MX2023000438A - Eter macrociclico que contiene derivados de indol como inhibidores de mcl-1. - Google Patents
Eter macrociclico que contiene derivados de indol como inhibidores de mcl-1.Info
- Publication number
- MX2023000438A MX2023000438A MX2023000438A MX2023000438A MX2023000438A MX 2023000438 A MX2023000438 A MX 2023000438A MX 2023000438 A MX2023000438 A MX 2023000438A MX 2023000438 A MX2023000438 A MX 2023000438A MX 2023000438 A MX2023000438 A MX 2023000438A
- Authority
- MX
- Mexico
- Prior art keywords
- mcl
- inhibitors
- indole derivatives
- ether containing
- containing indole
- Prior art date
Links
- 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 title abstract 2
- 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 title 2
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
La presente invención se relaciona con agentes farmacéuticos útiles para terapia y/o profilaxis en un sujeto, composición farmacéutica que comprende tales compuestos y su uso como inhibidores de MCL-1, útiles para tratar enfermedades tales como cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20184729 | 2020-07-08 | ||
PCT/EP2021/069037 WO2022008674A1 (en) | 2020-07-08 | 2021-07-08 | Macrocyclic ether containing indole derivatives as inhibitors of mcl-1 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023000438A true MX2023000438A (es) | 2023-02-09 |
Family
ID=71833112
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023000438A MX2023000438A (es) | 2020-07-08 | 2021-07-08 | Eter macrociclico que contiene derivados de indol como inhibidores de mcl-1. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20230250109A1 (es) |
EP (1) | EP4178677A1 (es) |
JP (1) | JP2023532592A (es) |
KR (1) | KR20230035621A (es) |
CN (1) | CN115776888A (es) |
AU (1) | AU2021306644A1 (es) |
BR (1) | BR112023000212A2 (es) |
CA (1) | CA3184877A1 (es) |
MX (1) | MX2023000438A (es) |
WO (1) | WO2022008674A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2020012137A (es) | 2018-05-14 | 2021-01-29 | Gilead Sciences Inc | Inhibidores de mcl-1. |
TWI778443B (zh) | 2019-11-12 | 2022-09-21 | 美商基利科學股份有限公司 | Mcl1抑制劑 |
US11325891B2 (en) | 2019-11-26 | 2022-05-10 | Gilead Sciences, Inc. | Processes and intermediates for preparing MCL1 inhibitors |
WO2022251247A1 (en) * | 2021-05-28 | 2022-12-01 | Zeno Management, Inc. | Macrocyclic compounds |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017182625A1 (en) | 2016-04-22 | 2017-10-26 | Astrazeneca Ab | Macrocyclic mcl1 inhibitors for treating cancer |
TW201904976A (zh) | 2017-03-31 | 2019-02-01 | 瑞典商阿斯特捷利康公司 | Mcl-1抑制劑及其使用方法 |
TWI781996B (zh) | 2017-03-31 | 2022-11-01 | 瑞典商阿斯特捷利康公司 | 合成mcl-1抑制劑之方法 |
AU2019347963A1 (en) | 2018-09-30 | 2021-05-27 | Jiangsu Hengrui Medicine Co., Ltd. | Indole macrocyclic derivative, preparation method therefor and application thereof in medicine |
CN111205309B (zh) * | 2018-11-21 | 2023-04-07 | 江苏恒瑞医药股份有限公司 | 吲哚类大环衍生物、其制备方法及其在医药上的应用 |
WO2020103864A1 (en) | 2018-11-22 | 2020-05-28 | Ascentage Pharma (Suzhou) Co., Ltd. | Macrocyclic indoles as mcl-1 inhibitors |
-
2021
- 2021-07-08 CN CN202180048462.9A patent/CN115776888A/zh active Pending
- 2021-07-08 BR BR112023000212A patent/BR112023000212A2/pt unknown
- 2021-07-08 KR KR1020237004322A patent/KR20230035621A/ko unknown
- 2021-07-08 US US18/004,322 patent/US20230250109A1/en active Pending
- 2021-07-08 JP JP2023500392A patent/JP2023532592A/ja active Pending
- 2021-07-08 EP EP21737480.0A patent/EP4178677A1/en active Pending
- 2021-07-08 CA CA3184877A patent/CA3184877A1/en active Pending
- 2021-07-08 MX MX2023000438A patent/MX2023000438A/es unknown
- 2021-07-08 WO PCT/EP2021/069037 patent/WO2022008674A1/en unknown
- 2021-07-08 AU AU2021306644A patent/AU2021306644A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2021306644A1 (en) | 2023-03-09 |
KR20230035621A (ko) | 2023-03-14 |
CN115776888A (zh) | 2023-03-10 |
JP2023532592A (ja) | 2023-07-28 |
BR112023000212A2 (pt) | 2023-01-31 |
US20230250109A1 (en) | 2023-08-10 |
CA3184877A1 (en) | 2022-01-13 |
WO2022008674A1 (en) | 2022-01-13 |
EP4178677A1 (en) | 2023-05-17 |
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