CL2020001576A1 - Componentes heterocíclicos bicíclicos sustituidos como inhibidores de prmt5. - Google Patents
Componentes heterocíclicos bicíclicos sustituidos como inhibidores de prmt5.Info
- Publication number
- CL2020001576A1 CL2020001576A1 CL2020001576A CL2020001576A CL2020001576A1 CL 2020001576 A1 CL2020001576 A1 CL 2020001576A1 CL 2020001576 A CL2020001576 A CL 2020001576A CL 2020001576 A CL2020001576 A CL 2020001576A CL 2020001576 A1 CL2020001576 A1 CL 2020001576A1
- Authority
- CL
- Chile
- Prior art keywords
- bicyclic heterocyclic
- substituted bicyclic
- prmt5 inhibitors
- heterocyclic components
- prmt5
- Prior art date
Links
- 125000002618 bicyclic heterocycle group Chemical group 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 101150097768 prmt5 gene Proteins 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 102100034607 Protein arginine N-methyltransferase 5 Human genes 0.000 abstract 2
- 101710084427 Protein arginine N-methyltransferase 5 Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 230000002018 overexpression Effects 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La invención se refiere a compuestos heterocíclicos bicíclicos sustituidos de fórmula (I), a sales farmacéuticamente aceptables de los mismos y a composiciones farmacéuticas para tratar enfermedades, trastornos o afecciones asociados con la sobreexpresión de la enzima PRMT5. La invención también se refiere a métodos para tratar enfermedades, trastornos o afecciones asociados con la sobreexpresión de la enzima PRMT5.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN201721044886 | 2017-12-13 | ||
IN201821024634 | 2018-07-02 | ||
IN201821040029 | 2018-10-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2020001576A1 true CL2020001576A1 (es) | 2020-11-06 |
Family
ID=65036860
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2020001576A CL2020001576A1 (es) | 2017-12-13 | 2020-06-11 | Componentes heterocíclicos bicíclicos sustituidos como inhibidores de prmt5. |
Country Status (27)
Country | Link |
---|---|
US (2) | US11459330B2 (es) |
EP (1) | EP3724190B1 (es) |
JP (1) | JP7282778B2 (es) |
CN (1) | CN111712498B (es) |
AU (1) | AU2018385664B2 (es) |
BR (1) | BR112020011746A2 (es) |
CA (1) | CA3085259A1 (es) |
CL (1) | CL2020001576A1 (es) |
CR (1) | CR20200263A (es) |
CU (1) | CU24621B1 (es) |
DK (1) | DK3724190T3 (es) |
ES (1) | ES2927860T3 (es) |
GE (1) | GEP20227359B (es) |
HR (1) | HRP20221207T1 (es) |
HU (1) | HUE059945T2 (es) |
IL (1) | IL274936B2 (es) |
LT (1) | LT3724190T (es) |
MX (1) | MX2020006181A (es) |
PE (1) | PE20211444A1 (es) |
PH (1) | PH12020550881A1 (es) |
PL (1) | PL3724190T3 (es) |
PT (1) | PT3724190T (es) |
RS (1) | RS63623B1 (es) |
SG (1) | SG11202004934QA (es) |
UA (1) | UA126349C2 (es) |
WO (1) | WO2019116302A1 (es) |
ZA (1) | ZA202003528B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
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US11077101B1 (en) | 2018-07-18 | 2021-08-03 | Tango Therapeutics, Inc. | Compounds and methods of use |
AU2019362753A1 (en) | 2018-10-05 | 2021-05-20 | Vertex Pharmaceuticals Incorporated | Modulators of alpha-1 antitrypsin |
JP2022522534A (ja) | 2019-04-02 | 2022-04-19 | アリゴス セラピューティクス インコーポレイテッド | Prmt5を標的にする化合物 |
US11884672B2 (en) | 2019-05-14 | 2024-01-30 | Vertex Pharmaceuticals Incorporated | Modulators of alpha-1 antitrypsin |
KR20220016194A (ko) * | 2019-05-30 | 2022-02-08 | 앤젝스 파마수티컬, 인크. | Prmt5 억제제로서의 헤테로시클릭 화합물 |
CN114026094B (zh) * | 2019-06-10 | 2024-06-25 | 印度鲁宾有限公司 | Prmt5抑制剂 |
CR20220175A (es) | 2019-10-22 | 2022-06-21 | Lupin Ltd | Combinación farmacéutica de inhibidores de PRMT5 |
AU2020370281A1 (en) * | 2019-10-25 | 2022-05-26 | Accent Therapeutics, Inc. | METTL3 modulators |
AU2020394887A1 (en) | 2019-12-03 | 2022-06-16 | Lupin Limited | Substituted nucleoside analogs as PRMT5 inhibitors |
US20220112194A1 (en) * | 2020-04-01 | 2022-04-14 | Aligos Therapeutics, Inc. | Compounds targeting prmt5 |
CN115697969A (zh) * | 2020-04-03 | 2023-02-03 | 弗特克斯药品有限公司 | 作为用于治疗α-1抗胰蛋白酶缺乏症(AATD)的α-1抗胰蛋白酶调节剂的7-或8-羟基-异喹啉和7-或8-羟基-喹啉衍生物 |
WO2022026892A1 (en) | 2020-07-31 | 2022-02-03 | Tango Therapeutics, Inc. | Piperidin-1- yl-n-pyrydi ne-3-yl-2-oxoacet am ide derivatives useful for the treatment of mtap-deficient and/or mt a-accumulating cancers |
MX2023008460A (es) | 2021-01-19 | 2023-09-12 | Lupin Ltd | Combinaciones farmacéuticas de inhibidores de sos1 para el tratamiento y/o prevención del cáncer. |
CN113234079B (zh) * | 2021-04-30 | 2022-02-01 | 上海湃隆生物科技有限公司 | 用作prmt5抑制剂的核苷类似物 |
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WO2004009574A1 (en) | 2002-07-22 | 2004-01-29 | Novartis Ag | Synthesis of discodermolide |
WO2005016878A2 (en) | 2003-08-13 | 2005-02-24 | Isis Pharmaceuticals, Inc. | METHODS FOR THE PREPARATION OF 5-FLUORO-PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS |
WO2006091905A1 (en) | 2005-02-25 | 2006-08-31 | Gilead Sciences, Inc. | Bicyclo (3.1.0) hexane derivatives as antiviral compounds |
US20080045521A1 (en) | 2006-06-09 | 2008-02-21 | Astrazeneca Ab | Phenylalanine derivatives |
SI2134691T1 (sl) | 2007-03-08 | 2012-06-29 | Janssen Pharmaceutica Nv | Derivati kvinolina kot PARP in TANK inhibitorji |
FR2926556B1 (fr) | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique |
SG10201506608RA (en) * | 2008-09-26 | 2015-09-29 | Agency Science Tech & Res | 3-deazaneplanocin derivatives |
GB0922332D0 (en) | 2009-12-22 | 2010-02-03 | Isis Innovation | Method of treatment and screening method |
US9044432B2 (en) | 2009-12-22 | 2015-06-02 | Ohio State Innovation Foundation | Compositions and methods for cancer detection and treatment |
TWI561512B (en) | 2010-06-30 | 2016-12-11 | Fujifilm Corp | Novel nicotinamide derivative or salt thereof |
WO2012037108A1 (en) | 2010-09-13 | 2012-03-22 | Glaxosmithkline Llc | Aminoquinoline derivatives as antiviral agents |
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EP2744333B1 (en) | 2011-08-19 | 2016-10-05 | Glaxosmithkline Intellectual Property (No. 2) Limited | Fatty acid synthase inhibitors |
EP2838898B1 (en) * | 2012-04-20 | 2017-01-18 | Advinus Therapeutics Limited | Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof |
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EP2935243B1 (en) | 2012-12-21 | 2018-03-14 | Epizyme, Inc. | Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof |
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JP2016505597A (ja) | 2012-12-21 | 2016-02-25 | エピザイム,インコーポレイティド | Prmt5阻害剤およびその使用 |
CA2894126A1 (en) * | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
KR102024417B1 (ko) | 2012-12-21 | 2019-11-07 | 에피자임, 인코포레이티드 | 테트라하이드로- 및 디하이드로-이소퀴놀린 prmt5 억제제 및 이의 용도 |
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GB201302927D0 (en) | 2013-02-20 | 2013-04-03 | Cancer Therapeutics Crc Pty Ltd | Compounds |
JP6510485B2 (ja) | 2013-03-15 | 2019-05-08 | オハイオ・ステイト・イノベーション・ファウンデーション | Prmt5インヒビターおよびそれらの使用方法 |
CN106488910B (zh) | 2013-10-10 | 2020-07-31 | 亚瑞克西斯制药公司 | Kras g12c的抑制剂 |
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2018
- 2018-12-13 ES ES18836520T patent/ES2927860T3/es active Active
- 2018-12-13 HU HUE18836520A patent/HUE059945T2/hu unknown
- 2018-12-13 HR HRP20221207TT patent/HRP20221207T1/hr unknown
- 2018-12-13 BR BR112020011746-3A patent/BR112020011746A2/pt unknown
- 2018-12-13 CN CN201880089329.6A patent/CN111712498B/zh active Active
- 2018-12-13 CR CR20200263A patent/CR20200263A/es unknown
- 2018-12-13 LT LTEPPCT/IB2018/060015T patent/LT3724190T/lt unknown
- 2018-12-13 CA CA3085259A patent/CA3085259A1/en active Pending
- 2018-12-13 EP EP18836520.9A patent/EP3724190B1/en active Active
- 2018-12-13 AU AU2018385664A patent/AU2018385664B2/en active Active
- 2018-12-13 PT PT188365209T patent/PT3724190T/pt unknown
- 2018-12-13 SG SG11202004934QA patent/SG11202004934QA/en unknown
- 2018-12-13 PE PE2020000761A patent/PE20211444A1/es unknown
- 2018-12-13 PL PL18836520.9T patent/PL3724190T3/pl unknown
- 2018-12-13 CU CU2020000051A patent/CU24621B1/es unknown
- 2018-12-13 DK DK18836520.9T patent/DK3724190T3/da active
- 2018-12-13 JP JP2020532614A patent/JP7282778B2/ja active Active
- 2018-12-13 UA UAA202004140A patent/UA126349C2/uk unknown
- 2018-12-13 GE GEAP201815385A patent/GEP20227359B/en unknown
- 2018-12-13 US US16/772,959 patent/US11459330B2/en active Active
- 2018-12-13 MX MX2020006181A patent/MX2020006181A/es unknown
- 2018-12-13 IL IL274936A patent/IL274936B2/en unknown
- 2018-12-13 WO PCT/IB2018/060015 patent/WO2019116302A1/en unknown
- 2018-12-13 RS RS20220931A patent/RS63623B1/sr unknown
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2020
- 2020-06-06 PH PH12020550881A patent/PH12020550881A1/en unknown
- 2020-06-11 CL CL2020001576A patent/CL2020001576A1/es unknown
- 2020-06-12 ZA ZA2020/03528A patent/ZA202003528B/en unknown
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2022
- 2022-05-06 US US17/738,370 patent/US11952380B2/en active Active
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