ITMI20121444A1 - Processo per la produzione di agomelatine - Google Patents

Processo per la produzione di agomelatine

Info

Publication number
ITMI20121444A1
ITMI20121444A1 IT001444A ITMI20121444A ITMI20121444A1 IT MI20121444 A1 ITMI20121444 A1 IT MI20121444A1 IT 001444 A IT001444 A IT 001444A IT MI20121444 A ITMI20121444 A IT MI20121444A IT MI20121444 A1 ITMI20121444 A1 IT MI20121444A1
Authority
IT
Italy
Prior art keywords
agomelatine
production
agomelatine production
Prior art date
Application number
IT001444A
Other languages
English (en)
Inventor
Alessandro Barozza
Paolo Paissoni
Jacopo Roletto
Martino Veronese
Original Assignee
Procos Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procos Spa filed Critical Procos Spa
Priority to IT001444A priority Critical patent/ITMI20121444A1/it
Priority to EP13179063.6A priority patent/EP2703383A1/en
Publication of ITMI20121444A1 publication Critical patent/ITMI20121444A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
IT001444A 2012-08-27 2012-08-27 Processo per la produzione di agomelatine ITMI20121444A1 (it)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IT001444A ITMI20121444A1 (it) 2012-08-27 2012-08-27 Processo per la produzione di agomelatine
EP13179063.6A EP2703383A1 (en) 2012-08-27 2013-08-02 Process for the preparation of agomelatine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT001444A ITMI20121444A1 (it) 2012-08-27 2012-08-27 Processo per la produzione di agomelatine

Publications (1)

Publication Number Publication Date
ITMI20121444A1 true ITMI20121444A1 (it) 2014-02-28

Family

ID=47138033

Family Applications (1)

Application Number Title Priority Date Filing Date
IT001444A ITMI20121444A1 (it) 2012-08-27 2012-08-27 Processo per la produzione di agomelatine

Country Status (2)

Country Link
EP (1) EP2703383A1 (it)
IT (1) ITMI20121444A1 (it)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2322508A1 (en) * 2008-07-29 2011-05-18 NHWA Pharma. Corporation Process for the manufacture of agomelatine and its intermediate
EP2562151A1 (en) * 2011-08-25 2013-02-27 Dr. Reddy's Laboratories Ltd. Processes for the preparation of agomelatine and its intermediates

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2658818B1 (fr) 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2734816B1 (fr) 1995-05-31 1997-07-04 Adir Nouveaux aryl (alkyl) propylamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2866337B1 (fr) 2004-02-13 2006-05-26 Servier Lab Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'aglomelatine
FR2866335B1 (fr) 2004-02-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'agomelatine
FR2866334B1 (fr) 2004-02-13 2006-05-26 Servier Lab Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine
FR2866336B1 (fr) 2004-02-13 2006-03-24 Servier Lab Nouveau procede de synthese du (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile et application a la synthese de l'agomelatine
FR2919606B1 (fr) 2007-08-03 2010-09-17 Servier Lab Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine.
FR2934855B1 (fr) 2008-08-05 2010-08-13 Servier Lab Nouveau procede de synthese de l'agomelatine
FR2934857B1 (fr) 2008-08-05 2010-08-27 Servier Lab Nouveau procede de synthese de l'agomelatine
FR2934859B1 (fr) 2008-08-05 2010-08-13 Servier Lab Nouveau procede de synthese de l'agomelatine
CN101486665B (zh) 2009-03-03 2013-04-17 上海医药工业研究院 阿戈美拉汀中间体2-(7-甲氧基-1-萘基)乙酰胺的制备方法
WO2011006387A1 (zh) 2009-07-11 2011-01-20 浙江华海药业股份有限公司 阿戈美拉汀的制备方法、阿戈美拉汀晶形及其制备方法
CN101709036B (zh) 2009-12-17 2012-07-04 天津药物研究院 阿戈美拉汀中间体2-(7-甲氧基-1-萘基)乙胺的制备
CN101735091A (zh) 2009-12-30 2010-06-16 北京德众万全药物技术开发有限公司 一种阿戈美拉汀的制备方法
CN102146046B (zh) 2010-02-05 2013-07-03 天津市汉康医药生物技术有限公司 一种n-[2-(7-甲氧基-1-萘基)乙基]乙酰胺新的制备方法
CN101792400B (zh) 2010-03-16 2013-01-30 华东师范大学 一种阿戈美拉汀的合成方法
CN102276492B (zh) 2010-06-08 2013-04-10 上海医药工业研究院 阿戈美拉汀中间体及其制备方法
EP2580183B1 (en) 2010-06-10 2014-07-23 Gador S.A. New process for the preparation of n-[2-(7-methoxy-1-naphthyl)-ethyl]acetamide
CN101973897B (zh) 2010-10-08 2013-05-29 齐云 一种合成阿戈美拉汀中间体2-(7-甲氧基萘-1-基)乙胺的方法
WO2012046253A2 (en) 2010-10-08 2012-04-12 Msn Laboratories Limited Process for the preparation of n-[2- (7-methoxy-l-naphthyl) ethyl] acetamide and its novel crystalline forms
CN102001960A (zh) 2010-11-24 2011-04-06 威海迪素制药有限公司 一种阿戈美拉汀的制备方法
WO2012070025A1 (en) 2010-11-26 2012-05-31 Cadila Pharmaceuticals Ltd Process for the preparation of agomelatine
CN102206170A (zh) 2011-03-18 2011-10-05 青岛黄海制药有限责任公司 一种制备阿戈美拉汀的方法
CN102367228A (zh) 2011-10-24 2012-03-07 南京工业大学 一种合成阿戈美拉汀的方法
CN102408350A (zh) 2011-10-24 2012-04-11 南京工业大学 一种阿戈美拉汀的制备方法
CN102531942B (zh) 2011-11-17 2014-04-09 成都欣捷高新技术开发有限公司 一种阿戈美拉汀ⅰ晶型的制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2322508A1 (en) * 2008-07-29 2011-05-18 NHWA Pharma. Corporation Process for the manufacture of agomelatine and its intermediate
EP2562151A1 (en) * 2011-08-25 2013-02-27 Dr. Reddy's Laboratories Ltd. Processes for the preparation of agomelatine and its intermediates

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LECLERC V ET AL: "Synthesis and structure-activity relationships of novel naphthalenic and bioisosteric related amidic derivatives as melatonin receptor ligands", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 6, no. 10, 1 October 1998 (1998-10-01), pages 1875 - 1887, XP027393080, ISSN: 0968-0896, [retrieved on 19981001] *

Also Published As

Publication number Publication date
EP2703383A1 (en) 2014-03-05

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