WO2018217894A8 - Fluorine-labelled halichondrin derivatives and related methods of synthesis - Google Patents
Fluorine-labelled halichondrin derivatives and related methods of synthesis Download PDFInfo
- Publication number
- WO2018217894A8 WO2018217894A8 PCT/US2018/034132 US2018034132W WO2018217894A8 WO 2018217894 A8 WO2018217894 A8 WO 2018217894A8 US 2018034132 W US2018034132 W US 2018034132W WO 2018217894 A8 WO2018217894 A8 WO 2018217894A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fluorine
- labelled
- synthesis
- related methods
- halichondrin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to halichondrin derivatives containing fluorine, e.g., fluorine-18, as well as methods of synthesizing the same.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762510350P | 2017-05-24 | 2017-05-24 | |
| US62/510,350 | 2017-05-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2018217894A1 WO2018217894A1 (en) | 2018-11-29 |
| WO2018217894A8 true WO2018217894A8 (en) | 2019-03-14 |
Family
ID=64395958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2018/034132 WO2018217894A1 (en) | 2017-05-24 | 2018-05-23 | Fluorine-labelled halichondrin derivatives and related methods of synthesis |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2018217894A1 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5735277B2 (en) | 2007-10-03 | 2015-06-17 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Intermediates and methods for the synthesis of halichondrin B analogues |
| US9783549B2 (en) | 2013-11-04 | 2017-10-10 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B |
| WO2016179607A1 (en) | 2015-05-07 | 2016-11-10 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides |
| WO2017139664A1 (en) | 2016-02-12 | 2017-08-17 | Eisai & R&D Management Co., Ltd. | Intermediates in the synthesis of eribulin and related methods of synthesis |
| US11136335B2 (en) | 2016-06-30 | 2021-10-05 | Eisai R&D Management Co., Ltd. | Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof |
| IL275729B2 (en) | 2018-01-03 | 2023-09-01 | Eisai R&D Man Co Ltd | Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof |
| US20230144203A1 (en) * | 2020-01-22 | 2023-05-11 | Shanghai Senhui Medicine Co., Ltd. | Drug conjugate of eribulin derivative, preparation method therefor and application thereof in medicine |
| CN114380840B (en) * | 2022-01-27 | 2024-01-26 | 江苏慧聚药业股份有限公司 | Synthesis of eribulin |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009064029A1 (en) * | 2007-11-16 | 2009-05-22 | Eisai R & D Management Co., Ltd. | Novel intermediate for halichondrin b analog synthesis and novel desulfonylation reaction used for the intermediate |
| IN2014MN02106A (en) * | 2012-03-30 | 2015-09-11 | Alphora Res Inc | |
| US9783549B2 (en) * | 2013-11-04 | 2017-10-10 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B |
| RU2676486C1 (en) * | 2013-12-06 | 2018-12-29 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Methods for synthesis of halichondrin b analogs |
| WO2016038624A1 (en) * | 2014-09-09 | 2016-03-17 | Cipla Limited | "process for the preparation of macrocyclic ketone analogs of halichondrin b or pharmaceutically acceptable salts and intermediates thereof" |
-
2018
- 2018-05-23 WO PCT/US2018/034132 patent/WO2018217894A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018217894A1 (en) | 2018-11-29 |
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