AR111304A1 - Métodos para sintetizar un inhibidor de mcl-1 - Google Patents

Métodos para sintetizar un inhibidor de mcl-1

Info

Publication number
AR111304A1
AR111304A1 ARP180100757A ARP180100757A AR111304A1 AR 111304 A1 AR111304 A1 AR 111304A1 AR P180100757 A ARP180100757 A AR P180100757A AR P180100757 A ARP180100757 A AR P180100757A AR 111304 A1 AR111304 A1 AR 111304A1
Authority
AR
Argentina
Prior art keywords
synthesizing
methods
mcl
inhibitor
compound
Prior art date
Application number
ARP180100757A
Other languages
English (en)
Inventor
Jan Koek
Cati Ferrar
Debasis Hazra
Xiaolan Zheng
Qing Ye
Alexander Hird
Andrew Stark
Simon Hardy
Craig Stewart
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR111304A1 publication Critical patent/AR111304A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
    • C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/74—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/76—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Lubricants (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se divulgan intermedios y métodos para sintetizar el Compuesto de fórmula (1). Reivindicación 1: Un compuesto que se selecciona del grupo de fórmulas (2), o una sal del mismo.
ARP180100757A 2017-03-31 2018-03-28 Métodos para sintetizar un inhibidor de mcl-1 AR111304A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762479493P 2017-03-31 2017-03-31

Publications (1)

Publication Number Publication Date
AR111304A1 true AR111304A1 (es) 2019-06-26

Family

ID=61827753

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180100757A AR111304A1 (es) 2017-03-31 2018-03-28 Métodos para sintetizar un inhibidor de mcl-1

Country Status (17)

Country Link
US (1) US11149024B2 (es)
EP (1) EP3601230B1 (es)
JP (1) JP7032428B2 (es)
KR (1) KR102604876B1 (es)
CN (1) CN110536884B (es)
AR (1) AR111304A1 (es)
AU (1) AU2018244180B2 (es)
BR (1) BR112019019686A2 (es)
CA (1) CA3056712A1 (es)
CO (1) CO2019010035A2 (es)
EA (1) EA038226B1 (es)
ES (1) ES2909751T3 (es)
IL (1) IL269410B2 (es)
MX (1) MX2019011468A (es)
TW (1) TWI781996B (es)
WO (1) WO2018178227A1 (es)
ZA (1) ZA201905645B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3781570A4 (en) * 2018-11-22 2021-06-02 Ascentage Pharma (Suzhou) Co., Ltd. MACROCYCLIC INDOLES AS MCL-1 INHIBITORS
TWI760685B (zh) * 2019-01-23 2022-04-11 大陸商蘇州亞盛藥業有限公司 作為mcl-1抑制劑的大環稠合的吡唑
CN114641481A (zh) 2019-06-21 2022-06-17 詹森药业有限公司 Mcl-1的大环抑制剂
KR20220034136A (ko) 2019-07-09 2022-03-17 얀센 파마슈티카 엔.브이. Mcl-1 억제제로서의 거대환식 스피로사이클 유도체
WO2021092053A1 (en) * 2019-11-08 2021-05-14 Unity Biotechnology, Inc. Mcl-1 inhibitor macrocycle compounds for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer
CA3157731A1 (en) 2019-11-21 2021-05-27 Frederik Jan Rita Rombouts Macrocyclic indole derivatives as mcl-1 inhibitors
CA3157590A1 (en) 2019-11-21 2021-05-27 Janssen Pharmaceutica Nv Macrocyclic sulfonyl derivatives as mcl-1 inhibitors
KR20220143906A (ko) 2020-02-21 2022-10-25 얀센 파마슈티카 엔.브이. Mcl-1의 억제제로서의 거대환식 인돌 유도체
US20230265105A1 (en) 2020-05-29 2023-08-24 Janssen Pharmaceutica Nv Macrocyclic 7-pyrazol-5-yl-indole derivatives as inhibitors of mcl-1
JP2023530985A (ja) 2020-06-19 2023-07-20 ヤンセン ファーマシューティカ エヌ．ベー． Ｍｃｌ－１の阻害剤としてのｎ結合大環状７－（ピラゾール－５－イル）－インドール誘導体
JP2023530148A (ja) 2020-06-19 2023-07-13 ヤンセン ファーマシューティカ エヌ．ベー． Ｍｃｌ－１阻害剤としてのｎ－結合大環状４－（ピラゾール－５－イル）－インドール誘導体
BR112023000212A2 (pt) 2020-07-08 2023-01-31 Janssen Pharmaceutica Nv Éter macrocíclico contendo derivados de indol como inibidores de mcl-1
WO2022032284A1 (en) * 2020-08-07 2022-02-10 Zeno Management, Inc. Macrocyclic compounds
MX2023007291A (es) 2020-12-17 2023-07-04 Janssen Pharmaceutica Nv Derivados de 4-(pirazol-5-il)-indol macrociclicos ramificados como inhibidores de mcl-1.
MX2023009475A (es) 2021-02-12 2023-08-22 Janssen Pharmaceutica Nv Derivados macrociclicos 1,3-con puente 6-cloro-7-pirazol-4-il-1h-i ndol-2-carboxilato y 6-cloro-7-pirimidina-5-il-1h-indol-2-carboxil ato como inhibidores de mcl-1 para el tratamiento del cancer.
US11931424B2 (en) 2021-06-11 2024-03-19 Gilead Sciences, Inc. Combination MCL-1 inhibitors with anti-body drug conjugates
TW202315637A (zh) 2021-06-11 2023-04-16 美商基利科學股份有限公司 Mcl-1抑制劑與抗癌劑之組合

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2915811A1 (en) * 2014-03-04 2015-09-09 Centre Régional de Lutte contre le Cancer - Centre François Baclesse MCL-1 modulating compounds for cancer treatment
US9949965B2 (en) * 2014-10-17 2018-04-24 Vanderbilt University Tricyclic indole Mcl-1 inhibitors and uses thereof
CN105061315B (zh) * 2015-08-06 2017-10-24 大连理工大学 一类1,5‑二苯基吡唑‑3‑羧酸类化合物及其应用
CR20180499A (es) 2016-04-22 2019-01-25 Astrazeneca Ab Inhibidores de mcl1 macrocicliclos para tratar el cancer
CN106478606B (zh) * 2016-09-21 2019-05-10 沈阳药科大学 N-取代吲哚类衍生物及其应用

Also Published As

Publication number Publication date
AU2018244180B2 (en) 2021-03-04
EA038226B1 (ru) 2021-07-27
US20210122735A1 (en) 2021-04-29
EP3601230A1 (en) 2020-02-05
EA201992235A1 (ru) 2020-02-10
KR20190136039A (ko) 2019-12-09
JP2020515557A (ja) 2020-05-28
CN110536884B (zh) 2023-05-02
WO2018178227A1 (en) 2018-10-04
CA3056712A1 (en) 2018-10-04
EP3601230B1 (en) 2022-01-26
MX2019011468A (es) 2019-11-01
AU2018244180A1 (en) 2019-11-07
CN110536884A (zh) 2019-12-03
US11149024B2 (en) 2021-10-19
BR112019019686A2 (pt) 2020-04-14
CO2019010035A2 (es) 2019-09-30
IL269410A (en) 2019-11-28
IL269410B (en) 2022-11-01
IL269410B2 (en) 2023-03-01
KR102604876B1 (ko) 2023-11-22
JP7032428B2 (ja) 2022-03-08
TW201902868A (zh) 2019-01-16
TWI781996B (zh) 2022-11-01
ES2909751T3 (es) 2022-05-10
ZA201905645B (en) 2020-05-27

Similar Documents

Publication Publication Date Title
AR111304A1 (es) Métodos para sintetizar un inhibidor de mcl-1
AR108711A1 (es) Compuestos moduladores de fxr (nr1h4)
CL2019003154A1 (es) Proceso de preparación de un compuesto intermediario de fórmula (vi) para la preparación de compuestos de cannabidiol. (divisional solicitud 201800079)
MD3810602T2 (ro) Compuşi
CL2020000610A1 (es) Compuestos de bisamida que activan el sarcómero y sus usos.
CY1119585T1 (el) Ενωσεις τετραϋδροπυρρολοθειαζινης
AR101995A1 (es) COMPUESTOS ANTAGONISTAS DE INTEGRINA avb6
EA201692418A1 (ru) Замещенные индазольные соединения в качестве irak4 ингибиторов
NI201600165A (es) Inhibidores de desmetilasa 1 específica a lisina
ECSP17054980A (es) Inhibidores selectivos de bace1
EA201792021A1 (ru) Ингибитор jak
AR102981A1 (es) Inhibidores de la necrosis celular y métodos de preparación de los mismos
AR105967A1 (es) Sales de un inhibidor de pim quinasa
CL2017000484A1 (es) Compuestos de azetidiniloxifenilpirrolidina
EA201991241A1 (ru) Способ получения метоксиметилпиридин дикарбоксилата
CL2018001067A1 (es) Compuesto piranodipiridínico.
MX2016010973A (es) Compuestos de aminocarbonilcarbamato.
CL2020000376A1 (es) Compuesto pentacíclico.
AR105821A1 (es) COMPUESTOS ÚTILES PARA INHIBIR ROR-g-T
EA201990238A1 (ru) ФОСФОРСОДЕРЖАЩИЕ ПРОЛЕКАРСТВА СТИМУЛЯТОРОВ sGC
CO2018007668A2 (es) Composición para el control de plagas y método para el control de plagas
EA201990313A1 (ru) Производное триазолопиразинона, пригодное в качестве ингибитора фдэ1 человека
CU20190002A7 (es) Combinación de un inhibidor de bcl-2 y un inhibidor de mcl1 para el tratamiento del cáncer y composiciones farmacéuticas que los comprenden
EA202190989A1 (ru) Новый способ синтеза производных пиперазинил-этокси-бромфенила и их применение в получении содержащих их соединений
AR107163A1 (es) Inhibidores de quinasa