MX2020008959A - Derivados de 10-(di(fenil)metil)-4-hidroxi-8,9,9a,10-tetrahidro-7h -pirrolo[1',2':4,5]pirazino[1,2-b]piridazina-3,5-diona y compuestos relacionados como inhibidores de la replicacion del ortomixovirus para el tratamiento de influenza. - Google Patents

Derivados de 10-(di(fenil)metil)-4-hidroxi-8,9,9a,10-tetrahidro-7h -pirrolo[1',2':4,5]pirazino[1,2-b]piridazina-3,5-diona y compuestos relacionados como inhibidores de la replicacion del ortomixovirus para el tratamiento de influenza.

Info

Publication number
MX2020008959A
MX2020008959A MX2020008959A MX2020008959A MX2020008959A MX 2020008959 A MX2020008959 A MX 2020008959A MX 2020008959 A MX2020008959 A MX 2020008959A MX 2020008959 A MX2020008959 A MX 2020008959A MX 2020008959 A MX2020008959 A MX 2020008959A
Authority
MX
Mexico
Prior art keywords
pyrazino
pyrrolo
pyridazine
tetrahydro
hydroxy
Prior art date
Application number
MX2020008959A
Other languages
English (en)
Inventor
Qian Zhao
Daniel Poon
Lifeng Wan
James R Manning
Xiaojing Michael Wang
Aregahegn Yifru
Rama Jain
Maxime Dauphinais
Dennis Christofer Koester
Vanessa Marx
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2020008959A publication Critical patent/MX2020008959A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La descripción actual se refiere a derivados de 10-(di(fenil)metil)-4-hidroxi-8,9,9a,10-tetrahidro- 7H-pirrolo[1',2':4,5]pirazino[1,2-b]piridazina-3,5-diona y compuestos relacionados de la Fórmula (A) como inhibidores de la replicación del ortomixovirus para el tratamiento de influenza. (ver fórmula) Un compuesto específico preferido es, por ejemplo, (9aR,10S)-10-((S)-(4-fluorofenil)(3- (trifluorometil)fenil)metil)- 4-hidroxi-8,9,9a,10-tetrahidro-7H-pirrolo[1',2':4,5]pirazino[1,2 b]piridazin-3,5- diona (ejemplo 1).
MX2020008959A 2018-02-28 2019-02-26 Derivados de 10-(di(fenil)metil)-4-hidroxi-8,9,9a,10-tetrahidro-7h -pirrolo[1',2':4,5]pirazino[1,2-b]piridazina-3,5-diona y compuestos relacionados como inhibidores de la replicacion del ortomixovirus para el tratamiento de influenza. MX2020008959A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862636378P 2018-02-28 2018-02-28
PCT/IB2019/051549 WO2019166950A1 (en) 2018-02-28 2019-02-26 10-(di(phenyl)methyl)-4-hydroxy-8,9,9a,10-tetrahydro-7h-pyrrolo[1 ',2':4,5]pyrazino[1,2-b]pyridazine-3,5-dione derivatives and related compounds as inhibitors of the orthomyxovirus replication for treating influenza

Publications (1)

Publication Number Publication Date
MX2020008959A true MX2020008959A (es) 2020-10-05

Family

ID=65911219

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020008959A MX2020008959A (es) 2018-02-28 2019-02-26 Derivados de 10-(di(fenil)metil)-4-hidroxi-8,9,9a,10-tetrahidro-7h -pirrolo[1',2':4,5]pirazino[1,2-b]piridazina-3,5-diona y compuestos relacionados como inhibidores de la replicacion del ortomixovirus para el tratamiento de influenza.
MX2023000084A MX2023000084A (es) 2018-02-28 2020-08-27 Derivados de 10-(di(fenil)metil)-4-hidroxi-8,9,9a,10-tetrahidro-7h -pirrolo[1',2':4,5]pirazino[1,2-b]piridazina-3,5-diona y compuestos relacionados como inhibidores de la replicacion del ortomixovirus para el tratamiento de influenza.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023000084A MX2023000084A (es) 2018-02-28 2020-08-27 Derivados de 10-(di(fenil)metil)-4-hidroxi-8,9,9a,10-tetrahidro-7h -pirrolo[1',2':4,5]pirazino[1,2-b]piridazina-3,5-diona y compuestos relacionados como inhibidores de la replicacion del ortomixovirus para el tratamiento de influenza.

Country Status (19)

Country Link
US (2) US11629149B2 (es)
EP (1) EP3759113A1 (es)
JP (3) JP7065989B2 (es)
KR (2) KR20230031990A (es)
CN (1) CN111801333A (es)
AU (1) AU2019227250B2 (es)
BR (1) BR112020017121A2 (es)
CA (1) CA3092544A1 (es)
CL (1) CL2020002202A1 (es)
CR (1) CR20200372A (es)
EA (1) EA202091696A1 (es)
IL (2) IL276901B2 (es)
MX (2) MX2020008959A (es)
NZ (1) NZ767072A (es)
PE (1) PE20210403A1 (es)
PH (1) PH12020500660A1 (es)
SG (1) SG11202007718SA (es)
UA (1) UA126253C2 (es)
WO (1) WO2019166950A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2881776T3 (es) 2016-03-08 2021-11-30 Novartis Ag Compuestos tricíclicos útiles para tratar las infecciones por ortomixovirus
JOP20170169A1 (ar) 2016-08-29 2019-01-30 Novartis Ag مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو
CR20200372A (es) * 2018-02-28 2020-10-26 Novartis Ag Derivados de 10-(di(fenil)metil)-4-hidroxi8,9,9a,10-tetrahidro-7h-pirrolo (1`, 2`:4-5) pirazino (1,2-b) piridazina-3, 5-diona y compuestos relacionados como inhibidores de la replicación del ortomixo virus para el tratamiento de la influenza

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8501542D0 (en) 1985-01-22 1985-02-20 Erba Farmitalia 4 5 6 7-tetrahydro-imidazo(4 5-clpyridine derivatives
AUPM354694A0 (en) 1994-01-27 1994-02-17 Biota Scientific Management Pty Ltd Chemical compounds
PT2266958T (pt) 2001-08-10 2017-05-10 Shionogi & Co Agente antiviral
WO2004078163A2 (en) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
TW200526635A (en) 2003-12-22 2005-08-16 Shionogi & Co Hydroxypyrimidinone derivative having HIV integrase inhibitory activity
CA2557926A1 (en) 2004-03-09 2005-09-22 Monica Donghi Hiv integrase inhibitors
FR2901795A1 (fr) 2006-05-30 2007-12-07 Fourtillan Snc Derives de pyrimidino[1',6'-1,2]pyrido[3,4-b]indoles et leur utilisation en therapeutique
WO2010050468A1 (ja) 2008-10-31 2010-05-06 塩野義製薬株式会社 カテコール基を有するセファロスポリン類
WO2010110231A1 (ja) 2009-03-26 2010-09-30 塩野義製薬株式会社 置換された３－ヒドロキシ－４－ピリドン誘導体
TWI518084B (zh) 2009-03-26 2016-01-21 鹽野義製藥股份有限公司 哌喃酮與吡啶酮衍生物之製造方法
PL2444400T3 (pl) * 2009-06-15 2018-08-31 Shionogi & Co., Ltd. Podstawiona policykliczna pochodna karbamoilopirydonowa
KR20120120252A (ko) 2009-12-23 2012-11-01 엘란 파마슈티칼스, 인크. 폴로-유사 키나제의 억제제로서의 프테리디논
WO2011123678A2 (en) 2010-03-31 2011-10-06 Arqule, Inc. Substituted benzo-pyrido-triazolo-diazepine compounds
US20120195857A1 (en) 2010-08-12 2012-08-02 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
PL2620436T3 (pl) 2010-09-24 2018-10-31 Shionogi & Co., Ltd. Prolek podstawionej policyklicznej pochodnej karbamoilopirydonowej
US9328075B2 (en) 2011-05-05 2016-05-03 St. Jude Children's Research Hospital Pyrimidinone compounds and methods for treating influenza
KR20140090197A (ko) 2011-10-12 2014-07-16 시오노기세야쿠 가부시키가이샤 인터그라아제 억제 활성을 갖는 폴리사이클릭 피리돈 유도체
KR101520302B1 (ko) 2012-09-20 2015-05-15 (주)셀트리온 돌라스타틴 10 유도체, 그의 제조방법 및 그를 포함하는 항암제 조성물
SG11201503946UA (en) 2013-01-08 2015-09-29 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
JP6485817B2 (ja) 2013-08-21 2019-03-20 ヤンセン バイオファーマ インク． 抗ウイルス化合物
WO2015038665A1 (en) 2013-09-11 2015-03-19 University Of Southern California A composition of stem cells having highly expressed fas ligand
WO2015038655A1 (en) * 2013-09-12 2015-03-19 Alios Biopharma, Inc. Aza-pyridone compounds and uses thereof
DK3030549T3 (da) * 2013-09-12 2019-05-13 Janssen Biopharma Inc Pyridazinonforbindelser og anvendelser deraf
WO2016005330A1 (en) 2014-07-07 2016-01-14 F. Hoffmann-La Roche Ag Dihydropyridopyrazine-1,8-diones and their use in the treatment, amelioration or prevention of viral diseases
WO2016145103A1 (en) * 2015-03-11 2016-09-15 Alios Biopharma, Inc. Aza-pyridone compounds and uses thereof
ES2881776T3 (es) * 2016-03-08 2021-11-30 Novartis Ag Compuestos tricíclicos útiles para tratar las infecciones por ortomixovirus
US10183945B2 (en) * 2016-03-10 2019-01-22 Alios Biopharma, Inc. Method of preparing AZA-pyridone compounds
WO2018005863A1 (en) 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Pyrimidine-based compounds for the treatment of cancer
MX2019000200A (es) 2016-07-01 2019-09-26 G1 Therapeutics Inc Agentes antiproliferativos basados en pirimidina.
CR20190123A (es) * 2016-08-10 2019-04-30 Shionogi & Co Composiciones farmacéuticas que contienen derivados de piridona policíclicos sustituídos y profármacos de los mismos
JOP20170169A1 (ar) * 2016-08-29 2019-01-30 Novartis Ag مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو
JP2019059697A (ja) 2017-09-28 2019-04-18 塩野義製薬株式会社 置換された多環性ピリダジン誘導体およびそのプロドラッグ
CN111848615B (zh) 2018-01-17 2022-05-17 江西彩石医药科技有限公司 吡啶酮衍生物及包含其的抗流感病毒药物组合物
CN110041327B (zh) * 2018-01-17 2022-01-21 江西彩石医药科技有限公司 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用
CR20200372A (es) 2018-02-28 2020-10-26 Novartis Ag Derivados de 10-(di(fenil)metil)-4-hidroxi8,9,9a,10-tetrahidro-7h-pirrolo (1`, 2`:4-5) pirazino (1,2-b) piridazina-3, 5-diona y compuestos relacionados como inhibidores de la replicación del ortomixo virus para el tratamiento de la influenza

Also Published As

Publication number Publication date
JP2022048391A (ja) 2022-03-25
KR20200125654A (ko) 2020-11-04
AU2019227250B2 (en) 2021-11-04
IL276901B1 (en) 2023-11-01
IL305957A (en) 2023-11-01
JP2024033009A (ja) 2024-03-12
EP3759113A1 (en) 2021-01-06
KR102521320B1 (ko) 2023-04-13
CL2020002202A1 (es) 2021-01-15
IL276901A (en) 2020-10-29
UA126253C2 (uk) 2022-09-07
AU2019227250A1 (en) 2020-09-03
JP2021514984A (ja) 2021-06-17
NZ767072A (en) 2024-03-22
US11629149B2 (en) 2023-04-18
CN111801333A (zh) 2020-10-20
WO2019166950A1 (en) 2019-09-06
IL276901B2 (en) 2024-03-01
US20230322793A1 (en) 2023-10-12
EA202091696A1 (ru) 2021-01-27
BR112020017121A2 (pt) 2020-12-22
CR20200372A (es) 2020-10-26
CA3092544A1 (en) 2019-09-06
SG11202007718SA (en) 2020-09-29
KR20230031990A (ko) 2023-03-07
MX2023000084A (es) 2023-02-09
US20200407366A1 (en) 2020-12-31
PH12020500660A1 (en) 2021-06-28
JP7065989B2 (ja) 2022-05-12
PE20210403A1 (es) 2021-03-02

Similar Documents

Publication Publication Date Title
CL2020002202A1 (es) Derivados de 10-(di(fenil)metil)-4-hidroxi-8,9,9a,10-tetrahidro-7h-pirrolo [1',2':4,5]pirazino[1,2-b]piridazina-3,5-diona y compuestos relacionados como inhibidores de la replicación del ortomixovirus para el tratamiento de la influenza
UY37847A (es) Sulfonilureas y sulfoniltioureas útiles como inhibidores de nlrp3
CL2017001426A1 (es) Nuevos compuestos de 5-amino-6h-tiazolo[4,5-d]pirimidin-2,7-diona 3-sustituidos para el tratamiento y profilaxis de infecciones virales.
PE20170666A1 (es) 2-(morfolin-4-il)-1,7-naftiridinas
CY1122046T1 (el) Δικυκλικα ετεροκυκλικα παραγωγα ως αναστολεις βρομοτομεων
PE20141540A1 (es) Derivados de 2-amino-4-(piridin-2-il)-5,6-dihidro-4h-1,3-oxazina y su uso como inhibidores de bace-1 y/o bace-2
CY1119499T1 (el) Ενωσεις 6,7-διυδροπυραζολο[1,5-α]πυραζιν-4(5η)-ονης και η χρηση τους ως αρνητικοι αλλοστερικοι τροποποιητες των υποδοχεων mglur2
PE20170189A1 (es) Nuevos derivados de pirazolo pirimidina y su uso como inhibidores de malt1
PE20190811A1 (es) Derivados de pirazolopirimidinas como inhibidor de quinasa
MX2007007103A (es) Derivados espiro como inhibidores de lipoxigenasa.
CL2008003786A1 (es) Compuestos derivados de 1h-pirazolo[3,4-c]piridazinilo, 1h pirazolo[3,4-b]piridinilo, ah-pirazolo[3,4-c]piridinilo e indazolilo, inhibidores no nucleosidicos de la transcriptasa reversa del vih-1(nnrti); composicion fa<rma<ceutica que comprende a dichos compuestos; y su uso para tratar enfermedades mediadas por viv, sida o arc.
MX2016016530A (es) Inhibidores de fosfatidilinositol 3-quinasa.
EA201591804A1 (ru) Производные 2-((4-амино-3-(3-фтор-5-гидроксифенил)-1h-пиразоло[3,4-d]пиримидин-1-ил)метил)-3-(2-(трифторметил)бензил)хиназолин-4(3h)-она и их применение в качестве ингибиторов фосфоинозитид-3-киназы
EA201101621A1 (ru) Производные бензоксазолона в качестве ингибиторов альдостеронсинтазы
CY1124346T1 (el) ΠΑΡΑΓΩΓΑ ΧΡΩΜΑΝΙΟΥ, ΙΣΟΧΡΩΜΑΝΙΟΥ ΚΑΙ ΔΙΥΔΡΟΪΣΟΒΕΝΖΟΦΟΥΡΑΝΙΟΥ ΩΣ mGluR2-APNHTIKOI ΑΛΛΟΣΤΕΡΙΚΟΙ ΔΙΑΜΟΡΦΩΤΕΣ, ΣΥΝΘΕΣΕΙΣ, ΚΑΙ ΧΡΗΣΗ ΑΥΤΩΝ
BR112017009012A2 (pt) derivados de anel benzo de seis membros como inibidor de dpp-4 e seu uso
CO2022000749A2 (es) Inhibidores de monoacilglicerol lipasa (magl) heterocíclicos
EA201991355A1 (ru) Производные имидазо[1,5-а]пиразина в качестве ингибиторов pi3kдельта
BR112021022255A2 (pt) Composto usado como inibidor de quinase e aplicação do mesmo
CL2023002486A1 (es) Compuestos heterocíclicos como inhibidores de delta-5 desaturasa y métodos de uso
PH12020550761A1 (en) 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZINONE DERIVATIVE AND MEDICAL USE THEREOF
CO2019013254A2 (es) Compuestos bicíclicos 5,6-fusionados y composiciones para el tratamiento de enfermedades parasitarias
BR112017007027A2 (pt) melhorias nos compostos orgânicos ou relativas aos mesmos
EA201001889A1 (ru) Производные дибензотиазепина и их применение
CY1122837T1 (el) Θεραπεια της γυροειδους αλωπεκιας