BR112018074287A2 - processo para preparação de eribulina e intermediários da mesma - Google Patents

processo para preparação de eribulina e intermediários da mesma

Info

Publication number
BR112018074287A2
BR112018074287A2 BR112018074287A BR112018074287A BR112018074287A2 BR 112018074287 A2 BR112018074287 A2 BR 112018074287A2 BR 112018074287 A BR112018074287 A BR 112018074287A BR 112018074287 A BR112018074287 A BR 112018074287A BR 112018074287 A2 BR112018074287 A2 BR 112018074287A2
Authority
BR
Brazil
Prior art keywords
intermediates
eribulin
preparing
preparing eribulin
halicondrin
Prior art date
Application number
BR112018074287A
Other languages
English (en)
Inventor
Kumar Mandal Amit
Basu Debjit
Sarvesh Kumar
Bandichhor Rakeshwar
Sai Sudhir
Kumar Neelam Uday
Hareshwar Dahanukar Vilas
Original Assignee
Dr Reddys Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Reddys Laboratories Ltd filed Critical Dr Reddys Laboratories Ltd
Publication of BR112018074287A2 publication Critical patent/BR112018074287A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/28—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom

Abstract

o presente pedido se refere a um processo para preparação do composto 4-metileno tetrahidrofurano da fórmula ii, que é útil como um intermediário para a preparação de análogos de halicondrina b, tais como, eribulina.
BR112018074287A 2016-05-26 2017-05-25 processo para preparação de eribulina e intermediários da mesma BR112018074287A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201641018136 2016-05-26
IN201641021480 2016-06-22
PCT/IB2017/053082 WO2017203459A1 (en) 2016-05-26 2017-05-25 Process for preparation of eribulin and intermediates thereof

Publications (1)

Publication Number Publication Date
BR112018074287A2 true BR112018074287A2 (pt) 2019-06-18

Family

ID=60412830

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018074287A BR112018074287A2 (pt) 2016-05-26 2017-05-25 processo para preparação de eribulina e intermediários da mesma

Country Status (7)

Country Link
US (1) US11059799B2 (pt)
EP (1) EP3464297B1 (pt)
JP (1) JP2019521969A (pt)
KR (1) KR20190009326A (pt)
CN (1) CN109415383A (pt)
BR (1) BR112018074287A2 (pt)
WO (1) WO2017203459A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10118890B2 (en) 2014-10-10 2018-11-06 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
WO2017203459A1 (en) 2016-05-26 2017-11-30 Dr. Reddy's Laboratories Limited Process for preparation of eribulin and intermediates thereof
BR112019010494A2 (pt) 2016-11-23 2019-09-17 Dr Reddys Laboratories Ltd processo para a preparação de eribulina e intermediários do mesmo

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI9911326B8 (pt) 1998-06-17 2021-05-25 Eisai Co Ltd análogos macrocíclicos e métodos para seu uso e preparação
EP2522663B1 (en) * 2004-06-03 2015-04-01 Eisai R&D Management Co., Ltd. Intermediates for the preparation of halichondrin B
EP2831082B1 (en) * 2012-03-30 2019-02-20 Sandoz AG Synthetic process for preparation of macrocyclic c1-keto analogs of halichondrin b and intermediates useful therein
AR096238A1 (es) * 2013-05-15 2015-12-16 Alphora Res Inc Proceso para preparar derivados de 3-((2s,5s)-4-metilen-5-(3-oxopropil)tetrahidrofuran-2-il)propanol e intermediarios útiles para el mismo
CN105713031B (zh) 2014-12-05 2021-05-07 正大天晴药业集团股份有限公司 一种用于制备艾日布林的中间体及其制备方法
WO2017064627A2 (en) * 2015-10-14 2017-04-20 Dr. Reddy's Laboratories Limited Process for preparation of eribulin and intermediates thereof
WO2017203459A1 (en) 2016-05-26 2017-11-30 Dr. Reddy's Laboratories Limited Process for preparation of eribulin and intermediates thereof
BR112019010494A2 (pt) * 2016-11-23 2019-09-17 Dr Reddys Laboratories Ltd processo para a preparação de eribulina e intermediários do mesmo

Also Published As

Publication number Publication date
CN109415383A (zh) 2019-03-01
EP3464297A1 (en) 2019-04-10
EP3464297B1 (en) 2023-10-25
US11059799B2 (en) 2021-07-13
KR20190009326A (ko) 2019-01-28
WO2017203459A1 (en) 2017-11-30
US20190177291A1 (en) 2019-06-13
EP3464297A4 (en) 2020-03-25
JP2019521969A (ja) 2019-08-08

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Legal Events

Date Code Title Description
B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 519/00

Ipc: C07D 519/00 (2006.01), A61P 35/00 (2006.01), C07C

B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements