EA201992235A1 - Синтез ингибитора mcl-1 - Google Patents

Синтез ингибитора mcl-1

Info

Publication number
EA201992235A1
EA201992235A1 EA201992235A EA201992235A EA201992235A1 EA 201992235 A1 EA201992235 A1 EA 201992235A1 EA 201992235 A EA201992235 A EA 201992235A EA 201992235 A EA201992235 A EA 201992235A EA 201992235 A1 EA201992235 A1 EA 201992235A1
Authority
EA
Eurasian Patent Office
Prior art keywords
mcl
synthesis inhibitor
inhibitor
synthesis
intermediates
Prior art date
Application number
EA201992235A
Other languages
English (en)
Other versions
EA038226B1 (ru
Inventor
Крейг Стюарт
Саймон Харди
Эндрю Старк
Александер Хирд
Цин Е
Сяолань Чжен
Кати Феррар
Ян Кук
Дебазис Хазра
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of EA201992235A1 publication Critical patent/EA201992235A1/ru
Publication of EA038226B1 publication Critical patent/EA038226B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
    • C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/74—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/76—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Раскрыты промежуточные соединения и способы синтеза соединения 1.
EA201992235A 2017-03-31 2018-03-29 Синтез ингибитора mcl-1 EA038226B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762479493P 2017-03-31 2017-03-31
PCT/EP2018/058056 WO2018178227A1 (en) 2017-03-31 2018-03-29 Synthesis of mcl-1 inhibitor

Publications (2)

Publication Number Publication Date
EA201992235A1 true EA201992235A1 (ru) 2020-02-10
EA038226B1 EA038226B1 (ru) 2021-07-27

Family

ID=61827753

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201992235A EA038226B1 (ru) 2017-03-31 2018-03-29 Синтез ингибитора mcl-1

Country Status (17)

Country Link
US (1) US11149024B2 (ru)
EP (1) EP3601230B1 (ru)
JP (1) JP7032428B2 (ru)
KR (1) KR102604876B1 (ru)
CN (1) CN110536884B (ru)
AR (1) AR111304A1 (ru)
AU (1) AU2018244180B2 (ru)
BR (1) BR112019019686A2 (ru)
CA (1) CA3056712A1 (ru)
CO (1) CO2019010035A2 (ru)
EA (1) EA038226B1 (ru)
ES (1) ES2909751T3 (ru)
IL (1) IL269410B2 (ru)
MX (1) MX2019011468A (ru)
TW (1) TWI781996B (ru)
WO (1) WO2018178227A1 (ru)
ZA (1) ZA201905645B (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020103864A1 (en) * 2018-11-22 2020-05-28 Ascentage Pharma (Suzhou) Co., Ltd. Macrocyclic indoles as mcl-1 inhibitors
WO2020151738A1 (en) * 2019-01-23 2020-07-30 Ascentage Pharma (Suzhou) Co., Ltd. Macrocyclic fused pyrrazoles as mcl-1 inhibitors
KR20220024694A (ko) 2019-06-21 2022-03-03 얀센 파마슈티카 엔.브이. Mcl-1의 거대환식 억제제
CA3144558A1 (en) 2019-07-09 2021-01-14 Janssen Pharmaceutica Nv Macrocyclic spirocycle derivatives as mcl-1 inhibitors
WO2021092053A1 (en) * 2019-11-08 2021-05-14 Unity Biotechnology, Inc. Mcl-1 inhibitor macrocycle compounds for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer
KR20220103984A (ko) 2019-11-21 2022-07-25 얀센 파마슈티카 엔.브이. Mcl-1 억제제로서의 거대환식 인돌 유도체
EP4061820A1 (en) 2019-11-21 2022-09-28 Janssen Pharmaceutica NV Macrocyclic sulfonyl derivatives as mcl-1 inhibitors
JP2023514364A (ja) 2020-02-21 2023-04-05 ヤンセン ファーマシューティカ エヌ．ベー． Ｍｃｌ－１の阻害剤としての大環状インドール誘導体
EP4157852A1 (en) 2020-05-29 2023-04-05 JANSSEN Pharmaceutica NV Macrocyclic 7-pyrazol-5-yl-indole derivatives as inhibitors of mcl-1
BR112022025631A2 (pt) 2020-06-19 2023-01-17 Janssen Pharmaceutica Nv Derivados de 4-(pirazol-5-il)-indol macrocíclico n-ligados como inibidores de mcl-1
EP4168412A1 (en) 2020-06-19 2023-04-26 JANSSEN Pharmaceutica NV N-linked macrocyclic 7-(pyrazol-5-yl)-indole derivatives as inhibitors of mcl-1
KR20230035621A (ko) 2020-07-08 2023-03-14 얀센 파마슈티카 엔.브이. Mcl-1의 억제제로서 인돌 유도체를 함유하는 마크로사이클릭 에테르
WO2022032284A1 (en) * 2020-08-07 2022-02-10 Zeno Management, Inc. Macrocyclic compounds
JP2023553719A (ja) 2020-12-17 2023-12-25 ヤンセン ファーマシューティカ エヌ．ベー． Ｍｃｌ－１阻害剤としての分岐大環状４－（ピラゾール－５－イル）－インドール誘導体
JP2024506648A (ja) 2021-02-12 2024-02-14 ヤンセン ファーマシューティカ エヌ．ベー． がんの治療のためのｍｃｌ－１阻害剤としての大環状１，３－架橋６－クロロ－７－ピラゾール－４－イル－１ｈ－インドール－２－カルボキシレート及び６－クロロ－７－ピリミジン－５－イル－１ｈ－インドール－２－カルボキシレート誘導体
US11957693B2 (en) 2021-06-11 2024-04-16 Gilead Sciences, Inc. Combination MCL-1 inhibitors with anti-cancer agents
TW202317200A (zh) 2021-06-11 2023-05-01 美商基利科學股份有限公司 Ｍｃｌ－１抑制劑與抗體藥物接合物之組合

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2915811A1 (en) * 2014-03-04 2015-09-09 Centre Régional de Lutte contre le Cancer - Centre François Baclesse MCL-1 modulating compounds for cancer treatment
US9949965B2 (en) * 2014-10-17 2018-04-24 Vanderbilt University Tricyclic indole Mcl-1 inhibitors and uses thereof
CN105061315B (zh) * 2015-08-06 2017-10-24 大连理工大学 一类1,5‑二苯基吡唑‑3‑羧酸类化合物及其应用
TWI742074B (zh) * 2016-04-22 2021-10-11 瑞典商阿斯特捷利康公司 Mcl-1抑制劑及其使用方法
CN106478606B (zh) * 2016-09-21 2019-05-10 沈阳药科大学 N-取代吲哚类衍生物及其应用

Also Published As

Publication number Publication date
CO2019010035A2 (es) 2019-09-30
KR102604876B1 (ko) 2023-11-22
EP3601230A1 (en) 2020-02-05
EP3601230B1 (en) 2022-01-26
CN110536884A (zh) 2019-12-03
CA3056712A1 (en) 2018-10-04
AU2018244180B2 (en) 2021-03-04
IL269410B (en) 2022-11-01
EA038226B1 (ru) 2021-07-27
TW201902868A (zh) 2019-01-16
KR20190136039A (ko) 2019-12-09
MX2019011468A (es) 2019-11-01
AR111304A1 (es) 2019-06-26
IL269410B2 (en) 2023-03-01
TWI781996B (zh) 2022-11-01
JP7032428B2 (ja) 2022-03-08
JP2020515557A (ja) 2020-05-28
CN110536884B (zh) 2023-05-02
AU2018244180A1 (en) 2019-11-07
BR112019019686A2 (pt) 2020-04-14
US11149024B2 (en) 2021-10-19
US20210122735A1 (en) 2021-04-29
WO2018178227A1 (en) 2018-10-04
IL269410A (en) 2019-11-28
ES2909751T3 (es) 2022-05-10
ZA201905645B (en) 2020-05-27

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