MX2023007297A - 3-fluoro-but-3-enamidas ramificadas macrociclicas como inhibidores de mcl-1. - Google Patents
3-fluoro-but-3-enamidas ramificadas macrociclicas como inhibidores de mcl-1.Info
- Publication number
- MX2023007297A MX2023007297A MX2023007297A MX2023007297A MX2023007297A MX 2023007297 A MX2023007297 A MX 2023007297A MX 2023007297 A MX2023007297 A MX 2023007297A MX 2023007297 A MX2023007297 A MX 2023007297A MX 2023007297 A MX2023007297 A MX 2023007297A
- Authority
- MX
- Mexico
- Prior art keywords
- mcl
- inhibitors
- enamides
- macrocyclic
- fluoro
- Prior art date
Links
- 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 title abstract 2
- 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- -1 3-fluoro-but-3-enamides Chemical class 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se relaciona con agentes farmacéuticos de la Fórmula (I) útiles para terapia y/o profilaxis en un sujeto, composición farmacéutica que comprende tales compuestos, y su uso como inhibidores de MCL-1, útiles para tratar enfermedades tales como cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20214807 | 2020-12-17 | ||
PCT/EP2021/086192 WO2022129331A1 (en) | 2020-12-17 | 2021-12-16 | Macrocyclic branched 3-fluoro-but-3-enamides as inhibitors of mcl-1 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023007297A true MX2023007297A (es) | 2023-07-04 |
Family
ID=73855218
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023007297A MX2023007297A (es) | 2020-12-17 | 2021-12-16 | 3-fluoro-but-3-enamidas ramificadas macrociclicas como inhibidores de mcl-1. |
Country Status (9)
Country | Link |
---|---|
US (1) | US20240083890A1 (es) |
EP (1) | EP4263558A1 (es) |
JP (1) | JP2023554070A (es) |
KR (1) | KR20230121806A (es) |
CN (1) | CN116670141A (es) |
AU (1) | AU2021404501A1 (es) |
CA (1) | CA3200704A1 (es) |
MX (1) | MX2023007297A (es) |
WO (1) | WO2022129331A1 (es) |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO3474B1 (ar) | 2014-08-29 | 2020-07-05 | Amgen Inc | مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1 |
WO2017147410A1 (en) | 2016-02-25 | 2017-08-31 | Amgen Inc. | Compounds that inhibit mcl-1 protein |
JP6453507B2 (ja) | 2017-03-30 | 2019-01-16 | アムジエン・インコーポレーテツド | Mcl−1タンパク質を阻害する化合物 |
EP3668878A1 (en) | 2017-08-18 | 2020-06-24 | Amgen Inc. | Compounds that inhibit mcl-1 protein |
EP3676270A1 (en) | 2017-08-29 | 2020-07-08 | Amgen Inc. | Macrocyclic compounds that inhibit mcl-1 protein |
MA54985A (fr) | 2018-03-05 | 2021-12-29 | Amgen Inc | Pharmacophores d'acide alpha-hydroxy phénylacétique ou antagonistes de la protéine bio-isostère mcl-1 |
MX2020012137A (es) | 2018-05-14 | 2021-01-29 | Gilead Sciences Inc | Inhibidores de mcl-1. |
JP2022506973A (ja) | 2018-11-09 | 2022-01-17 | プレリュード セラピューティクス,インコーポレイティド | 骨髄性細胞白血病-1(mcl-1)タンパク質の阻害剤としてのスピロ-スルホンアミド誘導体 |
CA3144558A1 (en) * | 2019-07-09 | 2021-01-14 | Janssen Pharmaceutica Nv | Macrocyclic spirocycle derivatives as mcl-1 inhibitors |
US20230212191A1 (en) | 2020-04-16 | 2023-07-06 | Prelude Therapeutics, Incorporated | Spiro-sulfonimidamide derivatives as inhibitors of myeloid cell leukemia-1 (mcl-1) protein |
-
2021
- 2021-12-16 KR KR1020237023585A patent/KR20230121806A/ko unknown
- 2021-12-16 CN CN202180085166.6A patent/CN116670141A/zh active Pending
- 2021-12-16 AU AU2021404501A patent/AU2021404501A1/en active Pending
- 2021-12-16 US US18/257,976 patent/US20240083890A1/en active Pending
- 2021-12-16 MX MX2023007297A patent/MX2023007297A/es unknown
- 2021-12-16 JP JP2023536813A patent/JP2023554070A/ja active Pending
- 2021-12-16 CA CA3200704A patent/CA3200704A1/en active Pending
- 2021-12-16 WO PCT/EP2021/086192 patent/WO2022129331A1/en active Application Filing
- 2021-12-16 EP EP21830695.9A patent/EP4263558A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20230121806A (ko) | 2023-08-21 |
EP4263558A1 (en) | 2023-10-25 |
CA3200704A1 (en) | 2023-06-23 |
US20240083890A1 (en) | 2024-03-14 |
CN116670141A (zh) | 2023-08-29 |
WO2022129331A1 (en) | 2022-06-23 |
JP2023554070A (ja) | 2023-12-26 |
AU2021404501A1 (en) | 2023-08-03 |
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