BR112014028589A2 - processo para fabricação de compostos de ciclopentilpirimidina hidroxilada - Google Patents
processo para fabricação de compostos de ciclopentilpirimidina hidroxiladaInfo
- Publication number
- BR112014028589A2 BR112014028589A2 BR112014028589A BR112014028589A BR112014028589A2 BR 112014028589 A2 BR112014028589 A2 BR 112014028589A2 BR 112014028589 A BR112014028589 A BR 112014028589A BR 112014028589 A BR112014028589 A BR 112014028589A BR 112014028589 A2 BR112014028589 A2 BR 112014028589A2
- Authority
- BR
- Brazil
- Prior art keywords
- manufacturing
- hydroxylated
- compounds
- cyclopentylpyrimidine compounds
- hydroxylated cyclopentylpyrimidine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261648473P | 2012-05-17 | 2012-05-17 | |
| US61/648,473 | 2012-05-17 | ||
| US201361785122P | 2013-03-14 | 2013-03-14 | |
| US61/785,122 | 2013-03-14 | ||
| PCT/US2013/041666 WO2013173768A1 (en) | 2012-05-17 | 2013-05-17 | Process for making hydroxylated cyclopentylpyrimidine compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112014028589A2 true BR112014028589A2 (pt) | 2017-07-25 |
| BR112014028589B1 BR112014028589B1 (pt) | 2022-08-23 |
Family
ID=48485537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014028589-6A BR112014028589B1 (pt) | 2012-05-17 | 2013-05-17 | Ciclopentilpirimidina hidroxilada, seu processo de fabricação e seus intermediários |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US9416110B2 (pt) |
| EP (1) | EP2861582B1 (pt) |
| JP (1) | JP6284928B2 (pt) |
| KR (1) | KR102067850B1 (pt) |
| CN (1) | CN104470913B (pt) |
| AU (1) | AU2013262505B2 (pt) |
| BR (1) | BR112014028589B1 (pt) |
| CA (1) | CA2873654C (pt) |
| DK (1) | DK2861582T3 (pt) |
| ES (1) | ES2582557T3 (pt) |
| HK (1) | HK1208451A1 (pt) |
| IL (1) | IL235715A (pt) |
| MX (1) | MX353384B (pt) |
| MY (1) | MY169028A (pt) |
| NZ (1) | NZ702935A (pt) |
| PL (1) | PL2861582T3 (pt) |
| RU (1) | RU2643811C2 (pt) |
| SG (1) | SG11201407616TA (pt) |
| SI (1) | SI2861582T1 (pt) |
| WO (1) | WO2013173768A1 (pt) |
| ZA (1) | ZA201409261B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY169028A (en) | 2012-05-17 | 2019-02-04 | Genentech Inc | Process for making hydroxylated cyclopentylpyrimidine compounds |
| RU2642311C2 (ru) | 2012-05-17 | 2018-01-24 | Дженентек, Инк. | Способ получения гидроксилированных циклопентапиримидиновых соединений и их солей |
| DK2858989T3 (da) | 2012-05-17 | 2020-06-02 | Genentech Inc | Amorf form af en AKT-hæmmende pyrimidinyl-cyclopentan-forbindelse, sammensætninger deraf og fremgangsmåder dertil |
| BR112014028570A2 (pt) | 2012-05-17 | 2018-04-24 | Array Biopharma Inc | processo para fabricação de compostos de ciclopentilpirimidina hidroxilada. |
| BR112016011048A8 (pt) * | 2013-11-15 | 2020-04-22 | Hoffmann La Roche | processo para preparar um composto, processos para fabricar compostos, compostos e composições farmacêuticas |
| RU2732404C2 (ru) * | 2014-09-26 | 2020-09-16 | Ф. Хоффманн-Ля Рош Аг | СПОСОБЫ ПОЛУЧЕНИЯ (ЦИКЛОПЕНТИЛ[d]ПИРИМИДИН-4-ИЛ)ПИПЕРАЗИНОВЫХ СОЕДИНЕНИЙ |
| EP3496722A1 (en) | 2016-08-10 | 2019-06-19 | H. Hoffnabb-La Roche Ag | Pharmaceutical compositions comprising akt protein kinase inhibitors |
| KR20230011368A (ko) | 2020-06-16 | 2023-01-20 | 에프. 호프만-라 로슈 아게 | 하이드록실화 사이클로펜틸피리미딘 화합물 제조 방법 |
| KR20230035773A (ko) * | 2021-09-06 | 2023-03-14 | 연세대학교 산학협력단 | Akt 신호경로 억제제를 유효성분으로 포함하는 아토피피부염의 예방 또는 치료용 조성물 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9408197A (pt) | 1993-12-12 | 1997-08-26 | Agrogene Ltd | Método para proteger plantas contra doenças fúngicas |
| EP0973396A4 (en) | 1997-04-07 | 2001-02-07 | Merck & Co Inc | METHOD FOR TREATING CANCER |
| US6201023B1 (en) | 1997-06-10 | 2001-03-13 | Agrogene Ltd. | Methods and compositions to protect crops against plant parasitic nematodes |
| EP0982300A3 (en) | 1998-07-29 | 2000-03-08 | Societe Civile Bioprojet | Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications |
| WO2000052134A2 (en) | 1999-03-03 | 2000-09-08 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| EP1188754B1 (en) * | 1999-06-03 | 2005-06-01 | Teikoku Hormone Mfg. Co., Ltd. | Substituted pyrazole compounds |
| AU7715300A (en) | 1999-09-27 | 2001-04-30 | Merck & Co., Inc. | Method of preventing osteoporosis |
| US7582766B2 (en) | 2003-06-09 | 2009-09-01 | Boehringer Ingelheim International Gmbh | Inhibitors of papilloma virus |
| US8927546B2 (en) | 2006-02-28 | 2015-01-06 | Dart Neuroscience (Cayman) Ltd. | Therapeutic piperazines |
| US8063050B2 (en) * | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| UA95641C2 (en) * | 2006-07-06 | 2011-08-25 | Эррей Биофарма Инк. | Hydroxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
| US20100298289A1 (en) | 2007-10-09 | 2010-11-25 | Ucb Pharma, S.A. | Heterobicyclic compounds as histamine h4-receptor antagonists |
| WO2010120935A1 (en) | 2009-04-15 | 2010-10-21 | Abbott Laboratories | Anti-viral compounds |
| ES2465094T3 (es) * | 2009-10-23 | 2014-06-05 | Eli Lilly And Company | Inhibidores de AKT |
| US9050334B2 (en) | 2010-07-16 | 2015-06-09 | Innov88 Llc | MIF inhibitors and their uses |
| WO2012177925A1 (en) | 2011-06-21 | 2012-12-27 | The Board Institute, Inc. | Akt inhibitors for treating cancer expressing a magi3 - akt3 fusion gene |
| MX350443B (es) | 2012-05-17 | 2017-09-06 | Genentech Inc | Proceso para hacer compuestos de aminoácidos. |
| RU2642311C2 (ru) | 2012-05-17 | 2018-01-24 | Дженентек, Инк. | Способ получения гидроксилированных циклопентапиримидиновых соединений и их солей |
| DK2858989T3 (da) | 2012-05-17 | 2020-06-02 | Genentech Inc | Amorf form af en AKT-hæmmende pyrimidinyl-cyclopentan-forbindelse, sammensætninger deraf og fremgangsmåder dertil |
| BR112014028570A2 (pt) | 2012-05-17 | 2018-04-24 | Array Biopharma Inc | processo para fabricação de compostos de ciclopentilpirimidina hidroxilada. |
| MY169028A (en) | 2012-05-17 | 2019-02-04 | Genentech Inc | Process for making hydroxylated cyclopentylpyrimidine compounds |
| US20140121193A1 (en) | 2012-11-01 | 2014-05-01 | Robert S. Katz | Methods for treating fibromyalgia |
| CN105263910A (zh) | 2013-02-18 | 2016-01-20 | 斯克利普斯研究所 | 具有治疗潜力的血管加压素受体调节剂 |
| CA2904662A1 (en) | 2013-03-15 | 2014-09-25 | Shifa Biomedical Corporation | Anti-pcsk9 compounds and methods for the treatment and/or prevention of cardiovascular diseases |
-
2013
- 2013-05-17 MY MYPI2014703415A patent/MY169028A/en unknown
- 2013-05-17 KR KR1020147035427A patent/KR102067850B1/ko active IP Right Grant
- 2013-05-17 SI SI201330261A patent/SI2861582T1/sl unknown
- 2013-05-17 ES ES13725042.9T patent/ES2582557T3/es active Active
- 2013-05-17 EP EP13725042.9A patent/EP2861582B1/en active Active
- 2013-05-17 AU AU2013262505A patent/AU2013262505B2/en active Active
- 2013-05-17 NZ NZ702935A patent/NZ702935A/en unknown
- 2013-05-17 WO PCT/US2013/041666 patent/WO2013173768A1/en active Application Filing
- 2013-05-17 SG SG11201407616TA patent/SG11201407616TA/en unknown
- 2013-05-17 DK DK13725042.9T patent/DK2861582T3/en active
- 2013-05-17 RU RU2014151050A patent/RU2643811C2/ru active
- 2013-05-17 MX MX2014013862A patent/MX353384B/es active IP Right Grant
- 2013-05-17 US US14/401,087 patent/US9416110B2/en active Active
- 2013-05-17 CN CN201380038057.4A patent/CN104470913B/zh active Active
- 2013-05-17 PL PL13725042.9T patent/PL2861582T3/pl unknown
- 2013-05-17 BR BR112014028589-6A patent/BR112014028589B1/pt active IP Right Grant
- 2013-05-17 CA CA2873654A patent/CA2873654C/en active Active
- 2013-05-17 JP JP2015512900A patent/JP6284928B2/ja active Active
-
2014
- 2014-11-13 IL IL235715A patent/IL235715A/en active IP Right Grant
- 2014-12-15 ZA ZA2014/09261A patent/ZA201409261B/en unknown
-
2015
- 2015-09-16 HK HK15109049.5A patent/HK1208451A1/xx unknown
-
2016
- 2016-07-07 US US15/204,715 patent/US9676730B2/en active Active
-
2017
- 2017-05-11 US US15/593,064 patent/US9790190B2/en active Active
- 2017-10-12 US US15/782,620 patent/US20180258054A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA. |
|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B15K | Others concerning applications: alteration of classification |
Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 403/04 Ipc: C07D 403/04 (2006.01), C07D 239/70 (2006.01), C07D |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/05/2013, OBSERVADAS AS CONDICOES LEGAIS |