MX2009006920A - Indoles. - Google Patents

Indoles.

Info

Publication number
MX2009006920A
MX2009006920A MX2009006920A MX2009006920A MX2009006920A MX 2009006920 A MX2009006920 A MX 2009006920A MX 2009006920 A MX2009006920 A MX 2009006920A MX 2009006920 A MX2009006920 A MX 2009006920A MX 2009006920 A MX2009006920 A MX 2009006920A
Authority
MX
Mexico
Prior art keywords
present
concerned
compounds
indoles
benzopyrrolone
Prior art date
Application number
MX2009006920A
Other languages
English (en)
Inventor
Mark Rogers-Evans
Raffaello Masciadri
Patrick Schnider
Hasane Ratni
Caterina Bissantz
Christophe Grundschober
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009006920A publication Critical patent/MX2009006920A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

La presente invención se refiere a nuevos derivados de indol-3-il-carbonil-piperidina-benzopirrolona, -benzoxazolona y -benzotriazol como antagonistas del receptor de V1a, a su obtención, a composiciones farmacéuticas que los contienen y a su utilización como medicamentos. Los compuestos activos de presente invención son útiles para la prevención y/o el tratamiento de ansiedad, trastornos depresivos y otras enfermedades. En particular, la presente invención se refiere a compuestos de fórmula general (I) (ver fórmula (I)) en donde X, Y y de R1 a R'° tienen los significados definidos en la descripción.
MX2009006920A 2006-12-28 2007-12-19 Indoles. MX2009006920A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06127307 2006-12-28
PCT/EP2007/064176 WO2008080842A1 (en) 2006-12-28 2007-12-19 Indoles

Publications (1)

Publication Number Publication Date
MX2009006920A true MX2009006920A (es) 2009-07-06

Family

ID=39198190

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006920A MX2009006920A (es) 2006-12-28 2007-12-19 Indoles.

Country Status (18)

Country Link
US (3) US20080167344A1 (es)
EP (1) EP2125785B1 (es)
JP (1) JP2010514726A (es)
KR (1) KR101134255B1 (es)
CN (1) CN101583609A (es)
AR (1) AR064546A1 (es)
AT (1) ATE533760T1 (es)
AU (1) AU2007341377B2 (es)
BR (1) BRPI0720968A2 (es)
CA (1) CA2674133A1 (es)
CL (1) CL2007003831A1 (es)
ES (1) ES2375520T3 (es)
MX (1) MX2009006920A (es)
NO (1) NO20092356L (es)
PE (1) PE20081401A1 (es)
RU (1) RU2009124111A (es)
TW (1) TWI345468B (es)
WO (1) WO2008080842A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010093578A1 (en) * 2009-02-10 2010-08-19 Glaxo Group Limited Indolinyl-, benzofuranyl-, and benzothienyl- amides as modulators of chemokine receptors
AU2016348493B2 (en) * 2015-11-06 2021-02-25 F. Hoffmann-La Roche Ag Indolin-2-one derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686624A (en) * 1992-01-30 1997-11-11 Sanofi 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
DE69430483D1 (de) * 1993-07-16 2002-05-29 Merck & Co Inc Benzoxazinon- und Benzopyrimidinon- piperidinyl-Verbindungen als tokolytische Oxytocin-Rezeptor-Antagonisten
JPH0920779A (ja) * 1995-05-01 1997-01-21 Japan Tobacco Inc 縮合ヘテロ５員環アゼピン化合物類及びその医薬用途
JP2008539220A (ja) * 2005-04-26 2008-11-13 ファイザー・リミテッド バソプレシンアンタゴニストとしてのトリアゾール誘導体
ES2314941T3 (es) 2005-07-21 2009-03-16 F. Hoffmann-La Roche Ag Derivados indol-3-il-carbonil-piperidin-benzoimidazol como antagonistas del receptor via.
EP1917255A2 (en) 2005-07-29 2008-05-07 F. Hoffmann-Roche AG Indol-3-yl-carbonyl-piperidin and piperazin derivatives
US20080139617A1 (en) * 2006-12-08 2008-06-12 Caterina Bissantz Indoles

Also Published As

Publication number Publication date
EP2125785B1 (en) 2011-11-16
BRPI0720968A2 (pt) 2014-03-11
JP2010514726A (ja) 2010-05-06
NO20092356L (no) 2009-06-30
US20080167344A1 (en) 2008-07-10
CA2674133A1 (en) 2008-07-10
EP2125785A1 (en) 2009-12-02
RU2009124111A (ru) 2011-02-10
WO2008080842A1 (en) 2008-07-10
KR20090094395A (ko) 2009-09-04
ES2375520T3 (es) 2012-03-01
TW200835491A (en) 2008-09-01
AU2007341377B2 (en) 2012-03-22
US20080161315A1 (en) 2008-07-03
CN101583609A (zh) 2009-11-18
PE20081401A1 (es) 2008-10-24
KR101134255B1 (ko) 2012-04-12
ATE533760T1 (de) 2011-12-15
TWI345468B (en) 2011-07-21
US20080161316A1 (en) 2008-07-03
AU2007341377A1 (en) 2008-07-10
CL2007003831A1 (es) 2008-07-11
AR064546A1 (es) 2009-04-08
US8143281B2 (en) 2012-03-27

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