ATE453638T1 - Amidinderivate von 2-heteroarylchinazolinen und chinolinen; wirksame analgetika und entzündungshemmende mittel - Google Patents

Amidinderivate von 2-heteroarylchinazolinen und chinolinen; wirksame analgetika und entzündungshemmende mittel

Info

Publication number
ATE453638T1
ATE453638T1 AT06778076T AT06778076T ATE453638T1 AT E453638 T1 ATE453638 T1 AT E453638T1 AT 06778076 T AT06778076 T AT 06778076T AT 06778076 T AT06778076 T AT 06778076T AT E453638 T1 ATE453638 T1 AT E453638T1
Authority
AT
Austria
Prior art keywords
compounds
quinolines
inflammatory
treatment
derivatives
Prior art date
Application number
AT06778076T
Other languages
English (en)
Inventor
Antonio Giordani
Stefano Mandelli
Simona Zanzola
Francesca Tarchino
Gianfranco Caselli
Teresa Simonetta Fiorentino
Silvio Mazzari
Francesco Makovec
Lucio Claudio Rovati
Original Assignee
Rottapharm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rottapharm Spa filed Critical Rottapharm Spa
Application granted granted Critical
Publication of ATE453638T1 publication Critical patent/ATE453638T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
AT06778076T 2006-07-31 2006-07-31 Amidinderivate von 2-heteroarylchinazolinen und chinolinen; wirksame analgetika und entzündungshemmende mittel ATE453638T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2006/064841 WO2008014815A1 (en) 2006-07-31 2006-07-31 Amidine derivatives of 2-heteroaryl-quinazolines and quinolines; potent analgesics and anti-inflammatory agents

Publications (1)

Publication Number Publication Date
ATE453638T1 true ATE453638T1 (de) 2010-01-15

Family

ID=37075652

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06778076T ATE453638T1 (de) 2006-07-31 2006-07-31 Amidinderivate von 2-heteroarylchinazolinen und chinolinen; wirksame analgetika und entzündungshemmende mittel

Country Status (11)

Country Link
US (1) US7968558B2 (de)
EP (1) EP2057148B1 (de)
JP (1) JP4997289B2 (de)
AT (1) ATE453638T1 (de)
CA (1) CA2659689C (de)
DE (1) DE602006011515D1 (de)
DK (1) DK2057148T3 (de)
ES (1) ES2338458T3 (de)
PL (1) PL2057148T3 (de)
PT (1) PT2057148E (de)
WO (1) WO2008014815A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103153062B (zh) * 2010-05-24 2015-07-15 因特利凯有限责任公司 杂环化合物及其用途
JP5808826B2 (ja) 2011-02-23 2015-11-10 インテリカイン， エルエルシー 複素環化合物およびその使用
CN102993109A (zh) * 2012-12-03 2013-03-27 浙江工业大学 一种脒化合物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0004054D0 (sv) * 2000-11-06 2000-11-06 Astrazeneca Ab N-type calcium channel antagonists for the treatment of pain
ITTO20040125A1 (it) 2004-03-01 2004-06-01 Rotta Research Lab Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica
US20060128702A1 (en) * 2004-11-23 2006-06-15 Manojit Pal Heterocyclic and bicyclic compounds, compositions and methods

Also Published As

Publication number Publication date
CA2659689C (en) 2014-02-18
JP4997289B2 (ja) 2012-08-08
JP2009545538A (ja) 2009-12-24
EP2057148B1 (de) 2009-12-30
WO2008014815A1 (en) 2008-02-07
ES2338458T3 (es) 2010-05-07
PT2057148E (pt) 2010-03-01
DK2057148T3 (da) 2010-04-26
US7968558B2 (en) 2011-06-28
PL2057148T3 (pl) 2010-06-30
US20090227609A1 (en) 2009-09-10
EP2057148A1 (de) 2009-05-13
DE602006011515D1 (de) 2010-02-11
CA2659689A1 (en) 2008-02-07

Similar Documents

Publication Publication Date Title
ATE440834T1 (de) Substituierte arylaminderivate und verwendungsverfahren
ATE404552T1 (de) Substituierte isochinolinderivate und anwendungsverfahren
NO20063928L (no) Substituerte kinolinforbindelser
NO20074592L (no) Acetylenyl-pyrazolo-pyrimidinderivater som mGluR2-antagonister
EA017278B9 (ru) Соединения азаиндазола и способы применения
UY30183A1 (es) Derivados de quinolina
MY146662A (en) Novel n-(8-heteroaryltetrahydronaphtalene-2yl) or n-(5-heteroarylchromane-3-yl) carboxamide derivatives for the treatment of pain
ATE517882T1 (de) Chinolinderivate
TW200716596A (en) Substituted amide derivatives and methods of use
EA201101243A1 (ru) 3h-имидазо[4,5-c]пиридин-6-карбоксамиды в качестве противовоспалительных средств
NO20083427L (no) Cystoksiske midler omfattende nye tomaymycinderivater og deres terapeutiske anvendelse
NO20044731L (no) Kinolin- og isokinolinderivater fremgangsmate for fremstilling derav og anvendelse derav som betennelseshemmere
MX2010005861A (es) Agonistas novedosos de los receptores de glucocorticoides.
ATE453636T1 (de) Substituierte 2,3-dihydro-1h-isoindol-1-one derivate und anwendungsverfahren
PT1902037E (pt) 2,4-diamino-pirimidinas como inibidores de aurora
IS8175A (is) Píperasín afleiður og aðferðir við notkun þeirra
EA200870302A1 (ru) 1,3-диоксанкарбоновые кислоты
BR112014006763A2 (pt) n-(3-(2-amino-6,6-difluoro-4,4a,5,6,7,7a-hexa-hidro-ciclopenta[e][1,3]oxazin-4-il)-fenil)-amidas como inibidores de bace1
NO20082112L (no) 3-Amino-2-arylpropylazaindoler og deres anvendelse
SE0403171D0 (sv) New compounds
DE602006009556D1 (de) Chinolin-derivate zur behandlung von mglur5-rezeptor-vermittelten erkrankungen
TW200833697A (en) Spiro-piperidine derivatives
ATE495159T1 (de) Diaminocyclohexan- und diaminocyclopentanderivate
ATE407126T1 (de) Herstellung von (s)-4-fluormethyl-dihydro-furan-2-on
NO20055997L (no) Diarylmetylidenpiperidinderivater og deres anvendelse som opiodreseptoragonister

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 2057148

Country of ref document: EP