DE602007006990D1 - Spiropiperidinderivate als antagonisten des via-rezeptors - Google Patents

Spiropiperidinderivate als antagonisten des via-rezeptors

Info

Publication number
DE602007006990D1
DE602007006990D1 DE602007006990T DE602007006990T DE602007006990D1 DE 602007006990 D1 DE602007006990 D1 DE 602007006990D1 DE 602007006990 T DE602007006990 T DE 602007006990T DE 602007006990 T DE602007006990 T DE 602007006990T DE 602007006990 D1 DE602007006990 D1 DE 602007006990D1
Authority
DE
Germany
Prior art keywords
antagonists
via receptor
spiropiperidine derivatives
spiropiperidine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007006990T
Other languages
English (en)
Inventor
Caterina Bissantz
Christophe Grundschober
Raffaello Masciadri
Hasane Ratni
Mark Rogers-Evans
Patrick Schnider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE602007006990D1 publication Critical patent/DE602007006990D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
DE602007006990T 2006-12-07 2007-11-29 Spiropiperidinderivate als antagonisten des via-rezeptors Active DE602007006990D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125634 2006-12-07
PCT/EP2007/062985 WO2008068185A1 (en) 2006-12-07 2007-11-29 Spiro-piperidine derivatives as via receptor antagonists

Publications (1)

Publication Number Publication Date
DE602007006990D1 true DE602007006990D1 (de) 2010-07-15

Family

ID=39295880

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007006990T Active DE602007006990D1 (de) 2006-12-07 2007-11-29 Spiropiperidinderivate als antagonisten des via-rezeptors

Country Status (21)

Country Link
US (3) US20080139554A1 (de)
EP (1) EP2102207B1 (de)
JP (1) JP2010511661A (de)
KR (1) KR101050568B1 (de)
CN (1) CN101547923A (de)
AR (1) AR064135A1 (de)
AT (1) ATE469900T1 (de)
AU (1) AU2007328995B2 (de)
BR (1) BRPI0720004A2 (de)
CA (1) CA2670674A1 (de)
CL (1) CL2007003482A1 (de)
DE (1) DE602007006990D1 (de)
ES (1) ES2344131T3 (de)
IL (1) IL198544A (de)
MX (1) MX2009005504A (de)
NO (1) NO20091830L (de)
PE (1) PE20081252A1 (de)
RU (1) RU2009119394A (de)
TW (1) TW200838518A (de)
WO (1) WO2008068185A1 (de)
ZA (1) ZA200903496B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008077810A2 (en) 2006-12-22 2008-07-03 F. Hoffmann-La Roche Ag Spiro-piperidine derivatives
PT2285808E (pt) 2008-04-29 2014-02-24 Novartis Ag Derivados de espiro-indole para o tratamento de doenças parasitárias
AU2015345102A1 (en) * 2014-11-14 2017-03-30 F. Hoffmann-La Roche Ag Spiro-thiazolones
CN108884096B (zh) * 2016-02-08 2022-03-22 豪夫迈·罗氏有限公司 作为ddr1抑制剂的螺二氢吲哚酮
ES2951874T3 (es) 2017-09-05 2023-10-25 Neumora Therapeutics Inc Antagonistas del receptor de vasopresina y productos y métodos relacionados con los mismos

Family Cites Families (40)

* Cited by examiner, † Cited by third party
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US3370091A (en) * 1964-06-15 1968-02-20 Hoffmann La Roche 2 aminobenzhydrylhalides
US3531467A (en) * 1966-12-23 1970-09-29 Hoffmann La Roche Process for the preparation of 2,3,4,5-tetrahydro - 5 - aryl - 1h - 1,4 - benzodiazepine derivatives
US4209625A (en) * 1977-04-21 1980-06-24 American Hoechst Corporation Spiro[indoline-3,4'-piperidine]s
DE3818830A1 (de) * 1988-06-03 1989-12-14 Boehringer Mannheim Gmbh Bicyclische carboxamide, verfahren zu ihrer herstellung, deren vorstufen, und diese verbindungen enthaltende arzneimittel
CA2037287A1 (en) * 1990-03-02 1991-09-03 Ben E. Evans Spirocyclic oxytocin antagonists
DK78692D0 (da) 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
WO1994007496A1 (en) 1992-10-07 1994-04-14 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
US5670509A (en) * 1993-09-27 1997-09-23 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
IT1271026B (it) 1994-10-21 1997-05-26 Isagro Ricerca Srl Derivati dell'acido b-amminopropionico ad attivita' fungicida
US5576321A (en) 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
AU707641B2 (en) 1995-12-14 1999-07-15 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
GB9601724D0 (en) * 1996-01-29 1996-03-27 Merck Sharp & Dohme Therapeutic agents
US6166209A (en) 1997-12-11 2000-12-26 Hoffmann-La Roche Inc. Piperidine derivatives
CO5150201A1 (es) 1998-09-07 2002-04-29 Hoffmann La Roche Derivados de piperidina
TWI279402B (en) * 1999-08-20 2007-04-21 Banyu Pharma Co Ltd Spiro compounds having NPY antagonistic activities and agents containing the same
GB0003397D0 (en) * 2000-02-14 2000-04-05 Merck Sharp & Dohme Therapeutic agents
RU2261250C2 (ru) 2000-05-12 2005-09-27 Солвей Фармасьютикалс Б.В. Соединения пиперазина и пиперидина
EP1325011B1 (de) 2000-09-29 2004-05-06 Eli Lilly And Company Verfahren und verbindungen zur behandlung proliferativer erkrankungen
WO2003045385A1 (en) 2001-11-27 2003-06-05 F. Hoffmann-La Roche Ag Benzothiazole derivatives
FR2833948B1 (fr) 2001-12-21 2004-02-06 Sod Conseils Rech Applic Nouveaux derives de benzimidazole et leur utilisation en tant que medicament
US20040152741A1 (en) 2002-09-09 2004-08-05 Nps Allelix Corporation Arylglycine derivatives and their use as glycine transport inhibitors
AU2003263155A1 (en) 2002-09-20 2004-04-08 H. Lundbeck A/S Method for manufacture of dihydroisobenzofuran derivatives
AU2003301436A1 (en) 2002-10-17 2004-05-04 Amgen Inc. Benzimidazole derivatives and their use as vanilloid receptor ligands
AU2003215549A1 (en) 2003-02-03 2004-08-30 Janssen Pharmaceutica N.V. Mercaptoimidazoles as ccr2 receptor antagonists
US7244852B2 (en) * 2003-02-27 2007-07-17 Abbott Laboratories Process for preparing 2-methylpyrrolidine and specific enantiomers thereof
ATE482747T1 (de) * 2003-04-11 2010-10-15 High Point Pharmaceuticals Llc Neue amide derivate und deren pharmazeutische verwendungen
CA2544602A1 (en) 2003-11-04 2005-05-26 Elixir Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
OA13347A (en) * 2003-12-22 2007-04-13 Pfizer Triazole derivatives as vasopressin antagonists.
AU2004309419A1 (en) 2003-12-23 2005-07-14 Arena Pharmaceuticals, Inc. Novel spiroindoline or spiroisoquinoline compounds, methods of use and compositions thereof
GB0400700D0 (en) * 2004-01-13 2004-02-18 Pfizer Ltd Compounds useful in therapy
WO2006013048A1 (en) 2004-08-05 2006-02-09 F.Hoffmann-La Roche Ag Indole, indazole or indoline derivatives
US8138342B2 (en) 2004-10-12 2012-03-20 High Point Pharmacueticals, LLC 11β-hydroxysteroid dehydrogenase type 1 active spiro compounds
CN100551006C (zh) * 2004-10-13 2009-10-14 索尼株式会社 再现装置、成像装置以及屏幕显示方法
US20080234252A1 (en) 2005-05-18 2008-09-25 Pfizer Inc Compounds Useful in Therapy
US8190027B2 (en) 2006-07-12 2012-05-29 Tellabs Operations, Inc. Multifunctional and reconfigurable optical node and optical network
DE602006004997D1 (de) * 2005-07-14 2009-03-12 Hoffmann La Roche Indol-3-carbonyl-spiro-piperidinderivate als antagonisten des v1a-rezeptors
JP2009507800A (ja) 2005-09-09 2009-02-26 ユーロ−セルティーク エス．エイ． 縮合およびスピロ環化合物ならびにその使用
WO2008077810A2 (en) * 2006-12-22 2008-07-03 F. Hoffmann-La Roche Ag Spiro-piperidine derivatives
JP2010514727A (ja) * 2006-12-29 2010-05-06 エフ．ホフマン−ラ ロシュ アーゲー アザスピロ誘導体
WO2008084005A1 (en) * 2007-01-12 2008-07-17 F. Hoffmann-La Roche Ag Spiropiperidine glycinamide derivatives

Also Published As

Publication number Publication date
CA2670674A1 (en) 2008-06-12
KR101050568B1 (ko) 2011-07-19
EP2102207A1 (de) 2009-09-23
ZA200903496B (en) 2010-03-31
TW200838518A (en) 2008-10-01
RU2009119394A (ru) 2011-01-20
US20080139554A1 (en) 2008-06-12
US8202993B2 (en) 2012-06-19
EP2102207B1 (de) 2010-06-02
US20080139553A1 (en) 2008-06-12
JP2010511661A (ja) 2010-04-15
AR064135A1 (es) 2009-03-18
IL198544A (en) 2012-06-28
AU2007328995B2 (en) 2012-04-26
WO2008068185A1 (en) 2008-06-12
AU2007328995A1 (en) 2008-06-12
PE20081252A1 (es) 2008-09-04
NO20091830L (no) 2009-07-06
ES2344131T3 (es) 2010-08-18
BRPI0720004A2 (pt) 2013-12-17
US20080146568A1 (en) 2008-06-19
MX2009005504A (es) 2009-06-03
CN101547923A (zh) 2009-09-30
ATE469900T1 (de) 2010-06-15
KR20090079255A (ko) 2009-07-21
CL2007003482A1 (es) 2008-07-04
IL198544A0 (en) 2010-02-17

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DE602007006990D1 (de) Spiropiperidinderivate als antagonisten des via-rezeptors