MX369349B - Metodos para hacer inhibidores de la proteina deacetilasa. - Google Patents

Metodos para hacer inhibidores de la proteina deacetilasa.

Info

Publication number
MX369349B
MX369349B MX2017015900A MX2017015900A MX369349B MX 369349 B MX369349 B MX 369349B MX 2017015900 A MX2017015900 A MX 2017015900A MX 2017015900 A MX2017015900 A MX 2017015900A MX 369349 B MX369349 B MX 369349B
Authority
MX
Mexico
Prior art keywords
methods
deacetylase inhibitors
protein deacetylase
making protein
making
Prior art date
Application number
MX2017015900A
Other languages
English (en)
Other versions
MX2017015900A (es
Inventor
H Van Duzer John
Seyedi Farzaneh
Original Assignee
Acetylon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acetylon Pharmaceuticals Inc filed Critical Acetylon Pharmaceuticals Inc
Publication of MX2017015900A publication Critical patent/MX2017015900A/es
Publication of MX369349B publication Critical patent/MX369349B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La presente invención se relaciona con un método e intermedios útiles para la síntesis de inhibidores de la proteína deacetilasa.
MX2017015900A 2015-06-08 2016-06-08 Metodos para hacer inhibidores de la proteina deacetilasa. MX369349B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562172624P 2015-06-08 2015-06-08
PCT/US2016/036434 WO2016200930A1 (en) 2015-06-08 2016-06-08 Methods of making protein deacetylase inhibitors

Publications (2)

Publication Number Publication Date
MX2017015900A MX2017015900A (es) 2018-11-09
MX369349B true MX369349B (es) 2019-11-06

Family

ID=56264043

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017015900A MX369349B (es) 2015-06-08 2016-06-08 Metodos para hacer inhibidores de la proteina deacetilasa.

Country Status (11)

Country Link
US (1) US10144714B2 (es)
EP (1) EP3303304B1 (es)
JP (1) JP6873053B2 (es)
CN (1) CN107922352B (es)
AR (1) AR105812A1 (es)
AU (2) AU2016276573A1 (es)
CA (1) CA2988594C (es)
ES (1) ES2769255T3 (es)
MX (1) MX369349B (es)
TW (1) TWI706937B (es)
WO (1) WO2016200930A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
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HUE030679T2 (en) * 2010-01-22 2017-05-29 Acetylon Pharmaceuticals Inc Reverse amide compounds as protein deacetylase inhibitors and methods of use
JP2015515279A (ja) 2012-04-19 2015-05-28 アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 治療に反応する患者を同定するバイオマーカーおよびそのような患者の治療
US10464906B2 (en) 2015-06-08 2019-11-05 Acetylon Pharmaceuticals, Inc. Crystalline forms of a histone deacetylase inhibitor
CA2988594C (en) 2015-06-08 2023-08-15 Acetylon Pharmaceuticals, Inc. Methods of making protein deacetylase inhibitors
AR109250A1 (es) * 2016-06-09 2018-11-14 Acetylon Pharmaceuticals Inc Métodos de uso y combinaciones farmacéuticas de inhibidores de hdac con inhibidores de proteínas bet
US11324744B2 (en) 2016-08-08 2022-05-10 Acetylon Pharmaceuticals Inc. Methods of use and pharmaceutical combinations of histone deacetylase inhibitors and CD20 inhibitory antibodies
JP7090611B2 (ja) 2016-11-23 2022-06-24 アセチロン ファーマシューティカルズ インコーポレイテッド ヒストン脱アセチル化酵素阻害剤とプログラム細胞死リガンド１（ｐｄ－ｌ１）阻害剤とを含む医薬組み合わせ物及びその使用方法

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US11324744B2 (en) 2016-08-08 2022-05-10 Acetylon Pharmaceuticals Inc. Methods of use and pharmaceutical combinations of histone deacetylase inhibitors and CD20 inhibitory antibodies

Also Published As

Publication number Publication date
AU2020267299A1 (en) 2020-12-10
WO2016200930A9 (en) 2017-02-23
CN107922352A (zh) 2018-04-17
US10144714B2 (en) 2018-12-04
ES2769255T3 (es) 2020-06-25
CA2988594A1 (en) 2016-12-15
JP6873053B2 (ja) 2021-05-19
AU2016276573A1 (en) 2018-01-04
CN107922352B (zh) 2021-08-06
TW201718517A (zh) 2017-06-01
EP3303304A1 (en) 2018-04-11
MX2017015900A (es) 2018-11-09
CA2988594C (en) 2023-08-15
US20160355486A1 (en) 2016-12-08
WO2016200930A1 (en) 2016-12-15
AR105812A1 (es) 2017-11-15
TWI706937B (zh) 2020-10-11
AU2020267299B2 (en) 2022-07-07
EP3303304B1 (en) 2019-11-20
JP2018518486A (ja) 2018-07-12

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