UA102817C2 - Способ синтеза агомелатина - Google Patents
Способ синтеза агомелатинаInfo
- Publication number
- UA102817C2 UA102817C2 UAA200908226A UAA200908226A UA102817C2 UA 102817 C2 UA102817 C2 UA 102817C2 UA A200908226 A UAA200908226 A UA A200908226A UA A200908226 A UAA200908226 A UA A200908226A UA 102817 C2 UA102817 C2 UA 102817C2
- Authority
- UA
- Ukraine
- Prior art keywords
- heading
- normal
- synthesis
- agomelatine
- agomelatine synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/06—Preparation of carboxylic acid amides from nitriles by transformation of cyano groups into carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
- C07C209/48—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/08—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
Abstract
Способ промышленного синтеза соединения формулы (I)(I).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0804463A FR2934857B1 (fr) | 2008-08-05 | 2008-08-05 | Nouveau procede de synthese de l'agomelatine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA102817C2 true UA102817C2 (ru) | 2013-08-27 |
Family
ID=40404415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200908226A UA102817C2 (ru) | 2008-08-05 | 2009-08-04 | Способ синтеза агомелатина |
Country Status (45)
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2580183B1 (en) | 2010-06-10 | 2014-07-23 | Gador S.A. | New process for the preparation of n-[2-(7-methoxy-1-naphthyl)-ethyl]acetamide |
| CN102229541A (zh) * | 2010-09-17 | 2011-11-02 | 福建广生堂药业有限公司 | 阿戈美拉汀n-[2-(7-甲氧基萘-1-基)乙基]乙酰胺的制备方法 |
| CN102206170A (zh) * | 2011-03-18 | 2011-10-05 | 青岛黄海制药有限责任公司 | 一种制备阿戈美拉汀的方法 |
| WO2013054273A2 (en) | 2011-10-11 | 2013-04-18 | Ranbaxy Laboratories Limited | Process for the preparation of agomelatine |
| US20140336380A1 (en) | 2011-12-01 | 2014-11-13 | Ranbaxy Laboratories Limited | Process for the preparation of agomelatine |
| ITMI20121444A1 (it) | 2012-08-27 | 2014-02-28 | Procos Spa | Processo per la produzione di agomelatine |
| CN102942501B (zh) * | 2012-12-10 | 2015-08-19 | 天津泰普药品科技发展有限公司 | 一种氢化制备阿戈美拉汀的生产方法 |
| CN104130154A (zh) * | 2013-05-03 | 2014-11-05 | 郭炳华 | 一种制备高纯度阿戈美拉汀的方法 |
| US9756532B2 (en) | 2013-09-20 | 2017-09-05 | Telefonaktiebolaget L M Ericsson (Publ) | Carrier aggregation sCell selection for LTE-A |
| US9781669B2 (en) | 2013-09-20 | 2017-10-03 | Telefonaktiebolaget Lm Ericsson (Publ) | Statistics-assisted sCell selection |
| FR3014437B1 (fr) * | 2013-12-05 | 2016-12-23 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
| US10149214B2 (en) | 2014-02-03 | 2018-12-04 | Telefonaktiebolaget Lm Ericsson (Publ) | Secondary cell selection based on geographic signatures |
| CN104557591B (zh) * | 2014-12-26 | 2016-09-07 | 扬子江药业集团四川海蓉药业有限公司 | 一种制备阿戈美拉汀乙酰二胺的方法 |
| JP6158255B2 (ja) * | 2015-07-13 | 2017-07-05 | 株式会社三共 | 遊技機 |
| CN107085044A (zh) * | 2017-03-27 | 2017-08-22 | 万全万特制药（厦门）有限公司 | 气相色谱法分离检测阿戈美拉汀中间体有关物质的方法 |
| CN107151221A (zh) * | 2017-06-19 | 2017-09-12 | 太仓卡斯特姆新材料有限公司 | 一种制备阿戈美拉汀重要中间体7‑甲氧基萘乙腈的方法 |
| CN107353229B (zh) * | 2017-08-08 | 2019-04-30 | 许昌恒生制药有限公司 | 一种阿戈美拉汀中间体的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1141276A (fr) * | 1955-02-14 | 1957-08-29 | Geigy Ag J R | Procédé de préparation de l'hexahydro-benzylamine |
| US3062869A (en) * | 1958-11-07 | 1962-11-06 | Fmc Corp | Reduction of nitriles |
| US6037495A (en) * | 1994-09-06 | 2000-03-14 | Shinonogi & Co., Ltd. | Process for producing alkoxyiminoacetamide derivatives |
| FR2773798B1 (fr) * | 1998-01-16 | 2001-02-02 | Adir | Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2866335B1 (fr) * | 2004-02-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
-
2008
- 2008-08-05 FR FR0804463A patent/FR2934857B1/fr not_active Expired - Fee Related
-
2009
- 2009-07-23 PE PE2009000982A patent/PE20100261A1/es active IP Right Grant
- 2009-07-23 SG SG200904971-9A patent/SG158829A1/en unknown
- 2009-07-24 CR CR10955A patent/CR10955A/es unknown
- 2009-07-27 AU AU2009203052A patent/AU2009203052B2/en not_active Ceased
- 2009-07-27 AP AP2009004935A patent/AP2009004935A0/xx unknown
- 2009-07-28 UY UY0001032013A patent/UY32013A/es not_active Application Discontinuation
- 2009-07-28 IL IL200127A patent/IL200127A/en not_active IP Right Cessation
- 2009-07-29 SV SV2009003342A patent/SV2009003342A/es active IP Right Grant
- 2009-07-29 MY MYPI20093145A patent/MY162033A/en unknown
- 2009-07-29 MX MX2009008047A patent/MX2009008047A/es active IP Right Grant
- 2009-07-30 NI NI200900151A patent/NI200900151A/es unknown
- 2009-07-30 ZA ZA200905333A patent/ZA200905333B/en unknown
- 2009-07-31 EC EC2009009550A patent/ECSP099550A/es unknown
- 2009-07-31 GT GT200900216A patent/GT200900216A/es unknown
- 2009-07-31 CO CO09080222A patent/CO6120162A1/es not_active Application Discontinuation
- 2009-07-31 MA MA32131A patent/MA31224B1/fr unknown
- 2009-08-02 JO JO2009285A patent/JO2816B1/en active
- 2009-08-02 SA SA109300497A patent/SA109300497B1/ar unknown
- 2009-08-03 CL CL2009001684A patent/CL2009001684A1/es unknown
- 2009-08-03 CA CA2674901A patent/CA2674901C/fr active Active
- 2009-08-03 US US12/462,363 patent/US8329947B2/en active Active
- 2009-08-03 NZ NZ578827A patent/NZ578827A/en unknown
- 2009-08-03 GE GEAP200911401A patent/GEP20115345B/en unknown
- 2009-08-04 CU CU20090139A patent/CU23861B1/es active IP Right Grant
- 2009-08-04 EP EP09290605A patent/EP2151427B1/fr active Active
- 2009-08-04 SI SI200930500T patent/SI2151427T1/sl unknown
- 2009-08-04 UA UAA200908226A patent/UA102817C2/ru unknown
- 2009-08-04 PL PL09290605T patent/PL2151427T3/pl unknown
- 2009-08-04 ME MEP-2013-153A patent/ME02073B/me unknown
- 2009-08-04 AR ARP090102982A patent/AR075644A1/es unknown
- 2009-08-04 BR BRPI0902948-6A patent/BRPI0902948A2/pt not_active Application Discontinuation
- 2009-08-04 DK DK09290605.6T patent/DK2151427T3/da active
- 2009-08-04 KR KR1020090071641A patent/KR101135336B1/ko active IP Right Grant
- 2009-08-04 ES ES09290605T patent/ES2401534T3/es active Active
- 2009-08-04 EA EA200900945A patent/EA015545B1/ru unknown
- 2009-08-04 RS RS20130056A patent/RS52644B/en unknown
- 2009-08-04 TW TW098126196A patent/TWI386385B/zh not_active IP Right Cessation
- 2009-08-04 WO PCT/FR2009/000971 patent/WO2010015744A1/fr active Application Filing
- 2009-08-04 PT PT92906056T patent/PT2151427E/pt unknown
- 2009-08-05 JP JP2009182088A patent/JP5112399B2/ja active Active
- 2009-08-05 CN CN200910160308.1A patent/CN101643433B/zh active Active
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2010
- 2010-08-09 HK HK10107581.8A patent/HK1141006A1/xx not_active IP Right Cessation
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2013
- 2013-02-25 CY CY20131100172T patent/CY1113716T1/el unknown
- 2013-03-08 HR HRP20130201AT patent/HRP20130201T1/hr unknown
Also Published As
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