BR112021022538A2 - Processos para preparar compostos de aminopirimidina - Google Patents

Processos para preparar compostos de aminopirimidina

Info

Publication number
BR112021022538A2
BR112021022538A2 BR112021022538A BR112021022538A BR112021022538A2 BR 112021022538 A2 BR112021022538 A2 BR 112021022538A2 BR 112021022538 A BR112021022538 A BR 112021022538A BR 112021022538 A BR112021022538 A BR 112021022538A BR 112021022538 A2 BR112021022538 A2 BR 112021022538A2
Authority
BR
Brazil
Prior art keywords
processes
aminopyrimidine compounds
compounds
preparing
preparing aminopyrimidine
Prior art date
Application number
BR112021022538A
Other languages
English (en)
Inventor
Reid Rosen Brandon
Harding Miles Dillon
Ul Sharif Ehesan
Patrick Powers Jay
Reddy Leleti Manmohan
Original Assignee
Arcus Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arcus Biosciences Inc filed Critical Arcus Biosciences Inc
Publication of BR112021022538A2 publication Critical patent/BR112021022538A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Health & Medical Sciences (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)

Abstract

processos para preparar compostos de aminopirimidina. são fornecidos neste documento processos aprimorados para a preparação de compostos de aminopirimidina de fórmula (i). os processos divulgados são vantajosamente conduzidos por um intermediário ß-dicetoéster de fórmula (a) e evitam a ligação direta de uma pirimidina e frações fenila. os métodos divulgados aumentam significativamente o rendimento dos compostos desejados e simplificam a via sintética.
BR112021022538A 2019-06-06 2020-06-05 Processos para preparar compostos de aminopirimidina BR112021022538A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962858050P 2019-06-06 2019-06-06
PCT/US2020/036379 WO2020247789A1 (en) 2019-06-06 2020-06-05 Processes for preparing aminopyrimidine compounds

Publications (1)

Publication Number Publication Date
BR112021022538A2 true BR112021022538A2 (pt) 2021-12-28

Family

ID=73652287

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021022538A BR112021022538A2 (pt) 2019-06-06 2020-06-05 Processos para preparar compostos de aminopirimidina

Country Status (13)

Country Link
US (1) US20220235031A1 (pt)
EP (1) EP3980013A4 (pt)
JP (1) JP2022534561A (pt)
KR (1) KR20220017898A (pt)
CN (1) CN114206334A (pt)
AU (1) AU2020289465A1 (pt)
BR (1) BR112021022538A2 (pt)
CA (1) CA3140030A1 (pt)
IL (1) IL288593A (pt)
MX (1) MX2021014130A (pt)
SG (1) SG11202112684SA (pt)
TW (1) TW202112765A (pt)
WO (1) WO2020247789A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202100267TA (en) 2018-07-18 2021-02-25 Arcus Biosciences Inc Solid forms of an azolopyrimidine compound
CN114907273A (zh) * 2022-06-09 2022-08-16 乐威医药（江苏）股份有限公司 2-氨基嘧啶-6-芳基化合物的制备方法
WO2024059142A1 (en) 2022-09-14 2024-03-21 Arcus Biosciences, Inc. Dispersions of etrumadenant
WO2024097736A1 (en) 2022-11-02 2024-05-10 Arcus Biosciences, Inc. Processes for preparing azolopyrimidine compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2778830A (en) * 1957-01-22 Production of z-aminopyrimidines
DK1379511T3 (da) * 2001-04-12 2005-11-07 Hoffmann La Roche Dihydro-benzo[b][1,4]diazepin-2-on-derivater som mGLuR2-antagonister II
EP2326640A1 (en) * 2008-07-30 2011-06-01 Ranbaxy Laboratories Limited Pyrrole carboxylic acid derivatives as antibacterial agents
US10953012B2 (en) * 2011-04-26 2021-03-23 Bioenergenix Llc Heterocyclic compounds for the inhibition of pask
CN110214012B (zh) * 2017-01-20 2023-05-09 艾库斯生物科学有限公司 用于治疗癌症相关疾病的唑嘧啶

Also Published As

Publication number Publication date
MX2021014130A (es) 2022-01-04
IL288593A (en) 2022-02-01
JP2022534561A (ja) 2022-08-02
TW202112765A (zh) 2021-04-01
WO2020247789A1 (en) 2020-12-10
CN114206334A (zh) 2022-03-18
EP3980013A4 (en) 2023-05-10
AU2020289465A1 (en) 2021-12-09
CA3140030A1 (en) 2020-12-10
SG11202112684SA (en) 2021-12-30
US20220235031A1 (en) 2022-07-28
KR20220017898A (ko) 2022-02-14
EP3980013A1 (en) 2022-04-13

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