ATE469900T1 - Spiropiperidinderivate als antagonisten des via- rezeptors - Google Patents

Spiropiperidinderivate als antagonisten des via- rezeptors

Info

Publication number
ATE469900T1
ATE469900T1 AT07847502T AT07847502T ATE469900T1 AT E469900 T1 ATE469900 T1 AT E469900T1 AT 07847502 T AT07847502 T AT 07847502T AT 07847502 T AT07847502 T AT 07847502T AT E469900 T1 ATE469900 T1 AT E469900T1
Authority
AT
Austria
Prior art keywords
spiropiperiden
antagonists
derivatives
via receptor
receptor
Prior art date
Application number
AT07847502T
Other languages
English (en)
Inventor
Caterina Bissantz
Christophe Grundschober
Raffaello Masciadri
Hasane Ratni
Mark Rogers-Evans
Patrick Schnider
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE469900T1 publication Critical patent/ATE469900T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT07847502T 2006-12-07 2007-11-29 Spiropiperidinderivate als antagonisten des via- rezeptors ATE469900T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125634 2006-12-07
PCT/EP2007/062985 WO2008068185A1 (en) 2006-12-07 2007-11-29 Spiro-piperidine derivatives as via receptor antagonists

Publications (1)

Publication Number Publication Date
ATE469900T1 true ATE469900T1 (de) 2010-06-15

Family

ID=39295880

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07847502T ATE469900T1 (de) 2006-12-07 2007-11-29 Spiropiperidinderivate als antagonisten des via- rezeptors

Country Status (21)

Country Link
US (3) US20080146568A1 (de)
EP (1) EP2102207B1 (de)
JP (1) JP2010511661A (de)
KR (1) KR101050568B1 (de)
CN (1) CN101547923A (de)
AR (1) AR064135A1 (de)
AT (1) ATE469900T1 (de)
AU (1) AU2007328995B2 (de)
BR (1) BRPI0720004A2 (de)
CA (1) CA2670674A1 (de)
CL (1) CL2007003482A1 (de)
DE (1) DE602007006990D1 (de)
ES (1) ES2344131T3 (de)
IL (1) IL198544A (de)
MX (1) MX2009005504A (de)
NO (1) NO20091830L (de)
PE (1) PE20081252A1 (de)
RU (1) RU2009119394A (de)
TW (1) TW200838518A (de)
WO (1) WO2008068185A1 (de)
ZA (1) ZA200903496B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008077810A2 (en) 2006-12-22 2008-07-03 F. Hoffmann-La Roche Ag Spiro-piperidine derivatives
EP2722333A1 (de) 2008-04-29 2014-04-23 Novartis AG Spiroindolderivate zur Behandlung von parasitären Erkrankungen
AU2015345102A1 (en) * 2014-11-14 2017-03-30 F. Hoffmann-La Roche Ag Spiro-thiazolones
EP3414247B1 (de) * 2016-02-08 2021-04-21 F. Hoffmann-La Roche AG Spiroindolinone als ddr1-hemmer
US10538530B2 (en) * 2017-09-05 2020-01-21 Blackthorn Therapeutics, Inc. Vasopressin receptor antagonists and products and methods related thereto

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3370091A (en) * 1964-06-15 1968-02-20 Hoffmann La Roche 2 aminobenzhydrylhalides
US3531467A (en) * 1966-12-23 1970-09-29 Hoffmann La Roche Process for the preparation of 2,3,4,5-tetrahydro - 5 - aryl - 1h - 1,4 - benzodiazepine derivatives
US4209625A (en) * 1977-04-21 1980-06-24 American Hoechst Corporation Spiro[indoline-3,4'-piperidine]s
DE3818830A1 (de) * 1988-06-03 1989-12-14 Boehringer Mannheim Gmbh Bicyclische carboxamide, verfahren zu ihrer herstellung, deren vorstufen, und diese verbindungen enthaltende arzneimittel
EP0450761A1 (de) * 1990-03-02 1991-10-09 Merck & Co. Inc. Spirocyclische Oxtocin-Antagonisten
DK78692D0 (da) 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
WO1994007496A1 (en) 1992-10-07 1994-04-14 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
US5670509A (en) 1993-09-27 1997-09-23 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
IT1271026B (it) 1994-10-21 1997-05-26 Isagro Ricerca Srl Derivati dell'acido b-amminopropionico ad attivita' fungicida
US5576321A (en) 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
SK77298A3 (en) 1995-12-14 1999-01-11 Merck & Co Inc Nonpeptide derivatives, pharmaceutical composition containing them and their use
GB9601724D0 (en) * 1996-01-29 1996-03-27 Merck Sharp & Dohme Therapeutic agents
US6166209A (en) 1997-12-11 2000-12-26 Hoffmann-La Roche Inc. Piperidine derivatives
CO5150201A1 (es) 1998-09-07 2002-04-29 Hoffmann La Roche Derivados de piperidina
TWI279402B (en) 1999-08-20 2007-04-21 Banyu Pharma Co Ltd Spiro compounds having NPY antagonistic activities and agents containing the same
GB0003397D0 (en) 2000-02-14 2000-04-05 Merck Sharp & Dohme Therapeutic agents
ATE255578T1 (de) 2000-05-12 2003-12-15 Solvay Pharm Bv Piperazin- und piperidinverbindungen
DK1325011T3 (da) 2000-09-29 2004-08-16 Lilly Co Eli Fremgangsmåder og forbindelser til behandling af proliferative sygdomme
ES2303558T3 (es) 2001-11-27 2008-08-16 F. Hoffmann-La Roche Ag Derivados de benzotiazol.
FR2833948B1 (fr) 2001-12-21 2004-02-06 Sod Conseils Rech Applic Nouveaux derives de benzimidazole et leur utilisation en tant que medicament
US20040152741A1 (en) 2002-09-09 2004-08-05 Nps Allelix Corporation Arylglycine derivatives and their use as glycine transport inhibitors
AU2003263155A1 (en) 2002-09-20 2004-04-08 H. Lundbeck A/S Method for manufacture of dihydroisobenzofuran derivatives
US7582761B2 (en) 2002-10-17 2009-09-01 Amgen Inc. Vanilloid receptor ligands and their use in treatments
WO2004069809A1 (en) 2003-02-03 2004-08-19 Janssen Pharmaceutica N.V. Mercaptoimidazoles as ccr2 receptor antagonists
US7244852B2 (en) * 2003-02-27 2007-07-17 Abbott Laboratories Process for preparing 2-methylpyrrolidine and specific enantiomers thereof
EP1618090A1 (de) * 2003-04-11 2006-01-25 Novo Nordisk A/S 11 beta-hydroxysteroiddehydrogenase-typ-1-aktive verbindungen
EP1682136A4 (de) 2003-11-04 2009-06-03 Elixir Pharmaceuticals Inc Therapeutische verbindungen und ihre verwendungen
BRPI0417267A (pt) * 2003-12-22 2007-04-17 Pfizer derivados de triazol como antagonistas de vasopressina
JP2007516298A (ja) 2003-12-23 2007-06-21 アリーナ ファーマシューティカルズ， インコーポレイテッド 新規なスピロインドリンまたはスピロイソキノリン化合物、それらの使用方法および組成物
GB0400700D0 (en) * 2004-01-13 2004-02-18 Pfizer Ltd Compounds useful in therapy
CN1993323B (zh) 2004-08-05 2011-04-20 霍夫曼-拉罗奇有限公司 吲哚，吲唑或二氢吲哚衍生物
EP1802623A1 (de) 2004-10-12 2007-07-04 Novo Nordisk A/S 11beta-hydroxysteroid-dehydrogenase-typ-1-aktive spiroverbindungen
CN100551006C (zh) * 2004-10-13 2009-10-14 索尼株式会社 再现装置、成像装置以及屏幕显示方法
CA2608718A1 (en) 2005-05-18 2006-11-23 Pfizer Limited 1, 2, 4-triazole derivatives as vasopressin antagonists
US8190027B2 (en) 2006-07-12 2012-05-29 Tellabs Operations, Inc. Multifunctional and reconfigurable optical node and optical network
KR100974967B1 (ko) * 2005-07-14 2010-08-09 에프. 호프만-라 로슈 아게 Ｖ1ａ 수용체 길항물질로서의인돌-3-카본일-스피로-피페리딘 유도체
JP2009507800A (ja) 2005-09-09 2009-02-26 ユーロ−セルティーク エス．エイ． 縮合およびスピロ環化合物ならびにその使用
WO2008077810A2 (en) * 2006-12-22 2008-07-03 F. Hoffmann-La Roche Ag Spiro-piperidine derivatives
DK2125827T3 (da) * 2006-12-29 2010-12-20 Hoffmann La Roche Azaspiroderivater
JP2010515700A (ja) * 2007-01-12 2010-05-13 エフ．ホフマン−ラ ロシュ アーゲー スピロピペリジングリシンアミド誘導体

Also Published As

Publication number Publication date
KR101050568B1 (ko) 2011-07-19
EP2102207B1 (de) 2010-06-02
EP2102207A1 (de) 2009-09-23
AR064135A1 (es) 2009-03-18
US20080139553A1 (en) 2008-06-12
TW200838518A (en) 2008-10-01
IL198544A0 (en) 2010-02-17
CN101547923A (zh) 2009-09-30
MX2009005504A (es) 2009-06-03
BRPI0720004A2 (pt) 2013-12-17
RU2009119394A (ru) 2011-01-20
NO20091830L (no) 2009-07-06
US8202993B2 (en) 2012-06-19
CA2670674A1 (en) 2008-06-12
WO2008068185A1 (en) 2008-06-12
US20080139554A1 (en) 2008-06-12
ES2344131T3 (es) 2010-08-18
KR20090079255A (ko) 2009-07-21
AU2007328995B2 (en) 2012-04-26
AU2007328995A1 (en) 2008-06-12
JP2010511661A (ja) 2010-04-15
US20080146568A1 (en) 2008-06-19
PE20081252A1 (es) 2008-09-04
ZA200903496B (en) 2010-03-31
CL2007003482A1 (es) 2008-07-04
IL198544A (en) 2012-06-28
DE602007006990D1 (de) 2010-07-15

Similar Documents

Publication Publication Date Title
ATE481405T1 (de) Thiazolpyrazolopyrimidine als antagonisten des crf1-rezeptors
ATE505467T1 (de) 2-aza-bicycloä3.1.0ühexanderivate als orexin- rezeptorantagonisten
DE602005027307D1 (de) Arylanilinderivate als agonisten des beta2-adrenergen rezeptors
ATE555111T1 (de) Chinuclidinol-derivate als muscarinrezeptor- antagonisten
DE602006015607D1 (de) Thiazol-4-carboxamid-derivate als mglur5-antagonisten
EP2150115A4 (de) Cyclopropylpyrrolidinorexin-rezeptorantagonisten
ATE413874T1 (de) Neue thiophen-derivate als sphingosin-1-phosphat- 1-rezeptorantagonisten
ATE540942T1 (de) Imidazolderivate als ccr2-rezeptor-antagonisten
EP2049110A4 (de) Verbrückte diazepanorexin-rezeptorantagonisten
EP2004654A4 (de) Kinase-antagonisten
EP1981902A4 (de) Nogo-rezeptorantagonisten
ATE537151T1 (de) Pyrazolinverbindungen als mineralocorticoidrezeptorantagonisten
ATE485270T1 (de) 2-phenylindole als antagonisten des prostaglandin-d2-rezeptors
ATE496051T1 (de) Pyrazolotetrahydropyridinderivate als orexinrezeptorantagonisten
DK2081951T3 (da) Progesteron-receptorantagonister
ATE523195T1 (de) Neue thiophen-derivate als sphingosin-1-phosphat- 1-rezeptorantagonisten
ZA200800320B (en) Indol-3-carbonyl-spiro-piperidine derivatives as Via receptor antagonists
ATE509928T1 (de) 8-azabicycloä3.2.1üoktan-verbindungen als mu- opioid-rezeptorantagonisten
ATE537149T1 (de) Sulfonyl-pyrazolinyl-1-carboxamidinderivate als 5-ht6-antagonisten
DE602007012300D1 (de) Chiniclidinderivate von (hetero)arylcycloheptancarbonsäuren als antagonisten am muskarinrezeptor
ATE477243T1 (de) 2-aminochinoline als 5-ht(5a)- rezeptorantagonisten
EP2254413A4 (de) Imidazobenzazepin-cgrp-rezeptorantagonisten
DE602006019624D1 (de) Piperidin-4-yl-pyridazin-3-yl-aminderivate als schnell dissoziierende antagonisten des dopamin-2-rezeptors
ATE547407T1 (de) Alkylthiopyrimidine als crth2-antagonisten
DK1973886T3 (da) Prokineticin-1-receptor-antagonister

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 2102207

Country of ref document: EP