ATE512137T1 - Benzoylpiperidinderivate als doppelmodulatoren des 5-ht2a- und des d3-rezeptors - Google Patents
Benzoylpiperidinderivate als doppelmodulatoren des 5-ht2a- und des d3-rezeptorsInfo
- Publication number
- ATE512137T1 ATE512137T1 AT08786606T AT08786606T ATE512137T1 AT E512137 T1 ATE512137 T1 AT E512137T1 AT 08786606 T AT08786606 T AT 08786606T AT 08786606 T AT08786606 T AT 08786606T AT E512137 T1 ATE512137 T1 AT E512137T1
- Authority
- AT
- Austria
- Prior art keywords
- ht2a
- receptor
- dual modulators
- benzoylpiperidine
- derivatives
- Prior art date
Links
- YXTROGRGRSPWKL-UHFFFAOYSA-N 1-benzoylpiperidine Chemical class C=1C=CC=CC=1C(=O)N1CCCCC1 YXTROGRGRSPWKL-UHFFFAOYSA-N 0.000 title 1
- 102100036321 5-hydroxytryptamine receptor 2A Human genes 0.000 title 1
- 101710138091 5-hydroxytryptamine receptor 2A Proteins 0.000 title 1
- 230000009977 dual effect Effects 0.000 title 1
- 102000005962 receptors Human genes 0.000 title 1
- 108020003175 receptors Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07114119 | 2007-08-09 | ||
| PCT/EP2008/059971 WO2009019174A1 (en) | 2007-08-09 | 2008-07-30 | Benzoyl-piperidine derivatives as dual modulators of the 5-ht2a and d3 receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE512137T1 true ATE512137T1 (de) | 2011-06-15 |
Family
ID=39865594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08786606T ATE512137T1 (de) | 2007-08-09 | 2008-07-30 | Benzoylpiperidinderivate als doppelmodulatoren des 5-ht2a- und des d3-rezeptors |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8097637B2 (de) |
| EP (1) | EP2185513B1 (de) |
| JP (1) | JP5296073B2 (de) |
| KR (1) | KR101171467B1 (de) |
| CN (1) | CN101778820B (de) |
| AR (1) | AR067873A1 (de) |
| AT (1) | ATE512137T1 (de) |
| AU (1) | AU2008285729B2 (de) |
| BR (1) | BRPI0814999A2 (de) |
| CA (1) | CA2694057A1 (de) |
| CL (1) | CL2008002310A1 (de) |
| ES (1) | ES2366766T3 (de) |
| MX (1) | MX2010001195A (de) |
| PE (1) | PE20090513A1 (de) |
| TW (1) | TW200914422A (de) |
| WO (1) | WO2009019174A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2396265C2 (ru) * | 2006-02-17 | 2010-08-10 | Ф. Хоффманн-Ля Рош Аг | Производные бензоилпиперидина в качестве модуляторов рецепторов 5ht2 и d3 |
| EP2183245B1 (de) * | 2007-07-26 | 2014-07-09 | F. Hoffmann-La Roche AG | Duale modulatoren von 5-ht2a- und d3-rezeptoren |
| US8586579B2 (en) | 2010-06-21 | 2013-11-19 | Hoffmann-La Roche Inc. | Anellated pyridine compounds |
| US8470828B2 (en) | 2010-07-06 | 2013-06-25 | Hoffmann-La Roche Inc. | Anellated pyridine compounds |
| US8921397B2 (en) | 2011-05-04 | 2014-12-30 | Hoffmann-La Roche Inc. | Benzofurane-piperidine compounds |
| EP2809156B1 (de) * | 2011-12-08 | 2017-05-24 | The Board of Regents of The University of Texas System | Allosterische modulatoren des 5-hydroxytryptamin-2c-rezeptors (5-ht2cr) |
| TWI739206B (zh) | 2014-12-12 | 2021-09-11 | 日商日本煙草產業股份有限公司 | 二氫嘧啶-２-酮化合物及其醫藥用途 |
| CN117550989B (zh) * | 2023-11-14 | 2024-09-27 | 泰州精英化成医药科技有限公司 | 一种反式-2-(4-氨基环己基)乙酸乙酯盐酸盐的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2717479B1 (fr) * | 1994-03-18 | 1996-06-07 | Pf Medicament | Nouvelles 3-(omega-benzoylpipéridino) alcoyl)-4H-Benzopyran-4-ones, leur préparation et leur application en thérapeutique. |
| HU227543B1 (en) * | 2001-09-28 | 2011-08-29 | Richter Gedeon Nyrt | N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them |
| HUP0103986A2 (hu) * | 2001-09-28 | 2003-06-28 | Richter Gedeon Vegyészeti Gyár Rt. | Új karbonsavamid szerkezetet tartalmazó piperidinil vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
| AU2002366766A1 (en) * | 2001-12-13 | 2003-07-09 | Sumitomo Pharmaceuticals Co., Ltd. | Serotonine reuptake inhibitor |
| RU2396265C2 (ru) * | 2006-02-17 | 2010-08-10 | Ф. Хоффманн-Ля Рош Аг | Производные бензоилпиперидина в качестве модуляторов рецепторов 5ht2 и d3 |
-
2008
- 2008-07-30 MX MX2010001195A patent/MX2010001195A/es active IP Right Grant
- 2008-07-30 CA CA2694057A patent/CA2694057A1/en not_active Abandoned
- 2008-07-30 JP JP2010519432A patent/JP5296073B2/ja not_active Expired - Fee Related
- 2008-07-30 EP EP08786606A patent/EP2185513B1/de not_active Not-in-force
- 2008-07-30 AT AT08786606T patent/ATE512137T1/de active
- 2008-07-30 KR KR1020107002763A patent/KR101171467B1/ko not_active IP Right Cessation
- 2008-07-30 WO PCT/EP2008/059971 patent/WO2009019174A1/en active Application Filing
- 2008-07-30 AU AU2008285729A patent/AU2008285729B2/en not_active Ceased
- 2008-07-30 ES ES08786606T patent/ES2366766T3/es active Active
- 2008-07-30 CN CN2008801026707A patent/CN101778820B/zh not_active Expired - Fee Related
- 2008-07-30 BR BRPI0814999-2A2A patent/BRPI0814999A2/pt not_active Application Discontinuation
- 2008-08-01 US US12/184,272 patent/US8097637B2/en not_active Expired - Fee Related
- 2008-08-06 CL CL2008002310A patent/CL2008002310A1/es unknown
- 2008-08-07 AR ARP080103450A patent/AR067873A1/es unknown
- 2008-08-07 PE PE2008001318A patent/PE20090513A1/es not_active Application Discontinuation
- 2008-08-08 TW TW097130407A patent/TW200914422A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101778820B (zh) | 2012-12-05 |
| JP2010535735A (ja) | 2010-11-25 |
| JP5296073B2 (ja) | 2013-09-25 |
| AU2008285729A1 (en) | 2009-02-12 |
| CA2694057A1 (en) | 2009-02-12 |
| KR101171467B1 (ko) | 2012-08-07 |
| PE20090513A1 (es) | 2009-04-29 |
| TW200914422A (en) | 2009-04-01 |
| ES2366766T3 (es) | 2011-10-25 |
| EP2185513B1 (de) | 2011-06-08 |
| EP2185513A1 (de) | 2010-05-19 |
| WO2009019174A1 (en) | 2009-02-12 |
| CL2008002310A1 (es) | 2009-05-29 |
| AR067873A1 (es) | 2009-10-28 |
| CN101778820A (zh) | 2010-07-14 |
| MX2010001195A (es) | 2010-03-01 |
| KR20100029850A (ko) | 2010-03-17 |
| BRPI0814999A2 (pt) | 2015-02-03 |
| US20090042943A1 (en) | 2009-02-12 |
| US8097637B2 (en) | 2012-01-17 |
| AU2008285729B2 (en) | 2012-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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