MX363652B - Sintesis de 3-(5-amino-2-metil-4-oxoquinazolin-3(4h)-il)piperidin- 2,6-diona. - Google Patents

Sintesis de 3-(5-amino-2-metil-4-oxoquinazolin-3(4h)-il)piperidin- 2,6-diona.

Info

Publication number
MX363652B
MX363652B MX2015015073A MX2015015073A MX363652B MX 363652 B MX363652 B MX 363652B MX 2015015073 A MX2015015073 A MX 2015015073A MX 2015015073 A MX2015015073 A MX 2015015073A MX 363652 B MX363652 B MX 363652B
Authority
MX
Mexico
Prior art keywords
oxoquinazolin
dione
piperidine
amino
methyl
Prior art date
Application number
MX2015015073A
Other languages
English (en)
Other versions
MX2015015073A (es
Inventor
Man Hon-Wah
M Cohen Benjamin
W Leong William
L Ruchelman Alexander
M Kreilein Matthew
Choudhury Anusuya
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of MX2015015073A publication Critical patent/MX2015015073A/es
Publication of MX363652B publication Critical patent/MX363652B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se proporcionan en la presente procesos para la preparación de 3- (5-amino-2-metil-4-oxoquinazolin-3(4H) - il)piperidin-2,6-diona, o un enantiómero o una mezcla de enantiómeros de los mismos; o una sal farmacéuticamente aceptable de los mismos.
MX2015015073A 2013-05-01 2014-04-30 Sintesis de 3-(5-amino-2-metil-4-oxoquinazolin-3(4h)-il)piperidin- 2,6-diona. MX363652B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361818254P 2013-05-01 2013-05-01
PCT/US2014/036083 WO2014179416A1 (en) 2013-05-01 2014-04-30 Synthesis of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl) piperidine-2,6-dione

Publications (2)

Publication Number Publication Date
MX2015015073A MX2015015073A (es) 2016-03-03
MX363652B true MX363652B (es) 2019-03-28

Family

ID=50885008

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015015073A MX363652B (es) 2013-05-01 2014-04-30 Sintesis de 3-(5-amino-2-metil-4-oxoquinazolin-3(4h)-il)piperidin- 2,6-diona.

Country Status (25)

Country Link
US (3) US9067912B2 (es)
EP (2) EP3199532A1 (es)
JP (2) JP6490055B2 (es)
KR (1) KR20160003228A (es)
CN (2) CN107935994A (es)
AR (1) AR096165A1 (es)
AU (2) AU2014260011A1 (es)
CA (1) CA2910971A1 (es)
CY (1) CY1119525T1 (es)
DK (1) DK2991976T3 (es)
ES (1) ES2645944T3 (es)
HR (1) HRP20171535T1 (es)
HU (1) HUE034770T2 (es)
LT (1) LT2991976T (es)
MX (1) MX363652B (es)
NZ (1) NZ628322A (es)
PH (1) PH12015502477A1 (es)
PL (1) PL2991976T3 (es)
PT (1) PT2991976T (es)
RS (1) RS56565B1 (es)
RU (1) RU2015151359A (es)
SG (1) SG11201508836XA (es)
SI (1) SI2991976T1 (es)
TW (1) TW201536766A (es)
WO (1) WO2014179416A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ME02829B (me) 2006-09-26 2018-01-20 Celgene Corp 5-supstituirani derivati kinazolinona kao sredstva protiv raka
RS56770B1 (sr) 2011-03-11 2018-04-30 Celgene Corp Čvrste forme 3-(5-amino-2-metil-4-okso-4h-hinazolin-3-il)-piperidin-2,6-diona i njihove farmaceutske smeše i upotrebe
US9682952B2 (en) 2012-09-04 2017-06-20 Celgene Corporation Isotopologues of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl) piperidine-2-6-dione and methods of preparation thereof
MX2018000216A (es) 2015-07-02 2018-05-22 Celgene Corp Terapia de combinacion para el tratamiento de canceres hematologicos y tumores solidos.
CN106083622B (zh) * 2016-06-16 2018-06-19 常州齐晖药业有限公司 一种甲苯咪唑中间体3,4-二氨基二苯甲酮的制备方法
US20180258064A1 (en) * 2017-03-07 2018-09-13 Celgene Corporation Solid forms of 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses
CN113101295A (zh) * 2020-03-20 2021-07-13 上海疆云医疗健康科技有限公司 二苯乙烯类似物在治疗糖尿病肾脏疾病中的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2655128A1 (en) * 2006-06-08 2007-12-21 Array Biopharma Inc. Quinoline compounds and methods of use
ME02829B (me) 2006-09-26 2018-01-20 Celgene Corp 5-supstituirani derivati kinazolinona kao sredstva protiv raka
CN107375293A (zh) * 2011-03-11 2017-11-24 细胞基因公司 利用3‑(5‑氨基‑2‑甲基‑4‑氧‑4h‑喹唑啉‑3‑基)‑哌啶‑2,6‑二酮治疗癌症的方法
RS56770B1 (sr) * 2011-03-11 2018-04-30 Celgene Corp Čvrste forme 3-(5-amino-2-metil-4-okso-4h-hinazolin-3-il)-piperidin-2,6-diona i njihove farmaceutske smeše i upotrebe
US9682952B2 (en) * 2012-09-04 2017-06-20 Celgene Corporation Isotopologues of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl) piperidine-2-6-dione and methods of preparation thereof
JP6359563B2 (ja) * 2013-01-14 2018-07-18 デュートルクス・リミテッド・ライアビリティ・カンパニーＤｅｕｔｅＲｘ， ＬＬＣ ３−（５置換−４−オキソキナゾリン−３（４ｈ）−イル）−３−ジュウテロピペリジン−２，６−ジオン誘導体

Also Published As

Publication number Publication date
RU2015151359A (ru) 2017-06-06
EP2991976B1 (en) 2017-09-20
US9266858B2 (en) 2016-02-23
SG11201508836XA (en) 2015-11-27
TW201536766A (zh) 2015-10-01
US20150274694A1 (en) 2015-10-01
PT2991976T (pt) 2017-11-14
MX2015015073A (es) 2016-03-03
PH12015502477A1 (en) 2016-02-22
NZ628322A (en) 2017-06-30
CN105377831A (zh) 2016-03-02
WO2014179416A1 (en) 2014-11-06
KR20160003228A (ko) 2016-01-08
US20160009685A1 (en) 2016-01-14
CN107935994A (zh) 2018-04-20
AR096165A1 (es) 2015-12-09
RS56565B1 (sr) 2018-02-28
HRP20171535T1 (hr) 2017-11-17
US9067912B2 (en) 2015-06-30
EP3199532A1 (en) 2017-08-02
JP6490055B2 (ja) 2019-03-27
CN105377831B (zh) 2018-02-02
HUE034770T2 (hu) 2018-02-28
DK2991976T3 (da) 2017-11-06
AU2014260011A1 (en) 2015-11-12
CA2910971A1 (en) 2014-11-06
US9303014B2 (en) 2016-04-05
JP2016517886A (ja) 2016-06-20
PL2991976T3 (pl) 2018-01-31
LT2991976T (lt) 2017-10-25
JP2019069958A (ja) 2019-05-09
ES2645944T3 (es) 2017-12-11
EP2991976A1 (en) 2016-03-09
AU2017200965A1 (en) 2017-03-02
US20140330016A1 (en) 2014-11-06
CY1119525T1 (el) 2018-03-07
SI2991976T1 (sl) 2017-11-30

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