BR112023000212A2 - Éter macrocíclico contendo derivados de indol como inibidores de mcl-1 - Google Patents
Éter macrocíclico contendo derivados de indol como inibidores de mcl-1Info
- Publication number
- BR112023000212A2 BR112023000212A2 BR112023000212A BR112023000212A BR112023000212A2 BR 112023000212 A2 BR112023000212 A2 BR 112023000212A2 BR 112023000212 A BR112023000212 A BR 112023000212A BR 112023000212 A BR112023000212 A BR 112023000212A BR 112023000212 A2 BR112023000212 A2 BR 112023000212A2
- Authority
- BR
- Brazil
- Prior art keywords
- mcl
- inhibitors
- ether containing
- indol derivatives
- macrocyclic ether
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Abstract
ÉTER MACROCÍCLICO CONTENDO DERIVADOS DE INDOL COMO INIBIDORES DE MCL-1. A presente invenção refere-se a agentes farmacêuticos úteis para terapia e/ou profilaxia em um indivíduo, composição farmacêutica compreendendo tais compostos e seu uso como inibidores de MCL-1, úteis para o tratamento de doenças como câncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20184729 | 2020-07-08 | ||
PCT/EP2021/069037 WO2022008674A1 (en) | 2020-07-08 | 2021-07-08 | Macrocyclic ether containing indole derivatives as inhibitors of mcl-1 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023000212A2 true BR112023000212A2 (pt) | 2023-01-31 |
Family
ID=71833112
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023000212A BR112023000212A2 (pt) | 2020-07-08 | 2021-07-08 | Éter macrocíclico contendo derivados de indol como inibidores de mcl-1 |
Country Status (10)
Country | Link |
---|---|
US (1) | US20230250109A1 (pt) |
EP (1) | EP4178677A1 (pt) |
JP (1) | JP2023532592A (pt) |
KR (1) | KR20230035621A (pt) |
CN (1) | CN115776888A (pt) |
AU (1) | AU2021306644A1 (pt) |
BR (1) | BR112023000212A2 (pt) |
CA (1) | CA3184877A1 (pt) |
MX (1) | MX2023000438A (pt) |
WO (1) | WO2022008674A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112020021648A2 (pt) | 2018-05-14 | 2021-01-26 | Gilead Sciences, Inc. | inibidores de mcl-1 |
TWI778443B (zh) | 2019-11-12 | 2022-09-21 | 美商基利科學股份有限公司 | Mcl1抑制劑 |
KR20220105661A (ko) | 2019-11-26 | 2022-07-27 | 길리애드 사이언시즈, 인코포레이티드 | Mcl1 억제제를 제조하기 위한 방법 및 중간체 |
WO2022251247A1 (en) * | 2021-05-28 | 2022-12-01 | Zeno Management, Inc. | Macrocyclic compounds |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI742074B (zh) | 2016-04-22 | 2021-10-11 | 瑞典商阿斯特捷利康公司 | Mcl-1抑制劑及其使用方法 |
TW201904976A (zh) | 2017-03-31 | 2019-02-01 | 瑞典商阿斯特捷利康公司 | Mcl-1抑制劑及其使用方法 |
TWI781996B (zh) | 2017-03-31 | 2022-11-01 | 瑞典商阿斯特捷利康公司 | 合成mcl-1抑制劑之方法 |
KR20210070312A (ko) | 2018-09-30 | 2021-06-14 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 인돌 거대 고리 유도체, 이의 제조 방법, 및 의약에서 이의 응용 |
CN111205309B (zh) * | 2018-11-21 | 2023-04-07 | 江苏恒瑞医药股份有限公司 | 吲哚类大环衍生物、其制备方法及其在医药上的应用 |
WO2020103864A1 (en) | 2018-11-22 | 2020-05-28 | Ascentage Pharma (Suzhou) Co., Ltd. | Macrocyclic indoles as mcl-1 inhibitors |
-
2021
- 2021-07-08 KR KR1020237004322A patent/KR20230035621A/ko unknown
- 2021-07-08 BR BR112023000212A patent/BR112023000212A2/pt unknown
- 2021-07-08 CA CA3184877A patent/CA3184877A1/en active Pending
- 2021-07-08 EP EP21737480.0A patent/EP4178677A1/en active Pending
- 2021-07-08 MX MX2023000438A patent/MX2023000438A/es unknown
- 2021-07-08 WO PCT/EP2021/069037 patent/WO2022008674A1/en unknown
- 2021-07-08 AU AU2021306644A patent/AU2021306644A1/en active Pending
- 2021-07-08 CN CN202180048462.9A patent/CN115776888A/zh active Pending
- 2021-07-08 JP JP2023500392A patent/JP2023532592A/ja active Pending
- 2021-07-08 US US18/004,322 patent/US20230250109A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
MX2023000438A (es) | 2023-02-09 |
JP2023532592A (ja) | 2023-07-28 |
US20230250109A1 (en) | 2023-08-10 |
AU2021306644A1 (en) | 2023-03-09 |
CA3184877A1 (en) | 2022-01-13 |
CN115776888A (zh) | 2023-03-10 |
EP4178677A1 (en) | 2023-05-17 |
KR20230035621A (ko) | 2023-03-14 |
WO2022008674A1 (en) | 2022-01-13 |
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