MX2023003516A - Inhibidores no covalentes de la cinasa dependiente de ciclina 7 (cdk7). - Google Patents
Inhibidores no covalentes de la cinasa dependiente de ciclina 7 (cdk7).Info
- Publication number
- MX2023003516A MX2023003516A MX2023003516A MX2023003516A MX2023003516A MX 2023003516 A MX2023003516 A MX 2023003516A MX 2023003516 A MX2023003516 A MX 2023003516A MX 2023003516 A MX2023003516 A MX 2023003516A MX 2023003516 A MX2023003516 A MX 2023003516A
- Authority
- MX
- Mexico
- Prior art keywords
- cdk7
- cyclin
- dependent kinase
- covalent inhibitors
- compounds
- Prior art date
Links
- 102100026810 Cyclin-dependent kinase 7 Human genes 0.000 title abstract 3
- 101710106276 Cyclin-dependent kinase 7 Proteins 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 101150059448 cdk7 gene Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La invención se refiere a compuestos farmacéuticos de fórmula (I) y composiciones farmacéuticas que comprenden dichos compuestos, a procesos para la preparación de dichos compuestos y al uso de dichos compuestos como inhibidores de la cinasa dependiente de ciclina 7 (CDK7) y a su uso en el tratamiento de enfermedades, p. ej., el cáncer. (ver Fórmula).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20198367 | 2020-09-25 | ||
| PCT/EP2021/076409 WO2022064009A1 (en) | 2020-09-25 | 2021-09-24 | Cyclin-dependent kinase 7 (cdk7) non-covalent inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023003516A true MX2023003516A (es) | 2023-04-19 |
Family
ID=72801289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023003516A MX2023003516A (es) | 2020-09-25 | 2021-09-24 | Inhibidores no covalentes de la cinasa dependiente de ciclina 7 (cdk7). |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240101554A1 (es) |
| EP (1) | EP4217356A1 (es) |
| JP (1) | JP2023542411A (es) |
| KR (1) | KR20230074762A (es) |
| CN (1) | CN116194103A (es) |
| AU (1) | AU2021350161A1 (es) |
| BR (1) | BR112023005005A2 (es) |
| CA (1) | CA3191993A1 (es) |
| MX (1) | MX2023003516A (es) |
| WO (1) | WO2022064009A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024088296A1 (zh) * | 2022-10-25 | 2024-05-02 | 上海拓界生物医药科技有限公司 | 哌啶并嘧啶类衍生物、其制备方法及其在医药上的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013021896A2 (pt) | 2011-02-28 | 2016-11-08 | Array Biopharma Inc | inibidores de serina/treonina cinase |
| CA2972239A1 (en) | 2014-12-23 | 2016-06-30 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
-
2021
- 2021-09-24 AU AU2021350161A patent/AU2021350161A1/en active Pending
- 2021-09-24 BR BR112023005005A patent/BR112023005005A2/pt unknown
- 2021-09-24 CA CA3191993A patent/CA3191993A1/en active Pending
- 2021-09-24 WO PCT/EP2021/076409 patent/WO2022064009A1/en active Application Filing
- 2021-09-24 KR KR1020237013733A patent/KR20230074762A/ko unknown
- 2021-09-24 CN CN202180065316.7A patent/CN116194103A/zh active Pending
- 2021-09-24 EP EP21782982.9A patent/EP4217356A1/en active Pending
- 2021-09-24 MX MX2023003516A patent/MX2023003516A/es unknown
- 2021-09-24 US US18/245,801 patent/US20240101554A1/en active Pending
- 2021-09-24 JP JP2023518934A patent/JP2023542411A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20230074762A (ko) | 2023-05-31 |
| EP4217356A1 (en) | 2023-08-02 |
| CN116194103A (zh) | 2023-05-30 |
| US20240101554A1 (en) | 2024-03-28 |
| JP2023542411A (ja) | 2023-10-06 |
| BR112023005005A2 (pt) | 2023-04-18 |
| CA3191993A1 (en) | 2022-03-31 |
| AU2021350161A9 (en) | 2024-02-08 |
| WO2022064009A1 (en) | 2022-03-31 |
| AU2021350161A1 (en) | 2023-06-08 |
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