AR067873A1 - Derivados de benzoil-piperidina como moduladores duales de receptores de 5-ht2a y de d3 - Google Patents

Derivados de benzoil-piperidina como moduladores duales de receptores de 5-ht2a y de d3

Info

Publication number
AR067873A1
AR067873A1 ARP080103450A ARP080103450A AR067873A1 AR 067873 A1 AR067873 A1 AR 067873A1 AR P080103450 A ARP080103450 A AR P080103450A AR P080103450 A ARP080103450 A AR P080103450A AR 067873 A1 AR067873 A1 AR 067873A1
Authority
AR
Argentina
Prior art keywords
alkyl
ht2a
receptors
haloalkyl
group
Prior art date
Application number
ARP080103450A
Other languages
English (en)
Inventor
Luca Gobbi
Georg Jaeschke
Sarmiento Rosa Maria Rodriguez
K Stewart
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR067873A1 publication Critical patent/AR067873A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Moduladores duales de los receptores de la serotonina 5-HT2a y de la dopamina D3, su obtencion, las composiciones farmacéuticas que los contienen y su utilizacion como medicamentos. Los compuestos de general formula (1) tienen una gran afinidad con los receptores de la dopamina D3 y de la serotonina (5-hidroxitriptamina; 5-HT) 5-HT2a y son eficaces para el tratamiento de trastornos psicoticos, así como otros trastornos, tales como la depresion y la ansiedad, la dependencia de fármacos, las demencias y los desequilibrios de memoria. Reivindicacion 1: un compuesto de la formula (1) en la que R1: es un resto de la formula (2) A es arilo o heteroarilo de 5 o 6 eslabones opcionalmente sustituido de una a cinco veces por sustituyentes elegidos entre el grupo formado por ciano, halogeno, alquilo C1-6, haloalquilo C1-6 y alcoxi C1-6; m es el numero 1, 2 o 3; n es el numero 1, 2, 3, 4 o 5; o es el numero 0, 1 o 2; R2 se elige entre el grupo formado por hidrogeno, hidroxilo alquilo C1-6, haloalquilo C1-6 y alcoxi C1-6; R3 se elige entre el grupo formado por hidrogeno, con la condicion de que R2 es distinto hidrogeno hidroxilo; alquilo C1-6; haloalquilo C1-6 haloalcoxi C1-6 oxo; -NR(CO)-alquilo C1-6; -O-alquilo C1-6; -O-cicloalquilo C3-7; y -O-(heterocicloalquilo de 3 a 7 eslabones); así como las sales farmacéuticamente aceptables del mismo.
ARP080103450A 2007-08-09 2008-08-07 Derivados de benzoil-piperidina como moduladores duales de receptores de 5-ht2a y de d3 AR067873A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07114119 2007-08-09

Publications (1)

Publication Number Publication Date
AR067873A1 true AR067873A1 (es) 2009-10-28

Family

ID=39865594

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080103450A AR067873A1 (es) 2007-08-09 2008-08-07 Derivados de benzoil-piperidina como moduladores duales de receptores de 5-ht2a y de d3

Country Status (16)

Country Link
US (1) US8097637B2 (es)
EP (1) EP2185513B1 (es)
JP (1) JP5296073B2 (es)
KR (1) KR101171467B1 (es)
CN (1) CN101778820B (es)
AR (1) AR067873A1 (es)
AT (1) ATE512137T1 (es)
AU (1) AU2008285729B2 (es)
BR (1) BRPI0814999A2 (es)
CA (1) CA2694057A1 (es)
CL (1) CL2008002310A1 (es)
ES (1) ES2366766T3 (es)
MX (1) MX2010001195A (es)
PE (1) PE20090513A1 (es)
TW (1) TW200914422A (es)
WO (1) WO2009019174A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2640807A1 (en) * 2006-02-17 2007-08-23 F. Hoffmann-La Roche Ag Benzoyl-piperidine derivatives as 5ht2/d3 modulators
ES2498673T3 (es) * 2007-07-26 2014-09-25 F. Hoffmann-La Roche Ag Moduladores duales de los receptores 5-HT2a y D3
US8586579B2 (en) 2010-06-21 2013-11-19 Hoffmann-La Roche Inc. Anellated pyridine compounds
US8470828B2 (en) 2010-07-06 2013-06-25 Hoffmann-La Roche Inc. Anellated pyridine compounds
US8921397B2 (en) * 2011-05-04 2014-12-30 Hoffmann-La Roche Inc. Benzofurane-piperidine compounds
EP2809156B1 (en) 2011-12-08 2017-05-24 The Board of Regents of The University of Texas System Allosteric modulators of 5-hydroxytryptamine 2c receptor (5-ht2cr)
EP3744713A1 (en) 2014-12-12 2020-12-02 Japan Tobacco Inc. Diyhydropyrimidine-2-one compounds and medicinal uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2717479B1 (fr) * 1994-03-18 1996-06-07 Pf Medicament Nouvelles 3-(omega-benzoylpipéridino) alcoyl)-4H-Benzopyran-4-ones, leur préparation et leur application en thérapeutique.
HUP0103986A2 (hu) * 2001-09-28 2003-06-28 Richter Gedeon Vegyészeti Gyár Rt. Új karbonsavamid szerkezetet tartalmazó piperidinil vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
HU227543B1 (en) * 2001-09-28 2011-08-29 Richter Gedeon Nyrt N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them
JPWO2003053928A1 (ja) * 2001-12-13 2005-04-28 住友製薬株式会社 セロトニン再取り込み阻害剤
CA2640807A1 (en) * 2006-02-17 2007-08-23 F. Hoffmann-La Roche Ag Benzoyl-piperidine derivatives as 5ht2/d3 modulators

Also Published As

Publication number Publication date
EP2185513A1 (en) 2010-05-19
JP5296073B2 (ja) 2013-09-25
ATE512137T1 (de) 2011-06-15
EP2185513B1 (en) 2011-06-08
BRPI0814999A2 (pt) 2015-02-03
CL2008002310A1 (es) 2009-05-29
US8097637B2 (en) 2012-01-17
JP2010535735A (ja) 2010-11-25
WO2009019174A1 (en) 2009-02-12
KR20100029850A (ko) 2010-03-17
ES2366766T3 (es) 2011-10-25
AU2008285729A1 (en) 2009-02-12
MX2010001195A (es) 2010-03-01
CA2694057A1 (en) 2009-02-12
PE20090513A1 (es) 2009-04-29
TW200914422A (en) 2009-04-01
AU2008285729B2 (en) 2012-11-01
US20090042943A1 (en) 2009-02-12
CN101778820B (zh) 2012-12-05
KR101171467B1 (ko) 2012-08-07
CN101778820A (zh) 2010-07-14

Similar Documents

Publication Publication Date Title
AR067662A1 (es) Derivados de benzo[d]isoxazol-3-il-piperidina, medicamentos que los contienen y usos terapeuticos para enfermedades asociadas al sistema nervioso.
AR067873A1 (es) Derivados de benzoil-piperidina como moduladores duales de receptores de 5-ht2a y de d3
AR073622A1 (es) Compuestos de benzo[d]isoxazol moduladores de receptores de dopamina d3 y de la serotonina 5-ht2a, proceso para prepararlos, composiciones farmaceuticas que los comprenden y uso de los mismos para el tratamiento de trastornos psicoticos
AR057989A1 (es) Derivados de indol-2-il-amida 1,5-sustituida. procesos de obtencion y composiciones farmaceuticas
AR073314A1 (es) Derivados de indazol o de 4,5,6,7-tetrahidro-indazol
AR069796A1 (es) Derivados de bencimidazol, sustituido por carboxilo o por hidroxilo, proceso para prepararlos y composiciones farmaceuticas que los contienen
AR056204A1 (es) Derivados de indano como antagonistas de receptores de mch, metodos para su preparacion, intermediarios de sintesis de los mismos, composiciones farmaceuticas que los comprenden y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades relacionadas
UY29393A1 (es) Nuevos derivados de amidas, sales farmacéuticas aceptables, composiciones que los contienen, procedimientos de preparación y aplicaciones.
AR078756A1 (es) Moduladores alostericos positivos (map)
AR054560A1 (es) Espiropiperidina como inhibidores de beta-secretasa para el tratamiento de la enfermedad de alzheimer
AR096371A1 (es) 2-fenilimidazo[1,2-a]pirimidinas
PE20160844A1 (es) Compuestos triciclicos como agentes anticancerigenos
AR077505A1 (es) Compuestos de piridina y sus usos
AR054024A1 (es) Derivados de piridina -3- carboxamida como agonistas inversos de cb1
AR060401A1 (es) Derivados de cromen-2-ona
AR073396A1 (es) Derivados de 3-amino-indazol o de 3-amino-4, 5, 6, 7-tetrahidro-indazol
AR079205A1 (es) Morfolinotiazoles como moduladores alostericos positivos alfa 7
CO6341581A2 (es) Derivados de heteroarilo como inhibidores de dgat1
AR082111A1 (es) Furopiridinas o tienopiridinas condensadas, composiciones farmaceuticas que las contienen utiles para tratar trastornos psicoticos y del sistema nervioso central, y metodo de preparacion de las mismas
AR059094A1 (es) Derivados de ciclohexil - sulfonamida
AR082004A1 (es) Compuestos de fusion de piridina
PE20140968A1 (es) Derivados de benzamida sustituida
UY30938A1 (es) Derivados de nicotinamida, sales y solvatos farmacéuticamente aceptables, composiciones y aplicaciones.
CO2020001326A2 (es) Nuevos compuestos heterocíclicos como inhibidores de cdk8/19
AR086024A1 (es) Derivados de 5-(fenil/piridinil-etinil)-2-piridina/2-pirimidina carboxamidas

Legal Events

Date Code Title Description
FB Suspension of granting procedure