MX2012007273A - Pteridinonas como inhibidores de la quinasa tipo polo. - Google Patents

Pteridinonas como inhibidores de la quinasa tipo polo.

Info

Publication number
MX2012007273A
MX2012007273A MX2012007273A MX2012007273A MX2012007273A MX 2012007273 A MX2012007273 A MX 2012007273A MX 2012007273 A MX2012007273 A MX 2012007273A MX 2012007273 A MX2012007273 A MX 2012007273A MX 2012007273 A MX2012007273 A MX 2012007273A
Authority
MX
Mexico
Prior art keywords
pteridinones
polo
kinase
inhibitors
compounds
Prior art date
Application number
MX2012007273A
Other languages
English (en)
Inventor
Simeon Bowers
Roy K Hom
Anh P Truong
Xiaocong Michael Ye
Danielle L Aubele
Jennifer Sealy
Yong-Liang Zhu
Robert A Galemmo Jr
Dean Richard Artis
R J Effrey Neitz
Marc Adler
John P Anderson
Paul Beroza
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of MX2012007273A publication Critical patent/MX2012007273A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/12—Heterocyclic compounds containing pteridine ring systems containing pteridine ring systems condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

La presente invención provee compuestos que tienen una estructura de acuerdo con la Fórmula (I) o una sal o solvato de la misma, en donde el anillo A, X, R1, R2, R3, R4, R5 y R6, son definidos en la presente. La invención provee además composiciones farmacéuticas que incluyen los compuestos de la invención y métodos para formar y usar los compuestos y composiciones de la invención, v.gr., en el tratamiento y prevención de varios trastornos, tales como enfermedad de Parkinson.
MX2012007273A 2009-12-23 2010-12-21 Pteridinonas como inhibidores de la quinasa tipo polo. MX2012007273A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28998009P 2009-12-23 2009-12-23
US40479710P 2010-10-08 2010-10-08
PCT/US2010/061535 WO2011079114A1 (en) 2009-12-23 2010-12-21 Pteridinones as inhibitors of polo - like kinase

Publications (1)

Publication Number Publication Date
MX2012007273A true MX2012007273A (es) 2012-12-17

Family

ID=43530443

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012007273A MX2012007273A (es) 2009-12-23 2010-12-21 Pteridinonas como inhibidores de la quinasa tipo polo.

Country Status (14)

Country Link
US (5) US8445503B2 (es)
EP (1) EP2516441B1 (es)
JP (1) JP2013515734A (es)
KR (1) KR20120120252A (es)
CN (1) CN102762568A (es)
AU (1) AU2010336509A1 (es)
BR (1) BR112012015714A2 (es)
CA (1) CA2783258A1 (es)
IL (1) IL220563A0 (es)
MX (1) MX2012007273A (es)
RU (1) RU2012131124A (es)
SG (1) SG181908A1 (es)
WO (2) WO2011079118A1 (es)
ZA (1) ZA201204136B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013148740A1 (en) * 2012-03-26 2013-10-03 The Trustees Of Columbia University In The City Of New York 4–aminopyridine as a therapeutic agent for spinal muscular atrophy
UA110697C2 (uk) * 2010-02-03 2016-02-10 Сігнал Фармасьютікалз, Елелсі ЗАСТОСУВАННЯ ІНГІБІТОРІВ TOR-КІНАЗИ ДЛЯ ЛІКУВАННЯ ПУХЛИННИХ ЗАХВОРЮВАНЬ У ПАЦІЄНТА ЗІ ЗНИЖЕНИМ РІВНЕМ БІЛКА pAMPK ТА/АБО АКТИВНОСТІ AMPK
JP2013539759A (ja) 2010-10-08 2013-10-28 エラン ファーマシューティカルズ，インコーポレイテッド ポロ様キナーゼの阻害剤
JP5931933B2 (ja) * 2011-02-25 2016-06-08 武田薬品工業株式会社 Ｎ−置換オキサジノプテリジンおよびオキサジノプテリジノン
AU2013326867B2 (en) * 2012-10-05 2018-03-08 Rigel Pharmaceuticals, Inc. GDF-8 inhibitors
AU2013203714B2 (en) 2012-10-18 2015-12-03 Signal Pharmaceuticals, Llc Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
WO2014127815A1 (en) * 2013-02-21 2014-08-28 Boehringer Ingelheim International Gmbh Dihydropteridinones i
MX2015014599A (es) 2013-04-17 2016-03-03 Signal Pharm Llc Terapia de combinacion que comprende un inhibidor de tor cinasa y un analogo de citidina para tracar cancer.
WO2014172430A1 (en) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Combination therapy comprising a tor kinase inhibitor and n-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide for treating cancer
EA030726B1 (ru) 2013-04-17 2018-09-28 СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи ФАРМАЦЕВТИЧЕСКИЕ СОСТАВЫ, СПОСОБЫ, ТВЕРДЫЕ ФОРМЫ И СПОСОБЫ ПРИМЕНЕНИЯ, ОТНОСЯЩИЕСЯ К 1-ЭТИЛ-7-(2-МЕТИЛ-6-(1H-1,2,4-ТРИАЗОЛ-3-ИЛ)ПИРИДИН-3-ИЛ)-3,4-ДИГИДРОПИРАЗИНО[2,3-b]ПИРАЗИН-2(1H)-ОНУ
TWI674897B (zh) 2013-04-17 2019-10-21 美商標誌製藥公司 藉二氫吡并吡化合物組合療法的癌症治療方法
CA2908830C (en) 2013-04-17 2021-12-07 Signal Pharmaceuticals, Llc Treatment of cancer with dihydropyrazino-pyrazines
BR112015026297B1 (pt) 2013-04-17 2022-08-23 Signal Pharmaceuticals, Llc Uso de um inibidor da quinase tor e quinazolinona 5-substituída, composição farmacêutica que os compreende, e kit
SG10201801965RA (en) 2013-04-17 2018-04-27 Signal Pharm Llc Treatment of cancer with dihydropyrazino-pyrazines
CN105407892B (zh) 2013-05-29 2019-05-07 西格诺药品有限公司 一种化合物的药物组合物、其固体形式及它们的使用方法
CN103819400B (zh) * 2013-09-16 2016-05-04 江西师范大学 一种多组分反应合成具有不对称结构1.4-二氢吡啶及其衍生物的方法
RU2550346C2 (ru) * 2013-09-26 2015-05-10 Общество с ограниченной ответственностью "Отечественные Фармацевтические Технологии" ООО"ФармТех" Новые химические соединения (варианты) и их применение для лечения онкологических заболеваний
NZ714742A (en) 2014-04-16 2017-04-28 Signal Pharm Llc Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
US9512129B2 (en) 2014-04-16 2016-12-06 Signal Pharmaceuticals, Llc Solid forms comprising 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one and a coformer
CN104496906B (zh) * 2014-11-05 2016-03-23 上海浩登材料科技有限公司 一种咪唑的制备方法
CN104402823B (zh) * 2014-11-05 2016-03-23 上海浩登材料科技有限公司 一种1，2-二甲基咪唑的制备方法
WO2017002089A1 (en) 2015-07-02 2017-01-05 Wockhardt Limited Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections
KR101796779B1 (ko) 2015-12-22 2017-11-10 한국화학연구원 다이하이드로프테리딘-온 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 pi3 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물
JOP20170169A1 (ar) 2016-08-29 2019-01-30 Novartis Ag مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو
EP3512837B1 (en) * 2016-09-15 2020-07-22 Boehringer Ingelheim International GmbH Pyridine and pyrazine compounds as inhibitors of ripk2
CN106543185B (zh) * 2016-11-10 2017-12-15 吉林大学 一种靶向泛素化降解plk1和brd4蛋白的化合物及其应用
CA3067585A1 (en) 2017-06-22 2018-12-27 Celgene Corporation Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection
AU2019227250B2 (en) 2018-02-28 2021-11-04 Novartis Ag 10-(di(phenyl)methyl)-4-hydroxy-8,9,9a,10-tetrahydro-7H-pyrrolo[1 ',2':4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza
CN108794493B (zh) * 2018-04-28 2020-04-24 北京施安泰医药技术开发有限公司 四氢吡咯并[2,1-h]蝶啶-6(5H)-酮衍生物、其药物组合物、制备方法和应用
WO2020076728A1 (en) 2018-10-08 2020-04-16 Takeda Pharmaceutical Company Limited SUBSTITUTED OXAZINOPTERIDINONES AS INHIBITORS OF mTOR
CN114369064B (zh) * 2022-01-10 2023-12-19 北京莱瑞森医药科技有限公司 一种西地那非中间体的制备方法
CN114671810B (zh) * 2022-03-21 2024-03-22 济南鸿湾生物技术有限公司 一种咪唑苯脲的制备方法
WO2023216910A1 (zh) * 2022-05-07 2023-11-16 苏州浦合医药科技有限公司 取代的双环杂芳基化合物作为usp1抑制剂

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2029651C (en) * 1989-11-17 2000-06-06 David D. Davey Tricyclic pteridinones and a process for their preparation
US6025489A (en) * 1989-11-17 2000-02-15 Schering Aktiengesellschaft Tricyclic pteridinones and a process for their preparation
US6129387A (en) * 1999-07-06 2000-10-10 Moore North America, Inc. Pressure sensitive library card holder
US6806272B2 (en) 2001-09-04 2004-10-19 Boehringer Ingelheim Pharma Kg Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
IL160440A0 (en) 2001-09-04 2004-07-25 Boehringer Ingelheim Pharma Novel dihydropteridinones, method for producing the same and the use thereof as medicaments
EP1312365A1 (de) 2001-11-20 2003-05-21 Jenapharm GmbH & Co. KG Pteridinone zur Behandlung der erektilen Dysfunktion
WO2004076454A1 (de) * 2003-02-26 2004-09-10 Boehringer Ingelheim Pharma Gmbh & Co Kg Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel
WO2005079799A1 (en) 2004-02-13 2005-09-01 Glaxo Group Limited 4-acyl-piperazines as anti-viral agents
US20060074088A1 (en) * 2004-08-14 2006-04-06 Boehringer Ingelheim International Gmbh Dihydropteridinones for the treatment of cancer diseases
US7728134B2 (en) * 2004-08-14 2010-06-01 Boehringer Ingelheim International Gmbh Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
US7439358B2 (en) * 2006-02-08 2008-10-21 Boehringer Ingelheim International Gmbh Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
CA2649324A1 (en) 2006-04-12 2007-10-25 Jean-Damien Charrier Tetrahydropteridines useful as inhibitors of protein kinases
CN101448830A (zh) 2006-05-19 2009-06-03 阿斯利康(瑞典)有限公司 作为抗增殖剂的二氢碟啶化合物
EP2078018B1 (en) 2006-10-19 2012-03-14 Signal Pharmaceuticals LLC Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors
ES2359467T3 (es) 2006-12-14 2011-05-23 Vertex Pharmceuticals Incorporated Compuestos útiles como inhibidores de proteína quinasas.
JP2010208945A (ja) * 2007-06-01 2010-09-24 Mitsubishi Tanabe Pharma Corp 複素環化合物
EP2185559A1 (en) 2007-08-03 2010-05-19 Boehringer Ingelheim International GmbH Crystalline form of a dihydropteridione derivative
US8461149B2 (en) 2007-08-15 2013-06-11 Vertex Pharmaceuticals Incorporated Compounds useful as protein kinase inhibitors
JP2009073743A (ja) * 2007-09-19 2009-04-09 Taiho Yakuhin Kogyo Kk 新規な縮合環式ピリミジン化合物又はその塩、及びその医薬組成物
CA2699607A1 (en) 2007-09-25 2009-04-02 Takeda Pharmaceutical Company Limited Polo-like kinase inhibitors
US8598172B2 (en) 2007-12-04 2013-12-03 Nerviano Medical Sciences S.R.L. Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors
EP2247748A2 (en) 2008-02-13 2010-11-10 Elan Pharma International Limited Alpha-synuclein kinase
EP2112152A1 (en) 2008-04-22 2009-10-28 GPC Biotech AG Dihydropteridinones as Plk Inhibitors
GB0807451D0 (en) 2008-04-24 2008-05-28 Chroma Therapeutics Ltd Inhibitors of PLK
PT2364314E (pt) 2008-12-09 2014-06-09 Gilead Sciences Inc Moduladores de recetores toll-like
CN101544642A (zh) * 2009-03-12 2009-09-30 山东省医药工业研究所 4-蝶啶氨类化合物及其制备和用途
WO2011025889A1 (en) * 2009-08-28 2011-03-03 Takeda Pharmaceutical Company Limited HEXAHYDROOXAZINOPTERINE COMPOUNDS FOR USE AS mTOR INHIBITORS
CN102020643A (zh) 2009-09-22 2011-04-20 上海恒瑞医药有限公司 二氢喋啶酮类衍生物、其制备方法及其在医药上的应用
US20120329803A1 (en) 2010-02-17 2012-12-27 Boehringer Ingelheim International Gmbh Dihydropteridinones, method for production and use thereof

Also Published As

Publication number Publication date
US20150126502A1 (en) 2015-05-07
AU2010336509A1 (en) 2012-07-19
IL220563A0 (en) 2012-08-30
EP2516441A1 (en) 2012-10-31
US20130331376A1 (en) 2013-12-12
US20130231335A1 (en) 2013-09-05
BR112012015714A2 (pt) 2017-04-25
KR20120120252A (ko) 2012-11-01
US8541418B2 (en) 2013-09-24
EP2516441B1 (en) 2015-01-21
ZA201204136B (en) 2013-08-28
RU2012131124A (ru) 2014-01-27
US20110212942A1 (en) 2011-09-01
CN102762568A (zh) 2012-10-31
US8445503B2 (en) 2013-05-21
WO2011079118A1 (en) 2011-06-30
WO2011079114A1 (en) 2011-06-30
US20110207716A1 (en) 2011-08-25
CA2783258A1 (en) 2011-06-30
SG181908A1 (en) 2012-08-30
JP2013515734A (ja) 2013-05-09

Similar Documents

Publication Publication Date Title
MX2012007273A (es) Pteridinonas como inhibidores de la quinasa tipo polo.
AU2012258977A8 (en) Inhibitors of LRRK2 kinase activity
WO2012048129A3 (en) Inhibitors of polo-like kinase
TW200726753A (en) 2,4-diamino-pyrimidines as aurora inhibitors
IN2012DN01233A (es)
MY147390A (en) Substituted isoindoles as bace inhibitors and their use
MX2011008276A (es) Inhibidores de quinasa jun n-terminal.
SG179120A1 (en) Novel compounds
EA200900023A1 (ru) Применение замещенных 2-аминотетралинов для изготовления лекарственного средства для предупреждения, облегчения и/или лечения разных видов боли
MX2010009752A (es) Compuestos de oxadiazoantraceno para el tratamiento de diabetes.
MX2009000333A (es) Pirrilopirimidinas para composiciones farmaceuticas.
MY149512A (en) Pyrazolylaminopyridine derivatives useful as kinase inhibitors
MX2009009590A (es) Aminopirimidinas utiles como inhibidores de proteinas cinasas.
MX2011011661A (es) Compuestos 1-cianoetilheterociclilcarboxamida sustituidos 750.
TW200734311A (en) New compounds
MX2011012337A (es) Nuevos derivados de pirimidina y su uso en el tratamiento de cancer y de otras enfermedades.
TW200630374A (en) Thiazolyldihydroindazoles
JO3007B1 (ar) مركبات و تركيبات كمثبطات كيناز بروتين
UA94944C2 (ru) 2,4-диаминопиримидины как ингибиторы киназ, которые принимают участие в регуляции клеточного цикла
TW200806300A (en) New therapeutic combinations for the treatment of depression
MY169274A (en) Fused, tricyclic sulfonamide inhibitors of gamma secretase
EP2091328A4 (en) SPIROPIPERIDININHIBITORS OF BETA-SECRETASE FOR THE TREATMENT OF ALZHEIMER DISEASE
MX2010009022A (es) Derivados 16 alfa, 17 alfa-acetal glucocorticoesteroideos y su uso.
MX2009011059A (es) Aminopirimidinas utiles como inhibidores de cinasas.
MY167898A (en) Co-crystals and salts of ccr3-inhibitors

Legal Events

Date Code Title Description
FG Grant or registration