AR069796A1 - Derivados de bencimidazol, sustituido por carboxilo o por hidroxilo, proceso para prepararlos y composiciones farmaceuticas que los contienen - Google Patents
Derivados de bencimidazol, sustituido por carboxilo o por hidroxilo, proceso para prepararlos y composiciones farmaceuticas que los contienenInfo
- Publication number
- AR069796A1 AR069796A1 ARP080105517A ARP080105517A AR069796A1 AR 069796 A1 AR069796 A1 AR 069796A1 AR P080105517 A ARP080105517 A AR P080105517A AR P080105517 A ARP080105517 A AR P080105517A AR 069796 A1 AR069796 A1 AR 069796A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- lower alkyl
- independently
- cooh
- fluor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Estos compuestos se fijan sobre el FXR y pueden utilizarse como medicamentos. Reivindicacion 1: Compuestos de la formula (1) en la que R1 se elige entre las formulas (2); R2 es hidrogeno o alquilo inferior; R3 es ciclohexilo o biciclo[2.2.1]heptilo; R4 es fenilo, que está sustituido en posicion 4 por halogeno, ciano o fluor-alquilo inferior, o piridilo, que está sustituido por 1 o 2 sustituyentes elegidos con independencia entre halogeno, amino, ciano y alcoxi inferior; R5 y R6 con independencia entre sí son hidrogeno o fluor; R7 y R9 con independencia entre sí se eligen entre el grupo formado por hidrogeno, alquilo inferior, halogeno, alcoxi inferior, fluor-alquilo inferior, fluor-alcoxi interior y ciano; R8 es -(CR12R13)n-COOH, en el que n es el numero 0, 1 o 2 y R12 y R13 con independencia entre sí son hidrogeno o alquilo inferior, o R12 y R13 junto con el átomo de carbono al que están unidos forman un anillo cicloalquilo, o -O-(CR14R15)p-COOH, en el que p es el numero 1 o 2 y R14 y R15 con independencia entre sí son hidrogeno o alquilo interior, o R14 y R15 junto con el átomo de carbono al que están unidos forman un anillo cicloalquilo, o R8 es tetrazol; R10 es hidroxi o (CH2)p-COOH, en el que p es el numero 0, 1 o 2; m es el numero 0 o 1; R11 es -COOH; y sus sales farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07150351 | 2007-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR069796A1 true AR069796A1 (es) | 2010-02-17 |
Family
ID=40666938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080105517A AR069796A1 (es) | 2007-12-21 | 2008-12-18 | Derivados de bencimidazol, sustituido por carboxilo o por hidroxilo, proceso para prepararlos y composiciones farmaceuticas que los contienen |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7816540B2 (es) |
| EP (1) | EP2225221A2 (es) |
| JP (1) | JP5247818B2 (es) |
| KR (3) | KR101294480B1 (es) |
| CN (1) | CN101903375B (es) |
| AR (1) | AR069796A1 (es) |
| AU (1) | AU2008340443A1 (es) |
| BR (1) | BRPI0821644A2 (es) |
| CA (1) | CA2708372C (es) |
| CL (1) | CL2008003789A1 (es) |
| IL (1) | IL206037A0 (es) |
| MX (1) | MX2010006565A (es) |
| PE (1) | PE20091519A1 (es) |
| RU (1) | RU2493153C2 (es) |
| TW (1) | TW200936576A (es) |
| WO (1) | WO2009080555A2 (es) |
| ZA (1) | ZA201004056B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
| DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008019907A1 (de) | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008028905A1 (de) | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
| EP2321282B1 (en) * | 2008-09-11 | 2013-03-27 | F. Hoffmann-La Roche AG | New benzimidazole derivatives |
| MX2011006682A (es) | 2008-12-22 | 2011-07-13 | Merck Patent Gmbh | Nuevas formas polimorficas de dihidrogeno-fosfato de 6-(1-metil-1h-pirazol-4-il)-2-{3-[5-(2-morfolin-4-il-etoxi)-pirim idin-2-il]-bencil}-2h-piridazin-3-ona y procesos para su preparacion. |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2013037482A1 (en) | 2011-09-15 | 2013-03-21 | Phenex Pharmaceuticals Ag | Farnesoid x receptor agonists for cancer treatment and prevention |
| JP6280912B2 (ja) | 2013-03-14 | 2018-02-14 | 武田薬品工業株式会社 | 複素環化合物 |
| EP3018123B1 (en) | 2013-07-03 | 2023-05-10 | Takeda Pharmaceutical Company Limited | Amide compound |
| WO2015002231A1 (ja) | 2013-07-03 | 2015-01-08 | 武田薬品工業株式会社 | 複素環化合物 |
| CA2923090C (en) | 2013-09-11 | 2018-08-21 | Poxel | Methods and pharmaceutical compositions for the treatment of hepatitis b virus infection |
| WO2017153235A1 (de) | 2016-03-09 | 2017-09-14 | Bayer Pharma Aktiengesellschaft | Substituierte n-cyclo-3-aryl-1-naphthamide und ihre verwendung |
| JP2020508316A (ja) | 2017-02-21 | 2020-03-19 | ジェンフィＧｅｎｆｉｔ | Ｐｐａｒアゴニストとｆｘｒアゴニストとの組合せ |
| WO2018178260A1 (en) | 2017-03-30 | 2018-10-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for reducing persistence and expression of episomal viruses |
| JP2022540699A (ja) | 2019-07-18 | 2022-09-16 | ウエヌイグレックオ・ファーマ | インターフェロンの有害作用を減少させる方法 |
| CN114945361A (zh) | 2020-01-15 | 2022-08-26 | 法国国家卫生及研究医学协会 | Fxr激动剂在治疗丁型肝炎病毒感染中的用途 |
| EP4277622A1 (en) | 2021-01-14 | 2023-11-22 | ENYO Pharma | Synergistic effect of a fxr agonist and ifn for the treatment of hbv infection |
| JP2024517181A (ja) | 2021-04-28 | 2024-04-19 | ウエヌイグレックオ・ファーマ | 組合せ治療としてｆｘｒアゴニストを使用するｔｌｒ３アゴニストの効果の強い増強 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3224512A1 (de) * | 1982-07-01 | 1984-01-05 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| PL347684A1 (en) * | 1998-11-17 | 2002-04-22 | Basf Ag | 2-phenylbenzimidazoles and 2-phenylindoles, and production and use thereof |
| CA2363274A1 (en) * | 1999-12-27 | 2001-07-05 | Japan Tobacco Inc. | Fused-ring compounds and use thereof as drugs for hepatitis c |
| GEP20053660B (en) * | 2001-03-28 | 2005-11-10 | Bristol Myers Squibb Co | Novel Tyrosine Kinase Inhibitors |
| US6855714B2 (en) * | 2001-07-06 | 2005-02-15 | Schering Aktiengesellschaft | 1-alkyl-2-aryl-benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives |
| SG159380A1 (en) * | 2002-02-06 | 2010-03-30 | Vertex Pharma | Heteroaryl compounds useful as inhibitors of gsk-3 |
| US20060178398A1 (en) * | 2004-09-16 | 2006-08-10 | Adams Alan D | Therapeutic compounds for treating dyslipidemic conditions |
| WO2007081335A1 (en) | 2006-01-12 | 2007-07-19 | Merck & Co., Inc. | Therapeutic compounds for treating dyslipidemic conditions |
| AU2007263807B2 (en) * | 2006-06-29 | 2011-06-02 | F. Hoffmann-La Roche Ag | Benzimidazole derivatives, method for the production thereof, their use as FXR agonists and pharmaceutical preparations containing the same |
-
2008
- 2008-12-10 US US12/331,461 patent/US7816540B2/en not_active Expired - Fee Related
- 2008-12-12 BR BRPI0821644-4A patent/BRPI0821644A2/pt active Search and Examination
- 2008-12-12 JP JP2010538603A patent/JP5247818B2/ja not_active Expired - Fee Related
- 2008-12-12 AU AU2008340443A patent/AU2008340443A1/en not_active Abandoned
- 2008-12-12 CN CN200880121964.4A patent/CN101903375B/zh not_active Expired - Fee Related
- 2008-12-12 KR KR1020107013529A patent/KR101294480B1/ko not_active IP Right Cessation
- 2008-12-12 EP EP08865563A patent/EP2225221A2/en not_active Withdrawn
- 2008-12-12 CA CA2708372A patent/CA2708372C/en not_active Expired - Fee Related
- 2008-12-12 MX MX2010006565A patent/MX2010006565A/es active IP Right Grant
- 2008-12-12 RU RU2010129541/04A patent/RU2493153C2/ru not_active IP Right Cessation
- 2008-12-12 KR KR1020147035990A patent/KR20150004440A/ko not_active Application Discontinuation
- 2008-12-12 KR KR1020137008203A patent/KR20130041376A/ko active Application Filing
- 2008-12-12 WO PCT/EP2008/067399 patent/WO2009080555A2/en active Application Filing
- 2008-12-17 PE PE2008002105A patent/PE20091519A1/es not_active Application Discontinuation
- 2008-12-18 AR ARP080105517A patent/AR069796A1/es not_active Application Discontinuation
- 2008-12-18 CL CL2008003789A patent/CL2008003789A1/es unknown
- 2008-12-18 TW TW097149418A patent/TW200936576A/zh unknown
-
2010
- 2010-05-27 IL IL206037A patent/IL206037A0/en unknown
- 2010-06-07 ZA ZA2010/04056A patent/ZA201004056B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2010129541A (ru) | 2012-01-27 |
| US7816540B2 (en) | 2010-10-19 |
| KR20100084575A (ko) | 2010-07-26 |
| CA2708372C (en) | 2016-06-07 |
| WO2009080555A3 (en) | 2009-10-01 |
| EP2225221A2 (en) | 2010-09-08 |
| KR20130041376A (ko) | 2013-04-24 |
| CA2708372A1 (en) | 2009-07-02 |
| WO2009080555A2 (en) | 2009-07-02 |
| MX2010006565A (es) | 2010-07-05 |
| RU2493153C2 (ru) | 2013-09-20 |
| KR20150004440A (ko) | 2015-01-12 |
| BRPI0821644A2 (pt) | 2015-06-16 |
| CL2008003789A1 (es) | 2010-02-05 |
| CN101903375B (zh) | 2014-05-21 |
| ZA201004056B (en) | 2011-02-23 |
| IL206037A0 (en) | 2010-11-30 |
| PE20091519A1 (es) | 2009-09-25 |
| KR101294480B1 (ko) | 2013-08-07 |
| JP5247818B2 (ja) | 2013-07-24 |
| CN101903375A (zh) | 2010-12-01 |
| US20090163552A1 (en) | 2009-06-25 |
| TW200936576A (en) | 2009-09-01 |
| JP2011506540A (ja) | 2011-03-03 |
| AU2008340443A1 (en) | 2009-07-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR069796A1 (es) | Derivados de bencimidazol, sustituido por carboxilo o por hidroxilo, proceso para prepararlos y composiciones farmaceuticas que los contienen | |
| AR062677A1 (es) | Derivados de biaril-sulfonamida, procesos de produccion y composiciones farmaceuticas que los comprenden | |
| AR070992A1 (es) | Derivados de 2-aril-6-fenil-inidazo[1,2a]piridinas, su preparacion, composiciones farmaceuticas y su uso en enfermedades que implican los receptores nucleares nurr-1 | |
| AR072962A1 (es) | Derivados de pirimidin-4-ona sustituidos | |
| AR052568A1 (es) | Derivados de pirazolo -pirimidina como antagonstas de mglur2 | |
| AR061739A1 (es) | Nuevos derivados naftalenicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen | |
| AR084768A1 (es) | Moduladores de la senda de complemento y usos de los mismos | |
| AR079260A1 (es) | Inhibidores de bencimidazol de la produccion de leucotrienos, un procedimiento para su preparacion, composiciones farmaceuticas que los comprenden y su empleo como medicamentos en el tratamiento de trastornos mediados por leucotrienos | |
| AR080878A1 (es) | Derivados heterociclicos de ariletinilo, composiciones farmaceuticas que los contienen, metodo para prepararlos y uso de los mismos en el tratamiento de la esquizofrenia y trastornos cognitivos. | |
| AR073136A1 (es) | Compuestos de pirrol | |
| AR056025A1 (es) | Compuestos de imidazol sustituidos como inhibidores de ksp | |
| AR059328A1 (es) | Derivados de antranilamida-2-amino-heteroareno-carboxamida, un proceso para su obtencion, composiciones farmaceuticas que los contienen y el uso de estos compuestos para la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por cetp | |
| AR078797A1 (es) | Inhibidores de la caseina quinasa, composiciones farmaceuticas y sus usos para tratar trastornos del snc | |
| AR062499A1 (es) | Derivados de n-fenil pirazol y piridil pirazoles, composiciones farmaceuticas que los contienen y usos como agentes antiagregantes plaquetarios y antitromboticos. | |
| AR070263A1 (es) | Derivados de oxazepinopirimidinona arilamido sustituidos, utiles en el tratamiento y/o prevencion de enfermedades neurodegenerativas y otras, medicamentos que los contienen y proceso de preparacion e intermediarios. | |
| CU20090048A7 (es) | Nuevos derivados de diosmetina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| AR066604A1 (es) | Derivados de arilamida pirimidona, medicamentos que los contienen y usos terapeuticos para prevenir y/o tratar enfermedades neurodegenerativas fundamentalmente. | |
| CU20100157A7 (es) | Nuevos derivados dihidroindolonas, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| AR066603A1 (es) | Derivados de arilamida pirimidona | |
| AR086024A1 (es) | Derivados de 5-(fenil/piridinil-etinil)-2-piridina/2-pirimidina carboxamidas | |
| ECSP088257A (es) | Derivados de amida | |
| AR085236A1 (es) | Compuestos de benzodioxol-piperazina como moduladores de los receptores 5-hty d | |
| AR067873A1 (es) | Derivados de benzoil-piperidina como moduladores duales de receptores de 5-ht2a y de d3 | |
| CO5660263A2 (es) | Derivados de imidazol heteroaril sustituidos como antagonistas del receptor de glutamato | |
| AR046753A1 (es) | Derivados de benzoxazina y usos de los mismos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |