SG11202001166RA - Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors - Google Patents

Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors

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Publication number
SG11202001166RA
SG11202001166RA SG11202001166RA SG11202001166RA SG11202001166RA SG 11202001166R A SG11202001166R A SG 11202001166RA SG 11202001166R A SG11202001166R A SG 11202001166RA SG 11202001166R A SG11202001166R A SG 11202001166RA SG 11202001166R A SG11202001166R A SG 11202001166RA
Authority
SG
Singapore
Prior art keywords
sulfonylthioureas
sulfonylureas
nlrp3 inhibitors
nlrp3
inhibitors
Prior art date
Application number
SG11202001166RA
Inventor
Matthew Cooper
David Miller
Angus Macleod
Stephen Thom
Stephen St-Gallay
Jonathan Shannon
Thomas Alanine
Stuart Onions
Ian Strutt
Arregui Jokin Carrillo
Original Assignee
Inflazome Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1713082.4A external-priority patent/GB201713082D0/en
Priority claimed from GBGB1718563.8A external-priority patent/GB201718563D0/en
Priority claimed from GBGB1721731.6A external-priority patent/GB201721731D0/en
Priority claimed from GBGB1721726.6A external-priority patent/GB201721726D0/en
Priority claimed from GBGB1810983.5A external-priority patent/GB201810983D0/en
Application filed by Inflazome Ltd filed Critical Inflazome Ltd
Publication of SG11202001166RA publication Critical patent/SG11202001166RA/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2018009840A (en) 2016-02-16 2019-01-21 Univ Queensland Sulfonylureas and related compounds and use of same.
TW201837021A (en) * 2017-01-23 2018-10-16 美商傑庫爾醫療股份有限公司 Chemical compounds as inhibitors of interleukin-1 activity
AU2017416068A1 (en) 2017-05-24 2019-10-31 The Provost, Fellows, Foundation Scholars, And Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Novel compounds and uses
US11370776B2 (en) * 2017-07-07 2022-06-28 Inflazome Limited Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors
TW201910314A (en) * 2017-08-15 2019-03-16 愛爾蘭商英弗雷佐姆有限公司 Novel compound
ES2944545T3 (en) 2017-08-15 2023-06-22 Agios Pharmaceuticals Inc Pyruvate kinase modulators and use thereof
WO2019034688A1 (en) * 2017-08-15 2019-02-21 Inflazome Limited Novel sulfonamide carboxamide compounds
CA3071150A1 (en) 2017-08-15 2019-02-21 Inflazome Limited Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors
EP3668842A1 (en) 2017-08-15 2020-06-24 Inflazome Limited Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors
WO2019034693A1 (en) 2017-08-15 2019-02-21 Inflazome Limited Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors
MX2020001778A (en) 2017-08-15 2020-03-24 Inflazome Ltd Novel sulfonamide carboxamide compounds.
US11518739B2 (en) 2017-08-15 2022-12-06 Inflazome Limited Sulfonamide carboxamide compounds
US11623922B2 (en) 2017-10-03 2023-04-11 Inflazome Limited Compounds
WO2019092171A1 (en) * 2017-11-09 2019-05-16 Inflazome Limited Novel sulfonamide carboxamide compounds
WO2019092170A1 (en) * 2017-11-09 2019-05-16 Inflazome Limited Novel sulfonamide carboxamide compounds
GB201721185D0 (en) 2017-12-18 2018-01-31 Nodthera Ltd Sulphonyl urea derivatives
EP3759102A1 (en) 2018-03-02 2021-01-06 Inflazome Limited Novel compounds
WO2019166629A1 (en) 2018-03-02 2019-09-06 Inflazome Limited Novel compounds
EP3759077A1 (en) 2018-03-02 2021-01-06 Inflazome Limited Novel compounds
EP3759103A1 (en) 2018-03-02 2021-01-06 Inflazome Limited Novel compounds
EP3759078A1 (en) 2018-03-02 2021-01-06 Inflazome Limited Novel compounds
SG11202010907VA (en) 2018-05-04 2020-12-30 Inflazome Ltd Novel compounds
WO2020010143A1 (en) 2018-07-03 2020-01-09 Novartis Inflammasome Research, Inc. Nlrp modulators
MX2021000660A (en) 2018-07-20 2021-03-25 Hoffmann La Roche Sulfonylurea compounds as inhibitors of interleukin-1 activity.
SG11202101480XA (en) 2018-08-15 2021-03-30 Inflazome Ltd Novel sulfonamideurea compounds
GB201902327D0 (en) 2019-02-20 2019-04-03 Inflazome Ltd Novel compounds
US20230011652A1 (en) 2018-10-24 2023-01-12 Novartis Ag Compounds and compositions for treating conditions associated with nlrp activity
GB201819083D0 (en) * 2018-11-23 2019-01-09 Inflazome Ltd Novel compounds
GB201905265D0 (en) 2019-04-12 2019-05-29 Inflazome Ltd Inflammasome inhibition
AR119731A1 (en) 2019-05-17 2022-01-05 Novartis Ag NLRP3 INFLAMASOME INHIBITORS
CN114641466A (en) 2019-06-12 2022-06-17 诺瑟拉有限公司 Sulfonylurea derivatives and use thereof
EP3986879A1 (en) 2019-06-21 2022-04-27 AC Immune SA Fused 1,2 thiazoles and 1,2 thiazines which act as nl3p3 modulators
KR20220066254A (en) * 2019-07-17 2022-05-24 조마젠 바이오사이언시즈 엘티디 NLRP3 modulators
WO2021032591A1 (en) 2019-08-16 2021-02-25 Inflazome Limited Macrocyclic sulfonylurea derivatives useful as nlrp3 inhibitors
US20220289692A1 (en) 2019-09-06 2022-09-15 Inflazome Limited Nlrp3 inhibitors
CN112851607A (en) * 2019-11-12 2021-05-28 成都百裕制药股份有限公司 Amide derivative, preparation method and medical application thereof
US20230399319A1 (en) * 2019-12-27 2023-12-14 Japan Tobacco Inc. Acylsulfamide Compound and Pharmaceutical Use Therefor
US11618751B1 (en) 2022-03-25 2023-04-04 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives
JP2023513935A (en) 2020-02-18 2023-04-04 インフレイゾーム リミテッド Compound
CN111217718B (en) * 2020-03-11 2023-06-16 安徽东健化工科技有限公司 Sulfur-free 2-bromo-4-fluoroacetanilide synthesis method
IL296488A (en) 2020-03-16 2022-11-01 Zomagen Biosciences Ltd Nlrp3 modulators
CN111362835B (en) * 2020-04-20 2022-08-30 苏州科晟通新材料科技有限公司 Carbodiimide compound with flame retardant and hydrolysis resistant functions and preparation method thereof
US11345681B1 (en) 2020-06-05 2022-05-31 Kinnate Biopharma Inc. Inhibitors of fibroblast growth factor receptor kinases
MX2022015495A (en) * 2020-06-08 2023-03-14 Halia Therapeutics Inc Inhibitors of nek7 kinase.
EP4166541A4 (en) * 2020-06-11 2024-09-04 Cisen Pharmaceutical Co Ltd Dimethylsulfoximine derivative
EP4168395A1 (en) 2020-06-19 2023-04-26 AC Immune SA Dihydrooxazole and thiourea or urea derivatives modulating the nlrp3 inflammasome pathway
CN112022862A (en) * 2020-08-21 2020-12-04 华东理工大学 New anti-aging application of sulfonylurea medicine
CN112137998A (en) * 2020-10-10 2020-12-29 上海交通大学医学院附属新华医院 Application of active ingredients in preparation of medicine for preventing and treating necrotizing enterocolitis
TW202231281A (en) * 2020-12-25 2022-08-16 大陸商上海拓界生物醫藥科技有限公司 A class of pyridazine containing compounds and medicinal uses thereof
CN117279903A (en) 2021-02-10 2023-12-22 杭州英创医药科技有限公司 Compounds as NLRP3 inhibitors
EP4408843A1 (en) * 2021-09-29 2024-08-07 Viva Star Biosciences (Suzhou) Co., Ltd. Novel substituted sulfonylurea compounds as inhibitors of interleukin-1 activity
TW202333678A (en) * 2021-12-22 2023-09-01 大陸商瑞石生物醫藥有限公司 A sulfonylurea compound
CN118541366A (en) 2021-12-22 2024-08-23 Ac免疫有限公司 Dihydrooxazole derivative compound
WO2024013395A1 (en) 2022-07-14 2024-01-18 Ac Immune Sa Pyrrolotriazine and imidazotriazine derivatives as modulators of the nlrp3 inflammasome pathway
WO2024023266A1 (en) 2022-07-28 2024-02-01 Ac Immune Sa Novel compounds

Family Cites Families (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB797474A (en) 1955-07-20 1958-07-02 Boehringer & Soehne Gmbh Sulphonylurea derivatives
NL129208C (en) 1965-07-14
BE754588A (en) 1969-08-07 1971-02-08 Hoechst Ag THIOPHENE-SULFONYL-UREES AND THE MEDICINAL PRODUCTS CONTAINING THESE SUBSTANCES
AU571869B2 (en) 1983-05-09 1988-04-28 E.I. Du Pont De Nemours And Company Pyridyl- and pyrimidyl- sulphonamides
EP0126711B1 (en) 1983-05-16 1989-08-02 Ciba-Geigy Ag Herbicidally active and plant growth regulating pyrimidine derivatives, their preparation and use
JPS6045573A (en) 1983-08-22 1985-03-12 Nissan Chem Ind Ltd Pyrazolesulfonylurea derivative, its preparation and selective herbicide containing said derivative
US4723991A (en) 1984-03-23 1988-02-09 E. I. Du Pont De Nemours And Company Lower alkyl 2-[[N-(3-cyano-pyridin-2-yl)aminocarbonyl]aminosulphonyl]benzoate derivatives having herbicidal activity
US4659369A (en) 1984-08-27 1987-04-21 E. I. Du Pont De Nemours And Company Herbicidal acetals and ketals
AU578307B2 (en) 1984-09-17 1988-10-20 E.I. Du Pont De Nemours And Company Herbicidal pyrazolesulfonamides
JPH0720958B2 (en) 1985-01-18 1995-03-08 日産化学工業株式会社 Pyrazol sulfonamide derivative, process and herbicide
FI855180A (en) 1985-01-18 1986-07-19 Nissan Chemical Ind Ltd PYRAZOLESULFONAMIDDERIVAT, FOERFARANDE FOER DESS FRAMSTAELLANDE OCH DET INNEHAOLLANDE OGRAESGIFT.
CA1231336A (en) 1985-05-30 1988-01-12 George Levitt Herbicidal sulfonamides
JPH0720957B2 (en) 1985-11-26 1995-03-08 日産化学工業株式会社 Pyrazole sulfonylurea derivative, process and herbicide
JP2570686B2 (en) 1985-12-23 1997-01-08 日産化学工業株式会社 Pyrazole derivatives
US4830660A (en) 1986-06-19 1989-05-16 Nissan Chemical Industries, Ltd. Imidazolesulfonamide derivatives and herbicides
DE3775686D1 (en) 1986-09-26 1992-02-13 Ciba Geigy Ag AMINOPYRAZINONE AND AMINOTRIAZINONE.
US4802908A (en) * 1987-01-22 1989-02-07 E. I. Du Pont De Nemours And Company Herbicidal 2-(1H)-pyrazinones
EP0511993A1 (en) 1990-01-22 1992-11-11 E.I. Du Pont De Nemours And Company Herbicidal sulfonylureas
ZA915371B (en) 1990-07-17 1993-03-31 Lilly Co Eli Antitumor compositions and methods of treatment
AU647830B2 (en) 1990-08-29 1994-03-31 E.I. Du Pont De Nemours And Company Herbicidal pyrrolesulfonylureas
DE4039733A1 (en) 1990-12-13 1992-06-17 Basf Ag SUBSTITUTED 5-AMINOPYRAZOLE
JPH06510762A (en) 1991-08-19 1994-12-01 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー Angiotensin 2 receptor blocking imidazolinone derivative
CZ36394A3 (en) 1991-08-19 1994-07-13 Du Pont Substituted imidazilonone derivatives and pharmaceutical preparations based thereon
US5169860A (en) 1992-03-13 1992-12-08 Eli Lilly And Company Antitumor compositions and methods of treatment
US5219856A (en) 1992-04-06 1993-06-15 E. I. Du Pont De Nemours And Company Angiotensin-II receptor blocking, heterocycle substituted imidazoles
JPH06199053A (en) 1992-12-28 1994-07-19 Sankyo Kagaku Kk Color element for heat transfer recording
JPH06199054A (en) 1992-12-28 1994-07-19 Dainippon Printing Co Ltd Heat transfer sheet
JPH06199047A (en) 1993-01-08 1994-07-19 New Oji Paper Co Ltd Heat-sensitive recording substance
AU7007696A (en) 1995-09-22 1997-04-09 E.I. Du Pont De Nemours And Company Arthropodicidal 1,4-dihydropyridines and 1,4-dihydropyrimidines
DE69622148T2 (en) 1995-09-28 2002-10-31 Suntory Limited, Osaka CHINAZOZINE DERIVATIVES AND THEIR USE
WO1997030978A1 (en) 1996-02-26 1997-08-28 Sumitomo Pharmaceuticals Company, Limited Sulfonylureidopyrazole derivatives
CZ293173B6 (en) 1997-01-29 2004-02-18 Pfizer Inc. Sulfonyl urea derivatives
EP1270565B1 (en) 1997-01-29 2004-06-30 Pfizer Inc. 4-Substituted furan-2-sulfonamide and its use in the preparation of sulfonyl urea derivatives
US6022984A (en) 1998-07-27 2000-02-08 Pfizer Inc. Efficient synthesis of furan sulfonamide compounds useful in the synthesis of new IL-1 inhibitors
JP2000053649A (en) 1998-08-11 2000-02-22 Sumitomo Pharmaceut Co Ltd Sulfonylureidopyrazole derivative
EP0987552A3 (en) 1998-08-31 2000-06-07 Pfizer Products Inc. Diarylsulfonylurea binding proteins
CA2368148A1 (en) 1999-03-15 2000-09-21 Axys Pharmaceuticals, Inc. Novel compounds and compositions as protease inhibitors
WO2001019390A1 (en) 1999-09-14 2001-03-22 Pfizer Products Inc. Combination treatment with il-1ra and diaryl sulphonyl urea compounds
DE60114994T2 (en) 2000-02-04 2006-08-03 Portola Pharmaceuticals, Inc., South San Francisco PLATELET ADP RECEPTOR INHIBITORS
US6906063B2 (en) 2000-02-04 2005-06-14 Portola Pharmaceuticals, Inc. Platelet ADP receptor inhibitors
GB0017676D0 (en) 2000-07-19 2000-09-06 Angeletti P Ist Richerche Bio Inhibitors of viral polymerase
CA2369967A1 (en) 2001-02-12 2002-08-12 Joseph Anthony Cornicelli Methods of treating nuclear factor-kappa b mediated diseases and disorders
AR039352A1 (en) 2001-05-18 2005-02-16 Solvay Pharm Gmbh USE OF A COMPOUND THAT HAS COMBINED INHIBITORY ACTIVITY AND CONCURRENT WITH NEUTRAL ENDOPEPTIDASE AND IGS5 METALOPROTEASE.
FI110677B (en) 2001-10-12 2003-03-14 Jujo Thermal Oy Heat-sensitive recording material for use in, e.g. stickers, has coating layer comprising chelate-type color forming system and leuco dye with urea-based developer
PT1441734E (en) 2001-10-26 2007-05-31 Isti Di Ric Di Bio Moleco P An Dihydroxypyrimidine carboxamide inhibitors of hiv integrase
AU2002341321A1 (en) 2001-11-30 2003-06-10 Pfizer Products Inc. Combination of an il-1/18 inhibitor with a tnf inhibitor for the treatment of inflammation
US7109354B2 (en) 2002-05-28 2006-09-19 3-Dimensional Pharmaceuticals, Inc. Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions
US20040092529A1 (en) 2002-10-30 2004-05-13 Pfizer Inc Methods of using piperazine derivatives
GB0319124D0 (en) 2003-08-14 2003-09-17 Smithkline Beecham Corp Chemical compounds
KR20060113699A (en) 2003-10-03 2006-11-02 포톨라 파마슈티컬스, 인코포레이티드 Substituted isoquinolinones
KR20060113700A (en) 2003-10-03 2006-11-02 포톨라 파마슈티컬스, 인코포레이티드 2,4-dioxo-3-quinazolinylaryl sulfonylureas
US7205296B2 (en) 2004-09-29 2007-04-17 Portola Pharmaceuticals, Inc. Substituted 2H-1,3-benzoxazin-4(3H)-ones
AR052900A1 (en) * 2005-02-11 2007-04-11 Astrazeneca Ab DERIVATIVES OF TIAZOL, A METHOD FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE IN THE PREPARATION OF MEDICINES FOR THE TREATMENT OF DISEASES MEDIATED BY ECE-1
TWI391378B (en) 2006-03-16 2013-04-01 Astellas Pharma Inc Quinolone derivative or pharmaceutically acceptable salt thereof
GB0701426D0 (en) 2007-01-25 2007-03-07 Univ Sheffield Compounds and their use
US8486987B2 (en) 2007-11-16 2013-07-16 University Of Medicine And Dentistry Of New Jersey Mechanism-based small-molecule parasite inhibitors
GB2474120B (en) 2009-10-01 2011-12-21 Amira Pharmaceuticals Inc Compounds as Lysophosphatidic acid receptor antagonists
MY183861A (en) 2010-03-05 2021-03-17 Kyowa Hakko Kirin Co Ltd Pyrazolopyrimidine derivative
KR20140075698A (en) * 2011-09-02 2014-06-19 교와 핫꼬 기린 가부시키가이샤 Chemokine receptor activity regulator
PL221813B1 (en) 2013-02-22 2016-05-31 Univ Medyczny W Lublinie Derivatives of 1-aryl-6-benzenesulfonylimidazo[1,2-a][1.3.5]triazine and their preparation
TW201501713A (en) 2013-03-01 2015-01-16 Kyowa Hakko Kirin Co Ltd Agent for preventing and/or treating ocular inflammatory disease
RS57179B1 (en) * 2013-11-05 2018-07-31 Novartis Ag Compositions and methods for modulating farnesoid x receptors
CN104513239B (en) 2014-12-10 2017-08-22 沈阳药科大学 The ketone compounds of pyrazolo [3,4 c] pyridine 7 and its application
TWI698430B (en) * 2015-02-13 2020-07-11 南北兄弟藥業投資有限公司 Tricyclic compounds and uses thereof in medicine
MA47440B1 (en) 2015-02-16 2021-08-31 The Provost Fellows Found Scholars And The Other Members Of Board Of The College Of The Holy & Undiv Sulfonylureas, Related Compounds, and Their Use
US10688077B2 (en) 2015-02-26 2020-06-23 H. Lee Moffitt Cancer Center And Research Institute, Inc. Inflammasome activation in myelodysplastic syndromes
ES2954596T3 (en) 2015-12-23 2023-11-23 Univ British Columbia Lipid-bound prodrugs
FR3046933B1 (en) 2016-01-25 2018-03-02 Galderma Research & Development NLRP3 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY SKIN CONDITIONS
MX2018009840A (en) * 2016-02-16 2019-01-21 Univ Queensland Sulfonylureas and related compounds and use of same.
WO2017184623A1 (en) 2016-04-18 2017-10-26 Ifm Therapeutics, Inc Compounds and compositions for treating conditions associated with nlrp activity
ES2940611T3 (en) 2016-04-18 2023-05-09 Novartis Ag Compounds and compositions for the treatment of conditions associated with NLRP activity
US10080741B2 (en) 2016-04-26 2018-09-25 Enanta Pharmaceuticals, Inc. Isoxazole derivatives as FXR agonists and methods of use thereof
EP3272739A1 (en) 2016-07-20 2018-01-24 NodThera Limited Sulfonyl urea derivatives and their use in the control of interleukin-1 activity
TW201837021A (en) 2017-01-23 2018-10-16 美商傑庫爾醫療股份有限公司 Chemical compounds as inhibitors of interleukin-1 activity
TWI674261B (en) 2017-02-17 2019-10-11 美商英能腫瘤免疫股份有限公司 Nlrp3 modulators
AU2017416068A1 (en) 2017-05-24 2019-10-31 The Provost, Fellows, Foundation Scholars, And Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Novel compounds and uses
WO2018225018A1 (en) 2017-06-09 2018-12-13 Cadila Healthcare Limited Novel substituted sulfoximine compounds
JP7235742B2 (en) 2017-07-07 2023-03-08 インフレイゾーム リミテッド Novel sulfonamide carboxamide compound
US11370776B2 (en) 2017-07-07 2022-06-28 Inflazome Limited Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors
CN117143042A (en) 2017-07-24 2023-12-01 诺华股份有限公司 Compounds and compositions for treating disorders associated with NLRP activity
ES2949404T3 (en) 2017-07-24 2023-09-28 Novartis Ag Compounds and compositions for the treatment of conditions associated with NLRP activity
WO2019034693A1 (en) 2017-08-15 2019-02-21 Inflazome Limited Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors
EP3668842A1 (en) 2017-08-15 2020-06-24 Inflazome Limited Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors
TW201910314A (en) * 2017-08-15 2019-03-16 愛爾蘭商英弗雷佐姆有限公司 Novel compound
US11518739B2 (en) 2017-08-15 2022-12-06 Inflazome Limited Sulfonamide carboxamide compounds
CA3071150A1 (en) 2017-08-15 2019-02-21 Inflazome Limited Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors
MX2020001778A (en) 2017-08-15 2020-03-24 Inflazome Ltd Novel sulfonamide carboxamide compounds.
WO2019034688A1 (en) 2017-08-15 2019-02-21 Inflazome Limited Novel sulfonamide carboxamide compounds
WO2019043610A1 (en) 2017-08-31 2019-03-07 Cadila Healthcare Limited Novel substituted sulfonylurea derivatives
US11623922B2 (en) 2017-10-03 2023-04-11 Inflazome Limited Compounds
EP3697758B1 (en) 2017-10-17 2022-07-06 Novartis AG Sulphonamides and compositions thereof for treating conditions associated with nlrp activity
WO2019092171A1 (en) 2017-11-09 2019-05-16 Inflazome Limited Novel sulfonamide carboxamide compounds
WO2019092172A1 (en) 2017-11-09 2019-05-16 Inflazome Limited Novel sulfonamide carboxamide compounds
WO2019092170A1 (en) 2017-11-09 2019-05-16 Inflazome Limited Novel sulfonamide carboxamide compounds
CN110151749B (en) 2018-02-13 2022-04-19 中国科学技术大学 Application of oridonin in preparing medicine for preventing or treating NLRP3 inflammation body related diseases
GB201803393D0 (en) 2018-03-02 2018-04-18 Inflazome Ltd Novel compounds
US20200399242A1 (en) 2018-03-02 2020-12-24 Inflazome Limited Novel compounds
EP3759078A1 (en) 2018-03-02 2021-01-06 Inflazome Limited Novel compounds
EP3759102A1 (en) 2018-03-02 2021-01-06 Inflazome Limited Novel compounds
WO2019166629A1 (en) 2018-03-02 2019-09-06 Inflazome Limited Novel compounds
GB201803394D0 (en) 2018-03-02 2018-04-18 Inflazome Ltd Novel compounds
EP3759077A1 (en) 2018-03-02 2021-01-06 Inflazome Limited Novel compounds
EP3759103A1 (en) 2018-03-02 2021-01-06 Inflazome Limited Novel compounds
WO2019166633A1 (en) 2018-03-02 2019-09-06 Inflazome Limited Sulfonamide derivates as nlrp3 inhibitors
GB201806578D0 (en) 2018-04-23 2018-06-06 Inflazome Ltd Novel compound
SG11202010907VA (en) 2018-05-04 2020-12-30 Inflazome Ltd Novel compounds
WO2020010143A1 (en) 2018-07-03 2020-01-09 Novartis Inflammasome Research, Inc. Nlrp modulators
JP2021529780A (en) 2018-07-03 2021-11-04 ノバルティス アーゲー Methods of Treatment or Selection of Treatment for Subjects Resistant to TNF Inhibitors Using NLRP3 Antagonists
MX2021000660A (en) 2018-07-20 2021-03-25 Hoffmann La Roche Sulfonylurea compounds as inhibitors of interleukin-1 activity.
GB201902327D0 (en) 2019-02-20 2019-04-03 Inflazome Ltd Novel compounds
SG11202101480XA (en) 2018-08-15 2021-03-30 Inflazome Ltd Novel sulfonamideurea compounds
GB201817038D0 (en) 2018-10-19 2018-12-05 Inflazome Ltd Novel processes
US20230011652A1 (en) 2018-10-24 2023-01-12 Novartis Ag Compounds and compositions for treating conditions associated with nlrp activity
AU2019379109B2 (en) 2018-11-13 2022-07-07 Novartis Ag Compounds and compositions for treating conditions associated with NLRP activity
GB201819083D0 (en) 2018-11-23 2019-01-09 Inflazome Ltd Novel compounds
CN109432078B (en) 2018-12-04 2020-09-01 南华大学 Application of compound in preparation of medicine for preventing or treating cognitive disorder caused by ionizing radiation
GB201905265D0 (en) 2019-04-12 2019-05-29 Inflazome Ltd Inflammasome inhibition
US20220389031A1 (en) 2019-08-16 2022-12-08 Inflazome Limited Macrocyclic sulfonylamide derivatives useful as nlrp3 inhibitors
WO2021032591A1 (en) 2019-08-16 2021-02-25 Inflazome Limited Macrocyclic sulfonylurea derivatives useful as nlrp3 inhibitors
US20220289692A1 (en) 2019-09-06 2022-09-15 Inflazome Limited Nlrp3 inhibitors
JP2023513935A (en) 2020-02-18 2023-04-04 インフレイゾーム リミテッド Compound

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