ATE477243T1 - 2-aminochinoline als 5-ht(5a)- rezeptorantagonisten - Google Patents
2-aminochinoline als 5-ht(5a)- rezeptorantagonistenInfo
- Publication number
- ATE477243T1 ATE477243T1 AT07847380T AT07847380T ATE477243T1 AT E477243 T1 ATE477243 T1 AT E477243T1 AT 07847380 T AT07847380 T AT 07847380T AT 07847380 T AT07847380 T AT 07847380T AT E477243 T1 ATE477243 T1 AT E477243T1
- Authority
- AT
- Austria
- Prior art keywords
- aminoquinolines
- receptor antagonists
- antagonists
- receptor
- Prior art date
Links
- 150000005013 2-aminoquinolines Chemical class 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Addiction (AREA)
- Reproductive Health (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06125604 | 2006-12-07 | ||
| PCT/EP2007/062853 WO2008068157A1 (en) | 2006-12-07 | 2007-11-27 | 2-aminoquinolines as 5-ht(5a) receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE477243T1 true ATE477243T1 (de) | 2010-08-15 |
Family
ID=39033366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07847380T ATE477243T1 (de) | 2006-12-07 | 2007-11-27 | 2-aminochinoline als 5-ht(5a)- rezeptorantagonisten |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7923561B2 (de) |
| EP (1) | EP2099763B1 (de) |
| JP (1) | JP5031846B2 (de) |
| KR (1) | KR101107807B1 (de) |
| CN (1) | CN101541753B (de) |
| AR (1) | AR064134A1 (de) |
| AT (1) | ATE477243T1 (de) |
| AU (1) | AU2007329064C1 (de) |
| BR (1) | BRPI0720078A2 (de) |
| CA (1) | CA2669590A1 (de) |
| CL (1) | CL2007003481A1 (de) |
| DE (1) | DE602007008469D1 (de) |
| ES (1) | ES2348208T3 (de) |
| IL (1) | IL198542A0 (de) |
| MX (1) | MX2009005509A (de) |
| PE (1) | PE20081446A1 (de) |
| TW (1) | TW200845985A (de) |
| WO (1) | WO2008068157A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007147762A1 (en) * | 2006-06-20 | 2007-12-27 | F. Hoffmann-La Roche Ag | Arylsulfonamidyl tetralin derivatives and uses thereof |
| WO2008068157A1 (en) | 2006-12-07 | 2008-06-12 | F. Hoffmann-La Roche Ag | 2-aminoquinolines as 5-ht(5a) receptor antagonists |
| WO2009109477A1 (en) * | 2008-03-05 | 2009-09-11 | F. Hoffmann-La Roche Ag | 2-aminoquinolines |
| CN101959864A (zh) | 2008-03-07 | 2011-01-26 | 弗·哈夫曼-拉罗切有限公司 | 2-氨基喹啉衍生物 |
| JP2011513352A (ja) * | 2008-03-07 | 2011-04-28 | エフ．ホフマン−ラ ロシュ アーゲー | ５−ｈｔ（５ａ）受容体アンタゴニストとしての２−アミノキノリン誘導体 |
| EP2328881A1 (de) * | 2008-09-08 | 2011-06-08 | F. Hoffmann-La Roche AG | 5-substituierte benzoxazine |
| ES2734552T3 (es) | 2010-04-16 | 2019-12-10 | Ac Immune Sa | Compuestos novedosos para el tratamiento de enfermedades asociadas a proteínas amiloides o de tipo amiloide |
| US12492178B2 (en) | 2021-09-01 | 2025-12-09 | Empathbio, Inc. | Stable polymorph of R-MDMA HCl |
| WO2023034510A1 (en) | 2021-09-01 | 2023-03-09 | ATAI Life Sciences AG | Synthesis of mdma or its optically active ( r)- or ( s)-mdma isomers |
| US11845736B2 (en) | 2021-10-01 | 2023-12-19 | Empathbio, Inc. | Prodrugs of MDMA, MDA, and derivatives thereof |
| US11912680B2 (en) | 2021-12-28 | 2024-02-27 | Empathbio, Inc. | Nitric oxide releasing prodrugs of MDA and MDMA |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001087845A2 (en) * | 2000-05-15 | 2001-11-22 | Fujisawa Pharmaceutical Co., Ltd. | N-containing heterocyclic compounds and their use as 5-ht antagonists |
| SE0103649D0 (sv) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic quinoline compounds |
| SE0200920D0 (sv) * | 2002-03-25 | 2002-03-25 | Astrazeneca Ab | Novel compounds |
| AU2003284217A1 (en) | 2002-10-16 | 2004-05-04 | Smithkline Beecham Corporation | Chemical compounds |
| MXPA05009722A (es) | 2003-03-10 | 2006-03-09 | Schering Corp | Inhibidores heterociclicos de cinasa: metodos de uso y sintesis. |
| GB0309781D0 (en) | 2003-04-29 | 2003-06-04 | Glaxo Group Ltd | Compounds |
| GB0312609D0 (en) | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
| DE102004008141A1 (de) | 2004-02-19 | 2005-09-01 | Abbott Gmbh & Co. Kg | Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren |
| NZ560917A (en) * | 2005-03-31 | 2011-01-28 | Pfizer Prod Inc | Cyclopentapyridine and tetrahydroquinoline derivatives |
| TWI291826B (en) * | 2006-02-27 | 2007-12-21 | Inventec Appliances Corp | Method for activating different functions of hot key at different time and the device thereof |
| KR101088451B1 (ko) | 2006-09-28 | 2011-12-01 | 에프. 호프만-라 로슈 아게 | 5-ｈｔ 결합 특성을 갖는 퀴놀린 유도체 |
| WO2008068157A1 (en) | 2006-12-07 | 2008-06-12 | F. Hoffmann-La Roche Ag | 2-aminoquinolines as 5-ht(5a) receptor antagonists |
| JP2011513352A (ja) * | 2008-03-07 | 2011-04-28 | エフ．ホフマン−ラ ロシュ アーゲー | ５−ｈｔ（５ａ）受容体アンタゴニストとしての２−アミノキノリン誘導体 |
-
2007
- 2007-11-27 WO PCT/EP2007/062853 patent/WO2008068157A1/en not_active Ceased
- 2007-11-27 CN CN2007800444208A patent/CN101541753B/zh not_active Expired - Fee Related
- 2007-11-27 CA CA002669590A patent/CA2669590A1/en not_active Abandoned
- 2007-11-27 ES ES07847380T patent/ES2348208T3/es active Active
- 2007-11-27 BR BRPI0720078-1A2A patent/BRPI0720078A2/pt not_active IP Right Cessation
- 2007-11-27 DE DE602007008469T patent/DE602007008469D1/de active Active
- 2007-11-27 MX MX2009005509A patent/MX2009005509A/es active IP Right Grant
- 2007-11-27 EP EP07847380A patent/EP2099763B1/de not_active Not-in-force
- 2007-11-27 JP JP2009539696A patent/JP5031846B2/ja not_active Expired - Fee Related
- 2007-11-27 AT AT07847380T patent/ATE477243T1/de active
- 2007-11-27 KR KR1020097011690A patent/KR101107807B1/ko not_active Expired - Fee Related
- 2007-11-27 AU AU2007329064A patent/AU2007329064C1/en not_active Ceased
- 2007-11-29 US US11/946,947 patent/US7923561B2/en not_active Expired - Fee Related
- 2007-12-04 TW TW096146119A patent/TW200845985A/zh unknown
- 2007-12-04 CL CL200703481A patent/CL2007003481A1/es unknown
- 2007-12-05 AR ARP070105425A patent/AR064134A1/es unknown
- 2007-12-06 PE PE2007001739A patent/PE20081446A1/es not_active Application Discontinuation
-
2009
- 2009-05-04 IL IL198542A patent/IL198542A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2669590A1 (en) | 2008-06-12 |
| JP5031846B2 (ja) | 2012-09-26 |
| CL2007003481A1 (es) | 2008-07-04 |
| EP2099763A1 (de) | 2009-09-16 |
| DE602007008469D1 (de) | 2010-09-23 |
| US20080146567A1 (en) | 2008-06-19 |
| CN101541753A (zh) | 2009-09-23 |
| AR064134A1 (es) | 2009-03-11 |
| PE20081446A1 (es) | 2008-10-18 |
| BRPI0720078A2 (pt) | 2013-12-24 |
| EP2099763B1 (de) | 2010-08-11 |
| WO2008068157A1 (en) | 2008-06-12 |
| TW200845985A (en) | 2008-12-01 |
| MX2009005509A (es) | 2009-06-03 |
| AU2007329064B2 (en) | 2012-08-02 |
| US7923561B2 (en) | 2011-04-12 |
| IL198542A0 (en) | 2010-02-17 |
| KR20090080545A (ko) | 2009-07-24 |
| AU2007329064A1 (en) | 2008-06-12 |
| JP2010511653A (ja) | 2010-04-15 |
| AU2007329064C1 (en) | 2013-01-17 |
| KR101107807B1 (ko) | 2012-01-25 |
| CN101541753B (zh) | 2012-06-13 |
| ES2348208T3 (es) | 2010-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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