UY37847A - Sulfonilureas y sulfoniltioureas útiles como inhibidores de nlrp3 - Google Patents
Sulfonilureas y sulfoniltioureas útiles como inhibidores de nlrp3Info
- Publication number
- UY37847A UY37847A UY0001037847A UY37847A UY37847A UY 37847 A UY37847 A UY 37847A UY 0001037847 A UY0001037847 A UY 0001037847A UY 37847 A UY37847 A UY 37847A UY 37847 A UY37847 A UY 37847A
- Authority
- UY
- Uruguay
- Prior art keywords
- nlrp3
- compounds
- sulfonilureas
- sulfoniltioureas
- inhibitors
- Prior art date
Links
- 102000000874 Pyrin Domain-Containing 3 Protein NLR Family Human genes 0.000 title abstract 2
- 108010001946 Pyrin Domain-Containing 3 Protein NLR Family Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229940100389 Sulfonylurea Drugs 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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Abstract
La presente invención hace referencia a sulfonilureas y sulfonilureas que comprenden un anillo heteroarilo que contiene nitrógeno de 5 miembros unido al grupo sulfonilo, en donde el anillo heteroarilo se sustituye con un grupo R1 que contiene nitrógeno, en donde R1 contiene de 1 a 7 átomos diferentes de hidrógeno o halógeno. La presente invención también hace referencia a sales, solvatos y profármacos de dichos compuestos, a composiciones farmacéuticas de dichos compuestos y al uso de dichos compuestos en el tratamiento y prevención de trastornos médicos y enfermedades, especialmente mediante la inhibición de NLRP3.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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GBGB1713082.4A GB201713082D0 (en) | 2017-08-15 | 2017-08-15 | Novel compounds |
GBGB1718563.8A GB201718563D0 (en) | 2017-11-09 | 2017-11-09 | Novel compounds |
GBGB1721731.6A GB201721731D0 (en) | 2017-12-22 | 2017-12-22 | Novel compounds |
GBGB1721726.6A GB201721726D0 (en) | 2017-12-22 | 2017-12-22 | Novel compounds |
GBGB1810983.5A GB201810983D0 (en) | 2018-07-04 | 2018-07-04 | Novel compounds |
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UY37847A true UY37847A (es) | 2019-03-29 |
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UY0001037847A UY37847A (es) | 2017-08-15 | 2018-08-15 | Sulfonilureas y sulfoniltioureas útiles como inhibidores de nlrp3 |
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CN (2) | CN111093773A (es) |
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2018
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- 2018-08-15 TW TW107128475A patent/TW201910316A/zh unknown
- 2018-08-15 UY UY0001037847A patent/UY37847A/es not_active Application Discontinuation
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BR112020003014A2 (pt) | 2020-07-28 |
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CN112789264A (zh) | 2021-05-11 |
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EP3837242A1 (en) | 2021-06-23 |
WO2020035465A1 (en) | 2020-02-20 |
MA49903A (fr) | 2020-06-24 |
US20210130359A1 (en) | 2021-05-06 |
US20210163412A1 (en) | 2021-06-03 |
CN111093773A (zh) | 2020-05-01 |
CA3071150A1 (en) | 2019-02-21 |
CL2020000367A1 (es) | 2020-08-28 |
JP2020531453A (ja) | 2020-11-05 |
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