лимитед | Производные индол-1-илуксусной кислоты и их терапевтическое применение |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3489767A (en) | 1966-01-12 | 1970-01-13 | Sumitomo Chemical Co | 1-(phenylsulfonyl)-3-indolyl aliphatic acid derivatives |
| US3557142A (en) | 1968-02-20 | 1971-01-19 | Sterling Drug Inc | 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters |
| BE790679A (fr) | 1971-11-03 | 1973-04-27 | Ici Ltd | Derives de l'indole |
| GB1407658A (en) | 1973-03-06 | 1975-09-24 | Ici Ltd | Process for the manufacture of indole derivatives |
| GB1460348A (en) | 1974-02-04 | 1977-01-06 | Ici Ltd | Quinazoline derivativesa |
| DK151884C (da) | 1979-03-07 | 1988-06-13 | Pfizer | Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf |
| US4363912A (en) | 1980-12-15 | 1982-12-14 | Pfizer Inc. | Indole thromboxane synthetase inhibitors |
| US4966911A (en) | 1984-11-20 | 1990-10-30 | Washington Research Foundation | Immunoregulatory agents |
| GB8607294D0 (en) | 1985-04-17 | 1986-04-30 | Ici America Inc | Heterocyclic amide derivatives |
| WO1993012786A1 (en) | 1986-07-10 | 1993-07-08 | Howard Harry R Jr | Indolinone derivatives |
| US5236945A (en) | 1990-06-11 | 1993-08-17 | Pfizer Inc. | 1H-indazole-3-acetic acids as aldose reductase inhibitors |
| GB9122590D0 (en) | 1991-10-24 | 1991-12-04 | Lilly Industries Ltd | Pharmaceutical compounds |
| US5612360A (en) | 1992-06-03 | 1997-03-18 | Eli Lilly And Company | Angiotensin II antagonists |
| GB9317764D0 (en) | 1993-08-26 | 1993-10-13 | Pfizer Ltd | Therapeutic compound |
| US5641800A (en) | 1994-07-21 | 1997-06-24 | Eli Lilly And Company | 1H-indole-1-functional sPLA2 inhibitors |
| IL117208A0 (en) | 1995-02-23 | 1996-06-18 | Nissan Chemical Ind Ltd | Indole type thiazolidines |
| JP3144805B2 (ja) | 1996-06-05 | 2001-03-12 | 株式会社 ビー・エム・エル | ヒトＴｈ２特異的タンパク質及びこれをコードする遺伝子（Ｂ１９）並びにこれに関連する形質転換体、組換えベクター及びモノクローナル抗体 |
| US6916841B2 (en) | 1998-02-25 | 2005-07-12 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| ID27280A (id) | 1998-02-25 | 2001-03-22 | Genetics Inst | Inhibitor-inhibitor dari enzim-enzim fosfolipase |
| ES2224632T3 (es) | 1998-03-31 | 2005-03-01 | The Institutes For Pharmaceutical Discovery, Inc. | Acidos indolalcanoicos sustituidos. |
| TNSN99224A1 (fr) | 1998-12-01 | 2005-11-10 | Inst For Pharm Discovery Inc | Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique |
| WO2001014882A1 (fr) | 1999-08-23 | 2001-03-01 | Bml, Inc. | Identification des proprietes d'une substance pour les recepteurs de prostaglandine d |
| AU2001232785A1 (en) | 2000-01-14 | 2001-07-24 | The Institutes For Pharmaceutical Discovery, Llc | Methods for lowering uric acid levels |
| AU2001238718A1 (en) | 2000-03-02 | 2001-09-12 | The Institutes For Pharmaceutical Discovery, Llc | Compositions containing a substituted indolealkanoic acid and an angiotensin converting enzyme inhibitor |
| JP2001247570A (ja) | 2000-03-08 | 2001-09-11 | Japan Tobacco Inc | インドール酢酸化合物及びその製造方法 |
| US6878522B2 (en) | 2000-07-07 | 2005-04-12 | Baiyong Li | Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2 |
| SE0200411D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| SE0200356D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| AU2003231509A1 (en) | 2002-05-16 | 2003-12-02 | Shionogi And Co., Ltd. | Compound exhibiting pgd 2 receptor antagonism |
| WO2003097042A1 (fr) | 2002-05-16 | 2003-11-27 | Shionogi & Co., Ltd. | Antagoniste de recepteur de pdg2 |
| TW200307542A (en) * | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
| SE0201635D0 (sv) | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
| DE60306547T2 (de) | 2002-12-10 | 2007-06-28 | Wyeth | Substituierte 3-alkyl- und 3-arylalkyl-1h-indol-1-yl-essigsäure-derivate als plasminogen-aktivator |
| US7321001B2 (en) | 2002-12-20 | 2008-01-22 | Amgen Inc. | Asthma and allergic inflammation modulators |
| CA2542716A1 (en) | 2003-10-14 | 2005-05-06 | Oxagen Limited | Compounds having crth2 antagonist activity |
| GB0504150D0 (en) * | 2005-03-01 | 2005-04-06 | Oxagen Ltd | Microcrystalline material |
| GB0605743D0 (en) | 2006-03-22 | 2006-05-03 | Oxagen Ltd | Salts with CRTH2 antagonist activity |
| US20110124683A1 (en) | 2007-11-13 | 2011-05-26 | Oxagen Limited | Use of CRTH2 Antagonist Compounds |
| US7750027B2 (en) | 2008-01-18 | 2010-07-06 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
| JP2011509991A (ja) * | 2008-01-22 | 2011-03-31 | オキサジェン リミテッド | Ｃｒｔｈ２アンタゴニスト活性を有する化合物 |
| EP2265581A1 (en) * | 2008-01-22 | 2010-12-29 | Oxagen Limited | Compounds having crth2 antagonist activity |
| WO2010142934A1 (en) * | 2009-06-12 | 2010-12-16 | Pulmagen Therapeutics (Asthma) Limited | Indole derivatives as ligands of crth2 receptors |
| WO2011055270A1 (en) * | 2009-11-04 | 2011-05-12 | Wyeth Llc | Indole based receptor crth2 antagonists |
| GB201103837D0 (en) | 2011-03-07 | 2011-04-20 | Oxagen Ltd | Amorphous (5-Fluoro-2-Methyl-3-Quinolin-2-Ylmethyl-Indol-1-Yl)-acetic acid |
| GB201121557D0 (en) | 2011-12-15 | 2012-01-25 | Oxagen Ltd | Process |
| GB201407820D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
| GB201407807D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
-
2013
- 2013-12-17 GB GBGB1322273.2A patent/GB201322273D0/en not_active Ceased
-
2014
- 2014-12-12 WO PCT/GB2014/053686 patent/WO2015092372A1/en active Application Filing
- 2014-12-12 DK DK14814989.1T patent/DK3083557T3/en active
- 2014-12-12 HU HUE14814989A patent/HUE036184T2/hu unknown
- 2014-12-12 EP EP14814989.1A patent/EP3083557B1/en active Active
- 2014-12-12 JP JP2016560049A patent/JP6312179B2/ja not_active Expired - Fee Related
- 2014-12-12 TR TR2018/02657T patent/TR201802657T4/tr unknown
- 2014-12-12 RU RU2016125326A patent/RU2676332C1/ru active
- 2014-12-12 PT PT148149891T patent/PT3083557T/pt unknown
- 2014-12-12 NO NO14814989A patent/NO3083557T3/no unknown
- 2014-12-12 PL PL14814989T patent/PL3083557T3/pl unknown
- 2014-12-12 SI SI201430614T patent/SI3083557T1/en unknown
- 2014-12-12 ES ES14814989.1T patent/ES2660467T3/es active Active
- 2014-12-12 US US15/307,998 patent/US9828359B2/en active Active
- 2014-12-12 UA UAA201607416A patent/UA117849C2/uk unknown
-
2018
- 2018-02-19 HR HRP20180298TT patent/HRP20180298T1/hr unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005044260A1 (en) * | 2003-10-23 | 2005-05-19 | Oxagen Limited | Use of crth2 antagonist compounds in therapy |
| WO2006095183A1 (en) * | 2005-03-11 | 2006-09-14 | Oxagen Limited | 1-acetic acid-indole derivatives with pgd2 antagonist activity |
| WO2008012511A1 (en) * | 2006-07-22 | 2008-01-31 | Oxagen Limited | Compounds having crth2 antagonist activity |
| EA017573B1 (ru) * | 2007-12-14 | 2013-01-30 | Пульмаджен Терапьютикс (Эсме) Лимитед | Производные индол-1-илуксусной кислоты и их терапевтическое применение |
| WO2009090414A1 (en) * | 2008-01-18 | 2009-07-23 | Oxagen Limited | Compounds having crth2 antagonist activity |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3083557A1 (en) | 2016-10-26 |
| PT3083557T (pt) | 2018-03-05 |
| NO3083557T3 (uk) | 2018-04-28 |
| DK3083557T3 (en) | 2018-03-12 |
| EP3083557B1 (en) | 2017-11-29 |
| PL3083557T3 (pl) | 2018-05-30 |
| JP2017501222A (ja) | 2017-01-12 |
| US9828359B2 (en) | 2017-11-28 |
| UA117849C2 (uk) | 2018-10-10 |
| SI3083557T1 (en) | 2018-04-30 |
| HRP20180298T1 (hr) | 2018-04-06 |
| JP6312179B2 (ja) | 2018-04-18 |
| WO2015092372A1 (en) | 2015-06-25 |
| HUE036184T2 (hu) | 2018-06-28 |
| ES2660467T3 (es) | 2018-03-22 |
| GB201322273D0 (en) | 2014-01-29 |
| TR201802657T4 (tr) | 2018-03-21 |
| US20170305879A1 (en) | 2017-10-26 |
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