MX2022004480A - Procedimiento para preparar esteres aciloximetilicos del acido (4s)-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6- naftiridin-3-carboxilico. - Google Patents
Procedimiento para preparar esteres aciloximetilicos del acido (4s)-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6- naftiridin-3-carboxilico.Info
- Publication number
- MX2022004480A MX2022004480A MX2022004480A MX2022004480A MX2022004480A MX 2022004480 A MX2022004480 A MX 2022004480A MX 2022004480 A MX2022004480 A MX 2022004480A MX 2022004480 A MX2022004480 A MX 2022004480A MX 2022004480 A MX2022004480 A MX 2022004480A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- producing
- relates
- hydrolase
- methoxyphenyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 11
- 125000005042 acyloxymethyl group Chemical group 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 8
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a un procedimiento para preparar ésteres aciloximetílicos del ácido (4S)-(4-ciano-2-metoxifenil)-5- etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxílico de la fórmula (IIa) por separación de racematos del compuesto de la fórmula (II) usando una hidrolasa. La invención se refiere también a un procedimiento para preparar (4S)-4-(4-ciano-2-metoxif enil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6-naftiridin-3-carboxamid a de la fórmula (Ia), en donde el procedimiento comprende la separación de racematos del compuesto de la fórmula (II) usando una hidrolasa. Además, la invención también se refiere al uso de una hidrolasa en un procedimiento para preparar un compuesto según la fórmula (IIa). La invención también se refiere al uso de una hidrolasa en un procedimiento para preparar un compuesto según la fórmula (Ia).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19203821 | 2019-10-17 | ||
PCT/EP2020/078611 WO2021074077A1 (de) | 2019-10-17 | 2020-10-12 | Verfahren zur herstellung von acyloxymethylestern der (4s) -(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbonsäure |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022004480A true MX2022004480A (es) | 2022-05-06 |
Family
ID=68281309
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022004480A MX2022004480A (es) | 2019-10-17 | 2020-10-12 | Procedimiento para preparar esteres aciloximetilicos del acido (4s)-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1,6- naftiridin-3-carboxilico. |
Country Status (16)
Country | Link |
---|---|
US (1) | US20240150344A1 (es) |
EP (1) | EP4045500A1 (es) |
JP (1) | JP2022553225A (es) |
KR (1) | KR20220084102A (es) |
CN (1) | CN114555599B (es) |
AU (1) | AU2020365314A1 (es) |
BR (1) | BR112022005605A2 (es) |
CA (1) | CA3157823A1 (es) |
CL (1) | CL2022000941A1 (es) |
CO (1) | CO2022004464A2 (es) |
CR (1) | CR20220161A (es) |
IL (1) | IL292194A (es) |
JO (1) | JOP20220148A1 (es) |
MX (1) | MX2022004480A (es) |
PE (1) | PE20221414A1 (es) |
WO (1) | WO2021074077A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114214375B (zh) * | 2021-12-27 | 2024-03-19 | 江苏威凯尔医药科技有限公司 | (r)-3-(4-卤代-1h-吡唑-1-基)-3-环戊基丙酸酯的制备方法 |
CN115340539B (zh) * | 2022-01-19 | 2024-02-27 | 奥锐特药业股份有限公司 | 制备非奈利酮及其中间体的方法 |
WO2023205164A1 (en) | 2022-04-18 | 2023-10-26 | Teva Pharmaceuticals International Gmbh | Processes for the preparation of finerenone |
WO2023223188A1 (en) * | 2022-05-16 | 2023-11-23 | Glenmark Life Sciences Limited | Process for the preparation of finerenone and intermediates thereof |
CN115322194B (zh) * | 2022-08-23 | 2024-04-09 | 浙江国邦药业有限公司 | 一种非奈利酮中间体羧酸拆分方法 |
CN116715664A (zh) * | 2023-06-12 | 2023-09-08 | 常州制药厂有限公司 | 一种非奈利酮关键中间体的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5234821A (en) * | 1990-09-01 | 1993-08-10 | Kazuo Achiwa | Process for preparing 1,4 dihydropyridine compounds |
DE102007009494A1 (de) * | 2007-02-27 | 2008-08-28 | Bayer Healthcare Ag | Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung |
MY198066A (en) * | 2014-08-01 | 2023-07-31 | Bayer Pharma AG | Method for the preparation of (4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carbox-amide and the purification thereof for use as an active pharmaceutical ingredient |
MX2018002105A (es) * | 2015-08-21 | 2018-06-15 | Bayer Pharma AG | Procedimiento para la preparacion de los metabolitos de (4s)- y (4r)-4-(4-ciano-2-metoxifenil)-5-etoxi-2,8-dimetil-1,4-dihidro-1, 6-naftiridina-3-carboxamida y el uso de los mismos. |
PE20180554A1 (es) * | 2015-08-21 | 2018-04-02 | Bayer Pharma AG | Procedimiento para la preparacion de (4s)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridina-3-carboxamida y su purificacion para su uso como principio activo farmaceutico |
CN108409731B (zh) * | 2018-03-07 | 2020-11-20 | 西华大学 | 芳基取代的1H-吡啶[3,4-b]吲哚-3-羧酸甲酯的手性拆分 |
-
2020
- 2020-10-12 JP JP2022522986A patent/JP2022553225A/ja active Pending
- 2020-10-12 WO PCT/EP2020/078611 patent/WO2021074077A1/de active Application Filing
- 2020-10-12 CN CN202080072389.4A patent/CN114555599B/zh active Active
- 2020-10-12 IL IL292194A patent/IL292194A/en unknown
- 2020-10-12 CR CR20220161A patent/CR20220161A/es unknown
- 2020-10-12 PE PE2022000593A patent/PE20221414A1/es unknown
- 2020-10-12 MX MX2022004480A patent/MX2022004480A/es unknown
- 2020-10-12 US US17/769,241 patent/US20240150344A1/en active Pending
- 2020-10-12 KR KR1020227015997A patent/KR20220084102A/ko unknown
- 2020-10-12 EP EP20789970.9A patent/EP4045500A1/de active Pending
- 2020-10-12 CA CA3157823A patent/CA3157823A1/en active Pending
- 2020-10-12 BR BR112022005605A patent/BR112022005605A2/pt not_active Application Discontinuation
- 2020-10-12 JO JOP/2022/0148A patent/JOP20220148A1/ar unknown
- 2020-10-12 AU AU2020365314A patent/AU2020365314A1/en active Pending
-
2022
- 2022-04-07 CO CONC2022/0004464A patent/CO2022004464A2/es unknown
- 2022-04-13 CL CL2022000941A patent/CL2022000941A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CL2022000941A1 (es) | 2022-11-11 |
AU2020365314A1 (en) | 2022-05-12 |
CR20220161A (es) | 2022-06-17 |
EP4045500A1 (de) | 2022-08-24 |
BR112022005605A2 (pt) | 2022-07-19 |
IL292194A (en) | 2022-06-01 |
CN114555599A (zh) | 2022-05-27 |
PE20221414A1 (es) | 2022-09-20 |
KR20220084102A (ko) | 2022-06-21 |
JOP20220148A1 (ar) | 2023-01-30 |
CA3157823A1 (en) | 2021-04-22 |
CN114555599B (zh) | 2024-06-07 |
CO2022004464A2 (es) | 2022-04-29 |
JP2022553225A (ja) | 2022-12-22 |
WO2021074077A1 (de) | 2021-04-22 |
US20240150344A1 (en) | 2024-05-09 |
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